LGR4 (leucine rich repeat containing G protein-coupled receptor 4) - Rat Genome Database

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Gene: LGR4 (leucine rich repeat containing G protein-coupled receptor 4) Pan paniscus
Analyze
Symbol: LGR4
Name: leucine rich repeat containing G protein-coupled receptor 4
RGD ID: 12027130
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); INVOLVED IN digestive tract development (ortholog); epithelial cell proliferation (ortholog); epithelial cell proliferation involved in renal tubule morphogenesis (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); glaucoma (ortholog); intellectual disability (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat-containing G-protein coupled receptor 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2929,576,585 - 29,683,037 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,577,034 - 29,683,557 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,330,279 - 27,437,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,232,801 - 27,291,571 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,229,963 - 27,291,571 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LGR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2929,576,585 - 29,683,037 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11129,577,034 - 29,683,557 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,330,279 - 27,437,201 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,232,801 - 27,291,571 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,229,963 - 27,291,571 (-)Ensemblpanpan1.1panPan2
LGR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381127,365,961 - 27,472,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1127,365,961 - 27,472,790 (-)EnsemblGRCh38hg38GRCh38
GRCh371127,387,508 - 27,494,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,344,084 - 27,450,910 (-)NCBINCBI36Build 36hg18NCBI36
Celera1127,532,862 - 27,640,072 (-)NCBICelera
Cytogenetic Map11p14.1NCBI
HuRef1127,084,852 - 27,193,084 (-)NCBIHuRef
CHM1_11127,386,916 - 27,493,708 (-)NCBICHM1_1
T2T-CHM13v2.01127,506,453 - 27,613,276 (-)NCBIT2T-CHM13v2.0
Lgr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,747,919 - 109,844,602 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2109,747,992 - 109,844,602 (+)EnsemblGRCm39 Ensembl
GRCm382109,917,647 - 110,014,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,917,647 - 110,014,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv372109,757,804 - 109,854,414 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362109,709,007 - 109,815,096 (+)NCBIMGSCv36mm8
Celera2111,078,651 - 111,175,891 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.65NCBI
Lgr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83116,901,968 - 117,004,584 (+)NCBIGRCr8
mRatBN7.2396,447,385 - 96,550,006 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,447,858 - 96,548,899 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3100,007,532 - 100,109,518 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03108,606,494 - 108,708,483 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03106,370,036 - 106,472,231 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03101,051,960 - 101,152,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,051,955 - 101,152,119 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03107,652,233 - 107,752,743 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4395,370,049 - 95,471,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1395,266,473 - 95,367,468 (+)NCBI
Celera395,472,374 - 95,573,289 (+)NCBICelera
Cytogenetic Map3q34NCBI
Lgr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,610,103 - 6,629,264 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554766,611,102 - 6,629,294 (-)NCBIChiLan1.0ChiLan1.0
LGR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12147,952,019 - 47,995,530 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2147,952,890 - 47,996,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2147,448,894 - 47,548,000 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02149,092,130 - 49,194,350 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2149,093,704 - 49,165,497 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12148,077,244 - 48,176,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02148,247,673 - 48,347,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02148,839,453 - 48,939,290 (-)NCBIUU_Cfam_GSD_1.0
Lgr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,597,365 - 36,690,743 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365405,752,197 - 5,845,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365405,752,319 - 5,846,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,871,871 - 32,979,148 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,871,837 - 32,979,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,582,601 - 35,614,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,632,748 - 37,741,100 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl137,632,710 - 37,741,330 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038134,942,734 - 135,051,210 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476617,112,909 - 17,147,785 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476617,110,809 - 17,147,585 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034932313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000033751   ⟹   ENSPPAP00000011096
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,229,963 - 27,291,571 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000033758   ⟹   ENSPPAP00000011103
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,234,706 - 27,282,280 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000033762   ⟹   ENSPPAP00000011107
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,234,706 - 27,281,245 (-)Ensembl
RefSeq Acc Id: XM_034932313   ⟹   XP_034788204
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2929,576,585 - 29,683,037 (-)NCBI
NHGRI_mPanPan11129,577,034 - 29,683,557 (-)NCBI
Mhudiblu_PPA_v01127,330,279 - 27,437,201 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034788204 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000011096.1
  ENSPPAP00000011103.1
  ENSPPAP00000011107.1
Reference Protein Sequences
RefSeq Acc Id: XP_034788204   ⟸   XM_034932313
RefSeq Acc Id: ENSPPAP00000011107   ⟸   ENSPPAT00000033762
RefSeq Acc Id: ENSPPAP00000011103   ⟸   ENSPPAT00000033758
RefSeq Acc Id: ENSPPAP00000011096   ⟸   ENSPPAT00000033751
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028741 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033751.1 UniProtKB/TrEMBL
  ENSPPAT00000033758.1 UniProtKB/TrEMBL
  ENSPPAT00000033762.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Gphrmn_rcpt_fam UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
NCBI Gene LGR4 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PRINTS GLYCHORMONER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
  L domain-like UniProtKB/TrEMBL
UniProt A0A2R9A1H5_PANPA UniProtKB/TrEMBL
  A0A2R9A1J4_PANPA UniProtKB/TrEMBL
  A0A2R9A6W1_PANPA UniProtKB/TrEMBL