Wnt7b (Wnt family member 7B) - Rat Genome Database

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Gene: Wnt7b (Wnt family member 7B) Rattus norvegicus
Analyze
Symbol: Wnt7b
Name: Wnt family member 7B
RGD ID: 1311441
Description: Predicted to enable chemoattractant activity involved in axon guidance and frizzled binding activity. Involved in several processes, including positive regulation of JNK cascade; regulation of cell projection size; and response to glucocorticoid. Located in extracellular space. Orthologous to human WNT7B (Wnt family member 7B); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling, the planar cell polarity pathway; Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC315196; protein Wnt-7b; wingless-related MMTV integration site 7B; wingless-type MMTV integration site family, member 7B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,514,684 - 118,559,316 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7118,514,684 - 118,559,316 (-)EnsemblGRCr8
mRatBN7.27116,634,817 - 116,679,459 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,634,814 - 116,679,581 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7118,387,429 - 118,429,756 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,613,164 - 120,655,493 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,582,608 - 120,624,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,423,418 - 126,465,724 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,420,656 - 126,465,723 (-)Ensemblrn6Rnor6.0
Rnor_5.07126,136,632 - 126,178,957 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47123,533,713 - 123,554,333 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7112,932,206 - 112,952,808 (-)NCBICelera
RGSC_v3.17123,567,943 - 123,588,563 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (EXP)
celastrol  (ISO)
choline  (ISO)
cisplatin  (ISO)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
drometrizole  (ISO)
endosulfan  (ISO)
ethylbenzene  (ISO)
ethylparaben  (ISO)
fipronil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fucoxanthin  (ISO)
glucose  (ISO)
glycidol  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-Nitrosopyrrolidine  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxamic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
propanal  (ISO)
retinyl acetate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure regression  (ISO)
angiogenesis  (ISO)
animal organ development  (IEA)
apoptotic process involved in blood vessel morphogenesis  (ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation  (IEA)
cell proliferation in forebrain  (ISO)
cellular response to retinoic acid  (IEA,ISO)
central nervous system vasculogenesis  (ISO)
chemoattraction of dopaminergic neuron axon  (ISO)
chorio-allantoic fusion  (ISO)
developmental growth involved in morphogenesis  (ISO)
embryonic organ development  (ISO)
embryonic placenta morphogenesis  (ISO)
establishment or maintenance of polarity of embryonic epithelium  (ISO)
fibroblast proliferation  (IEA,ISO)
forebrain regionalization  (IEA,ISO)
homeostatic process  (ISO)
in utero embryonic development  (ISO)
inner medullary collecting duct development  (ISO)
intracellular oxygen homeostasis  (ISO)
lobar bronchus development  (ISO)
lung development  (ISO)
lung epithelium development  (ISO)
lung morphogenesis  (ISO)
lung-associated mesenchyme development  (ISO)
mammary gland epithelium development  (IEA,ISO)
metanephric collecting duct development  (ISO)
metanephric epithelium development  (ISO)
metanephric loop of Henle development  (ISO)
metanephros morphogenesis  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of smoothened signaling pathway  (ISO)
neuron differentiation  (IEA,ISO)
neuron projection development  (IMP)
neuron projection morphogenesis  (IDA)
odontogenesis of dentin-containing tooth  (ISO)
outer medullary collecting duct development  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of JNK cascade  (IDA,IMP)
positive regulation of osteoblast differentiation  (ISO)
regulation of cell projection size  (IDA)
renal inner medulla development  (ISO)
renal outer medulla development  (ISO)
response to glucocorticoid  (IEP)
smooth muscle cell differentiation  (ISO)
stem cell development  (ISO)
stem cell proliferation  (IEA,ISO)
synapse organization  (ISO)
system development  (IEA)
tissue development  (IEA)
trachea cartilage morphogenesis  (ISO)
vasculature development  (ISO)
Wnt signaling pathway  (IEA,ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The p53 transcriptional target gene wnt7b contributes to NGF-inducible neurite outgrowth in neuronal PC12 cells. Brynczka C and Merrick BA, Differentiation. 2008 Jan 2;.
2. High expression of Wnt7b in human superficial bladder cancer vs invasive bladder cancer. Bui TD, etal., Br J Cancer. 1998;77(2):319-24.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Huguet EL, etal., Cancer Res. 1994 May 15;54(10):2615-21.
6. Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis. Maekawa M, etal., Genes Cells. 2005 Oct;10(10):1001-14.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma. Milovanovic T, etal., Int J Oncol. 2004 Nov;25(5):1337-42.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
14. Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development. Rosso SB, etal., Nat Neurosci. 2005 Jan;8(1):34-42. Epub 2004 Dec 19.
15. Transformation by Wnt family proteins correlates with regulation of beta-catenin. Shimizu H, etal., Cell Growth Differ. 1997 Dec;8(12):1349-58.
16. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
17. Zhonghua er ke za zhi. Chinese journal of pediatrics Wang Q and Zhao DY, Zhonghua Er Ke Za Zhi. 2008 Apr;46(4):286-90.
18. Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Wang Z, etal., Mol Cell Biol. 2005 Jun;25(12):5022-30.
19. Differential transformation of mammary epithelial cells by Wnt genes. Wong GT, etal., Mol Cell Biol. 1994 Sep;14(9):6278-86.
Additional References at PubMed
PMID:8167409   PMID:10781055   PMID:11543617   PMID:12147135   PMID:12239632   PMID:12429992   PMID:12843296   PMID:15164427   PMID:15576404   PMID:16163358   PMID:16818724   PMID:17804636  
PMID:18056042   PMID:18343501   PMID:18367557   PMID:19023080   PMID:19060336   PMID:19129494   PMID:19690384   PMID:19734317   PMID:21106844   PMID:26429533   PMID:28733458   PMID:31001900  
PMID:36942896  


Genomics

Comparative Map Data
Wnt7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87118,514,684 - 118,559,316 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7118,514,684 - 118,559,316 (-)EnsemblGRCr8
mRatBN7.27116,634,817 - 116,679,459 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7116,634,814 - 116,679,581 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7118,387,429 - 118,429,756 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07120,613,164 - 120,655,493 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07120,582,608 - 120,624,937 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07126,423,418 - 126,465,724 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7126,420,656 - 126,465,723 (-)Ensemblrn6Rnor6.0
Rnor_5.07126,136,632 - 126,178,957 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47123,533,713 - 123,554,333 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7112,932,206 - 112,952,808 (-)NCBICelera
RGSC_v3.17123,567,943 - 123,588,563 (-)NCBI
Cytogenetic Map7q34NCBI
WNT7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382245,920,366 - 45,977,162 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2245,920,366 - 45,977,162 (-)Ensemblhg38GRCh38
GRCh372246,316,246 - 46,373,042 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362244,696,316 - 44,751,395 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342244,638,195 - 44,666,564NCBI
Cytogenetic Map22q13.31NCBI
HuRef2229,261,652 - 29,291,436 (-)NCBIHuRef
CHM1_12246,275,362 - 46,332,075 (-)NCBICHM1_1
T2T-CHM13v2.02246,405,017 - 46,461,763 (-)NCBIT2T-CHM13v2.0
Wnt7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391585,419,638 - 85,466,022 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1585,419,638 - 85,466,674 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381585,535,437 - 85,581,821 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1585,535,437 - 85,582,473 (-)Ensemblmm10GRCm38
MGSCv371585,365,867 - 85,412,251 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361585,363,207 - 85,409,348 (-)NCBIMGSCv36mm8
Celera1587,665,622 - 87,712,020 (-)NCBICelera
Cytogenetic Map15E2NCBI
cM Map1540.39NCBI
Wnt7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541330,144,869 - 30,181,791 (-)Ensembl
ChiLan1.0NW_00495541330,146,185 - 30,185,693 (-)NCBIChiLan1.0ChiLan1.0
WNT7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22355,751,220 - 55,807,107 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12258,449,387 - 58,504,009 (-)NCBINHGRI_mPanPan1
PanPan1.12244,988,647 - 45,039,601 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2244,988,647 - 45,044,841 (-)EnsemblpanPan2panpan1.1
WNT7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11020,160,916 - 20,208,786 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1020,160,206 - 20,243,160 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1020,083,094 - 20,132,215 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01020,894,626 - 20,943,739 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1020,894,149 - 20,976,956 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11020,614,947 - 20,664,056 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01020,927,809 - 20,976,907 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01021,108,730 - 21,157,847 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wnt7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049453,869,498 - 3,909,805 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366293,869,523 - 3,909,808 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366293,869,976 - 3,907,932 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl53,521,288 - 3,572,314 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.153,521,412 - 3,572,322 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25654,961 - 707,041 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WNT7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11928,387,324 - 28,444,019 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1928,385,422 - 28,441,350 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604596,912,041 - 96,943,508 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247523,818,025 - 3,857,027 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247523,818,073 - 3,856,602 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Wnt7b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11254,891,098 - 254,934,344 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wnt7b
278 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:80
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000021196
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)7116269196132020414Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7118556868125929417Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D7Rat60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,651,888 - 116,652,094 (+)MAPPERmRatBN7.2
Rnor_6.07126,438,538 - 126,438,743NCBIRnor6.0
Rnor_5.07126,151,750 - 126,151,955UniSTSRnor5.0
RGSC_v3.47123,548,833 - 123,549,038UniSTSRGSC3.4
RGSC_v3.47123,548,832 - 123,549,038RGDRGSC3.4
RGSC_v3.17123,583,062 - 123,583,268RGD
FHH x ACI Map754.48UniSTS
FHH x ACI Map754.48RGD
Cytogenetic Map7q34UniSTS
D7Rat97  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87118,556,868 - 118,557,047 (+)Marker Load Pipeline
mRatBN7.27116,677,010 - 116,677,189 (+)MAPPERmRatBN7.2
Rnor_6.07126,463,649 - 126,463,827NCBIRnor6.0
Rnor_5.07126,176,882 - 126,177,060UniSTSRnor5.0
RGSC_v3.47123,574,473 - 123,574,930RGDRGSC3.4
RGSC_v3.47123,574,502 - 123,574,680UniSTSRGSC3.4
Celera7112,972,542 - 112,972,733UniSTS
RGSC_v3.17123,608,732 - 123,608,910RGD
RH 3.4 Map7908.3RGD
RH 3.4 Map7908.3UniSTS
RH 2.0 Map7688.9RGD
SHRSP x BN Map770.2799RGD
FHH x ACI Map754.48RGD
Cytogenetic Map7q34UniSTS
Wnt7b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,634,873 - 116,635,350 (+)MAPPERmRatBN7.2
Rnor_6.07126,421,533 - 126,422,009NCBIRnor6.0
Rnor_5.07126,134,747 - 126,135,223UniSTSRnor5.0
RGSC_v3.47123,531,828 - 123,532,304UniSTSRGSC3.4
Celera7112,930,321 - 112,930,797UniSTS
Cytogenetic Map7q34UniSTS
Wnt7b  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27116,636,793 - 116,637,178 (+)MAPPERmRatBN7.2
Rnor_6.07126,423,453 - 126,423,837NCBIRnor6.0
Rnor_5.07126,136,667 - 126,137,051UniSTSRnor5.0
RGSC_v3.47123,533,748 - 123,534,132UniSTSRGSC3.4
Celera7112,932,241 - 112,932,625UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 3 32 130 75 81 50 26 50 6 215 69 3 116 81 91 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000021196   ⟹   ENSRNOP00000021196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7126,423,418 - 126,465,723 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081032   ⟹   ENSRNOP00000072573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7118,514,684 - 118,555,193 (-)Ensembl
mRatBN7.2 Ensembl7116,634,814 - 116,675,400 (-)Ensembl
Rnor_6.0 Ensembl7126,420,656 - 126,461,658 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108799   ⟹   ENSRNOP00000093131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7118,514,684 - 118,559,316 (-)Ensembl
mRatBN7.2 Ensembl7116,634,814 - 116,679,581 (-)Ensembl
RefSeq Acc Id: NM_001009695   ⟹   NP_001009695
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,514,684 - 118,559,316 (-)NCBI
mRatBN7.27116,634,817 - 116,679,459 (-)NCBI
Rnor_6.07126,423,418 - 126,465,724 (-)NCBI
Rnor_5.07126,136,632 - 126,178,957 (-)NCBI
RGSC_v3.47123,533,713 - 123,554,333 (-)RGD
Celera7112,932,206 - 112,952,808 (-)RGD
Sequence:
RefSeq Acc Id: NM_001412610   ⟹   NP_001399539
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,514,684 - 118,555,193 (-)NCBI
mRatBN7.27116,634,817 - 116,675,335 (-)NCBI
RefSeq Acc Id: XM_039079298   ⟹   XP_038935226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87118,514,684 - 118,537,235 (-)NCBI
mRatBN7.27116,634,817 - 116,657,377 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001009695 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399539 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAD83363 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072573
  ENSRNOP00000072573.1
  ENSRNOP00000093131
  ENSRNOP00000093131.1
RefSeq Acc Id: NP_001009695   ⟸   NM_001009695
- Peptide Label: isoform 1
- UniProtKB: Q5NSW6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021196   ⟸   ENSRNOT00000021196
Ensembl Acc Id: ENSRNOP00000072573   ⟸   ENSRNOT00000081032
RefSeq Acc Id: XP_038935226   ⟸   XM_039079298
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000093131   ⟸   ENSRNOT00000108799
RefSeq Acc Id: NP_001399539   ⟸   NM_001412610
- Peptide Label: isoform 2
- UniProtKB: A0A0G2K3B7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3B7-F1-model_v2 AlphaFold A0A0G2K3B7 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311441 AgrOrtholog
BioCyc Gene G2FUF-32544 BioCyc
Ensembl Genes ENSRNOG00000015750 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081032 ENTREZGENE
  ENSRNOT00000081032.3 UniProtKB/TrEMBL
  ENSRNOT00000108799 ENTREZGENE
  ENSRNOT00000108799.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt7 UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_grthfactor_CS UniProtKB/TrEMBL
  Wnt_SF UniProtKB/TrEMBL
KEGG Report rno:315196 UniProtKB/TrEMBL
NCBI Gene 315196 ENTREZGENE
PANTHER PROTEIN WNT-7B UniProtKB/TrEMBL
  Wnt UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt7b PhenoGen
PRINTS WNT7PROTEIN UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015750 RatGTEx
SMART WNT1 UniProtKB/TrEMBL
UniProt A0A0G2K3B7 ENTREZGENE, UniProtKB/TrEMBL
  Q5NSW6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt7b  Wnt family member 7B  Wnt7b  wingless-type MMTV integration site family, member 7B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt7b  wingless-type MMTV integration site family, member 7B  Wnt7b  wingless-related MMTV integration site 7B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Wnt7b  wingless-related MMTV integration site 7B  Wnt7b_predicted  wingless-related MMTV integration site 7B (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Wnt7b_predicted  wingless-related MMTV integration site 7B (predicted)      Symbol and Name status set to approved 70820 APPROVED