Hacl1 (2-hydroxyacyl-CoA lyase 1) - Rat Genome Database

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Gene: Hacl1 (2-hydroxyacyl-CoA lyase 1) Rattus norvegicus
Analyze
Symbol: Hacl1
Name: 2-hydroxyacyl-CoA lyase 1
RGD ID: 619849
Description: Enables carbon-carbon lyase activity and thiamine pyrophosphate binding activity. Involved in fatty acid alpha-oxidation and methyl-branched fatty acid metabolic process. Located in peroxisome. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1); PARTICIPATES IN phytanic acid degradation pathway; Refsum disease pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-HPCL; 2-hydroxyphytanoyl-CoA lyase; 2-hydroxyphytanoyl-Coenzyme A lyase; Hpcl2; Phyh2; phytanoyl-CoA 2-hydroxylase 2; phytanoyl-Coenzyme A 2-hydroxylase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,831,293 - 6,869,410 (-)NCBIGRCr8
mRatBN7.2166,826,881 - 6,863,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,824,906 - 6,863,027 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,830,764 - 6,867,047 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,975,662 - 8,011,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,838,214 - 6,874,501 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,720,047 - 7,758,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,714,465 - 7,758,189 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,646,580 - 7,682,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,073,038 - 7,108,830 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,073,036 - 7,108,828 (-)NCBI
Celera168,335,334 - 8,371,457 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromuconazole  (EXP)
buspirone  (EXP)
C60 fullerene  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
chenodeoxycholic acid  (ISO)
cholesterol  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
ivermectin  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
nimesulide  (EXP)
oxycodone  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
tioguanine  (EXP)
triphenyl phosphate  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
valproic acid  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids. Foulon V, etal., Proc Natl Acad Sci U S A 1999 Aug 31;96(18):10039-44.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11171065   PMID:14561759   PMID:15644336   PMID:16189514   PMID:20178365   PMID:21708296   PMID:25416956   PMID:28289220   PMID:28629946  


Genomics

Comparative Map Data
Hacl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,831,293 - 6,869,410 (-)NCBIGRCr8
mRatBN7.2166,826,881 - 6,863,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,824,906 - 6,863,027 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,830,764 - 6,867,047 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,975,662 - 8,011,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,838,214 - 6,874,501 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,720,047 - 7,758,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,714,465 - 7,758,189 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,646,580 - 7,682,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,073,038 - 7,108,830 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,073,036 - 7,108,828 (-)NCBI
Celera168,335,334 - 8,371,457 (+)NCBICelera
Cytogenetic Map16p16NCBI
HACL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38315,560,699 - 15,601,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl315,560,699 - 15,601,852 (-)EnsemblGRCh38hg38GRCh38
GRCh37315,602,206 - 15,643,076 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36315,577,243 - 15,618,134 (-)NCBINCBI36Build 36hg18NCBI36
Celera315,540,467 - 15,581,279 (-)NCBICelera
Cytogenetic Map3p25.1NCBI
HuRef315,537,616 - 15,578,260 (-)NCBIHuRef
CHM1_1315,553,051 - 15,593,804 (-)NCBICHM1_1
T2T-CHM13v2.0315,563,097 - 15,603,888 (-)NCBIT2T-CHM13v2.0
Hacl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391431,329,183 - 31,364,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1431,320,687 - 31,363,243 (-)EnsemblGRCm39 Ensembl
GRCm381431,607,226 - 31,640,965 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,598,730 - 31,641,286 (-)EnsemblGRCm38mm10GRCm38
MGSCv371432,420,412 - 32,454,151 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361430,436,235 - 30,469,970 (-)NCBIMGSCv36mm8
Celera1427,864,878 - 27,898,614 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.23NCBI
Hacl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,053,640 - 2,096,432 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,055,774 - 2,096,260 (-)NCBIChiLan1.0ChiLan1.0
HACL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2215,546,138 - 15,586,459 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1315,550,904 - 15,591,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0315,486,897 - 15,526,552 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1315,823,979 - 15,863,982 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl315,823,979 - 15,863,982 (-)Ensemblpanpan1.1panPan2
LOC608697
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12327,069,676 - 27,188,247 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2327,043,917 - 27,162,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02327,572,135 - 27,700,471 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12327,271,635 - 27,389,865 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02327,333,444 - 27,451,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02327,581,893 - 27,700,406 (+)NCBIUU_Cfam_GSD_1.0
Hacl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118169,684,583 - 169,717,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364732,823,123 - 2,856,077 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364732,823,183 - 2,856,077 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HACL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl132,766,514 - 2,840,902 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1132,786,007 - 2,840,882 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2132,714,442 - 2,737,983 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HACL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11560,360,380 - 60,433,528 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1560,322,722 - 60,433,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604133,390,238 - 33,465,437 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hacl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248225,079,634 - 5,145,503 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248225,078,925 - 5,189,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hacl1
267 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:16
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000026588
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
D10Mgh3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21095,600,334 - 95,600,487 (+)MAPPERmRatBN7.2
Rnor_6.01098,939,209 - 98,939,361NCBIRnor6.0
Rnor_5.01098,640,137 - 98,640,289UniSTSRnor5.0
RGSC_v3.410100,090,302 - 100,090,454UniSTSRGSC3.4
RGSC_v3.410100,090,301 - 100,090,454RGDRGSC3.4
RGSC_v3.110100,104,671 - 100,104,824RGD
Celera1094,250,177 - 94,250,329UniSTS
RH 3.4 Map101080.69RGD
RH 3.4 Map101080.69UniSTS
RH 2.0 Map101218.6RGD
SHRSP x BN Map1077.15RGD
FHH x ACI Map1081.3499RGD
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000026588   ⟹   ENSRNOP00000026588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,824,906 - 6,863,015 (-)Ensembl
Rnor_6.0 Ensembl167,714,465 - 7,758,189 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098301   ⟹   ENSRNOP00000090429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,824,906 - 6,863,015 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102645   ⟹   ENSRNOP00000090650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,849,713 - 6,863,027 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108746   ⟹   ENSRNOP00000082285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,827,012 - 6,863,027 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111010   ⟹   ENSRNOP00000085929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,852,297 - 6,863,027 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117524   ⟹   ENSRNOP00000091949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl166,824,906 - 6,863,015 (-)Ensembl
RefSeq Acc Id: NM_053493   ⟹   NP_445945
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,833,268 - 6,869,410 (-)NCBI
mRatBN7.2166,826,881 - 6,863,027 (-)NCBI
Rnor_6.0167,720,047 - 7,758,119 (-)NCBI
Rnor_5.0167,646,580 - 7,682,704 (-)NCBI
RGSC_v3.4167,073,038 - 7,108,830 (-)RGD
Celera168,335,334 - 8,371,457 (+)RGD
Sequence:
RefSeq Acc Id: XM_063275790   ⟹   XP_063131860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,833,268 - 6,869,362 (-)NCBI
RefSeq Acc Id: XM_063275791   ⟹   XP_063131861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,833,465 - 6,869,362 (-)NCBI
RefSeq Acc Id: XM_063275792   ⟹   XP_063131862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,831,293 - 6,869,362 (-)NCBI
RefSeq Acc Id: XR_010058324
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,831,293 - 6,869,362 (-)NCBI
RefSeq Acc Id: NP_445945   ⟸   NM_053493
- UniProtKB: Q8CHM7 (UniProtKB/Swiss-Prot),   A6KFY4 (UniProtKB/TrEMBL),   A0A8I6ACR4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026588   ⟸   ENSRNOT00000026588
Ensembl Acc Id: ENSRNOP00000085929   ⟸   ENSRNOT00000111010
Ensembl Acc Id: ENSRNOP00000090650   ⟸   ENSRNOT00000102645
Ensembl Acc Id: ENSRNOP00000091949   ⟸   ENSRNOT00000117524
Ensembl Acc Id: ENSRNOP00000082285   ⟸   ENSRNOT00000108746
Ensembl Acc Id: ENSRNOP00000090429   ⟸   ENSRNOT00000098301
RefSeq Acc Id: XP_063131862   ⟸   XM_063275792
- Peptide Label: isoform X3
- UniProtKB: Q8CHM7 (UniProtKB/Swiss-Prot),   A6KFY4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131860   ⟸   XM_063275790
- Peptide Label: isoform X1
- UniProtKB: A0A8I6G9A1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131861   ⟸   XM_063275791
- Peptide Label: isoform X2
Protein Domains
Thiamine pyrophosphate enzyme central   Thiamine pyrophosphate enzyme N-terminal TPP-   Thiamine pyrophosphate enzyme TPP-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CHM7-F1-model_v2 AlphaFold Q8CHM7 1-581 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699935
Promoter ID:EPDNEW_R10458
Type:multiple initiation site
Name:Hacl1_1
Description:2-hydroxyacyl-CoA lyase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0167,758,117 - 7,758,177EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619849 AgrOrtholog
BioCyc Gene G2FUF-12137 BioCyc
BioCyc Pathway PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
BioCyc Pathway Image PWY66-387 BioCyc
  PWY66-388 BioCyc
Ensembl Genes ENSRNOG00000019630 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026588.4 UniProtKB/Swiss-Prot
  ENSRNOT00000098301.1 UniProtKB/TrEMBL
  ENSRNOT00000102645.1 UniProtKB/TrEMBL
  ENSRNOT00000108746.1 UniProtKB/TrEMBL
  ENSRNOT00000111010.1 UniProtKB/TrEMBL
  ENSRNOT00000117524.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110355 IMAGE-MGC_LOAD
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HACL1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiamin_PyroP_enz_cen_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiamin_PyroP_enz_TPP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP_enzyme-bd_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:85255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93083 IMAGE-MGC_LOAD
NCBI Gene 85255 ENTREZGENE
PANTHER 2-HYDROXYACYL-COA LYASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43710 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TPP_enzyme_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP_enzyme_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPP_enzyme_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hacl1 PhenoGen
RatGTEx ENSRNOG00000019630 RatGTEx
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A4D4_RAT UniProtKB/TrEMBL
  A0A8I6ACR4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AE81_RAT UniProtKB/TrEMBL
  A0A8I6G9A1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIV8_RAT UniProtKB/TrEMBL
  A6KFY4 ENTREZGENE, UniProtKB/TrEMBL
  HACL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Hacl1  2-hydroxyacyl-CoA lyase 1  Phyh2  phytanoyl-CoA 2-hydroxylase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Phyh2  phytanoyl-CoA 2-hydroxylase 2    phytanoyl-Coenzyme A 2-hydroxylase 2  Symbol and Name updated 1299863 APPROVED
2006-03-27 Phyh2  phytanoyl-Coenzyme A 2-hydroxylase 2  Hpcl2  2-hydroxyphytanoyl-Coenzyme A lyase  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-20 Hpcl2  2-hydroxyphytanoyl-Coenzyme A lyase    2-hydroxyphytanoyl-CoA lyase  Name updated 1299863 APPROVED
2002-08-07 Hpcl2  2-hydroxyphytanoyl-CoA lyase      Symbol and Name status set to provisional 70820 PROVISIONAL