Eif2s1 (eukaryotic translation initiation factor 2 subunit alpha) - Rat Genome Database

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Gene: Eif2s1 (eukaryotic translation initiation factor 2 subunit alpha) Rattus norvegicus
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Symbol: Eif2s1
Name: eukaryotic translation initiation factor 2 subunit alpha
RGD ID: 620963
Description: Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including positive regulation of type B pancreatic cell apoptotic process; response to kainic acid; and response to manganese-induced endoplasmic reticulum stress. Located in glial limiting end-foot. Part of eukaryotic translation initiation factor 2 complex and translation initiation ternary complex. Used to study middle cerebral artery infarction. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha); PARTICIPATES IN translation initiation pathway; Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (R,R)-tramadol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eIF-2-alpha; EIF-2A; EIF-2alpha; eIF2-alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2 subunit 1 alpha; eukaryotic translation initiation factor 2, subunit 1 (alpha ); eukaryotic translation initiation factor 2, subunit 1 alpha; MGC93488
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86103,405,880 - 103,430,549 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6103,405,788 - 103,431,649 (+)EnsemblGRCr8
mRatBN7.2697,672,829 - 97,697,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,672,766 - 97,706,225 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx698,102,349 - 98,127,010 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,401,511 - 98,426,172 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0697,788,465 - 97,813,132 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,048,372 - 102,073,041 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)Ensemblrn6Rnor6.0
Rnor_5.06111,422,397 - 111,447,066 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46101,495,444 - 101,520,113 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera696,060,793 - 96,085,462 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(R)-lipoic acid  (EXP)
(R,R)-tramadol  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dichlorophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-Methoxyflavone  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
agomelatine  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (EXP,ISO)
Aloe emodin  (ISO)
alpha-naphthoflavone  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anandamide  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
Aurin  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
bupropion  (ISO)
busulfan  (ISO)
C.I. Natural Red 20  (EXP)
cadmium acetate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (EXP,ISO)
Cannabidivarin  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
chlorogenic acid  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
chrysophanol  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dantrolene  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dihydrocapsaicin  (ISO)
dihydroxyacetone  (ISO)
Dinitramine  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
ebselen  (EXP)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxomicin  (ISO)
erastin  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (ISO)
flavokawain B  (ISO)
flavonoids  (EXP)
flufenoxuron  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (EXP)
GSK2656157  (EXP,ISO)
Guanabenz  (EXP,ISO)
hexadecanoic acid  (ISO)
homocysteic acid  (EXP)
homocysteine  (ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
indoxyl sulfate  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (ISO)
L-glutamic acid  (EXP)
lead diacetate  (EXP)
lead(II) chloride  (ISO)
leflunomide  (ISO)
Leonurine  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
luteolin  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
mevastatin  (ISO)
minocycline  (EXP,ISO)
mitoxantrone  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methylnicotinate  (ISO)
naloxone  (ISO)
nefazodone  (EXP)
niclosamide  (ISO)
nicotine  (EXP)
nimesulide  (EXP)
NORCANTHARIDIN  (ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP,ISO)
oxycodone  (EXP,ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
Pendulone  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
Perhexiline maleate  (ISO)
phenethyl isothiocyanate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
potassium atom  (EXP)
proanthocyanidin  (EXP)
procymidone  (ISO)
propiconazole  (EXP)
pyrazinecarboxamide  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
quinolinic acid  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
ricolinostat  (ISO)
rifampicin  (EXP)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
selenomethionine  (EXP)
sertraline  (ISO)
Shikonin  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Sodium iodate  (ISO)
staurosporine  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
syringic acid  (EXP)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
Tartrolon D  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
titanium dioxide  (ISO)
toosendanin  (ISO)
tramadol  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
triclocarban  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vanillic acid  (ISO)
vildagliptin  (EXP)
zidovudine  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice. Althausen S, etal., J Neurochem. 2001 Aug;78(4):779-87.
2. Shape and location of eukaryotic initiation factor eIF-2 on the 40S ribosomal subunit of rat liver. Immunoelectron-microscopic and hydrodynamic investigations. Bommer UA, etal., Eur J Biochem. 1988 Mar 15;172(3):653-62.
3. Identification of proteins of the 40 S ribosomal subunit involved in interaction with initiation factor eIF-2 in the quaternary initiation complex by means of monospecific antibodies. Bommer UA, etal., FEBS Lett. 1988 Jun 6;233(1):114-8.
4. Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat. Burda J, etal., Biochem J. 1994 Sep 1;302 ( Pt 2):335-8.
5. Rat fibroblasts transfected with the human 70-kDa heat shock gene exhibit altered translation and eukaryotic initiation factor 2 alpha phosphorylation following heat shock. Chang GC, etal., Int J Hyperthermia. 1994 May-Jun;10(3):325-37.
6. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. Cnop M, etal., J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.
7. Alpha subunit of eukaryotic translational initiation factor-2 is a heat-shock protein. Colbert RA, etal., J Biol Chem. 1987 Dec 15;262(35):16763-6.
8. Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha. DeGracia DJ, etal., J Cereb Blood Flow Metab. 1997 Dec;17(12):1291-302.
9. Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. Ernst H, etal., J Biol Chem 1987 Jan 25;262(3):1206-12.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Ultrastructural localization of phosphorylated eIF2alpha in rat dorsal hippocampus during reperfusion. Goldstein EN, etal., Acta Neuropathol. 1999 Nov;98(5):493-505.
13. [Role of PERK/eIF2a signaling pathway in hepatocyte apoptosis of alcoholic liver injury rats]. Han XH, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Oct;18(10):768-72. doi: 10.3760/cma.j.issn.1007-3418.2010.10.011.
14. The mechanism of eukaryotic translation initiation: new insights and challenges. Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
15. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
16. Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging. Hussain SG and Ramaiah KV, Biochem Biophys Res Commun. 2007 Apr 6;355(2):365-70. Epub 2007 Feb 6.
17. Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis. Kimball SR, etal., Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E772-80. Epub 2004 Jun 8.
18. Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b. Kimball SR, etal., J Biol Chem. 1998 May 22;273(21):12841-5.
19. TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's beta-amyloid oligomers in mice and monkeys. Lourenco MV, etal., Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Renal ischemia and reperfusion activates the eIF 2 alpha kinase PERK. Montie HL, etal., Biochim Biophys Acta. 2005 Sep 25;1741(3):314-24.
22. Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in rats. Nakka VP, etal., Neurotox Res. 2010 Feb;17(2):189-202. doi: 10.1007/s12640-009-9110-5.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease. Paccalin M, etal., Dement Geriatr Cogn Disord. 2006;22(4):320-6. Epub 2006 Sep 4.
25. Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model. Petrov T, etal., J Neurotrauma. 2001 Aug;18(8):799-812.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain. Sokka AL, etal., J Neurosci. 2007 Jan 24;27(4):901-8.
31. Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo. Unterberger U, etal., J Neuropathol Exp Neurol. 2006 Apr;65(4):348-57.
32. Regulation of eukaryotic initiation factor-2 expression during sepsis. Vary TC, etal., Am J Physiol. 1994 Feb;266(2 Pt 1):E193-201.
33. Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis. Wu CX, etal., Neurosci Lett. 2013 Jun 24;546:57-62. doi: 10.1016/j.neulet.2013.04.060. Epub 2013 May 10.
34. alpha-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Xu B, etal., Mol Neurobiol. 2014 Feb;49(1):399-412. doi: 10.1007/s12035-013-8527-2. Epub 2013 Aug 10.
Additional References at PubMed
PMID:10882126   PMID:11106749   PMID:11323413   PMID:12176355   PMID:12388085   PMID:12477932   PMID:15489334   PMID:15937339   PMID:16176978   PMID:16289705   PMID:16452087   PMID:16854843  
PMID:17894550   PMID:18508033   PMID:19139267   PMID:19861488   PMID:19946888   PMID:20458337   PMID:22082260   PMID:22658674   PMID:22681889   PMID:22883908   PMID:23063529   PMID:23376485  
PMID:24006279   PMID:25057203   PMID:26120832   PMID:27338925   PMID:27430620   PMID:29289717   PMID:30053369   PMID:33450132   PMID:35352799   PMID:36438488  


Genomics

Comparative Map Data
Eif2s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86103,405,880 - 103,430,549 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6103,405,788 - 103,431,649 (+)EnsemblGRCr8
mRatBN7.2697,672,829 - 97,697,499 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,672,766 - 97,706,225 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx698,102,349 - 98,127,010 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,401,511 - 98,426,172 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0697,788,465 - 97,813,132 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,048,372 - 102,073,041 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)Ensemblrn6Rnor6.0
Rnor_5.06111,422,397 - 111,447,066 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46101,495,444 - 101,520,113 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera696,060,793 - 96,085,462 (+)NCBICelera
Cytogenetic Map6q24NCBI
EIF2S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381467,360,328 - 67,386,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,360,011 - 67,386,516 (+)Ensemblhg38GRCh38
GRCh371467,827,045 - 67,853,233 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361466,896,787 - 66,922,986 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341466,896,837 - 66,921,909NCBI
Celera1447,886,088 - 47,912,287 (+)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1447,996,958 - 48,023,152 (+)NCBIHuRef
CHM1_11467,765,718 - 67,791,923 (+)NCBICHM1_1
T2T-CHM13v2.01461,567,453 - 61,593,639 (+)NCBIT2T-CHM13v2.0
Eif2s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391278,908,846 - 78,933,784 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1278,908,593 - 78,933,784 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381278,862,072 - 78,887,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1278,861,819 - 78,887,010 (+)Ensemblmm10GRCm38
MGSCv371279,963,059 - 79,987,997 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361279,780,910 - 79,804,371 (+)NCBIMGSCv36mm8
Celera1280,326,532 - 80,351,470 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
Eif2s1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,838,785 - 2,855,172 (-)Ensembl
ChiLan1.0NW_0049554662,838,785 - 2,855,443 (-)NCBIChiLan1.0ChiLan1.0
EIF2S1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21568,465,765 - 68,489,430 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11467,682,677 - 67,708,545 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01447,935,691 - 47,960,055 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11466,813,953 - 66,839,866 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1466,813,953 - 66,839,866 (+)EnsemblpanPan2panpan1.1
EIF2S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1841,354,400 - 41,371,676 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,351,244 - 41,371,056 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha841,045,920 - 41,062,790 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0841,581,554 - 41,598,447 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,581,926 - 41,600,736 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,200,418 - 41,217,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,273,999 - 41,290,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,632,932 - 41,649,922 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eif2s1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,422,172 - 63,445,032 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649510,745,923 - 10,773,199 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649510,746,687 - 10,769,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2S1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl791,085,335 - 91,109,827 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1791,085,025 - 91,109,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,394,525 - 97,417,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,599,017 - 44,623,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,598,287 - 44,623,298 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605332,828,857 - 32,856,268 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2s1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,621,782 - 33,640,549 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473433,624,246 - 33,640,667 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Eif2s1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1792,972,866 - 92,998,250 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Eif2s1
86 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:236
Count of miRNA genes:150
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000013375
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat

Markers in Region
RH127504  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,697,117 - 97,697,300 (+)MAPPERmRatBN7.2
Rnor_6.06102,072,660 - 102,072,842NCBIRnor6.0
Rnor_5.06111,446,685 - 111,446,867UniSTSRnor5.0
RGSC_v3.46101,519,732 - 101,519,914UniSTSRGSC3.4
Celera696,085,081 - 96,085,263UniSTS
Cytogenetic Map6q24UniSTS
BI292531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2697,697,583 - 97,697,760 (+)MAPPERmRatBN7.2
Rnor_6.06102,073,126 - 102,073,302NCBIRnor6.0
Rnor_5.06111,447,151 - 111,447,327UniSTSRnor5.0
RGSC_v3.46101,520,198 - 101,520,374UniSTSRGSC3.4
Celera696,085,547 - 96,085,723UniSTS
RH 3.4 Map6689.9UniSTS
Cytogenetic Map6q24UniSTS
Eif2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21925,412,659 - 25,412,966 (-)MAPPERmRatBN7.2
mRatBN7.21654,401,102 - 54,401,395 (+)MAPPERmRatBN7.2
Rnor_6.01657,881,477 - 57,881,769NCBIRnor6.0
Rnor_6.01923,844,155 - 23,844,461NCBIRnor6.0
Rnor_5.01934,828,004 - 34,828,310UniSTSRnor5.0
Rnor_5.01657,565,260 - 57,565,552UniSTSRnor5.0
RGSC_v3.41658,041,512 - 58,041,804UniSTSRGSC3.4
RGSC_v3.41927,151,277 - 27,151,583UniSTSRGSC3.4
Celera1924,947,364 - 24,947,670UniSTS
Celera1652,484,247 - 52,484,539UniSTS
Cytogenetic Map19q11UniSTS
Cytogenetic Map6q24UniSTS
Cytogenetic Map16q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013375   ⟹   ENSRNOP00000013375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6103,405,788 - 103,431,649 (+)Ensembl
mRatBN7.2 Ensembl697,672,766 - 97,706,225 (+)Ensembl
Rnor_6.0 Ensembl6102,048,372 - 102,073,041 (+)Ensembl
RefSeq Acc Id: NM_019356   ⟹   NP_062229
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86103,405,880 - 103,430,549 (+)NCBI
mRatBN7.2697,672,829 - 97,697,499 (+)NCBI
Rnor_6.06102,048,372 - 102,073,041 (+)NCBI
Rnor_5.06111,422,397 - 111,447,066 (+)NCBI
RGSC_v3.46101,495,444 - 101,520,113 (+)RGD
Celera696,060,793 - 96,085,462 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062229 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41110 (Get FASTA)   NCBI Sequence Viewer  
  AAH87019 (Get FASTA)   NCBI Sequence Viewer  
  EDM03706 (Get FASTA)   NCBI Sequence Viewer  
  EDM03707 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013375
  ENSRNOP00000013375.2
GenBank Protein P68101 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062229   ⟸   NM_019356
- UniProtKB: P68101 (UniProtKB/Swiss-Prot),   A6HCF1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013375   ⟸   ENSRNOT00000013375
Protein Domains
S1 motif

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P68101-F1-model_v2 AlphaFold P68101 1-315 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694688
Promoter ID:EPDNEW_R5213
Type:initiation region
Name:Eif2s1_1
Description:eukaryotic translation initiation factor 2 subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06102,048,273 - 102,048,333EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620963 AgrOrtholog
BioCyc Gene G2FUF-36986 BioCyc
Ensembl Genes ENSRNOG00000009432 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013375 ENTREZGENE
  ENSRNOT00000013375.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.140 UniProtKB/Swiss-Prot
  3.30.70.1130 UniProtKB/Swiss-Prot
  Translation initiation factor 2, subunit 1, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191037 IMAGE-MGC_LOAD
InterPro NA-bd_OB-fold UniProtKB/Swiss-Prot
  S1_domain UniProtKB/Swiss-Prot
  S1_IF2_alpha UniProtKB/Swiss-Prot
  TIF2_asu_C UniProtKB/Swiss-Prot
  TIF2_asu_middle_sf UniProtKB/Swiss-Prot
  TIF_2_asu UniProtKB/Swiss-Prot
KEGG Report rno:54318 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93488 IMAGE-MGC_LOAD
NCBI Gene 54318 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1 UniProtKB/Swiss-Prot
  PTHR10602 UniProtKB/Swiss-Prot
Pfam EIF_2_alpha UniProtKB/Swiss-Prot
  PF00575 UniProtKB/Swiss-Prot
PhenoGen Eif2s1 PhenoGen
PROSITE PS50126 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009432 RatGTEx
SMART SM00316 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF110993 UniProtKB/Swiss-Prot
  SSF116742 UniProtKB/Swiss-Prot
  SSF50249 UniProtKB/Swiss-Prot
UniProt A6HCF1 ENTREZGENE, UniProtKB/TrEMBL
  A6HCF2_RAT UniProtKB/TrEMBL
  IF2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P05199 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Eif2s1  eukaryotic translation initiation factor 2 subunit alpha  Eif2s1  eukaryotic translation initiation factor 2 subunit 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-26 Eif2s1  eukaryotic translation initiation factor 2 subunit 1 alpha  Eif2s1  eukaryotic translation initiation factor 2 subunit 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Eif2s1  eukaryotic translation initiation factor 2 subunit 1  Eif2s1  eukaryotic translation initiation factor 2, subunit 1 alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Eif2s1  eukaryotic translation initiation factor 2, subunit 1 alpha    eukaryotic translation initiation factor 2, subunit 1 (alpha )  Name updated 1299863 APPROVED
2002-08-07 Eif2s1  eukaryotic translation initiation factor 2, subunit 1 (alpha )      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 315 amino acids; 36.1 kDa 728211