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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2165
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf3
Name: activating transcription factor 3
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf3affects response to substanceEXP 6480464CTDATF3 protein affects the susceptibility to resveratrolPMID:24911970
Atf3multiple interactionsEXP 6480464CTDATF3 protein affects the reaction [resveratrol results in increased expression of KL mRNA]; resveratrol affects the localization of and results in increased expression of ATF3 protein; resveratrol promotes the reaction [ATF3 protein binds to JUN protein]; resveratrol promotes the reaction [ATF3 protein binds to KL promoter]PMID:24911970
Atf3affects response to substanceISOATF3 (Homo sapiens)6480464CTDATF3 protein affects the susceptibility to resveratrolPMID:24911970
Atf3decreases expressionISOATF3 (Homo sapiens)6480464CTDresveratrol results in decreased expression of ATF3 mRNAPMID:19167446
Atf3increases expressionISOATF3 (Homo sapiens)6480464CTDresveratrol results in increased expression of ATF3 mRNA; resveratrol results in increased expression of ATF3 proteinPMID:12002526 PMID:15280659 PMID:15897233 PMID:21205742 PMID:21554132
Atf3multiple interactionsISOATF3 (Homo sapiens)6480464CTDATF3 protein affects the reaction [resveratrol results in increased expression of KL mRNA]; ATF3 protein promotes the reaction [resveratrol results in increased activity of CASP3 protein]; ATF3 protein promotes the reaction [resveratrol results in increased activity of CASP7 protein]; resveratrol promotes the reaction [[[EGR1 protein binds to KLF4 protein] which binds to ATF3 promoter] which results in increased expression of ATF3 mRNA]; resveratrol promotes the reaction [[EGR1 protein binds to ATF3 promoter] which results in increased expression of ATF3 mRNA]; resveratrol promotes the reaction [[KLF4 protein binds to ATF3 promoter] which results in increased expression of ATF3 mRNA]PMID:21205742 PMID:24911970
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