Tcn2 (transcobalamin 2) - Rat Genome Database

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Gene: Tcn2 (transcobalamin 2) Rattus norvegicus
Analyze
Symbol: Tcn2
Name: transcobalamin 2
RGD ID: 620681
Description: Enables cobalamin binding activity. Predicted to be involved in cobalamin transport. Located in extracellular space. Human ortholog(s) of this gene implicated in Parkinson's disease; megaloblastic anemia; and transcobalamin II deficiency. Orthologous to human TCN2 (transcobalamin 2); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: TC II; TC-2; Tc2; TCII; Tcn2p; transcobalamin II; transcobalamin II precursor; transcobalamin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,036,935 - 83,052,187 (-)NCBIGRCr8
mRatBN7.21478,813,343 - 78,828,549 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,813,343 - 78,828,489 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,254,381 - 83,269,024 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,494,463 - 84,509,106 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,940,036 - 80,954,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,173,992 - 84,189,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,174,138 - 84,189,266 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,857,864 - 84,873,021 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,579,191 - 84,593,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,598,335 - 84,612,786 (-)NCBI
Celera1477,725,351 - 77,739,968 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
dexamethasone  (ISO)
doxorubicin  (ISO)
enniatin  (ISO)
ethanol  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
inulin  (ISO)
isoprenaline  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylseleninic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
rac-lactic acid  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cobalamin transport  (IBA,IEA,ISO,ISS,TAS)
cobalt ion transport  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transcobalamin II. A specific marker of renal involvement in essential mixed cryoglobulinemia. Biosca M, etal., Nephron. 1987;45(3):255-6.
2. Transfer of cobalamin from intrinsic factor to transcobalamin II. Brada N, etal., J Nutr Biochem. 2001 Apr;12(4):200-206.
3. Binding of vitamin B12--rat transcobalamin II and free vitamin B12 to plasma membranes isolated from rat liver. Fiedler-Nagy C, etal., Br J Haematol. 1975 Nov;31(3):311-21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. [Transcobalamin II levels in blood plasma of children with acute leukemia]. Gudkova MV, etal., Gematol Transfuziol. 1996 Mar-Apr;41(2):10-3.
6. Identification of two mutant alleles of transcobalamin II in an affected family. Li N, etal., Hum Mol Genet. 1994 Oct;3(10):1835-40.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra. Orozco-Barrios CE, etal., PLoS One. 2009 Dec 21;4(12):e8268. doi: 10.1371/journal.pone.0008268.
11. A transcobalamin gene polymorphism and the risk of venous thrombosis. The BRATROS (Brazilian Thrombosis Study). Pereira AC, etal., Thromb Res. 2006 Mar 10;.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Transcobalamin II and its cell surface receptor. Seetharam B and Li N, Vitam Horm 2000;59:337-66.
16. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. Zetterberg H, etal., Thromb Res. 2002 Nov 1;108(2-3):127-31.
17. The three transcobalamins in myeloproliferative disorders and acute leukaemia. Zittoun J, etal., Br J Haematol. 1975 Nov;31(3):287-98.
Additional References at PubMed
PMID:8443384   PMID:15488467   PMID:16537422   PMID:23376485   PMID:24006456   PMID:27411955  


Genomics

Comparative Map Data
Tcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,036,935 - 83,052,187 (-)NCBIGRCr8
mRatBN7.21478,813,343 - 78,828,549 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,813,343 - 78,828,489 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,254,381 - 83,269,024 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,494,463 - 84,509,106 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,940,036 - 80,954,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,173,992 - 84,189,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,174,138 - 84,189,266 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,857,864 - 84,873,021 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,579,191 - 84,593,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,598,335 - 84,612,786 (-)NCBI
Celera1477,725,351 - 77,739,968 (-)NCBICelera
Cytogenetic Map14q21NCBI
TCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,607,174 - 30,627,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,607,003 - 30,627,271 (+)EnsemblGRCh38hg38GRCh38
GRCh372231,003,161 - 31,023,258 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,333,161 - 29,353,047 (+)NCBINCBI36Build 36hg18NCBI36
Build 342229,327,714 - 29,347,601NCBI
Celera2214,802,947 - 14,823,211 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,965,286 - 13,985,550 (+)NCBIHuRef
CHM1_12230,962,510 - 30,982,925 (+)NCBICHM1_1
T2T-CHM13v2.02231,070,745 - 31,090,856 (+)NCBIT2T-CHM13v2.0
Tcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,867,077 - 3,882,078 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,867,192 - 3,882,159 (-)EnsemblGRCm39 Ensembl
GRCm38113,917,077 - 3,932,078 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,917,192 - 3,932,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,817,080 - 3,832,081 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,817,193 - 3,831,586 (-)NCBIMGSCv36mm8
Celera114,411,604 - 4,426,160 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.76NCBI
Tcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,826,694 - 4,849,613 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,827,030 - 4,849,810 (+)NCBIChiLan1.0ChiLan1.0
TCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,566,388 - 40,586,364 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,264,719 - 43,284,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,635,107 - 11,655,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,435,506 - 29,455,494 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,435,517 - 29,455,494 (+)Ensemblpanpan1.1panPan2
TCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,693,664 - 23,710,342 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,693,773 - 23,709,832 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,564,400 - 23,581,079 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02624,077,931 - 24,094,603 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,078,013 - 24,094,603 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,779,098 - 23,796,016 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,042,019 - 24,058,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,102,548 - 24,119,234 (+)NCBIUU_Cfam_GSD_1.0
Tcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,620,289 - 116,636,698 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493690495,542 - 113,985 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493690497,535 - 113,886 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,502,715 - 47,515,965 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,496,245 - 47,515,966 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,598,159 - 50,627,102 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,489,849 - 13,511,360 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,490,645 - 13,511,810 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,616,329 - 112,637,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,971,289 - 6,987,440 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,970,707 - 6,987,946 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tcn2
92 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:42
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000005934
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat

Markers in Region
AW208754  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21478,813,667 - 78,813,756 (+)MAPPERmRatBN7.2
Rnor_6.01484,174,317 - 84,174,405NCBIRnor6.0
Rnor_5.01484,858,042 - 84,858,130UniSTSRnor5.0
RGSC_v3.41484,579,367 - 84,579,455UniSTSRGSC3.4
Celera1477,725,676 - 77,725,764UniSTS
Cytogenetic Map14q21UniSTS
BE099486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21478,823,875 - 78,824,030 (+)MAPPERmRatBN7.2
Rnor_6.01484,184,671 - 84,184,825NCBIRnor6.0
Rnor_5.01484,868,396 - 84,868,550UniSTSRnor5.0
RGSC_v3.41484,589,575 - 84,589,729UniSTSRGSC3.4
Celera1477,735,884 - 77,736,038UniSTS
RH 3.4 Map14543.6UniSTS
Cytogenetic Map14q21UniSTS
RH127671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21478,813,622 - 78,813,839 (+)MAPPERmRatBN7.2
Rnor_6.01484,174,272 - 84,174,488NCBIRnor6.0
Rnor_5.01484,857,997 - 84,858,213UniSTSRnor5.0
RGSC_v3.41484,579,322 - 84,579,538UniSTSRGSC3.4
Celera1477,725,631 - 77,725,847UniSTS
RH 3.4 Map14545.2UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005934   ⟹   ENSRNOP00000005934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1478,813,492 - 78,828,489 (-)Ensembl
Rnor_6.0 Ensembl1484,174,138 - 84,189,266 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093962   ⟹   ENSRNOP00000077856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1478,813,343 - 78,824,964 (-)Ensembl
RefSeq Acc Id: NM_022534   ⟹   NP_071979
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,036,935 - 83,051,552 (-)NCBI
mRatBN7.21478,813,343 - 78,827,960 (-)NCBI
Rnor_6.01484,173,992 - 84,188,755 (-)NCBI
Rnor_5.01484,857,864 - 84,873,021 (-)NCBI
RGSC_v3.41484,579,191 - 84,593,641 (-)RGD
Celera1477,725,351 - 77,739,968 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251366   ⟹   XP_006251428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,037,082 - 83,052,187 (-)NCBI
mRatBN7.21478,813,490 - 78,828,531 (-)NCBI
Rnor_6.01484,174,139 - 84,189,299 (-)NCBI
Rnor_5.01484,857,864 - 84,873,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251367   ⟹   XP_006251429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,037,082 - 83,052,095 (-)NCBI
mRatBN7.21478,813,490 - 78,828,492 (-)NCBI
Rnor_6.01484,174,139 - 84,189,297 (-)NCBI
Rnor_5.01484,857,864 - 84,873,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251368   ⟹   XP_006251430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,037,082 - 83,052,141 (-)NCBI
mRatBN7.21478,813,490 - 78,828,549 (-)NCBI
Rnor_6.01484,174,139 - 84,189,295 (-)NCBI
Rnor_5.01484,857,864 - 84,873,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006251370   ⟹   XP_006251432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,037,082 - 83,052,101 (-)NCBI
mRatBN7.21478,813,490 - 78,828,510 (-)NCBI
Rnor_6.01484,174,139 - 84,189,290 (-)NCBI
Rnor_5.01484,857,864 - 84,873,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599370   ⟹   XP_017454859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81483,037,082 - 83,052,093 (-)NCBI
mRatBN7.21478,813,490 - 78,828,448 (-)NCBI
Rnor_6.01484,174,139 - 84,189,288 (-)NCBI
Sequence:
RefSeq Acc Id: NP_071979   ⟸   NM_022534
- Peptide Label: precursor
- UniProtKB: Q9R0D6 (UniProtKB/Swiss-Prot),   G3V6K1 (UniProtKB/TrEMBL),   A6IKD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251428   ⟸   XM_006251366
- Peptide Label: isoform X1
- UniProtKB: Q9R0D6 (UniProtKB/Swiss-Prot),   G3V6K1 (UniProtKB/TrEMBL),   A6IKD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251430   ⟸   XM_006251368
- Peptide Label: isoform X1
- UniProtKB: Q9R0D6 (UniProtKB/Swiss-Prot),   G3V6K1 (UniProtKB/TrEMBL),   A6IKD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251429   ⟸   XM_006251367
- Peptide Label: isoform X1
- UniProtKB: Q9R0D6 (UniProtKB/Swiss-Prot),   G3V6K1 (UniProtKB/TrEMBL),   A6IKD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006251432   ⟸   XM_006251370
- Peptide Label: isoform X1
- UniProtKB: Q9R0D6 (UniProtKB/Swiss-Prot),   G3V6K1 (UniProtKB/TrEMBL),   A6IKD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454859   ⟸   XM_017599370
- Peptide Label: isoform X1
- UniProtKB: Q9R0D6 (UniProtKB/Swiss-Prot),   G3V6K1 (UniProtKB/TrEMBL),   A6IKD4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005934   ⟸   ENSRNOT00000005934
Ensembl Acc Id: ENSRNOP00000077856   ⟸   ENSRNOT00000093962
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0D6-F1-model_v2 AlphaFold Q9R0D6 1-427 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699434
Promoter ID:EPDNEW_R9958
Type:initiation region
Name:Tcn2_1
Description:transcobalamin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01484,189,248 - 84,189,308EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620681 AgrOrtholog
BioCyc Gene G2FUF-15207 BioCyc
Ensembl Genes ENSRNOG00000004280 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005934.4 UniProtKB/TrEMBL
  ENSRNOT00000093962.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.170.130.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cbl-bd_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cobalamin_Transport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64365 UniProtKB/TrEMBL
NCBI Gene 64365 ENTREZGENE
PANTHER TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCOBALAMIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cobalamin_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF4430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tcn2 PhenoGen
PROSITE COBALAMIN_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004280 RatGTEx
UniProt A0A8I5YCJ2_RAT UniProtKB/TrEMBL
  A6IKD3_RAT UniProtKB/TrEMBL
  A6IKD4 ENTREZGENE, UniProtKB/TrEMBL
  A6IKD6_RAT UniProtKB/TrEMBL
  G3V6K1 ENTREZGENE, UniProtKB/TrEMBL
  Q9R0D6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-04-22 Tcn2  transcobalamin 2  Tcn2p  transcobalamin II precursor  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 Tcn2p  transcobalamin II precursor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein mature product is a nonglycoprotein secretory protein of molecular mass 43 kDa 724784