Atf3 (activating transcription factor 3) - Rat Genome Database

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Gene: Atf3 (activating transcription factor 3) Rattus norvegicus
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Symbol: Atf3
Name: activating transcription factor 3
RGD ID: 2165
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of cell population proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi apparatus; microtubule organizing center; and nuclear lumen. Predicted to be part of CHOP-ATF3 complex and RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human ATF3 (activating transcription factor 3); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH (S)-amphetamine; 1,2,4-trimethylbenzene; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP-dependent transcription factor ATF-3; cyclic AMP-dependent transcription factor ATF-3; cyclic AMP-dependent transcription factor ATF-3-like; liver regeneration factor 1; LOC100911428; LRF-1; LRFI
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,274,103 - 105,331,653 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl13105,282,440 - 105,295,750 (-)EnsemblGRCr8
mRatBN7.213102,751,278 - 102,800,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,751,321 - 102,764,631 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx13105,271,388 - 105,284,695 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013106,655,344 - 106,668,650 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013103,870,330 - 103,883,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.013109,817,892 - 109,849,632 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13109,817,728 - 109,849,632 (-)Ensemblrn6Rnor6.0
Rnor_5.013114,411,692 - 114,443,432 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.413107,191,622 - 107,223,850 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera13102,216,359 - 102,219,172 (-)NCBICelera
RGSC_v3.113107,380,725 - 107,412,954 (-)NCBI
RH 3.4 Map13723.4RGD
Cytogenetic Map13q27NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+-)-suloctidil  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
(E)-thiamethoxam  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (ISO)
2-butoxyethanol  (ISO)
2-Ethylhexyl acrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4',5-tetrachlorosalicylanilide  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dichloroaniline  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-aminobenzohydrazide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrobenzyl bromide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
abietic acid  (ISO)
acetamide  (EXP)
aconitic acid  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
alexidine  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apilimod  (ISO)
arachidonic acid  (ISO)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
astemizole  (ISO)
atrazine  (EXP,ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
benzyl benzoate  (ISO)
Benzyl salicylate  (ISO)
benzylpenicillin  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
bortezomib  (EXP,ISO)
bromocriptine  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
celastrol  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (EXP,ISO)
cobicistat  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
DDE  (ISO)
DDT  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl phthalate  (ISO)
diethylenetriamine  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dodecan-1-ol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
echinacoside  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol dimethacrylate  (ISO)
ethylenediamine  (ISO)
eugenol  (ISO)
farnesol  (ISO)
fenamidone  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
Garcinol  (ISO)
gedunin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyoxal  (ISO)
graphene oxide  (ISO)
graphite  (EXP)
GSK-J4  (ISO)
GSK2656157  (ISO)
hydralazine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imidazopyrazole  (ISO)
imidurea  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isoeugenol  (ISO)
isoprenaline  (EXP,ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
limonene  (ISO)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
mefloquine  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
metacetamol  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
minocycline  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
motexafin gadolinium  (ISO)
muramyl dipeptide  (ISO)
N(4)-hydroxycytidine  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naphthalene  (ISO)
naphthalenes  (EXP)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
Nivalenol  (ISO)
nonivamide  (ISO)
ochratoxin A  (ISO)
octanoic acid  (ISO)
okadaic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (ISO)
phenyl benzoate  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phosgene  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
potassium bromate  (EXP,ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
Pulsatilla saponin D  (ISO)
pyrazinecarboxamide  (EXP)
quartz  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-nitrosoglutathione  (ISO)
Salinomycin  (ISO)
salubrinal  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SC-58125  (ISO)
SCH 23390  (EXP)
senecionine  (ISO)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium hypochlorite  (ISO)
Soman  (EXP)
streptozocin  (ISO)
styrene  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thiamethoxam  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toosendanin  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trans-isoeugenol  (ISO)
triacsin C  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
undecanal  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
xi-3-(4-Isopropylphenyl)-2-methylpropanal  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4. Smad transcription factors. Massagué J, etal., Genes Dev. 2005 Dec 1;19(23):2783-810.
5. Fibronectin type I repeat is a nonactivating ligand for EphA1 and inhibits ATF3-dependent angiogenesis. Masuda J, etal., J Biol Chem. 2008 May 9;283(19):13148-55. doi: 10.1074/jbc.M702164200. Epub 2008 Feb 28.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction. Okamoto Y, etal., Am J Pathol. 2001 Aug;159(2):639-50.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. How the Smads regulate transcription. Ross S and Hill CS, Int J Biochem Cell Biol. 2008;40(3):383-408. Epub 2007 Oct 7.
13. Induction of ER stress in macrophages of tuberculosis granulomas. Seimon TA, etal., PLoS One. 2010 Sep 15;5(9):e12772. doi: 10.1371/journal.pone.0012772.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. Tamura K, etal., EMBO J. 2005 Jul 20;24(14):2590-601. Epub 2005 Jun 30.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Expression of activating transcription factor 3 and growth-associated protein 43 in the rat geniculate ganglion neurons after chorda tympani injury. Tsuzuki K, etal., Acta Otolaryngol 2002 Mar;122(2):161-7.
18. Edelfosine Promotes Apoptosis in Androgen-Deprived Prostate Tumors by Increasing ATF3 and Inhibiting Androgen Receptor Activity. Udayakumar TS, etal., Mol Cancer Ther. 2016 Jun;15(6):1353-63. doi: 10.1158/1535-7163.MCT-15-0332. Epub 2016 Mar 4.
19. Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells. Wang Z, etal., Oncogene. 2016 Jul 7;35(27):3555-64. doi: 10.1038/onc.2015.417. Epub 2015 Nov 2.
Additional References at PubMed
PMID:1902565   PMID:2516827   PMID:8622660   PMID:11916968   PMID:12220541   PMID:12832543   PMID:14559366   PMID:14667575   PMID:14729979   PMID:15135228   PMID:15231818   PMID:15489334  
PMID:15911351   PMID:16291753   PMID:16300731   PMID:16644691   PMID:16713293   PMID:17276007   PMID:17962349   PMID:18192274   PMID:18255255   PMID:18305237   PMID:18801180   PMID:19192484  
PMID:19559011   PMID:19796622   PMID:19913522   PMID:20140008   PMID:20413626   PMID:20470869   PMID:20627820   PMID:21280179   PMID:21396734   PMID:21616101   PMID:21912089   PMID:21984568  
PMID:22053207   PMID:22147266   PMID:22390138   PMID:22446192   PMID:23471575   PMID:23644055   PMID:23765588   PMID:23916985   PMID:24420912   PMID:24801224   PMID:24810525   PMID:24939851  
PMID:25074928   PMID:25136830   PMID:25247596   PMID:25614048   PMID:25848832   PMID:26224859   PMID:27169499   PMID:27190312   PMID:27264359   PMID:27484784   PMID:28365312   PMID:35263513  
PMID:36340581   PMID:37918704   PMID:37932484   PMID:38650141  


Genomics

Comparative Map Data
Atf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,274,103 - 105,331,653 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl13105,282,440 - 105,295,750 (-)EnsemblGRCr8
mRatBN7.213102,751,278 - 102,800,520 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,751,321 - 102,764,631 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx13105,271,388 - 105,284,695 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013106,655,344 - 106,668,650 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013103,870,330 - 103,883,636 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.013109,817,892 - 109,849,632 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13109,817,728 - 109,849,632 (-)Ensemblrn6Rnor6.0
Rnor_5.013114,411,692 - 114,443,432 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.413107,191,622 - 107,223,850 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera13102,216,359 - 102,219,172 (-)NCBICelera
RGSC_v3.113107,380,725 - 107,412,954 (-)NCBI
RH 3.4 Map13723.4RGD
Cytogenetic Map13q27NCBI
ATF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,565,407 - 212,620,777 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,565,334 - 212,620,777 (+)Ensemblhg38GRCh38
GRCh371212,738,749 - 212,794,119 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,805,320 - 210,860,740 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341209,170,507 - 209,182,494NCBI
Celera1185,964,759 - 186,020,178 (+)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1183,415,472 - 183,470,943 (+)NCBIHuRef
CHM1_11214,011,558 - 214,066,986 (+)NCBICHM1_1
T2T-CHM13v2.01211,810,345 - 211,865,712 (+)NCBIT2T-CHM13v2.0
Atf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391190,902,493 - 190,915,530 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1190,902,493 - 190,950,236 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381191,170,296 - 191,183,333 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1191,170,296 - 191,218,039 (-)Ensemblmm10GRCm38
MGSCv371192,994,175 - 193,007,212 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361192,870,911 - 192,883,948 (-)NCBIMGSCv36mm8
Celera1198,095,832 - 198,108,890 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.28NCBI
Atf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554064,875,613 - 4,889,242 (-)Ensembl
ChiLan1.0NW_0049554064,875,672 - 4,889,173 (-)NCBIChiLan1.0ChiLan1.0
ATF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2136,782,154 - 36,794,324 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1136,746,605 - 36,759,088 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01188,176,728 - 188,188,842 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11193,036,704 - 193,049,148 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1193,036,793 - 193,049,150 (+)EnsemblpanPan2panpan1.1
ATF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1710,784,445 - 10,795,285 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl710,782,064 - 10,794,163 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha710,359,482 - 10,370,301 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0710,490,061 - 10,500,881 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl710,486,862 - 10,500,881 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1710,412,838 - 10,423,650 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0710,514,041 - 10,524,904 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0710,637,865 - 10,648,720 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Atf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934463,669,870 - 63,682,329 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936557908,318 - 922,624 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936557909,302 - 922,619 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9130,772,262 - 130,785,506 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19130,772,259 - 130,829,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29143,690,544 - 143,703,886 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12516,910,312 - 16,922,598 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605517,407,083 - 17,419,122 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477118,050,039 - 18,060,802 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477118,009,111 - 18,060,796 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Atf3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11069,249,894 - 69,264,028 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Atf3
202 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:118
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000005085
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH142301  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.213102,751,745 - 102,751,941 (+)MAPPERmRatBN7.2
Rnor_6.013109,818,320 - 109,818,515NCBIRnor6.0
Rnor_6.013109,776,724 - 109,776,919NCBIRnor6.0
Rnor_5.013114,412,120 - 114,412,315UniSTSRnor5.0
RGSC_v3.413107,192,047 - 107,192,242UniSTSRGSC3.4
Celera13102,216,787 - 102,216,982UniSTS
RH 3.4 Map13723.4UniSTS
Cytogenetic Map13q27UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 88 59 6 352 188 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005085   ⟹   ENSRNOP00000005085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl13105,282,440 - 105,295,750 (-)Ensembl
mRatBN7.2 Ensembl13102,751,321 - 102,764,631 (-)Ensembl
Rnor_6.0 Ensembl13109,817,895 - 109,849,632 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089841   ⟹   ENSRNOP00000071188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13109,817,728 - 109,844,359 (-)Ensembl
RefSeq Acc Id: NM_012912   ⟹   NP_037044
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,282,437 - 105,295,744 (-)NCBI
mRatBN7.213102,751,318 - 102,764,625 (-)NCBI
Rnor_6.013109,817,892 - 109,849,632 (-)NCBI
Rnor_5.013114,411,692 - 114,443,432 (-)NCBI
RGSC_v3.413107,191,622 - 107,223,850 (-)RGD
Celera13102,216,359 - 102,219,172 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090385   ⟹   XP_038946313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,274,103 - 105,331,653 (-)NCBI
mRatBN7.213102,751,278 - 102,800,520 (-)NCBI
Protein Sequences
Protein RefSeqs NP_037044 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946313 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41542 (Get FASTA)   NCBI Sequence Viewer  
  AAH78903 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005085
  ENSRNOP00000005085.1
GenBank Protein P29596 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037044   ⟸   NM_012912
- UniProtKB: P29596 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071188   ⟸   ENSRNOT00000089841
Ensembl Acc Id: ENSRNOP00000005085   ⟸   ENSRNOT00000005085
RefSeq Acc Id: XP_038946313   ⟸   XM_039090385
- Peptide Label: isoform X1
- UniProtKB: P29596 (UniProtKB/Swiss-Prot)
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29596-F1-model_v2 AlphaFold P29596 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2165 AgrOrtholog
BioCyc Gene G2FUF-16860 BioCyc
Ensembl Genes ENSRNOG00000003745 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005085 ENTREZGENE
  ENSRNOT00000005085.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100767 IMAGE-MGC_LOAD
InterPro AP-1 UniProtKB/Swiss-Prot
  bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
KEGG Report rno:25389 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93651 IMAGE-MGC_LOAD
NCBI Gene 25389 ENTREZGENE
PANTHER PTHR23351 UniProtKB/Swiss-Prot
  PTHR23351:SF23 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
PhenoGen Atf3 PhenoGen
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003745 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
TIGR TC226994
UniProt ATF3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Atf3  activating transcription factor 3  LOC100911428  cyclic AMP-dependent transcription factor ATF-3-like  Data merged from RGD:6492959 737654 PROVISIONAL
2012-07-05 LOC100911428  cyclic AMP-dependent transcription factor ATF-3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Atf3  Activating transcription factor 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process is a marker for neuronal injury 631315