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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2165
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf3
Name: activating transcription factor 3
Acc ID: CHEBI:146194
Term: 15-acetyldeoxynivalenol
Definition: A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-15. A skin and eye irritant, along with its 3-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.
Chemical ID: MESH:C046760
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf3increases expressionISOATF3 (Homo sapiens)6480464CTD15-acetyldeoxynivalenol results in increased expression of ATF3 mRNAPMID:19101521 PMID:22003189 PMID:23792671
Atf3multiple interactionsISOATF3 (Homo sapiens)6480464CTD[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [15-acetyldeoxynivalenol results in increased expression of ATF3 mRNA]PMID:22003189
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