LGR4 (leucine rich repeat containing G protein-coupled receptor 4) - Rat Genome Database

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Gene: LGR4 (leucine rich repeat containing G protein-coupled receptor 4) Sus scrofa
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Symbol: LGR4
Name: leucine rich repeat containing G protein-coupled receptor 4
RGD ID: 14251680
Description: ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); transmembrane signaling receptor activity (ortholog); INVOLVED IN circadian rhythm (ortholog); digestive tract development (ortholog); epithelial cell proliferation (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH intellectual disability (ortholog); osteoporosis (ortholog); FOUND IN integral component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: leucine-rich repeat-containing G-protein coupled receptor 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,871,871 - 32,979,148 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,871,837 - 32,979,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,582,601 - 35,614,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
LGR4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,871,871 - 32,979,148 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,871,837 - 32,979,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,582,601 - 35,614,283 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGR4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1127,365,961 - 27,472,790 (-)EnsemblGRCh38hg38GRCh38
GRCh381127,365,961 - 27,472,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371127,387,508 - 27,494,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,344,084 - 27,450,910 (-)NCBINCBI36hg18NCBI36
Celera1127,532,862 - 27,640,072 (-)NCBI
Cytogenetic Map11p14.1NCBI
HuRef1127,084,852 - 27,193,084 (-)NCBIHuRef
CHM1_11127,386,916 - 27,493,708 (-)NCBICHM1_1
Lgr4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,747,919 - 109,844,602 (+)NCBIGRCm39mm39
GRCm39 Ensembl2109,747,992 - 109,844,602 (+)Ensembl
GRCm382109,917,647 - 110,014,257 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,917,647 - 110,014,257 (+)EnsemblGRCm38mm10GRCm38
MGSCv372109,757,804 - 109,854,414 (+)NCBIGRCm37mm9NCBIm37
MGSCv362109,709,007 - 109,815,096 (+)NCBImm8
Celera2111,078,651 - 111,175,891 (+)NCBICelera
Cytogenetic Map2E3NCBI
Lgr4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2396,447,385 - 96,550,006 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl396,447,858 - 96,548,899 (+)Ensembl
Rnor_6.03101,051,960 - 101,152,119 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,051,955 - 101,152,119 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03107,652,233 - 107,752,743 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4395,370,049 - 95,471,040 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1395,266,473 - 95,367,468 (+)NCBI
Celera395,472,374 - 95,573,289 (+)NCBICelera
Cytogenetic Map3q34NCBI
Lgr4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,610,103 - 6,629,264 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554766,611,102 - 6,629,294 (-)NCBIChiLan1.0ChiLan1.0
LGR4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11127,232,801 - 27,291,571 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,229,963 - 27,291,571 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01127,330,279 - 27,437,201 (-)NCBIMhudiblu_PPA_v0panPan3
LGR4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12147,952,019 - 47,995,530 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2147,952,890 - 47,996,288 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2147,448,894 - 47,548,000 (-)NCBI
ROS_Cfam_1.02149,092,130 - 49,194,350 (-)NCBI
UMICH_Zoey_3.12148,077,244 - 48,176,850 (-)NCBI
UNSW_CanFamBas_1.02148,247,673 - 48,347,510 (-)NCBI
UU_Cfam_GSD_1.02148,839,453 - 48,939,290 (-)NCBI
Lgr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,597,365 - 36,690,743 (+)NCBI
SpeTri2.0NW_0049365405,752,319 - 5,846,074 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGR4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,632,748 - 37,741,100 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl137,632,710 - 37,741,330 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038134,942,734 - 135,051,210 (+)NCBIVero_WHO_p1.0
Lgr4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476617,110,809 - 17,147,585 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 3 23 2 3
Low 4 5 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014563   ⟹   ENSSSCP00000014168
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl232,871,903 - 32,979,148 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000070761   ⟹   ENSSSCP00000070978
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl232,872,334 - 32,978,386 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000080709   ⟹   ENSSSCP00000067759
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl232,871,871 - 32,959,554 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085341   ⟹   ENSSSCP00000073698
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl232,872,398 - 32,979,148 (+)Ensembl
RefSeq Acc Id: XM_013994475   ⟹   XP_013849929
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1232,907,051 - 32,979,150 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083233   ⟹   XP_020938892
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1232,871,837 - 32,979,150 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013849929 (Get FASTA)   NCBI Sequence Viewer  
  XP_020938892 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020938892   ⟸   XM_021083233
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013849929   ⟸   XM_013994475
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000067759   ⟸   ENSSSCT00000080709
RefSeq Acc Id: ENSSSCP00000073698   ⟸   ENSSSCT00000085341
RefSeq Acc Id: ENSSSCP00000070978   ⟸   ENSSSCT00000070761
RefSeq Acc Id: ENSSSCP00000014168   ⟸   ENSSSCT00000014563
Protein Domains
G_PROTEIN_RECEP_F1_2   LRRNT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013335 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070005006 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014168 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000067759 UniProtKB/TrEMBL
  ENSSSCP00000070978 UniProtKB/TrEMBL
  ENSSSCP00000073698 UniProtKB/TrEMBL
  ENSSSCP00070007812 UniProtKB/TrEMBL
  ENSSSCP00070007817 UniProtKB/TrEMBL
  ENSSSCP00070007837 UniProtKB/TrEMBL
  ENSSSCP00070007843 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014563 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000070761 UniProtKB/TrEMBL
  ENSSSCT00000080709 UniProtKB/TrEMBL
  ENSSSCT00000085341 UniProtKB/TrEMBL
  ENSSSCT00070009527 UniProtKB/TrEMBL
  ENSSSCT00070009533 UniProtKB/TrEMBL
  ENSSSCT00070009553 UniProtKB/TrEMBL
  ENSSSCT00070009559 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Gphrmn_rcpt_fam UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
KEGG Report ssc:100518646 UniProtKB/TrEMBL
NCBI Gene LGR4 ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
PRINTS GLYCHORMONER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
UniProt A0A4X1SXY8_PIG UniProtKB/TrEMBL
  A0A4X1SY07_PIG UniProtKB/TrEMBL
  A0A4X1SY12_PIG UniProtKB/TrEMBL
  A0A4X1SZK5_PIG UniProtKB/TrEMBL
  A0A5G2QUC8_PIG UniProtKB/TrEMBL
  A0A5G2R3R2_PIG UniProtKB/TrEMBL
  A0A5G2R8U8_PIG UniProtKB/TrEMBL
  F1SGM5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:89703 ENTREZGENE