Ppp1r3c (protein phosphatase 1, regulatory subunit 3C) - Rat Genome Database

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Gene: Ppp1r3c (protein phosphatase 1, regulatory subunit 3C) Rattus norvegicus
Analyze
Symbol: Ppp1r3c
Name: protein phosphatase 1, regulatory subunit 3C
RGD ID: 1309132
Description: Enables [phosphorylase] phosphatase activity and enzyme binding activity. Contributes to phosphoprotein phosphatase activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule. Orthologous to human PPP1R3C (protein phosphatase 1 regulatory subunit 3C); PARTICIPATES IN glycogen biosynthetic pathway; glycogen degradation pathway; insulin signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100910671; LOC309513; PP1 subunit R5; protein phosphatase 1 regulatory subunit 3C; protein phosphatase 1 regulatory subunit 3C-like; protein phosphatase 1 regulatory subunit 5; protein phosphatase 1, regulatory (inhibitor) subunit 3C; protein targeting to glycogen; PTG; R5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,873,524 - 243,878,527 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1243,871,704 - 243,878,835 (-)EnsemblGRCr8
mRatBN7.21234,460,958 - 234,465,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,460,652 - 234,465,961 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1242,855,971 - 242,860,979 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01249,778,292 - 249,783,285 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,616,484 - 242,621,477 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,371,830 - 255,376,833 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,371,810 - 255,376,833 (-)Ensemblrn6Rnor6.0
Rnor_5.01262,628,937 - 262,633,940 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41240,991,884 - 240,996,887 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1231,556,257 - 231,561,260 (-)NCBICelera
RGSC_v3.11241,175,278 - 241,180,280 (-)NCBI
Cytogenetic Map1q53NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
clothianidin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
N(4)-hydroxycytidine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nimesulide  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
triticonazole  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Browne GJ, etal., Biochem J. 2001 Dec 1;360(Pt 2):449-59.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. Munro S, etal., FEBS J. 2005 Mar;272(6):1478-89.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9045612   PMID:10683377   PMID:12477932   PMID:15632090   PMID:18852261   PMID:21471512   PMID:21552327  


Genomics

Comparative Map Data
Ppp1r3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,873,524 - 243,878,527 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1243,871,704 - 243,878,835 (-)EnsemblGRCr8
mRatBN7.21234,460,958 - 234,465,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,460,652 - 234,465,961 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1242,855,971 - 242,860,979 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01249,778,292 - 249,783,285 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,616,484 - 242,621,477 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,371,830 - 255,376,833 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,371,810 - 255,376,833 (-)Ensemblrn6Rnor6.0
Rnor_5.01262,628,937 - 262,633,940 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41240,991,884 - 240,996,887 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1231,556,257 - 231,561,260 (-)NCBICelera
RGSC_v3.11241,175,278 - 241,180,280 (-)NCBI
Cytogenetic Map1q53NCBI
PPP1R3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381091,628,442 - 91,633,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1091,628,442 - 91,633,071 (-)Ensemblhg38GRCh38
GRCh371093,388,199 - 93,392,828 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361093,378,179 - 93,382,838 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341093,378,180 - 93,382,838NCBI
Celera1087,131,841 - 87,136,500 (-)NCBICelera
Cytogenetic Map10q23.32NCBI
HuRef1087,016,754 - 87,021,415 (-)NCBIHuRef
CHM1_11093,669,964 - 93,674,625 (-)NCBICHM1_1
T2T-CHM13v2.01092,511,668 - 92,516,296 (-)NCBIT2T-CHM13v2.0
Ppp1r3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391936,709,131 - 36,714,004 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1936,709,131 - 36,714,053 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381936,731,731 - 36,736,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1936,731,731 - 36,736,653 (-)Ensemblmm10GRCm38
MGSCv371936,806,221 - 36,811,094 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361936,796,877 - 36,801,797 (-)NCBIMGSCv36mm8
Celera1937,506,440 - 37,511,313 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1931.89NCBI
Ppp1r3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554251,606,069 - 1,611,586 (+)Ensembl
ChiLan1.0NW_0049554251,606,069 - 1,611,001 (+)NCBIChiLan1.0ChiLan1.0
PPP1R3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28103,668,222 - 103,673,064 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110103,673,537 - 103,678,379 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01088,377,396 - 88,382,205 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11091,900,112 - 91,904,764 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1091,900,112 - 91,904,764 (-)EnsemblpanPan2panpan1.1
PPP1R3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,167,532 - 6,172,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,168,917 - 6,172,004 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha286,341,554 - 6,346,099 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0286,423,121 - 6,427,666 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl286,423,123 - 6,427,604 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1286,146,246 - 6,150,797 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0286,178,972 - 6,183,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0286,342,849 - 6,347,399 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp1r3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721341,297,720 - 41,302,426 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,930,208 - 2,935,092 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,930,250 - 2,935,024 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14103,273,405 - 103,278,762 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114103,273,401 - 103,278,757 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214112,652,689 - 112,657,293 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1984,918,592 - 84,923,281 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl984,918,591 - 84,923,334 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604845,645,616 - 45,650,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r3c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247372,893,256 - 2,901,452 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247372,896,677 - 2,901,393 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp1r3c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1237,072,510 - 37,077,774 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppp1r3c
21 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:518
Count of miRNA genes:249
Interacting mature miRNAs:304
Transcripts:ENSRNOT00000024941, ENSRNOT00000073381
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
RH129209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,460,983 - 234,461,163 (+)MAPPERmRatBN7.2
Rnor_6.01255,371,856 - 255,372,035NCBIRnor6.0
Rnor_5.01262,669,381 - 262,669,560UniSTSRnor5.0
Rnor_5.01262,628,963 - 262,629,142UniSTSRnor5.0
RGSC_v3.41240,991,910 - 240,992,089UniSTSRGSC3.4
Celera1231,556,283 - 231,556,462UniSTS
RH 3.4 Map11582.5UniSTS
Cytogenetic Map1q53UniSTS
RH138361  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,462,295 - 234,462,468 (+)MAPPERmRatBN7.2
Rnor_6.01255,373,168 - 255,373,340NCBIRnor6.0
Rnor_5.01262,670,693 - 262,670,865UniSTSRnor5.0
Rnor_5.01262,630,275 - 262,630,447UniSTSRnor5.0
RGSC_v3.41240,993,222 - 240,993,394UniSTSRGSC3.4
Celera1231,557,595 - 231,557,767UniSTS
RH 3.4 Map11582.1UniSTS
Cytogenetic Map1q53UniSTS
RH127645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,461,029 - 234,461,216 (+)MAPPERmRatBN7.2
Rnor_6.01255,371,902 - 255,372,088NCBIRnor6.0
Rnor_5.01262,669,427 - 262,669,613UniSTSRnor5.0
Rnor_5.01262,629,009 - 262,629,195UniSTSRnor5.0
RGSC_v3.41240,991,956 - 240,992,142UniSTSRGSC3.4
Celera1231,556,329 - 231,556,515UniSTS
RH 3.4 Map11582.5UniSTS
Cytogenetic Map1q53UniSTS
RH140525  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,461,029 - 234,461,170 (+)MAPPERmRatBN7.2
Rnor_6.01255,371,902 - 255,372,042NCBIRnor6.0
Rnor_5.01262,669,427 - 262,669,567UniSTSRnor5.0
Rnor_5.01262,629,009 - 262,629,149UniSTSRnor5.0
RGSC_v3.41240,991,956 - 240,992,096UniSTSRGSC3.4
Celera1231,556,329 - 231,556,469UniSTS
RH 3.4 Map11583.0UniSTS
Cytogenetic Map1q53UniSTS
AA800273  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81243,873,763 - 243,873,968 (+)Marker Load Pipeline
mRatBN7.21234,461,197 - 234,461,402 (+)MAPPERmRatBN7.2
Rnor_6.01255,372,070 - 255,372,274NCBIRnor6.0
Rnor_5.01262,669,595 - 262,669,799UniSTSRnor5.0
Rnor_5.01262,629,177 - 262,629,381UniSTSRnor5.0
RGSC_v3.41240,992,124 - 240,992,328UniSTSRGSC3.4
Celera1231,556,497 - 231,556,701UniSTS
RH 3.4 Map11582.7UniSTS
Cytogenetic Map1q53UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 41 59 6 305 141 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024941   ⟹   ENSRNOP00000024941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1243,872,428 - 243,878,835 (-)Ensembl
mRatBN7.2 Ensembl1234,460,962 - 234,465,961 (-)Ensembl
Rnor_6.0 Ensembl1255,371,810 - 255,376,833 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107925   ⟹   ENSRNOP00000082332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1243,872,428 - 243,878,835 (-)Ensembl
mRatBN7.2 Ensembl1234,460,652 - 234,465,837 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000160519   ⟹   ENSRNOP00000102875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1243,871,704 - 243,878,835 (-)Ensembl
RefSeq Acc Id: NM_001012072   ⟹   NP_001012072
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,873,524 - 243,878,527 (-)NCBI
mRatBN7.21234,460,958 - 234,465,961 (-)NCBI
Rnor_6.01255,371,830 - 255,376,833 (-)NCBI
Rnor_5.01262,628,937 - 262,633,940 (-)NCBI
RGSC_v3.41240,991,884 - 240,996,887 (-)RGD
Celera1231,556,257 - 231,561,260 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85894 (Get FASTA)   NCBI Sequence Viewer  
  EDM13188 (Get FASTA)   NCBI Sequence Viewer  
  Q5U2R5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012072   ⟸   NM_001012072
- UniProtKB: Q5U2R5 (UniProtKB/Swiss-Prot),   A6I157 (UniProtKB/TrEMBL),   G3V8E0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024941   ⟸   ENSRNOT00000024941
Ensembl Acc Id: ENSRNOP00000082332   ⟸   ENSRNOT00000107925
Ensembl Acc Id: ENSRNOP00000102875   ⟸   ENSRNOT00000160519
Protein Domains
CBM21

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2R5-F1-model_v2 AlphaFold Q5U2R5 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690873
Promoter ID:EPDNEW_R1398
Type:single initiation site
Name:Ppp1r3c_1
Description:protein phosphatase 1, regulatory subunit 3C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01255,376,841 - 255,376,901EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309132 AgrOrtholog
BioCyc Gene G2FUF-55824 BioCyc
Ensembl Genes ENSRNOG00000018494 Ensembl
Gene3D-CATH 2.60.40.2440 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192942 IMAGE-MGC_LOAD
InterPro CBM21_dom UniProtKB/Swiss-Prot
  CBM21_dom_sf UniProtKB/Swiss-Prot
  Pase-1_reg-su_3B/C/D_met UniProtKB/Swiss-Prot
  PP1_3C UniProtKB/Swiss-Prot
  PP1_regulatory_subunit_3 UniProtKB/Swiss-Prot
KEGG Report rno:309513 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94701 IMAGE-MGC_LOAD
NCBI Gene 309513 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT UniProtKB/Swiss-Prot
  PTHR12307:SF15 UniProtKB/Swiss-Prot
Pfam CBM_21 UniProtKB/Swiss-Prot
PhenoGen Ppp1r3c PhenoGen
PIRSF PP1_GT_animal UniProtKB/Swiss-Prot
  PP1_PTG UniProtKB/Swiss-Prot
PROSITE CBM21 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018494 RatGTEx
UniProt A6I157 ENTREZGENE, UniProtKB/TrEMBL
  G3V8E0 ENTREZGENE, UniProtKB/TrEMBL
  PPR3C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-13 Ppp1r3c  protein phosphatase 1, regulatory subunit 3C  LOC100910671  protein phosphatase 1 regulatory subunit 3C-like  Data merged from RGD:6497444 737654 PROVISIONAL
2012-07-05 LOC100910671  protein phosphatase 1 regulatory subunit 3C-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-10-18 Ppp1r3c  protein phosphatase 1, regulatory subunit 3C  Ppp1r3c  protein phosphatase 1, regulatory (inhibitor) subunit 3C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ppp1r3c  protein phosphatase 1, regulatory (inhibitor) subunit 3C  Ppp1r3c_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 3C (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ppp1r3c_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 3C (predicted)      Symbol and Name status set to approved 70820 APPROVED