Naip (NLR family apoptosis inhibitory protein) - Rat Genome Database

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Gene: Naip (NLR family apoptosis inhibitory protein) Chinchilla lanigera
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Symbol: Naip
Name: NLR family apoptosis inhibitory protein
RGD ID: 8822956
Description: ENCODES a protein that exhibits ATP binding (ortholog); protein serine/threonine kinase binding (ortholog); INVOLVED IN cellular response to estrogen stimulus (ortholog); defense response to bacterium (ortholog); detection of bacterium (ortholog); ASSOCIATED WITH amenorrhea (ortholog); brain glioma (ortholog); brain ischemia (ortholog); FOUND IN IPAF inflammasome complex (ortholog); neuronal cell body (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: baculoviral IAP repeat-containing protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955575249,659 - 283,378 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NaipChinchillabrain glioma exacerbatesISONAIP (Homo sapiens)9068941mRNA:increased expression:brain (human)RGDPMID:31964418 and REF_RGD_ID:153344516
NaipChinchillabrain ischemia  ISONaip6 (Rattus norvegicus)9068941protein:increased expression:thalamus (rat)RGDPMID:9288726 and REF_RGD_ID:2317254
NaipChinchillabreast carcinoma disease_progressionISONAIP (Homo sapiens)9068941mRNA:decreased expression:breast (human)RGDPMID:31964418 and REF_RGD_ID:153344516
NaipChinchillacolon adenocarcinoma exacerbatesISONAIP (Homo sapiens)9068941mRNA:increased expression:colon (human)RGDPMID:31964418 and REF_RGD_ID:153344516
NaipChinchillaCOVID-19  ISONAIP (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
NaipChinchillagastric adenocarcinoma disease_progressionISONAIP (Homo sapiens)9068941mRNA:increased expression:stomach (human)RGDPMID:31964418 and REF_RGD_ID:153344516
NaipChinchillahead and neck squamous cell carcinoma amelioratesISONAIP (Homo sapiens)9068941mRNA:increased expression:head or neck skin (human)RGDPMID:31964418 and REF_RGD_ID:153344516
NaipChinchillalung adenocarcinoma amelioratesISONAIP (Homo sapiens)9068941mRNA:increased expression:lung (human)RGDPMID:31964418 and REF_RGD_ID:153344516
NaipChinchillaoral squamous cell carcinoma  ISONAIP (Homo sapiens)9068941protein:increased expression:oral cavity (human)RGDPMID:20967871 and REF_RGD_ID:152999012
NaipChinchillaparaganglioma exacerbatesISONAIP (Homo sapiens)9068941mRNA:increased expression:adrenal gland and chromaffin cell (human)RGDPMID:31964418 and REF_RGD_ID:153344516
NaipChinchillaskin melanoma exacerbatesISONAIP (Homo sapiens)9068941mRNA:increased expression:zone of skin (human)RGDPMID:31964418 and REF_RGD_ID:153344516
NaipChinchillaTesticular Germ Cell Tumor exacerbatesISONAIP (Homo sapiens)9068941mRNA:increased expression:testis (human)RGDPMID:31964418 and REF_RGD_ID:153344516
NaipChinchillathymoma amelioratesISONAIP (Homo sapiens)9068941mRNA:increased expression:thymus (human)RGDPMID:31964418 and REF_RGD_ID:153344516
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NaipChinchillaamenorrhea  ISONAIP (Homo sapiens)8554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106
NaipChinchillaNeurodevelopmental Disorders  ISONAIP (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868


Biological Process
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1 to 11 of 11 rows

Cellular Component

  

Molecular Function

  


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:30032202  



Naip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955575249,659 - 283,378 (+)NCBIChiLan1.0ChiLan1.0
NAIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38570,968,166 - 71,025,339 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl570,968,166 - 71,025,339 (-)EnsemblGRCh38hg38GRCh38
GRCh37570,263,993 - 70,321,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36570,300,066 - 70,356,697 (-)NCBINCBI36Build 36hg18NCBI36
Build 34570,300,065 - 70,356,279NCBI
Celera566,394,371 - 66,408,214 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef565,886,900 - 65,888,549 (-)NCBIHuRef
HuRef565,863,251 - 65,868,495 (-)NCBIHuRef
CHM1_1569,715,438 - 69,772,054 (-)NCBICHM1_1
T2T-CHM13v2.0571,424,931 - 71,482,091 (-)NCBIT2T-CHM13v2.0
Naip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,280,571 - 100,338,630 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,280,571 - 100,338,600 (-)EnsemblGRCm39 Ensembl
GRCm3813100,144,063 - 100,202,122 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,144,063 - 100,202,092 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713100,914,018 - 100,972,047 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,244,320 - 101,302,349 (-)NCBIMGSCv36mm8
Celera13103,797,627 - 103,855,588 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.01NCBI
Naip6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,241,520 - 33,293,184 (-)NCBIGRCr8
mRatBN7.2231,507,423 - 31,559,098 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,507,424 - 31,570,542 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0230,377,505 - 30,418,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,376,419 - 30,458,542 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0249,536,672 - 49,574,799 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,166,720 - 31,201,797 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,100,786 - 31,119,653 (-)NCBI
Celera227,529,653 - 27,570,845 (-)NCBICelera
Cytogenetic Map2q12NCBI
NAIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,265,292 - 44,320,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,418,918 - 42,474,063 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,345,623 - 44,401,358 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1545,920,125 - 45,970,355 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl545,920,125 - 45,973,937 (-)Ensemblpanpan1.1panPan2
Naip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213185,788,922 - 185,858,502 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365495,000,526 - 5,069,110 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11647,700,869 - 47,710,036 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,648,307 - 51,657,385 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NAIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,693,044 - 65,742,527 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604914,433,473 - 14,486,335 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Naip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624905437,799 - 485,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






RefSeq Acc Id: XM_005413916   ⟹   XP_005413973
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955575249,659 - 282,608 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509579   ⟹   XP_013365033
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955575249,659 - 282,221 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509580   ⟹   XP_013365034
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955575249,659 - 280,420 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509581   ⟹   XP_013365035
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955575249,659 - 283,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509582   ⟹   XP_013365036
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955575249,659 - 279,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509583   ⟹   XP_013365037
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955575249,659 - 279,692 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013509584   ⟹   XP_013365038
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955575259,037 - 282,608 (+)NCBI
Sequence:
RefSeq Acc Id: XR_265067
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955575249,659 - 282,219 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005413973   ⟸   XM_005413916
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YHZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013365035   ⟸   XM_013509581
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013365033   ⟸   XM_013509579
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013365034   ⟸   XM_013509580
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013365036   ⟸   XM_013509582
- Peptide Label: isoform X3
- Sequence:
NACHT



1 to 28 of 28 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000000091 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000000095 ENTREZGENE
  ENSCLAT00000000095.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A UniProtKB/TrEMBL
InterPro BIR_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  Naip UniProtKB/TrEMBL
  Nlrc4-like_WHD UniProtKB/TrEMBL
  NLRC4_HD UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Naip ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  PTHR46914 UniProtKB/TrEMBL
Pfam BIR UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
  Nlrc4-like_WHD UniProtKB/TrEMBL
  NLRC4_HD UniProtKB/TrEMBL
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
SMART BIR UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/TrEMBL
  RNI-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2YHZ6 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Naip  NLR family apoptosis inhibitory protein    NLR family, apoptosis inhibitory protein  Symbol and/or name change 5135510 APPROVED