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Gene: Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) Rattus norvegicus

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Symbol:

Hgs

Name:

hepatocyte growth factor-regulated tyrosine kinase substrate

RGD ID:

69225

Description:

Predicted to enable several functions, including ubiquitin binding activity; ubiquitin-like protein ligase binding activity; and ubiquitin-modified protein reader activity. Involved in endosome to lysosome transport. Located in secretory granule. Orthologous to human HGS (hepatocyte growth factor-regulated tyrosine kinase substrate); PARTICIPATES IN autophagy pathway; vascular endothelial growth factor signaling pathway; endocytosis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

HGF-regulated tyrosine kinase substrate; Hrs; SNAP-25-interacting protein Hrs-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,237,988 - 106,256,174 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	106,237,824 - 106,256,174 (+)	Ensembl				GRCr8
mRatBN7.2	10	105,739,617 - 105,757,838 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,739,296 - 105,757,835 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	110,844,188 - 110,862,000 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,307,219 - 110,325,031 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,660,239 - 105,678,295 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,638,944 - 109,657,460 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,638,767 - 109,657,456 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	109,232,509 - 109,250,728 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	109,861,289 - 109,869,587 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	104,283,857 - 104,301,769 (+)	NCBI		Celera
RGSC_v3.1	10	109,875,792 - 109,883,652 (+)	NCBI
Cytogenetic Map	10	q32.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

actinomycin D (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

butan-1-ol (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbonyl sulfide (EXP)

cobalt dichloride (EXP,ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

ethanol (EXP)

fenthion (ISO)

flavonoids (EXP)

flutamide (EXP)

fulvestrant (ISO)

furfural (ISO)

gentamycin (EXP)

indometacin (EXP)

ivermectin (ISO)

linsidomine (EXP)

lipopolysaccharide (ISO)

methidathion (ISO)

methotrexate (ISO)

nefazodone (EXP)

Nutlin-3 (ISO)

ozone (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

perfluorooctanoic acid (EXP)

quercetin (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

tacrolimus hydrate (ISO)

tetrachloromethane (EXP)

thapsigargin (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endocytic recycling (IBA)

endosome to lysosome transport (IMP)

membrane invagination (IEA,ISO)

negative regulation of angiogenesis (IEA,ISO)

negative regulation of platelet-derived growth factor receptor signaling pathway (IEA,ISO)

negative regulation of receptor signaling pathway via JAK-STAT (IEA,ISO)

negative regulation of vascular endothelial growth factor receptor signaling pathway (IEA,ISO)

positive regulation of exosomal secretion (IEA,ISO)

positive regulation of gene expression (IEA,ISO)

protein localization to membrane (IEA,ISO)

protein targeting to lysosome (IEA,ISO)

protein transport (IEA)

receptor internalization (IBA)

regulation of MAP kinase activity (ISO)

Cellular Component

cytoplasm (IEA,ISO)

early endosome (IBA,IEA,ISO)

early endosome membrane (IEA)

endosome (IEA,ISO)

ESCRT-0 complex (IEA,ISO)

lysosome (IEA,ISO)

multivesicular body membrane (IEA)

secretory granule (IDA)

Molecular Function

identical protein binding (ISO)

metal ion binding (IEA)

phosphatidylinositol binding (IEA)

protein binding (IPI,ISO)

protein domain specific binding (IEA,ISO,NAS)

ubiquitin binding (IBA,IEA)

ubiquitin-like protein ligase binding (IEA,ISO)

ubiquitin-modified protein reader activity (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

autophagy pathway (ISO)

endocytosis pathway (IEA)

phagocytosis pathway (IEA)

vascular endothelial growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15.	Bean AJ, etal., J Biol Chem. 2000 May 19;275(20):15271-8.
2.	Hrs-2 is an ATPase implicated in calcium-regulated secretion.	Bean AJ, etal., Nature 1997 Feb 27;385(6619):826-9.
3.	Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor.	Chin LS, etal., J Biol Chem 2001 Mar 9;276(10):7069-78.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis.	Kwong J, etal., J Cell Sci 2000 Jun;113 ( Pt 12):2273-84.
7.	Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.	Leithe E, etal., J Cell Sci. 2009 Nov 1;122(Pt 21):3883-93. Epub 2009 Oct 6.
8.	Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking.	Li Y, etal., J Biol Chem 2002 Aug 2;277(31):28212-21.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	How do ESCRT proteins control autophagy?	Rusten TE and Stenmark H, J Cell Sci. 2009 Jul 1;122(Pt 13):2179-83.
14.	Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin.	Stephens DJ and Banting G, J Biol Chem. 1999 Oct 15;274(42):30080-6.
15.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:7565774	PMID:9798906	PMID:10510169	PMID:10861283	PMID:11916981	PMID:11984006	PMID:12444102	PMID:12477932	PMID:12847087	PMID:15489334	PMID:15611048	PMID:16083858
PMID:16615908	PMID:17062640	PMID:17714434	PMID:18767904	PMID:18977327	PMID:19056867	PMID:19351881	PMID:20675381	PMID:22871113	PMID:24105262	PMID:24790097

Genomics

Comparative Map Data

Hgs
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,237,988 - 106,256,174 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	10	106,237,824 - 106,256,174 (+)	Ensembl				GRCr8
mRatBN7.2	10	105,739,617 - 105,757,838 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,739,296 - 105,757,835 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	10	110,844,188 - 110,862,000 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,307,219 - 110,325,031 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,660,239 - 105,678,295 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,638,944 - 109,657,460 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,638,767 - 109,657,456 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	10	109,232,509 - 109,250,728 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	10	109,861,289 - 109,869,587 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	10	104,283,857 - 104,301,769 (+)	NCBI		Celera
RGSC_v3.1	10	109,875,792 - 109,883,652 (+)	NCBI
Cytogenetic Map	10	q32.3	NCBI

HGS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	81,684,011 - 81,702,121 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	81,683,326 - 81,703,138 (+)	Ensembl			hg38	GRCh38
GRCh37	17	79,651,041 - 79,669,151 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,261,425 - 77,279,553 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	17	77,261,424 - 77,279,550	NCBI
Celera	17	76,295,942 - 76,314,294 (+)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,097,132 - 75,115,050 (+)	NCBI		HuRef
CHM1_1	17	79,737,183 - 79,755,370 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,600,905 - 82,619,025 (+)	NCBI		T2T-CHM13v2.0

Hgs
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,358,431 - 120,374,810 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,358,461 - 120,374,805 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	11	120,467,605 - 120,483,984 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,467,635 - 120,483,979 (+)	Ensembl			mm10	GRCm38
MGSCv37	11	120,328,949 - 120,345,298 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,283,781 - 120,300,069 (+)	NCBI		MGSCv36	mm8
Celera	11	132,203,066 - 132,219,316 (+)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	84.16	NCBI

Hgs
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	1,405,543 - 1,418,095 (-)	Ensembl
ChiLan1.0	NW_004955506	1,405,543 - 1,418,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

HGS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,273,839 - 98,292,160 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,174,297 - 103,192,557 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,143,212 - 76,161,469 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	81,844,379 - 81,862,335 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	81,844,379 - 81,862,335 (+)	Ensembl			panPan2	panpan1.1

HGS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	499,071 - 513,375 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	499,116 - 514,308 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	1,101,298 - 1,115,455 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	1,092,550 - 1,106,872 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	1,092,550 - 1,107,809 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	1,117,545 - 1,131,697 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,244,142 - 1,258,290 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,323,173 - 1,337,298 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Hgs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	1,110,692 - 1,126,331 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,285,551 - 5,301,233 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	5,285,678 - 5,301,267 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HGS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	1,207,036 - 1,219,715 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	12	1,207,036 - 1,219,750 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

HGS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,613,711 - 73,632,527 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,613,786 - 73,632,016 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666077	45,022,394 - 45,041,222 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hgs
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,620,753 - 10,634,341 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624801	10,620,717 - 10,634,670 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Hgs
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	9	63,540,680 - 63,558,463 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Hgs
90 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	327
Count of miRNA genes:	195
Interacting mature miRNAs:	225
Transcripts:	ENSRNOT00000054966
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	65390777	107713808	Rat
1354641	Bvd2	Brain ventricular dilatation QTL 2	6.36	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	10	93723381	107556066	Rat
8657410	Bp374	Blood pressure QTL 374			heart left ventricle size trait (VT:0002753)	heart left ventricle end-diastolic diameter (CMO:0000982)	10	67476608	107713808	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63719161	107713808	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
12903252	Cm113	Cardiac mass QTL 113		0.047	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68920187	107713808	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	64939013	107713808	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	65307813	107713808	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76951790	107713808	Rat
70168	Eae12	Experimental allergic encephalomyelitis QTL 12		0.0009	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	73599825	107713808	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	89039175	107713808	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61843496	106843496	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70698731	107713808	Rat
12903269	Am15	Aortic mass QTL 15		0.042	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
1576313	Pia25	Pristane induced arthritis QTL 25			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96620293	107713808	Rat
12903266	Cm114	Cardiac mass QTL 114		0.02	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	66817119	107713808	Rat
1578672	Bmd16	Bone mineral density QTL 16	6.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	97202388	107556066	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
1576307	Cia28	Collagen induced arthritis QTL 28			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96620293	107713808	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62556066	107556066	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	66108888	107555881	Rat
12880372	Am12	Aortic mass QTL 12		0.003	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	66817119	107713808	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62556066	107556066	Rat
12880375	Kidm66	Kidney mass QTL 66		0.009	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87807758	107713808	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
12880370	Cm105	Cardiac mass QTL 105		0.008	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
12880371	Cm106	Cardiac mass QTL 106		0.007	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	66817119	107713808	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72724423	107713808	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	76128947	107713808	Rat
1300137	Bp186	Blood pressure QTL 186	3.57		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	10	91127270	107556066	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	61997479	106997479	Rat
61436	Cia5	Collagen induced arthritis QTL 5	4.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	91727883	107713808	Rat
11565453	Kidm58	Kidney mass QTL 58		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	66817119	107713808	Rat
2301405	Cm69	Cardiac mass QTL 69		0.031	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	10	66817119	107713808	Rat
1578663	Bss18	Bone structure and strength QTL 18	3.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	10	97202388	107556066	Rat

Markers in Region

RH138117

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	105,737,931 - 105,738,095 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	109,637,247 - 109,637,410	NCBI	Rnor6.0
Rnor_5.0	10	109,230,811 - 109,230,974	UniSTS	Rnor5.0
Celera	10	104,281,966 - 104,282,129	UniSTS
Cytogenetic Map	10	q32.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	356	192	11	143	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001399620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_019387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039086712	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB002811	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF036344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U87863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000054966 ⟹ ENSRNOP00000051849

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,237,824 - 106,256,167 (+)	Ensembl
mRatBN7.2 Ensembl	10	105,739,296 - 105,757,835 (+)	Ensembl
Rnor_6.0 Ensembl	10	109,638,767 - 109,657,456 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110912 ⟹ ENSRNOP00000087685

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,239,061 - 106,256,174 (+)	Ensembl
mRatBN7.2 Ensembl	10	105,740,724 - 105,757,400 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000135875 ⟹ ENSRNOP00000102539

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,238,203 - 106,256,174 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000168248 ⟹ ENSRNOP00000103548

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,238,137 - 106,256,167 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000172328 ⟹ ENSRNOP00000108384

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	10	106,238,125 - 106,256,167 (+)	Ensembl

RefSeq Acc Id:

NM_001399619 ⟹ NP_001386548

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,238,118 - 106,256,174 (+)	NCBI
mRatBN7.2	10	105,739,781 - 105,757,838 (+)	NCBI

RefSeq Acc Id:

NM_001399620 ⟹ NP_001386549

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,238,118 - 106,256,174 (+)	NCBI
mRatBN7.2	10	105,739,781 - 105,757,838 (+)	NCBI

RefSeq Acc Id:

NM_019387 ⟹ NP_062260

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,238,118 - 106,256,174 (+)	NCBI
mRatBN7.2	10	105,739,781 - 105,757,838 (+)	NCBI
Rnor_6.0	10	109,639,138 - 109,657,459 (+)	NCBI
Rnor_5.0	10	109,232,509 - 109,250,728 (+)	NCBI
RGSC_v3.4	10	109,861,289 - 109,869,587 (+)	RGD
Celera	10	104,283,857 - 104,301,769 (+)	RGD

Sequence:

show sequence

GGAGTGGGGTCGCCATGGGGCGAGGCAGCGGCACCTTCGAGCGTCTCCTAGACAAAGCCACCAG
CCAGCTTCTATTGGAGACAGACTGGGAGTCCATTCTACAGATCTGCGACCTGATCCGTCAGGGG
GACACACAAGCAAAATATGCTGTAAACTCCATCAAGAAGAAGGTCAATGATAAGAACCCACATG
TGGCTTTGTATGCTCTGGAGGTGATGGAGTCTGTGGTAAAGAACTGTGGCCAGACAGTCCATGA
TGAAGTGGCCAACAAACAGACCATGGAAGAACTGAAGGAGCTGCTGAAGAGGCAAGTGGAAGTT
AATGTTCGGAACAAGATCTTGTACCTGATCCAGGCCTGGGCACATGCGTTCCGGAATGAACCCA
AGTACAAGGTGGTCCAGGACACATACCAGATCATGAAGGTAGAAGGACATGTCTTCCCTGAGTT
TAAGGAGAGCGACGCCATGTTTGCTGCTGAAAGAGCCCCTGACTGGGTGGATGCTGAGGAGTGC
CATCGGTGCAGAGTACAGTTTGGAGTGGTGACCCGCAAGCATCACTGCCGAGCGTGTGGGCAGA
TCTTTTGTGGCAAGTGTTCCTCCAAGTACTCCACCATCCCCAAGTTCGGCATTGAGAAGGAAGT
GCGCGTGTGTGAGCCCTGCTATGAGCAGCTGAACAAGAAGGCAGAAGGGAAAGCTGCCTCTACC
ACTGAGCTGCCCCCAGAGTACCTGACCAGCCCCCTGTCACAGCAGTCTCAGCTGCCCCCAAAGC
GGGATGAGACAGCACTGCAAGAAGAGGAGGAGCTACAGCTGGCGCTGGCCCTATCACAGTCAGA
GGCTGAGGAGAAGGAAAGGATGAGACAGAAGTCAACATACACAGCGCATCCAAAGTCAGAGCCT
GCGCCCTTGGCTTCCTCTGCACCCCCAGCTGGTAGCCTGTACTCCTCGCCTGTGAACTCATCAG
CACCTCTGGCTGAGGACATCGACCCTGAGCTTGCAAGATACCTCAACCGGAACTACTGGGAGAA
GAAACAGGAAGAAGCTCGGAAGAGCCCCACACCATCTGCACCTGTGCCCCTGACCGAGCCAGCT
GCCCAGCCCGGAGAAGGACATACAGCCCCCAACAGCATGGTAGAGGCCCCTCTTCCAGAGACAG
ACTCTCAGCCCATAACTTCCTGCAGTGGCCCCTTTAGTGAGCAGTACCAGAACGGGGAGTCGGA
GGAGAGCCACGAGCAGTTCCTCAAGGCCCTGCAGAATGCAGTCAGCACTTTTGTCAACCGCATG
AAGAGCAACCACATGAGGGGCCGCAGTATCACCAATGACTCGGCTGTGCTGTCCCTCTTCCAGT
CCATCAATAGCACACACCCACAGCTGCTCGAGCTGCTCAACCGGCTGGATGAGCGCAGGCTGTA
CTACGAGGGGCTTCAGGACAAGCTGGCACAGATACGTGATGCCCGAGGGGCCCTGAGTGCCCTG
CGTGAAGAGCACAGGGAGAAGCTGCGCCGGGCAGCTGAGGAGGCGGAGCGTCAACGTCAGATCC
AGCTGGCACAGAAGCTGGAGATCATGAGACAAAAGAAGCAGGAGTATCTGGAGGTGCAGAGACA
GCTAGCTATCCAGCGTCTGCAGGAACAGGAGAAGGAACGGCAGATGCGCCTGGAGCAACAGAAG
CAGACTGTCCAGATGCGTGCCCAGATGCCTGCCTTCCCCTTGCCTTATGCCCAGCTCCAGGCTA
TGCCCACAGCTGGGGGTGTACTCTACCAGCCCTCAGGCCCAACCAGCTTTCCTGGCACCTTTAG
CCCAGCAGGCTCAGTAGAGGGCTCTCCGATGCATGGTGTGTATATGAGCCAGCCAGCCCCAGCC
ACTGGCCCCTACCCCAGCATGCCTGGCACCACAGCAGATCCCAGCATGGTCAGCGCCTACATGT
ACCCAGCAGGTGCCCCTGGGGCACAGGCAGCCCCTCAGGCCCAGGCCGGGCCCACCACCAACCC
TGCCTACTCCTCGTACCAGCCTACTCCAACCCCAGGCTACCAGGCCCCACAGAGCCTCCCAGCC
ATCTCCCAGCCTCCACAGACCAGCAACATTGGCTACATGGGGAGCCAGCCAATGTCCATGGGCT
ACCAGCCATACAACATGCAGAATCTCATGACCACCCTTCCAGGCCAGGATGCGTCTCTGCCAGC
CCAGCAGCCCTACATCACAGGGCAGCAGCCCATGTACCAGCAGATGGCACCCAGCACTGGCCCT
CCCCAGCAGCAGCCCCCTGTGGCCCAACCGCCACCTACACAGGGACCGCCAGCACAGGGCAATG
AGACCCAGCTCATCTCCTTCGACTGACCTTGAGTCTGGCGCTCACCATCCAGAGTAACACTACA
GTTCTCCAGAAACCACTTATATGTCTAACTAGCCATTTCCTCCCATTACTGCCCTGTAGTGTCC
CTTCTGTGAGCAAGGGGTGGGCCTTCACCCTTGGCCCTCCTCCCTGTCCTCAGTGGTCTGGCTC
CTGTCACTGGTTCCCTGCTTTGGTCCTGATGCAGTCCAACCTTCCCGGGACTGGGACTCTGCAG
GACAAGTAGGACCTTTTCTGGAGAATGCCCAGCTGTGTCGGGGCCTGCCAGAGGTGACTGCTGT
GGGGATGGTTAGCCTGGCCCAGAGTCCGATGTGAACTGTGTGGTGTCCAGGCATGGCCCTGGTA
CCCAGAAGAACGATGTGACCCATGCACAGCAAGGGTAGAAGTTTCAGGCATCTCTGTCTCCCCT
ACTCCTTGGATGTCATCTCTCCAGTGCAGAACAGTGAAAATAAAATGTATTTCAAAATTAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039086708 ⟹ XP_038942636

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,237,988 - 106,256,171 (+)	NCBI
mRatBN7.2	10	105,739,617 - 105,757,838 (+)	NCBI

RefSeq Acc Id:

XM_039086709 ⟹ XP_038942637

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,238,054 - 106,256,171 (+)	NCBI
mRatBN7.2	10	105,739,617 - 105,757,798 (+)	NCBI

RefSeq Acc Id:

XM_039086710 ⟹ XP_038942638

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,238,054 - 106,256,171 (+)	NCBI
mRatBN7.2	10	105,739,617 - 105,757,838 (+)	NCBI

RefSeq Acc Id:

XM_039086712 ⟹ XP_038942640

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	106,238,357 - 106,256,171 (+)	NCBI
mRatBN7.2	10	105,740,026 - 105,757,798 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001386548	(Get FASTA)	NCBI Sequence Viewer
	NP_001386549	(Get FASTA)	NCBI Sequence Viewer
	NP_062260	(Get FASTA)	NCBI Sequence Viewer
	XP_038942636	(Get FASTA)	NCBI Sequence Viewer
	XP_038942637	(Get FASTA)	NCBI Sequence Viewer
	XP_038942638	(Get FASTA)	NCBI Sequence Viewer
	XP_038942640	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB49681	(Get FASTA)	NCBI Sequence Viewer
	AAF76251	(Get FASTA)	NCBI Sequence Viewer
	AAH83561	(Get FASTA)	NCBI Sequence Viewer
	BAD08342	(Get FASTA)	NCBI Sequence Viewer
	EDM06841	(Get FASTA)	NCBI Sequence Viewer
	EDM06842	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000102539
	ENSRNOP00000103548
	ENSRNOP00000108384
GenBank Protein	Q9JJ50	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_062260 ⟸ NM_019387
- Peptide Label:	isoform 1
- UniProtKB:	A0A8I6A993 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYA LEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVV QDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGK CSSKYSTIPKFGIEKEVRVCEPCYEQLNKKAEGKAASTTELPPEYLTSPLSQQSQLPPKRDETA LQEEEELQLALALSQSEAEEKERMRQKSTYTAHPKSEPAPLASSAPPAGSLYSSPVNSSAPLAE DIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHTAPNSMVEAPLPETDSQPI TSCSGPFSEQYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLFQSINST HPQLLELLNRLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQK LEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPTAG GVLYQPSGPTSFPGTFSPAGSVEGSPMHGVYMSQPAPATGPYPSMPGTTADPSMVSAYMYPAGA PGAQAAPQAQAGPTTNPAYSSYQPTPTPGYQAPQSLPAISQPPQTSNIGYMGSQPMSMGYQPYN MQNLMTTLPGQDASLPAQQPYITGQQPMYQQMAPSTGPPQQQPPVAQPPPTQGPPAQGNETQLI SFD hide sequence

Ensembl Acc Id:

ENSRNOP00000051849 ⟸ ENSRNOT00000054966

RefSeq Acc Id:	XP_038942636 ⟸ XM_039086708
- Peptide Label:	isoform X2
- UniProtKB:	A0A140TAH1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038942638 ⟸ XM_039086710
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I6A993 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038942637 ⟸ XM_039086709
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A993 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038942640 ⟸ XM_039086712
- Peptide Label:	isoform X4
- UniProtKB:	A0A8I6A993 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000087685 ⟸ ENSRNOT00000110912

RefSeq Acc Id:	NP_001386548 ⟸ NM_001399619
- Peptide Label:	isoform 2
- UniProtKB:	Q9JJ50 (UniProtKB/Swiss-Prot), Q5XIV8 (UniProtKB/Swiss-Prot), P97847 (UniProtKB/Swiss-Prot), Q76N76 (UniProtKB/Swiss-Prot), A0A8I6A993 (UniProtKB/TrEMBL), A6HLD6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	NP_001386549 ⟸ NM_001399620
- Peptide Label:	isoform 3
- UniProtKB:	A0A8I6A993 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000102539 ⟸ ENSRNOT00000135875

Ensembl Acc Id:

ENSRNOP00000103548 ⟸ ENSRNOT00000168248

Ensembl Acc Id:

ENSRNOP00000108384 ⟸ ENSRNOT00000172328

Protein Domains

FYVE-type UIM VHS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JJ50-F1-model_v2	AlphaFold	Q9JJ50	1-776	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69225	AgrOrtholog
BioCyc Gene	G2FUF-22427	BioCyc
Ensembl Genes	ENSRNOG00000036696	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000135875	ENTREZGENE
	ENSRNOT00000168248	ENTREZGENE
	ENSRNOT00000172328	ENTREZGENE
Gene3D-CATH	1.20.5.1940	UniProtKB/Swiss-Prot
	1.25.40.90	UniProtKB/Swiss-Prot
	3.30.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7133877	IMAGE-MGC_LOAD
InterPro	ENTH_VHS	UniProtKB/Swiss-Prot
	HRS_helical	UniProtKB/Swiss-Prot
	Ubi-bd_Hrs_VPS27	UniProtKB/Swiss-Prot
	UIM_dom	UniProtKB/Swiss-Prot
	VHS_dom	UniProtKB/Swiss-Prot
	Znf_FYVE	UniProtKB/Swiss-Prot
	Znf_FYVE-rel	UniProtKB/Swiss-Prot
	Znf_FYVE_PHD	UniProtKB/Swiss-Prot
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot
KEGG Report	rno:56084	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93483	IMAGE-MGC_LOAD
NCBI Gene	56084	ENTREZGENE
PANTHER	HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE	UniProtKB/Swiss-Prot
	PTHR46275	UniProtKB/Swiss-Prot
Pfam	FYVE	UniProtKB/Swiss-Prot
	Hrs_helical	UniProtKB/Swiss-Prot
	VHS	UniProtKB/Swiss-Prot
PhenoGen	Hgs	PhenoGen
PIRSF	Hrs_Vps27	UniProtKB/Swiss-Prot
PROSITE	UIM	UniProtKB/Swiss-Prot
	VHS	UniProtKB/Swiss-Prot
	ZF_FYVE	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000036696	RatGTEx
SMART	FYVE	UniProtKB/Swiss-Prot
	VHS	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48464	UniProtKB/Swiss-Prot
	SSF57903	UniProtKB/Swiss-Prot
TIGR	TC229632
UniProt	A0A140TAH1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A993	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LBM3_RAT	UniProtKB/TrEMBL
	A0ABK0LCE8_RAT	UniProtKB/TrEMBL
	A0ABK0LPT3_RAT	UniProtKB/TrEMBL
	A6HLD6	ENTREZGENE, UniProtKB/TrEMBL
	A6HLD7_RAT	UniProtKB/TrEMBL
	HGS_RAT	UniProtKB/Swiss-Prot
	P97847	ENTREZGENE
	Q5XIV8	ENTREZGENE
	Q76N76	ENTREZGENE
	Q9JJ50	ENTREZGENE
UniProt Secondary	P97847	UniProtKB/Swiss-Prot
	Q5XIV8	UniProtKB/Swiss-Prot
	Q76N76	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-24	Hgs	hepatocyte growth factor-regulated tyrosine kinase substrate	Hgs	HGF-regulated tyrosine kinase substrate	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Hgs	HGF-regulated tyrosine kinase substrate			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localizes to both cytosolic and membrane-associated pools	632855

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)