Tdg (thymine-DNA glycosylase) - Rat Genome Database

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Gene: Tdg (thymine-DNA glycosylase) Rattus norvegicus
Analyze
Symbol: Tdg
Name: thymine-DNA glycosylase
RGD ID: 620959
Description: Enables DNA-binding transcription factor binding activity and protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body and plasma membrane. Predicted to be active in nucleus. Orthologous to human TDG (thymine DNA glycosylase); PARTICIPATES IN base excision repair pathway; INTERACTS WITH (+)-pilocarpine; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G/T mismatch-specific thymine DNA glycosylase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Tdg-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,965,388 - 22,990,311 (-)NCBIGRCr8
mRatBN7.2721,077,853 - 21,097,617 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl721,077,853 - 21,097,567 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx723,052,578 - 23,072,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0725,215,283 - 25,234,966 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,992,359 - 25,012,044 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0727,194,000 - 27,213,676 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl727,193,998 - 27,214,236 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,313,355 - 27,333,031 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,300,450 - 23,320,095 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,320,723 - 23,340,366 (-)NCBI
Celera718,257,668 - 18,277,353 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA,ISO)
plasma membrane  (IEA,ISO)
PML body  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression of long-patch and short-patch DNA mismatch repair proteins in the embryonic and adult mammalian brain. Marietta C, etal., Brain Res Mol Brain Res. 1998 Jan;53(1-2):317-20.
3. The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription. Missero C, etal., J Biol Chem 2001 Sep 7;276(36):33569-75.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Expression of T:G mismatch-specific thymidine-DNA glycosylase and DNA methyl transferase genes during development and tumorigenesis. Niederreither K, etal., Oncogene. 1998 Sep 24;17(12):1577-85.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Expression and activity of the DNA repair enzyme uracil DNA glycosylase during organogenesis in the rat conceptus and following methotrexate exposure in vitro. Vinson RK and Hales BF, Biochem Pharmacol 2002 Aug 15;64(4):711-21.
10. Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding. Zhou J, etal., J Biol Chem. 2008 Dec 19;283(51):35383-92. Epub 2008 Oct 21.
Additional References at PubMed
PMID:8662714   PMID:11889051   PMID:12477932   PMID:15569683   PMID:15959518   PMID:16626738   PMID:18512959   PMID:19966277   PMID:21278727   PMID:21722948   PMID:21817016   PMID:21862836  
PMID:22327402   PMID:22573813   PMID:31518169  


Genomics

Comparative Map Data
Tdg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,965,388 - 22,990,311 (-)NCBIGRCr8
mRatBN7.2721,077,853 - 21,097,617 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl721,077,853 - 21,097,567 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx723,052,578 - 23,072,261 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0725,215,283 - 25,234,966 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,992,359 - 25,012,044 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0727,194,000 - 27,213,676 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl727,193,998 - 27,214,236 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,313,355 - 27,333,031 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,300,450 - 23,320,095 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,320,723 - 23,340,366 (-)NCBI
Celera718,257,668 - 18,277,353 (-)NCBICelera
Cytogenetic Map7q13NCBI
TDG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812103,965,872 - 103,988,874 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12103,965,822 - 103,988,874 (+)EnsemblGRCh38hg38GRCh38
GRCh3712104,359,650 - 104,382,652 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612102,883,747 - 102,906,786 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412102,862,083 - 102,885,122NCBI
Celera12104,023,344 - 104,046,415 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12101,419,052 - 101,442,123 (+)NCBIHuRef
CHM1_112104,325,507 - 104,348,573 (+)NCBICHM1_1
T2T-CHM13v2.012103,927,571 - 103,950,593 (+)NCBIT2T-CHM13v2.0
Tdg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391082,465,649 - 82,486,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1082,465,662 - 82,486,633 (+)EnsemblGRCm39 Ensembl
GRCm381082,629,814 - 82,650,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1082,629,828 - 82,650,799 (+)EnsemblGRCm38mm10GRCm38
MGSCv371082,092,583 - 82,113,239 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361082,059,680 - 82,080,598 (+)NCBIMGSCv36mm8
Celera1084,612,863 - 84,633,428 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Tdg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540538,673,180 - 38,678,481 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540538,661,687 - 38,680,138 (+)NCBIChiLan1.0ChiLan1.0
TDG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210112,030,023 - 112,053,392 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112112,026,680 - 112,049,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012101,543,945 - 101,567,035 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112104,938,543 - 104,961,284 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12104,938,519 - 104,961,284 (+)Ensemblpanpan1.1panPan2
TDG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11542,493,593 - 42,516,868 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1542,493,737 - 42,515,448 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1542,863,005 - 42,886,348 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01543,151,141 - 43,174,489 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1543,151,223 - 43,174,538 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11542,417,248 - 42,440,580 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01542,515,997 - 42,539,627 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01542,787,401 - 42,810,747 (+)NCBIUU_Cfam_GSD_1.0
Tdg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494517,466,063 - 17,495,748 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649210,475,183 - 10,497,151 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649210,476,472 - 10,506,144 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TDG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl580,473,234 - 80,492,287 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1580,473,233 - 80,492,295 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TDG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11199,168,051 - 99,191,168 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1199,181,608 - 99,193,591 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037145,814,432 - 145,837,331 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tdg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247504,708,944 - 4,722,872 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247504,707,347 - 4,723,307 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tdg
292 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:297
Count of miRNA genes:184
Interacting mature miRNAs:228
Transcripts:ENSRNOT00000034213
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat

Markers in Region
D3Mco19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23145,871,677 - 145,871,858 (+)MAPPERmRatBN7.2
mRatBN7.2721,089,863 - 21,090,040 (+)MAPPERmRatBN7.2
Rnor_6.0727,206,010 - 27,206,186NCBIRnor6.0
Rnor_6.03153,327,515 - 153,327,695NCBIRnor6.0
Rnor_5.03158,391,833 - 158,392,013UniSTSRnor5.0
Rnor_5.0727,325,365 - 27,325,541UniSTSRnor5.0
RGSC_v3.4723,312,460 - 23,312,636UniSTSRGSC3.4
RGSC_v3.43147,799,021 - 147,799,201UniSTSRGSC3.4
RGSC_v3.13147,704,929 - 147,705,110RGD
Celera718,269,688 - 18,269,864UniSTS
Celera3144,577,423 - 144,577,603UniSTS
Cytogenetic Map7q13UniSTS
RH129740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21911,574,635 - 11,574,831 (+)MAPPERmRatBN7.2
mRatBN7.2721,077,908 - 21,078,103 (+)MAPPERmRatBN7.2
Rnor_6.0727,194,056 - 27,194,250NCBIRnor6.0
Rnor_6.01912,453,070 - 12,453,265NCBIRnor6.0
Rnor_5.01923,566,835 - 23,567,030UniSTSRnor5.0
Rnor_5.0727,313,411 - 27,313,605UniSTSRnor5.0
RGSC_v3.4723,300,506 - 23,300,700UniSTSRGSC3.4
RGSC_v3.41912,015,325 - 12,015,520UniSTSRGSC3.4
Celera1911,451,608 - 11,451,803UniSTS
Celera718,257,724 - 18,257,918UniSTS
Cytogenetic Map7q13UniSTS
AI010217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2721,080,764 - 21,080,977 (+)MAPPERmRatBN7.2
Rnor_6.0727,196,912 - 27,197,124NCBIRnor6.0
Rnor_5.0727,316,267 - 27,316,479UniSTSRnor5.0
RGSC_v3.4723,303,362 - 23,303,574UniSTSRGSC3.4
Celera718,260,580 - 18,260,792UniSTS
RH 3.4 Map7120.6UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000034213   ⟹   ENSRNOP00000037966
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl727,194,002 - 27,214,236 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076468   ⟹   ENSRNOP00000068361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl721,077,853 - 21,089,256 (-)Ensembl
Rnor_6.0 Ensembl727,193,998 - 27,213,704 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077041   ⟹   ENSRNOP00000067921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl721,077,853 - 21,097,567 (-)Ensembl
Rnor_6.0 Ensembl727,193,998 - 27,213,651 (-)Ensembl
RefSeq Acc Id: NM_001388503   ⟹   NP_001375432
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,965,388 - 22,985,100 (-)NCBI
mRatBN7.2721,077,853 - 21,097,566 (-)NCBI
RefSeq Acc Id: NM_053729   ⟹   NP_446181
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,965,388 - 22,985,100 (-)NCBI
mRatBN7.2721,077,853 - 21,097,566 (-)NCBI
Rnor_6.0727,194,000 - 27,213,676 (-)NCBI
Rnor_5.0727,313,355 - 27,333,031 (-)NCBI
RGSC_v3.4723,300,450 - 23,320,095 (-)RGD
Celera718,257,668 - 18,277,353 (-)RGD
Sequence:
RefSeq Acc Id: XM_039078241   ⟹   XP_038934169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,965,388 - 22,990,311 (-)NCBI
mRatBN7.2721,077,853 - 21,097,574 (-)NCBI
RefSeq Acc Id: XM_039078242   ⟹   XP_038934170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,965,388 - 22,985,060 (-)NCBI
mRatBN7.2721,077,853 - 21,097,617 (-)NCBI
RefSeq Acc Id: NP_446181   ⟸   NM_053729
- Peptide Label: isoform 2
- UniProtKB: A6IFI8 (UniProtKB/TrEMBL),   Q99NG8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067921   ⟸   ENSRNOT00000077041
Ensembl Acc Id: ENSRNOP00000037966   ⟸   ENSRNOT00000034213
Ensembl Acc Id: ENSRNOP00000068361   ⟸   ENSRNOT00000076468
RefSeq Acc Id: XP_038934170   ⟸   XM_039078242
- Peptide Label: isoform X2
- UniProtKB: A1L1J2 (UniProtKB/TrEMBL),   Q99NG8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934169   ⟸   XM_039078241
- Peptide Label: isoform X1
- UniProtKB: A0A096MK32 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001375432   ⟸   NM_001388503
- Peptide Label: isoform 1
- UniProtKB: A0A096MIY3 (UniProtKB/TrEMBL),   A0A096MK32 (UniProtKB/TrEMBL)
Protein Domains
Uracil-DNA glycosylase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MIY3-F1-model_v2 AlphaFold A0A096MIY3 1-410 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695120
Promoter ID:EPDNEW_R5638
Type:initiation region
Name:Tdg_1
Description:thymine-DNA glycosylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0727,213,692 - 27,213,752EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620959 AgrOrtholog
BioCyc Gene G2FUF-34547 BioCyc
Ensembl Genes ENSRNOG00000027124 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076468.3 UniProtKB/TrEMBL
  ENSRNOT00000077041.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.470.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8362408 IMAGE-MGC_LOAD
InterPro DNA_glycosylase_G/T-mismatch UniProtKB/TrEMBL
  Thymine-DNA_glycosylase UniProtKB/TrEMBL
  Uracil-DNA_glycosylase-like UniProtKB/TrEMBL
  Uracil-DNA_glycosylase-like_sf UniProtKB/TrEMBL
MGC_CLONE MGC:156614 IMAGE-MGC_LOAD
NCBI Gene 114521 ENTREZGENE
PANTHER G/T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE UniProtKB/TrEMBL
  PTHR12159 UniProtKB/TrEMBL
Pfam UDG UniProtKB/TrEMBL
PharmGKB TDG RGD
PhenoGen Tdg PhenoGen
RatGTEx ENSRNOG00000027124 RatGTEx
Superfamily-SCOP UDNA_glycsylseSF UniProtKB/TrEMBL
UniProt A0A096MIY3 ENTREZGENE, UniProtKB/TrEMBL
  A0A096MK32 ENTREZGENE, UniProtKB/TrEMBL
  A1L1J2 ENTREZGENE, UniProtKB/TrEMBL
  A6IFI8 ENTREZGENE, UniProtKB/TrEMBL
  A6IFI9_RAT UniProtKB/TrEMBL
  Q99NG8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Tdg  thymine-DNA glycosylase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Tdg  thymine-DNA glycosylase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with transcription factor thyroid transcription factor-1 (TTF-1) 634482