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ONTOLOGY REPORT - ANNOTATIONS

Term:estrogen biosynthetic process
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Accession:GO:0006703 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
Synonyms:exact_synonym: estrogen anabolism;   estrogen biosynthesis;   estrogen formation;   estrogen synthesis;   oestrogen biosynthesis;   oestrogen biosynthetic process
 xref: Reactome:R-HSA-193144 "Estrogen biosynthesis"


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estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 involved_in IDA
IEA 		estrone
GO_REF:0000107 		Ensembl
RGD		 PMID:19665544 GO_REF:0000107, RGD:4891164 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 involved_in IDA
ISO
IEA
IBA 		estradiol
(PMID:8994190)
GO_REF:0000041
GO_REF:0000033
GO_REF:0000002
GO_REF:0000107
GO_REF:0000117
(PMID:9658408) 		RGD
UniProt
GO_Central
InterPro
Ensembl		 PMID:8994190 PMID:9658408 PMID:8612487 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000117, RGD:728619 NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210 		JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 involved_in IEA GO_REF:0000041
GO_REF:0000107 		UniProt
Ensembl		 GO_REF:0000041 GO_REF:0000107 NCBI chr 3:100,445,393...100,568,898
Ensembl chr 3:100,445,400...100,568,938 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 involved_in IDA
IEA
ISO 		estrone
GO_REF:0000107
(PMID:11940569) 		Ensembl
RGD		 PMID:11940569 PMID:8612487 GO_REF:0000107, RGD:728619 NCBI chr19:62,662,320...62,733,944
Ensembl chr19:62,662,098...62,733,943 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 involved_in IDA
IEA
ISO 		PMID:9658408
GO_REF:0000041
GO_REF:0000107
(PMID:12732193)
GO_REF:0000117
(PMID:12732193), (PMID:9658408) 		UniProt
Ensembl
RGD		 PMID:9658408 PMID:12732193 PMID:9658408 GO_REF:0000041 GO_REF:0000107 GO_REF:0000117, RGD:30309934 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754 		JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 involved_in IEA
IBA
ISO
ISS 		GO_REF:0000041
GO_REF:0000033
(PMID:17978863)
GO_REF:0000024 		UniProt
GO_Central
RGD		 PMID:17978863 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 NCBI chr20:4,828,571...4,830,635
Ensembl chr20:4,828,608...4,830,634 		JBrowse link
G Rdh8 retinol dehydrogenase 8 involved_in IEA GO_REF:0000002
GO_REF:0000117 		InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr 8:27,629,380...27,636,651
Ensembl chr 8:27,629,380...27,636,651 		JBrowse link
G Star steroidogenic acute regulatory protein IMP estradiol; positive regulation RGD PMID:16579833 RGD:1600078 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447 		JBrowse link
negative regulation of estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin involved_in ISO (PMID:24530842) RGD PMID:24530842 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19688
    cellular process 18845
      metabolic process 11694
        hormone metabolic process 277
          hormone biosynthetic process 71
            estrogen biosynthetic process 9
              negative regulation of estrogen biosynthetic process 1
              positive regulation of estrogen biosynthetic process 0
              regulation of estrogen biosynthetic process + 1
Path 2
Term Annotations click to browse term
  biological_process 19688
    cellular process 18845
      metabolic process 11694
        primary metabolic process 10271
          lipid metabolic process 1494
            lipid biosynthetic process 743
              steroid biosynthetic process 196
                steroid hormone biosynthetic process 49
                  estrogen biosynthetic process 9
                    negative regulation of estrogen biosynthetic process 1
                    positive regulation of estrogen biosynthetic process 0
                    regulation of estrogen biosynthetic process + 1
paths to the root