Tcn2 (transcobalamin 2) - Rat Genome Database

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Gene: Tcn2 (transcobalamin 2) Heterocephalus glaber
Analyze
Symbol: Tcn2
Name: transcobalamin 2
RGD ID: 18927308
Description: ENCODES a protein that exhibits cargo receptor ligand activity (ortholog); cobalamin binding (ortholog); INVOLVED IN cobalamin transport (inferred); cobalt ion transport (inferred); ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); adenoma (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Transcobalamin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,971,289 - 6,987,440 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,970,707 - 6,987,946 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tcn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,971,289 - 6,987,440 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,970,707 - 6,987,946 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TCN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,607,174 - 30,627,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,607,003 - 30,627,271 (+)EnsemblGRCh38hg38GRCh38
GRCh372231,003,161 - 31,023,258 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,333,161 - 29,353,047 (+)NCBINCBI36Build 36hg18NCBI36
Build 342229,327,714 - 29,347,601NCBI
Celera2214,802,947 - 14,823,211 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,965,286 - 13,985,550 (+)NCBIHuRef
CHM1_12230,962,510 - 30,982,925 (+)NCBICHM1_1
T2T-CHM13v2.02231,070,745 - 31,090,856 (+)NCBIT2T-CHM13v2.0
Tcn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,867,077 - 3,882,078 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,867,192 - 3,882,159 (-)EnsemblGRCm39 Ensembl
GRCm38113,917,077 - 3,932,078 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,917,192 - 3,932,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,817,080 - 3,832,081 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,817,193 - 3,831,586 (-)NCBIMGSCv36mm8
Celera114,411,604 - 4,426,160 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.76NCBI
Tcn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,036,935 - 83,052,187 (-)NCBIGRCr8
mRatBN7.21478,813,343 - 78,828,549 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,813,343 - 78,828,489 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,254,381 - 83,269,024 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,494,463 - 84,509,106 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,940,036 - 80,954,783 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,173,992 - 84,189,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,174,138 - 84,189,266 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,857,864 - 84,873,021 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,579,191 - 84,593,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11484,598,335 - 84,612,786 (-)NCBI
Celera1477,725,351 - 77,739,968 (-)NCBICelera
Cytogenetic Map14q21NCBI
Tcn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,826,694 - 4,849,613 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,827,030 - 4,849,810 (+)NCBIChiLan1.0ChiLan1.0
TCN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,566,388 - 40,586,364 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,264,719 - 43,284,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,635,107 - 11,655,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,435,506 - 29,455,494 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,435,517 - 29,455,494 (+)Ensemblpanpan1.1panPan2
TCN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,693,664 - 23,710,342 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,693,773 - 23,709,832 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,564,400 - 23,581,079 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02624,077,931 - 24,094,603 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,078,013 - 24,094,603 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,779,098 - 23,796,016 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,042,019 - 24,058,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,102,548 - 24,119,234 (+)NCBIUU_Cfam_GSD_1.0
Tcn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,620,289 - 116,636,698 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493690495,542 - 113,985 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493690497,535 - 113,886 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TCN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,502,715 - 47,515,965 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,496,245 - 47,515,966 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,598,159 - 50,627,102 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TCN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,489,849 - 13,511,360 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,490,645 - 13,511,810 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,616,329 - 112,637,803 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000025041   ⟹   ENSHGLP00000024819
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247476,971,289 - 6,987,440 (+)Ensembl
RefSeq Acc Id: XM_004843456   ⟹   XP_004843513
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247476,970,707 - 6,987,946 (+)NCBI
RefSeq Acc Id: XM_021257206   ⟹   XP_021112865
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247476,970,707 - 6,987,946 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004843513 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112865 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB01101 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000024819
GenBank Protein JAN96155 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004843513   ⟸   XM_004843456
- Peptide Label: isoform X1
- UniProtKB: G5AVP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112865   ⟸   XM_021257206
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000024819   ⟸   ENSHGLT00000025041


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000017695 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000025041 ENTREZGENE
Gene3D-CATH 1.50.10.20 UniProtKB/TrEMBL
  2.170.130.30 UniProtKB/TrEMBL
InterPro Cbl-bd_prot UniProtKB/TrEMBL
  Cobalamin_Transport UniProtKB/TrEMBL
KEGG Report hgl:101722041 UniProtKB/TrEMBL
NCBI Gene Tcn2 ENTREZGENE
PANTHER TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR UniProtKB/TrEMBL
  TRANSCOBALAMIN-2 UniProtKB/TrEMBL
Pfam Cobalamin_bind UniProtKB/TrEMBL
UniProt G5AVP0 ENTREZGENE, UniProtKB/TrEMBL