Hacl1 (2-hydroxyacyl-CoA lyase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hacl1 (2-hydroxyacyl-CoA lyase 1) Mus musculus
Analyze
Symbol: Hacl1
Name: 2-hydroxyacyl-CoA lyase 1
RGD ID: 1553280
MGI Page MGI
Description: Enables carbon-carbon lyase activity. Involved in fatty acid alpha-oxidation. Acts upstream of or within lipid metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in peroxisome. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human HACL1 (2-hydroxyacyl-CoA lyase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1600020H07Rik; 2-HPCL; 2-hydroxyphytanoyl-CoA lyase; Hp; Hpcl; Phyh; Phyh2; phytanoyl-CoA 2-hydroxylase 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391431,329,183 - 31,364,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1431,320,687 - 31,363,243 (-)EnsemblGRCm39 Ensembl
GRCm381431,607,226 - 31,640,965 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,598,730 - 31,641,286 (-)EnsemblGRCm38mm10GRCm38
MGSCv371432,420,412 - 32,454,151 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361430,436,235 - 30,469,970 (-)NCBIMGSCv36mm8
Celera1427,864,878 - 27,898,614 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hacl1Mouse3p deletion syndrome  ISOHACL1 (Homo sapiens)8554872ClinVar Annotator: match by term: 3p- syndromeClinVarPMID:31690835
Hacl1Mousebiotinidase deficiency  ISOHACL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Biotinidase deficiencyClinVarPMID:20083419 and PMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hacl1MouseChemical and Drug Induced Liver Injury  ISOHACL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26881866
Hacl1Mousecholestasis  ISOHACL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26881866
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hacl1Mousecongenital myasthenic syndrome 5  ISOLOC608697 (Canis lupus familiaris)9068941Myasthenic syndrome more ...OMIAPMID:25166616 more ...

1 to 20 of 124 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hacl1Mouse1-naphthyl isothiocyanate decreases expressionISOHacl1 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in decreased expression of HACL1 mRNACTDPMID:30723492
Hacl1Mouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of HACL1 mRNACTDPMID:19484750 and PMID:39298647
Hacl1Mouse17beta-estradiol affects expressionISOHacl1 (Rattus norvegicus)6480464Estradiol affects the expression of HACL1 mRNACTDPMID:32145629
Hacl1Mouse2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOHacl1 (Rattus norvegicus)6480464[3 more ...CTDPMID:16984957
Hacl1Mouse2,2',4,4'-Tetrabromodiphenyl ether affects expressionEXP 64804642 more ...CTDPMID:30294300
Hacl1Mouse2,3,7,8-tetrabromodibenzodioxine increases expressionEXP 64804642 more ...CTDPMID:27604104
Hacl1Mouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of HACL1 mRNA and AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of HACL1 mRNA]CTDPMID:19759094 and PMID:25975270
Hacl1Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOHacl1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of HACL1 mRNACTDPMID:20959002 more ...
Hacl1Mouse2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHacl1 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin affects the expression of HACL1 mRNACTDPMID:22298810
Hacl1Mouse2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of HACL1 mRNACTDPMID:18796159 more ...
Hacl1Mouse2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionEXP 64804642 more ...CTDPMID:38648751
Hacl1Mouse2,4-dinitrotoluene affects expressionISOHacl1 (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of HACL1 mRNACTDPMID:21346803
Hacl1Mouse2,6-dinitrotoluene affects expressionISOHacl1 (Rattus norvegicus)64804642 and 6-dinitrotoluene affects the expression of HACL1 mRNACTDPMID:21346803
Hacl1Mouse3,3',4,4',5-pentachlorobiphenyl multiple interactionsISOHacl1 (Rattus norvegicus)6480464[3 more ...CTDPMID:16984957
Hacl1Mouse3,3',4,4',5-pentachlorobiphenyl decreases expressionISOHacl1 (Rattus norvegicus)64804643 more ...CTDPMID:20959002
Hacl1Mouse3H-1,2-dithiole-3-thione decreases expressionISOHacl1 (Rattus norvegicus)64804641 and 2-dithiol-3-thione results in decreased expression of HACL1 mRNACTDPMID:19162173
Hacl1Mouse4,4'-sulfonyldiphenol increases expressionEXP 6480464bisphenol S results in increased expression of HACL1 mRNACTDPMID:33297965 and PMID:39298647
Hacl1Mouse4,4'-sulfonyldiphenol increases expressionISOHACL1 (Homo sapiens)6480464bisphenol S results in increased expression of HACL1 proteinCTDPMID:34186270
Hacl1Mouse4-hydroxyphenyl retinamide decreases expressionEXP 6480464Fenretinide results in decreased expression of HACL1 mRNACTDPMID:28973697
Hacl1Mouseacetamide decreases expressionISOHacl1 (Rattus norvegicus)6480464acetamide results in decreased expression of HACL1 mRNACTDPMID:31881176

1 to 20 of 124 rows

Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hacl1Mousefatty acid alpha-oxidation involved_inISOHacl1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Hacl1Mousefatty acid alpha-oxidation involved_inISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mousefatty acid alpha-oxidation involved_inIMP 2290270 PMID:28629946UniProtPMID:28629946
Hacl1Mousefatty acid alpha-oxidation involved_inISSUniProtKB:Q9UJ832290270 HGNC-UCLGO_REF:0000024
Hacl1Mousefatty acid alpha-oxidation involved_inIBAPANTHER:PTN000438683 more ...2290270 GO_CentralGO_REF:0000033
Hacl1Mousefatty acid metabolic process involved_inISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mouselipid metabolic process acts_upstream_of_or_withinIDA 2290270 PMID:11171065MGIPMID:11171065
Hacl1Mousemethyl-branched fatty acid metabolic process involved_inISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mousemethyl-branched fatty acid metabolic process involved_inISOHacl1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Hacl1Mousemethyl-branched fatty acid metabolic process involved_inISSUniProtKB:Q9UJ832290270 UniProtGO_REF:0000024
Hacl1Mousephytanic acid metabolic process involved_inISSUniProtKB:Q9UJ832290270 UniProtGO_REF:0000024
Hacl1Mousephytanic acid metabolic process involved_inISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mouseprotein targeting to peroxisome involved_inISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mouseprotein targeting to peroxisome involved_inISSUniProtKB:Q9UJ832290270 UniProtGO_REF:0000024
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hacl1Mousenucleoplasm located_inISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mousenucleoplasm located_inIEAUniProtKB:Q9UJ83 and ensembl:ENSP000003238112290270 EnsemblGO_REF:0000107
Hacl1Mouseperoxisome located_inISOHacl1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Hacl1Mouseperoxisome located_inTAS 2290270 PMID:11171065MGIPMID:11171065
Hacl1Mouseperoxisome located_inISSUniProtKB:Q9UJ832290270 HGNC-UCLGO_REF:0000024
Hacl1Mouseperoxisome is_active_inIBAPANTHER:PTN000438685 more ...2290270 GO_CentralGO_REF:0000033
Hacl1Mouseperoxisome located_inISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119

Molecular Function
1 to 19 of 19 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hacl1Mouse2-hydroxyacyl-CoA lyase activity enablesISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mouse2-hydroxyphytanoyl-CoA lyase activity enablesIEARHEA:253552290270 RHEAGO_REF:0000116
Hacl1MouseATP binding enablesIEAUniProtKB:Q9UJ83 and ensembl:ENSP000003238112290270 EnsemblGO_REF:0000107
Hacl1MouseATP binding enablesISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mousecarbon-carbon lyase activity enablesIMP 2290270 PMID:28629946UniProtPMID:28629946
Hacl1Mousecarbon-carbon lyase activity enablesISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mousecarbon-carbon lyase activity enablesISOHacl1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Hacl1Mousecarbon-carbon lyase activity enablesISSUniProtKB:Q9UJ832290270 HGNC-UCLGO_REF:0000024
Hacl1Mouseidentical protein binding enablesISSUniProtKB:Q9UJ832290270 UniProtGO_REF:0000024
Hacl1Mouseidentical protein binding enablesISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mouselyase activity enablesIDA 2290270 PMID:11171065MGIPMID:11171065
Hacl1Mousemagnesium ion binding enablesISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mousemagnesium ion binding enablesISSUniProtKB:Q9UJ832290270 UniProtGO_REF:0000024
Hacl1Mouseprotein binding enablesISOUniProtKB:Q96E359068941 PMID:16189514 and PMID:32296183IntActPMID:16189514 and PMID:32296183
Hacl1Mouseprotein binding enablesISOUniProtKB:Q8N7X4 and UniProtKB:Q96E359068941 PMID:25416956IntActPMID:25416956
Hacl1Mousethiamine pyrophosphate binding enablesISOHacl1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Hacl1Mousethiamine pyrophosphate binding enablesISOUniProtKB:Q9UJ832290270 GO_CentralGO_REF:0000119
Hacl1Mousethiamine pyrophosphate binding enablesIBAPANTHER:PTN000438683 more ...2290270 GO_CentralGO_REF:0000033
Hacl1Mousethiamine pyrophosphate binding enablesISSUniProtKB:Q9UJ832290270 HGNC-UCLGO_REF:0000024
1 to 19 of 19 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hacl1Mousephytanic acid degradation pathway  ISOHACL1 (Homo sapiens)10402751 SMPDBSMP:00450
Hacl1MouseRefsum disease pathway  ISOHACL1 (Homo sapiens)10402751 SMPDBSMP:00451
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Hacl1Mouseabnormal eye morphology  IEA 5509061 MGI 
Hacl1Mouseenlarged heart  IEA 5509061 MGI 

#
Reference Title
Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11171065   PMID:12477932   PMID:12520002   PMID:15489334   PMID:15644336   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17208939  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:24194600   PMID:24323699   PMID:27626380   PMID:28629946   PMID:29027957   PMID:30973865   PMID:32325033   PMID:35055171   PMID:38355793  



Hacl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391431,329,183 - 31,364,201 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1431,320,687 - 31,363,243 (-)EnsemblGRCm39 Ensembl
GRCm381431,607,226 - 31,640,965 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,598,730 - 31,641,286 (-)EnsemblGRCm38mm10GRCm38
MGSCv371432,420,412 - 32,454,151 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361430,436,235 - 30,469,970 (-)NCBIMGSCv36mm8
Celera1427,864,878 - 27,898,614 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.23NCBI
HACL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38315,560,699 - 15,601,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl315,560,699 - 15,601,852 (-)EnsemblGRCh38hg38GRCh38
GRCh37315,602,206 - 15,643,076 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36315,577,243 - 15,618,134 (-)NCBINCBI36Build 36hg18NCBI36
Celera315,540,467 - 15,581,279 (-)NCBICelera
Cytogenetic Map3p25.1NCBI
HuRef315,537,616 - 15,578,260 (-)NCBIHuRef
CHM1_1315,553,051 - 15,593,804 (-)NCBICHM1_1
T2T-CHM13v2.0315,563,097 - 15,603,888 (-)NCBIT2T-CHM13v2.0
Hacl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,831,293 - 6,869,410 (-)NCBIGRCr8
mRatBN7.2166,826,881 - 6,863,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,824,906 - 6,863,027 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,830,764 - 6,867,047 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,975,662 - 8,011,946 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,838,214 - 6,874,501 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,720,047 - 7,758,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,714,465 - 7,758,189 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,646,580 - 7,682,704 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4167,073,038 - 7,108,830 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1167,073,036 - 7,108,828 (-)NCBI
Celera168,335,334 - 8,371,457 (+)NCBICelera
Cytogenetic Map16p16NCBI
Hacl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,053,640 - 2,096,432 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,055,774 - 2,096,260 (-)NCBIChiLan1.0ChiLan1.0
HACL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2215,546,138 - 15,586,459 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1315,550,904 - 15,591,223 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0315,486,897 - 15,526,552 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1315,823,979 - 15,863,982 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl315,823,979 - 15,863,982 (-)Ensemblpanpan1.1panPan2
LOC608697
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12327,069,676 - 27,188,247 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2327,043,917 - 27,162,593 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02327,572,135 - 27,700,471 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12327,271,635 - 27,389,865 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02327,333,444 - 27,451,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02327,581,893 - 27,700,406 (+)NCBIUU_Cfam_GSD_1.0
Hacl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118169,684,583 - 169,717,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364732,823,123 - 2,856,077 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364732,823,183 - 2,856,077 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HACL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl132,766,514 - 2,840,902 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1132,786,007 - 2,840,882 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2132,714,442 - 2,737,983 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HACL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11560,360,380 - 60,433,528 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1560,322,722 - 60,433,647 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604133,390,238 - 33,465,437 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hacl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248225,079,634 - 5,145,503 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248225,078,925 - 5,189,253 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Hacl1
1078 total Variants

Predicted Target Of
Summary Value
Count of predictions:2507
Count of miRNA genes:760
Interacting mature miRNAs:957
Transcripts:ENSMUST00000022437, ENSMUST00000127204, ENSMUST00000128629, ENSMUST00000134626, ENSMUST00000135751, ENSMUST00000139501, ENSMUST00000140078, ENSMUST00000155210, ENSMUST00000156189, ENSMUST00000156431, ENSMUST00000165955, ENSMUST00000167066, ENSMUST00000167175, ENSMUST00000171414
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 19 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse

1 to 10 of 19 rows






Ensembl Acc Id: ENSMUST00000022437   ⟹   ENSMUSP00000022437
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,329,156 - 31,362,921 (-)Ensembl
GRCm38.p6 Ensembl1431,607,199 - 31,640,964 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127204   ⟹   ENSMUSP00000120452
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,329,968 - 31,362,869 (-)Ensembl
GRCm38.p6 Ensembl1431,608,011 - 31,640,912 (-)Ensembl
Ensembl Acc Id: ENSMUST00000128629
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,351,724 - 31,363,214 (-)Ensembl
GRCm38.p6 Ensembl1431,629,767 - 31,641,257 (-)Ensembl
Ensembl Acc Id: ENSMUST00000134626   ⟹   ENSMUSP00000114879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,348,383 - 31,363,129 (-)Ensembl
GRCm38.p6 Ensembl1431,626,426 - 31,641,172 (-)Ensembl
Ensembl Acc Id: ENSMUST00000135751
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,357,605 - 31,363,243 (-)Ensembl
GRCm38.p6 Ensembl1431,635,648 - 31,641,286 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139501
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,329,926 - 31,332,291 (-)Ensembl
GRCm38.p6 Ensembl1431,607,969 - 31,610,334 (-)Ensembl
Ensembl Acc Id: ENSMUST00000140078   ⟹   ENSMUSP00000154592
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,329,622 - 31,336,268 (-)Ensembl
GRCm38.p6 Ensembl1431,607,665 - 31,614,311 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155210
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,352,536 - 31,362,903 (-)Ensembl
GRCm38.p6 Ensembl1431,630,579 - 31,640,946 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156189
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,357,466 - 31,362,868 (-)Ensembl
GRCm38.p6 Ensembl1431,635,509 - 31,640,911 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156431   ⟹   ENSMUSP00000114922
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,320,687 - 31,362,901 (-)Ensembl
GRCm38.p6 Ensembl1431,598,730 - 31,640,944 (-)Ensembl
Ensembl Acc Id: ENSMUST00000165955   ⟹   ENSMUSP00000129090
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,329,968 - 31,362,835 (-)Ensembl
GRCm38.p6 Ensembl1431,608,011 - 31,640,878 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167066   ⟹   ENSMUSP00000132913
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,329,968 - 31,362,835 (-)Ensembl
GRCm38.p6 Ensembl1431,608,011 - 31,640,878 (-)Ensembl
Ensembl Acc Id: ENSMUST00000171414   ⟹   ENSMUSP00000130268
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1431,329,968 - 31,362,835 (-)Ensembl
GRCm38.p6 Ensembl1431,608,011 - 31,640,878 (-)Ensembl
RefSeq Acc Id: NM_019975   ⟹   NP_064359
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391431,329,183 - 31,362,922 (-)NCBI
GRCm381431,607,226 - 31,640,965 (-)NCBI
MGSCv371432,420,412 - 32,454,151 (-)RGD
Celera1427,864,878 - 27,898,614 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036158767   ⟹   XP_036014660
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391431,329,822 - 31,364,201 (-)NCBI
Sequence:
1 to 12 of 12 rows
Protein RefSeqs NP_064359 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014660 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH21360 (Get FASTA)   NCBI Sequence Viewer  
  BAB24085 (Get FASTA)   NCBI Sequence Viewer  
  BAC31032 (Get FASTA)   NCBI Sequence Viewer  
  BAC34059 (Get FASTA)   NCBI Sequence Viewer  
  CAB65550 (Get FASTA)   NCBI Sequence Viewer  
  EDL24815 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000022437
  ENSMUSP00000022437.9
  ENSMUSP00000114922.2
GenBank Protein Q9QXE0 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_064359   ⟸   NM_019975
- UniProtKB: Q543K1 (UniProtKB/Swiss-Prot),   Q9DAV1 (UniProtKB/Swiss-Prot),   Q9QXE0 (UniProtKB/Swiss-Prot),   D3YZ54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000120452   ⟸   ENSMUST00000127204
Ensembl Acc Id: ENSMUSP00000130268   ⟸   ENSMUST00000171414
Ensembl Acc Id: ENSMUSP00000129090   ⟸   ENSMUST00000165955
Ensembl Acc Id: ENSMUSP00000022437   ⟸   ENSMUST00000022437
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXE0-F1-model_v2 AlphaFold Q9QXE0 1-581 view protein structure

RGD ID:8681840
Promoter ID:EPDNEW_M18951
Type:multiple initiation site
Name:Hacl1_1
Description:Mus musculus 2-hydroxyacyl-CoA lyase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381431,640,961 - 31,641,021EPDNEW
RGD ID:6825054
Promoter ID:MM_KWN:16116
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000060715
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361432,423,466 - 32,424,217 (-)MPROMDB
RGD ID:6825053
Promoter ID:MM_KWN:16117
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000060361
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361432,427,616 - 32,428,367 (-)MPROMDB
RGD ID:6825055
Promoter ID:MM_KWN:16118
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   MEF_B6,   Spleen
Transcripts:NM_019975,   OTTMUST00000060362,   OTTMUST00000060363,   OTTMUST00000060374,   OTTMUST00000060375,   OTTMUST00000060376,   OTTMUST00000060377,   UC007SXW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361432,454,071 - 32,455,417 (-)MPROMDB


1 to 35 of 35 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000021884 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000022437 ENTREZGENE
  ENSMUST00000022437.16 UniProtKB/Swiss-Prot
  ENSMUST00000156431.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.970 UniProtKB/Swiss-Prot
  TPP-binding domain UniProtKB/Swiss-Prot
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/Swiss-Prot
  HACL1-like UniProtKB/Swiss-Prot
  THDP-binding UniProtKB/Swiss-Prot
  Thiamin_PyroP_enz_cen_dom UniProtKB/Swiss-Prot
  Thiamin_PyroP_enz_TPP-bd_dom UniProtKB/Swiss-Prot
  TPP_enzyme-bd_C UniProtKB/Swiss-Prot
KEGG Report mmu:56794 UniProtKB/Swiss-Prot
MGD MGI:1929657 ENTREZGENE
NCBI Gene 56794 ENTREZGENE
PANTHER 2-HYDROXYACYL-COA LYASE 1 UniProtKB/Swiss-Prot
  PTHR43710 UniProtKB/Swiss-Prot
Pfam TPP_enzyme_C UniProtKB/Swiss-Prot
  TPP_enzyme_M UniProtKB/Swiss-Prot
  TPP_enzyme_N UniProtKB/Swiss-Prot
PhenoGen Hacl1 PhenoGen
Superfamily-SCOP SSF52467 UniProtKB/Swiss-Prot
  SSF52518 UniProtKB/Swiss-Prot
UniProt A0A2I3BRS0_MOUSE UniProtKB/TrEMBL
  D3YZ54 ENTREZGENE, UniProtKB/TrEMBL
  D6RDE9_MOUSE UniProtKB/TrEMBL
  E9PWM4_MOUSE UniProtKB/TrEMBL
  E9Q0K0_MOUSE UniProtKB/TrEMBL
  E9Q7H7_MOUSE UniProtKB/TrEMBL
  HACL1_MOUSE UniProtKB/Swiss-Prot
  Q543K1 ENTREZGENE
  Q9DAV1 ENTREZGENE
  Q9QXE0 ENTREZGENE
UniProt Secondary Q543K1 UniProtKB/Swiss-Prot
  Q9DAV1 UniProtKB/Swiss-Prot
1 to 35 of 35 rows