Lgr4 (leucine-rich repeat-containing G protein-coupled receptor 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Lgr4 (leucine-rich repeat-containing G protein-coupled receptor 4) Rattus norvegicus
Analyze
Symbol: Lgr4
Name: leucine-rich repeat-containing G protein-coupled receptor 4
RGD ID: 628615
Description: Predicted to enable Roundabout binding activity; heparin binding activity; and transmembrane signaling receptor activity. Predicted to be involved in several processes, including metanephric nephron development; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; intestinal stem cell homeostasis; and male genitalia development. Predicted to be located in plasma membrane. Orthologous to human LGR4 (leucine rich repeat containing G protein-coupled receptor 4); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 48; G-protein coupled receptor 48; Gpr48; leucine-rich repeat-containing G-protein coupled receptor 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83116,901,968 - 117,004,584 (+)NCBIGRCr8
mRatBN7.2396,447,385 - 96,550,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,447,858 - 96,548,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3100,007,532 - 100,109,518 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,606,494 - 108,708,483 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,370,036 - 106,472,231 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03101,051,960 - 101,152,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,051,955 - 101,152,119 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03107,652,233 - 107,752,743 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4395,370,049 - 95,471,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1395,266,473 - 95,367,468 (+)NCBI
Celera395,472,374 - 95,573,289 (+)NCBICelera
Cytogenetic Map3q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methoxyethanol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydralazine  (ISO)
hydroquinone  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (EXP)
methoxyacetic acid  (ISO)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Hsu SY, etal., Mol Endocrinol 1998 Dec;12(12):1830-45.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Wang J, etal., Nat Cell Biol. 2013 Dec;15(12):1455-63. doi: 10.1038/ncb2867. Epub 2013 Nov 10.
Additional References at PubMed
PMID:16406039   PMID:19605502   PMID:21523854   PMID:21693646   PMID:21727895   PMID:22815884   PMID:23393138   PMID:23589304   PMID:24280058   PMID:24353284   PMID:24680895   PMID:25188337  
PMID:35772369  


Genomics

Comparative Map Data
Lgr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83116,901,968 - 117,004,584 (+)NCBIGRCr8
mRatBN7.2396,447,385 - 96,550,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,447,858 - 96,548,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3100,007,532 - 100,109,518 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,606,494 - 108,708,483 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,370,036 - 106,472,231 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03101,051,960 - 101,152,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,051,955 - 101,152,119 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03107,652,233 - 107,752,743 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4395,370,049 - 95,471,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1395,266,473 - 95,367,468 (+)NCBI
Celera395,472,374 - 95,573,289 (+)NCBICelera
Cytogenetic Map3q34NCBI
LGR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381127,365,961 - 27,472,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1127,365,961 - 27,472,790 (-)EnsemblGRCh38hg38GRCh38
GRCh371127,387,508 - 27,494,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,344,084 - 27,450,910 (-)NCBINCBI36Build 36hg18NCBI36
Celera1127,532,862 - 27,640,072 (-)NCBICelera
Cytogenetic Map11p14.1NCBI
HuRef1127,084,852 - 27,193,084 (-)NCBIHuRef
CHM1_11127,386,916 - 27,493,708 (-)NCBICHM1_1
T2T-CHM13v2.01127,506,453 - 27,613,276 (-)NCBIT2T-CHM13v2.0
Lgr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,747,919 - 109,844,602 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2109,747,992 - 109,844,602 (+)EnsemblGRCm39 Ensembl
GRCm382109,917,647 - 110,014,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,917,647 - 110,014,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv372109,757,804 - 109,854,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362109,709,007 - 109,815,096 (+)NCBIMGSCv36mm8
Celera2111,078,651 - 111,175,891 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.65NCBI
Lgr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,610,103 - 6,629,264 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554766,611,102 - 6,629,294 (-)NCBIChiLan1.0ChiLan1.0
LGR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2929,576,585 - 29,683,037 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,577,034 - 29,683,557 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,330,279 - 27,437,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,232,801 - 27,291,571 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,229,963 - 27,291,571 (-)Ensemblpanpan1.1panPan2
LGR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12147,952,019 - 47,995,530 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2147,952,890 - 47,996,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2147,448,894 - 47,548,000 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02149,092,130 - 49,194,350 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2149,093,704 - 49,165,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12148,077,244 - 48,176,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02148,247,673 - 48,347,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02148,839,453 - 48,939,290 (-)NCBIUU_Cfam_GSD_1.0
Lgr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,597,365 - 36,690,743 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365405,752,197 - 5,845,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365405,752,319 - 5,846,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,871,871 - 32,979,148 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,871,837 - 32,979,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,582,601 - 35,614,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,632,748 - 37,741,100 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl137,632,710 - 37,741,330 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038134,942,734 - 135,051,210 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476617,112,909 - 17,147,785 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476617,110,809 - 17,147,585 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lgr4
442 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:65
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000007681
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)396127817102200699Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 57 41 8 41 8 9 74 35 36 10 8
Low 3 11 2 5 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007681   ⟹   ENSRNOP00000007681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl396,447,858 - 96,548,899 (+)Ensembl
Rnor_6.0 Ensembl3101,051,955 - 101,152,119 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103127   ⟹   ENSRNOP00000093244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl396,447,865 - 96,548,899 (+)Ensembl
RefSeq Acc Id: NM_173328   ⟹   NP_775450
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,901,968 - 117,004,153 (+)NCBI
mRatBN7.2396,447,385 - 96,549,575 (+)NCBI
Rnor_6.03101,051,960 - 101,152,119 (+)NCBI
Rnor_5.03107,652,233 - 107,752,743 (+)NCBI
RGSC_v3.4395,370,049 - 95,471,040 (+)RGD
Celera395,472,374 - 95,573,289 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104411   ⟹   XP_038960339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83116,925,546 - 117,004,584 (+)NCBI
mRatBN7.2396,470,950 - 96,550,006 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_775450   ⟸   NM_173328
- Peptide Label: precursor
- UniProtKB: Q9Z2H4 (UniProtKB/Swiss-Prot),   G3V6R1 (UniProtKB/Swiss-Prot),   A0A8I6AJN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007681   ⟸   ENSRNOT00000007681
RefSeq Acc Id: XP_038960339   ⟸   XM_039104411
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000093244   ⟸   ENSRNOT00000103127
Protein Domains
G-protein coupled receptors family 1 profile   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2H4-F1-model_v2 AlphaFold Q9Z2H4 1-951 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692282
Promoter ID:EPDNEW_R2806
Type:single initiation site
Name:Lgr4_1
Description:leucine-rich repeat-containing G protein-coupled receptor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03101,051,964 - 101,052,024EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628615 AgrOrtholog
BioCyc Gene G2FUF-48477 BioCyc
Ensembl Genes ENSRNOG00000005715 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055023472 UniProtKB/Swiss-Prot
  ENSRNOG00060001759 UniProtKB/Swiss-Prot
  ENSRNOG00065016106 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007681 ENTREZGENE
  ENSRNOT00000007681.5 UniProtKB/Swiss-Prot
  ENSRNOT00000103127.1 UniProtKB/TrEMBL
  ENSRNOT00055040404 UniProtKB/Swiss-Prot
  ENSRNOT00060002720 UniProtKB/Swiss-Prot
  ENSRNOT00065026804 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gphrmn_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:286994 UniProtKB/Swiss-Prot
NCBI Gene 286994 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPR INSULIN LIKE RECEPTOR 1 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lgr4 PhenoGen
PRINTS GLYCHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005715 RatGTEx
  ENSRNOG00055023472 RatGTEx
  ENSRNOG00060001759 RatGTEx
  ENSRNOG00065016106 RatGTEx
SMART LRR_BAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AJN3 ENTREZGENE, UniProtKB/TrEMBL
  G3V6R1 ENTREZGENE
  LGR4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V6R1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Lgr4  leucine-rich repeat-containing G protein-coupled receptor 4  Gpr48  G protein-coupled receptor 48  Symbol and Name updated 1299863 APPROVED
2004-02-26 Gpr48  G protein-coupled receptor 48      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Gpr48  G protein-coupled receptor 48      Symbol and Name status set to provisional 70820 PROVISIONAL