Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) - Rat Genome Database

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Gene: Hgs (hepatocyte growth factor-regulated tyrosine kinase substrate) Heterocephalus glaber
Analyze
Symbol: Hgs
Name: hepatocyte growth factor-regulated tyrosine kinase substrate
RGD ID: 18919411
Description: ENCODES a protein that exhibits identical protein binding (ortholog); ubiquitin-modified protein reader activity (ortholog); INVOLVED IN endosome to lysosome transport (ortholog); PARTICIPATES IN autophagy pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN ESCRT-0 complex (ortholog); secretory granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,620,753 - 10,634,341 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,620,717 - 10,634,670 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Hgs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,620,753 - 10,634,341 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,620,717 - 10,634,670 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HGS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,684,011 - 81,702,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,683,326 - 81,703,138 (+)EnsemblGRCh38hg38GRCh38
GRCh371779,651,041 - 79,669,151 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,261,425 - 77,279,553 (+)NCBINCBI36Build 36hg18NCBI36
Build 341777,261,424 - 77,279,550NCBI
Celera1776,295,942 - 76,314,294 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,097,132 - 75,115,050 (+)NCBIHuRef
CHM1_11779,737,183 - 79,755,370 (+)NCBICHM1_1
T2T-CHM13v2.01782,600,905 - 82,619,025 (+)NCBIT2T-CHM13v2.0
Hgs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,358,431 - 120,374,810 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,358,461 - 120,374,805 (+)EnsemblGRCm39 Ensembl
GRCm3811120,467,605 - 120,483,984 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,467,635 - 120,483,979 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711120,328,949 - 120,345,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611120,283,781 - 120,300,069 (+)NCBIMGSCv36mm8
Celera11132,203,066 - 132,219,316 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.16NCBI
Hgs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,237,988 - 106,256,174 (+)NCBIGRCr8
mRatBN7.210105,739,617 - 105,757,838 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,739,296 - 105,757,835 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,844,188 - 110,862,000 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,307,219 - 110,325,031 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,660,239 - 105,678,295 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,638,944 - 109,657,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,638,767 - 109,657,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010109,232,509 - 109,250,728 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,861,289 - 109,869,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,875,792 - 109,883,652 (+)NCBI
Celera10104,283,857 - 104,301,769 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
Hgs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,405,543 - 1,418,095 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,405,543 - 1,418,095 (-)NCBIChiLan1.0ChiLan1.0
HGS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,273,839 - 98,292,160 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,174,297 - 103,192,557 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,143,212 - 76,161,469 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,844,379 - 81,862,335 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,844,379 - 81,862,335 (+)Ensemblpanpan1.1panPan2
HGS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19499,071 - 513,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9499,116 - 514,308 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,101,298 - 1,115,455 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,092,550 - 1,106,872 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,092,550 - 1,107,809 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,117,545 - 1,131,697 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,244,142 - 1,258,290 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,323,173 - 1,337,298 (-)NCBIUU_Cfam_GSD_1.0
Hgs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,110,692 - 1,126,331 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,285,551 - 5,301,233 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,285,678 - 5,301,267 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HGS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,207,036 - 1,219,715 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,207,036 - 1,219,750 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HGS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,613,711 - 73,632,527 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,613,786 - 73,632,016 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607745,022,394 - 45,041,222 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000011836   ⟹   ENSHGLP00000011708
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462480110,620,753 - 10,634,341 (+)Ensembl
RefSeq Acc Id: XM_004860939   ⟹   XP_004860996
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,620,717 - 10,634,670 (+)NCBI
RefSeq Acc Id: XM_004860940   ⟹   XP_004860997
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,620,717 - 10,634,670 (+)NCBI
RefSeq Acc Id: XM_004860941   ⟹   XP_004860998
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,620,717 - 10,634,461 (+)NCBI
RefSeq Acc Id: XM_004860942   ⟹   XP_004860999
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,620,717 - 10,634,315 (+)NCBI
RefSeq Acc Id: XM_021241246   ⟹   XP_021096905
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,620,717 - 10,634,670 (+)NCBI
RefSeq Acc Id: XM_021241247   ⟹   XP_021096906
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,621,008 - 10,634,670 (+)NCBI
RefSeq Acc Id: XM_021241248   ⟹   XP_021096907
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,621,192 - 10,634,670 (+)NCBI
RefSeq Acc Id: XM_021241249   ⟹   XP_021096908
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,620,717 - 10,634,151 (+)NCBI
RefSeq Acc Id: XM_021241250   ⟹   XP_021096909
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462480110,620,717 - 10,634,150 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004860996   ⟸   XM_004860939
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021096905   ⟸   XM_021241246
- Peptide Label: isoform X3
- UniProtKB: G5BJ71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004860997   ⟸   XM_004860940
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004860998   ⟸   XM_004860941
- Peptide Label: isoform X6
- UniProtKB: G5BJ71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004860999   ⟸   XM_004860942
- Peptide Label: isoform X7
- UniProtKB: A0A0P6JEL9 (UniProtKB/TrEMBL),   G5BJ71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021096908   ⟸   XM_021241249
- Peptide Label: isoform X5
- UniProtKB: G5BJ71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021096909   ⟸   XM_021241250
- Peptide Label: isoform X8
- UniProtKB: G5BJ71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021096906   ⟸   XM_021241247
- Peptide Label: isoform X4
RefSeq Acc Id: XP_021096907   ⟸   XM_021241248
- Peptide Label: isoform X4
RefSeq Acc Id: ENSHGLP00000011708   ⟸   ENSHGLT00000011836


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008394 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000011836 ENTREZGENE
Gene3D-CATH 1.20.5.1940 UniProtKB/TrEMBL
  1.25.40.90 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro ENTH_VHS UniProtKB/TrEMBL
  HRS_helical UniProtKB/TrEMBL
  Ubi-bd_Hrs_VPS27 UniProtKB/TrEMBL
  UIM_dom UniProtKB/TrEMBL
  VHS_dom UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
NCBI Gene Hgs ENTREZGENE
PANTHER HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE UniProtKB/TrEMBL
  PTHR46275 UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
  Hrs_helical UniProtKB/TrEMBL
  VHS UniProtKB/TrEMBL
PIRSF Hrs_Vps27 UniProtKB/TrEMBL
PROSITE UIM UniProtKB/TrEMBL
  VHS UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
SMART FYVE UniProtKB/TrEMBL
  VHS UniProtKB/TrEMBL
Superfamily-SCOP SSF48464 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A0P6JEL9 ENTREZGENE, UniProtKB/TrEMBL
  G5BJ71 ENTREZGENE, UniProtKB/TrEMBL