Naip6 (NLR family, apoptosis inhibitory protein 6) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Naip6 (NLR family, apoptosis inhibitory protein 6) Rattus norvegicus
Analyze
Symbol: Naip6
Name: NLR family, apoptosis inhibitory protein 6
RGD ID: 621281
Description: Predicted to enable ATP binding activity and protein serine/threonine kinase binding activity. Involved in response to amino acid and response to axon injury. Located in perikaryon. Biomarker of brain ischemia. Orthologous to human NAIP (NLR family apoptosis inhibitory protein); INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC135826.1; Baculoviral IAP repeat-containing 1; baculoviral IAP repeat-containing 1b; baculoviral IAP repeat-containing protein 1b; Birc1; Birc1a; Birc1b; Naip; Naip2; neuronal apoptosis inhibitory protein; NLR family, apoptosis inhibitory protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,241,520 - 33,293,184 (-)NCBIGRCr8
mRatBN7.2231,507,423 - 31,559,098 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,507,424 - 31,570,542 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0230,377,505 - 30,418,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,376,419 - 30,458,542 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0249,536,672 - 49,574,799 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,166,720 - 31,201,797 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,100,786 - 31,119,653 (-)NCBI
Celera227,529,653 - 27,570,845 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (EXP)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
furosemide  (EXP)
genistein  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
isoflurane  (EXP)
kainic acid  (EXP,ISO)
L-methionine  (ISO)
microcystin-LR  (ISO)
morphine  (EXP)
Myrtucommulone A  (ISO)
nickel atom  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
trichostatin A  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of inhibitor of apoptosis family proteins in human oral squamous cell carcinogenesis. Chen YK, etal., Head Neck. 2011 Jul;33(7):985-98. doi: 10.1002/hed.21582. Epub 2010 Oct 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Endogenous expression of inhibitor of apoptosis proteins in facial motoneurons of neonatal and adult rats following axotomy. McPhail LT, etal., Neuroscience 2003;117(3):567-75.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Cloning and characterization of rat neuronal apoptosis inhibitory protein cDNA. Shin SW, etal., Neurochem Int 2003 May;42(6):481-91.
8. Involvement of transforming growth factor alpha in the regulation of rat ovarian X-linked inhibitor of apoptosis protein expression and follicular growth by follicle-stimulating hormone. Wang Y, etal., Biol Reprod 2002 Jun;66(6):1672-80.
9. Distribution of neuronal apoptosis inhibitory protein-like immunoreactivity in the rat central nervous system. Xu DG, etal., J Comp Neurol. 1997 Jun 2;382(2):247-59.
10. Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus. Xu DG, etal., Nat Med. 1997 Sep;3(9):997-1004.
Additional References at PubMed
PMID:11813002   PMID:11896143   PMID:17222062   PMID:17901126   PMID:21371431   PMID:21874021   PMID:23376485   PMID:33237375  


Genomics

Comparative Map Data
Naip6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,241,520 - 33,293,184 (-)NCBIGRCr8
mRatBN7.2231,507,423 - 31,559,098 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,507,424 - 31,570,542 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0230,377,505 - 30,418,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,376,419 - 30,458,542 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0249,536,672 - 49,574,799 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,166,720 - 31,201,797 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,100,786 - 31,119,653 (-)NCBI
Celera227,529,653 - 27,570,845 (-)NCBICelera
Cytogenetic Map2q12NCBI
NAIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38570,968,166 - 71,025,339 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl570,968,166 - 71,025,339 (-)EnsemblGRCh38hg38GRCh38
GRCh37570,263,993 - 70,321,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36570,300,066 - 70,356,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 34570,300,065 - 70,356,279NCBI
Celera566,394,371 - 66,408,214 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef565,886,900 - 65,888,549 (-)NCBIHuRef
HuRef565,863,251 - 65,868,495 (-)NCBIHuRef
CHM1_1569,715,438 - 69,772,054 (-)NCBICHM1_1
T2T-CHM13v2.0571,424,931 - 71,482,091 (-)NCBIT2T-CHM13v2.0
Naip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,280,571 - 100,338,630 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,280,571 - 100,338,600 (-)EnsemblGRCm39 Ensembl
GRCm3813100,144,063 - 100,202,122 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,144,063 - 100,202,092 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713100,914,018 - 100,972,047 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,244,320 - 101,302,349 (-)NCBIMGSCv36mm8
Celera13103,797,627 - 103,855,588 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.01NCBI
Naip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955575249,659 - 283,378 (+)NCBIChiLan1.0ChiLan1.0
NAIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,265,292 - 44,320,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,418,918 - 42,474,063 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,345,623 - 44,401,358 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1545,920,125 - 45,970,355 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl545,920,125 - 45,973,937 (-)Ensemblpanpan1.1panPan2
Naip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213185,788,922 - 185,858,502 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365495,000,526 - 5,069,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11647,700,869 - 47,710,036 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,648,307 - 51,657,385 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NAIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,693,044 - 65,742,527 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604914,433,473 - 14,486,335 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Naip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624905437,799 - 485,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Naip6
767 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1222
Count of miRNA genes:233
Interacting mature miRNAs:277
Transcripts:ENSRNOT00000024501, ENSRNOT00000061195, ENSRNOT00000072926, ENSRNOT00000073781, ENSRNOT00000073996, ENSRNOT00000074365
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
D2Rat94  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2231,523,409 - 31,523,629 (+)MAPPERmRatBN7.2
Rnor_6.0230,393,491 - 30,393,710NCBIRnor6.0
Rnor_5.0249,552,658 - 49,552,877UniSTSRnor5.0
RGSC_v3.4231,182,282 - 31,182,501UniSTSRGSC3.4
RGSC_v3.4231,182,168 - 31,182,521RGDRGSC3.4
RGSC_v3.1231,102,651 - 31,102,870RGD
Celera227,545,608 - 27,545,827UniSTS
RH 3.4 Map262.7RGD
RH 3.4 Map262.7UniSTS
RH 2.0 Map2117.7RGD
SHRSP x BN Map210.4998RGD
FHH x ACI Map218.6499RGD
Cytogenetic Map2q14-q16UniSTS
RH133013  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2231,555,898 - 31,556,109 (+)MAPPERmRatBN7.2
Rnor_6.0230,426,020 - 30,426,230NCBIRnor6.0
Rnor_5.0249,585,233 - 49,585,443UniSTSRnor5.0
RGSC_v3.4231,215,128 - 31,215,338UniSTSRGSC3.4
Celera227,578,275 - 27,578,485UniSTS
RH 3.4 Map262.9UniSTS
Cytogenetic Map2q14-q16UniSTS
D13Die25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2231,526,544 - 31,526,711 (+)MAPPERmRatBN7.2
mRatBN7.2231,575,356 - 31,575,523 (+)MAPPERmRatBN7.2
Rnor_6.0230,445,478 - 30,445,644NCBIRnor6.0
Rnor_6.0230,396,626 - 30,396,792NCBIRnor6.0
Rnor_5.0249,604,702 - 49,604,868UniSTSRnor5.0
Rnor_5.0249,555,793 - 49,555,959UniSTSRnor5.0
RGSC_v3.4231,185,417 - 31,185,583UniSTSRGSC3.4
RGSC_v3.4231,235,344 - 31,235,510UniSTSRGSC3.4
Celera227,597,693 - 27,597,859UniSTS
Celera227,548,743 - 27,548,909UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map2q14-q16UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_138824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC135826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF361881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000072926   ⟹   ENSRNOP00000065975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,507,424 - 31,570,542 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097441   ⟹   ENSRNOP00000083788
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,507,424 - 31,570,542 (-)Ensembl
RefSeq Acc Id: NM_138824   ⟹   NP_620179
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,520 - 33,279,612 (-)NCBI
mRatBN7.2231,507,423 - 31,545,520 (-)NCBI
RefSeq Acc Id: XM_006231862   ⟹   XP_006231924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,293,184 (-)NCBI
mRatBN7.2231,507,423 - 31,559,098 (-)NCBI
Rnor_6.0230,377,505 - 30,417,167 (-)NCBI
Rnor_5.0249,536,672 - 49,574,799 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231863   ⟹   XP_006231925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,280,204 (-)NCBI
mRatBN7.2231,507,429 - 31,559,098 (-)NCBI
Rnor_6.0230,377,511 - 30,415,747 (-)NCBI
Rnor_5.0249,536,672 - 49,574,799 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760695   ⟹   XP_008758917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,293,184 (-)NCBI
mRatBN7.2231,507,423 - 31,559,098 (-)NCBI
Rnor_6.0230,377,505 - 30,418,578 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008760697   ⟹   XP_008758919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,293,184 (-)NCBI
mRatBN7.2231,507,423 - 31,559,098 (-)NCBI
Rnor_6.0230,377,505 - 30,418,578 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591176   ⟹   XP_017446665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,293,184 (-)NCBI
mRatBN7.2231,507,423 - 31,559,098 (-)NCBI
Rnor_6.0230,377,505 - 30,418,578 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591177   ⟹   XP_017446666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,279,502 (-)NCBI
mRatBN7.2231,507,429 - 31,545,411 (-)NCBI
Rnor_6.0230,377,511 - 30,414,026 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039103479   ⟹   XP_038959407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,293,184 (-)NCBI
mRatBN7.2231,507,423 - 31,559,098 (-)NCBI
RefSeq Acc Id: XM_063281269   ⟹   XP_063137339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,280,952 (-)NCBI
RefSeq Acc Id: XM_063281270   ⟹   XP_063137340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,280,203 (-)NCBI
RefSeq Acc Id: XM_063281271   ⟹   XP_063137341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,241,526 - 33,274,224 (-)NCBI
RefSeq Acc Id: XP_006231924   ⟸   XM_006231862
- Peptide Label: isoform X1
- UniProtKB: A6I587 (UniProtKB/TrEMBL),   M0R915 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231925   ⟸   XM_006231863
- Peptide Label: isoform X1
- UniProtKB: A6I587 (UniProtKB/TrEMBL),   M0R915 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758919   ⟸   XM_008760697
- Peptide Label: isoform X1
- UniProtKB: A6I587 (UniProtKB/TrEMBL),   M0R915 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758917   ⟸   XM_008760695
- Peptide Label: isoform X1
- UniProtKB: A6I587 (UniProtKB/TrEMBL),   M0R915 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446665   ⟸   XM_017591176
- Peptide Label: isoform X1
- UniProtKB: A6I587 (UniProtKB/TrEMBL),   M0R915 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446666   ⟸   XM_017591177
- Peptide Label: isoform X1
- UniProtKB: A6I587 (UniProtKB/TrEMBL),   M0R915 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038959407   ⟸   XM_039103479
- Peptide Label: isoform X1
- UniProtKB: A6I587 (UniProtKB/TrEMBL),   M0R915 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083788   ⟸   ENSRNOT00000097441
Ensembl Acc Id: ENSRNOP00000065975   ⟸   ENSRNOT00000072926
RefSeq Acc Id: NP_620179   ⟸   NM_138824
- UniProtKB: A6I587 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137339   ⟸   XM_063281269
- Peptide Label: isoform X1
- UniProtKB: A6I587 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137340   ⟸   XM_063281270
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137341   ⟸   XM_063281271
- Peptide Label: isoform X3
Protein Domains
NACHT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R915-F1-model_v2 AlphaFold M0R915 1-1403 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621281 AgrOrtholog
BioCyc Gene G2FUF-54672 BioCyc
Ensembl Genes ENSRNOG00000033693 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072926.4 UniProtKB/TrEMBL
  ENSRNOT00000097441.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro BIR_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  Naip UniProtKB/TrEMBL
  Nlrc4-like_WHD UniProtKB/TrEMBL
  NLRC4_HD UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 191568 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  PTHR46914 UniProtKB/TrEMBL
Pfam BIR UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  Nlrc4-like_WHD UniProtKB/TrEMBL
  NLRC4_HD UniProtKB/TrEMBL
PhenoGen Naip6 PhenoGen
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033693 RatGTEx
SMART BIR UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8I5ZWN7_RAT UniProtKB/TrEMBL
  A6I587 ENTREZGENE, UniProtKB/TrEMBL
  M0R915 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Naip6  NLR family, apoptosis inhibitory protein 6  Naip2  NLR family, apoptosis inhibitory protein 2  Data merged from RGD:15004055 737654 PROVISIONAL
2020-08-20 Naip2  NLR family, apoptosis inhibitory protein 2  AC135826.1    Symbol and/or name change 19259462 PROVISIONAL
2019-11-08 AC135826.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2012-10-05 Naip6  NLR family, apoptosis inhibitory protein 6  Naip2  NLR family, apoptosis inhibitory protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Naip2  NLR family, apoptosis inhibitory protein 2  Birc1b  baculoviral IAP repeat-containing 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Birc1b  baculoviral IAP repeat-containing 1b  Birc1  Baculoviral IAP repeat-containing 1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Birc1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease human homolog may modify the severity of infantile spinal muscular atrophy 634756