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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Grik1 | Rat | (+)-pilocarpine | multiple interactions | EXP | | 6480464 | [Excitatory Amino Acid Antagonists binds to and results in decreased activity of GRIK1 protein] which results in decreased susceptibility to Pilocarpine | CTD | PMID:12080343 | Grik1 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of GRIK1 mRNA | CTD | PMID:26496021 | Grik1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of GRIK1 mRNA | CTD | PMID:21802500 | Grik1 | Rat | 2-hydroxypropanoic acid | increases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of GRIK1 mRNA | CTD | PMID:30851411 | Grik1 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of GRIK1 mRNA | CTD | PMID:24780913 and PMID:25825206 | Grik1 | Rat | all-trans-retinoic acid | increases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of GRIK1 mRNA | CTD | PMID:21934132 | Grik1 | Rat | amitriptyline | decreases expression | EXP | | 6480464 | Amitriptyline results in decreased expression of GRIK1 mRNA | CTD | PMID:22341215 | Grik1 | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of GRIK1 mRNA | CTD | PMID:16483693 | Grik1 | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of GRIK1 gene | CTD | PMID:28931070 and PMID:35440735 | Grik1 | Rat | belinostat | increases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | belinostat results in increased expression of GRIK1 mRNA | CTD | PMID:27188386 | Grik1 | Rat | benzo[a]pyrene | increases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of GRIK1 mRNA | CTD | PMID:21802500 | Grik1 | Rat | benzo[a]pyrene | affects methylation | ISO | GRIK1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of GRIK1 intron | CTD | PMID:30157460 | Grik1 | Rat | benzo[a]pyrene | decreases methylation | ISO | GRIK1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of GRIK1 exon | CTD | PMID:27901495 | Grik1 | Rat | benzo[a]pyrene | increases methylation | ISO | Grik1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased methylation of GRIK1 intron | CTD | PMID:27901495 | Grik1 | Rat | benzo[a]pyrene | increases methylation | ISO | GRIK1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of GRIK1 promoter | CTD | PMID:27901495 | Grik1 | Rat | benzo[e]pyrene | increases methylation | ISO | GRIK1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of GRIK1 intron | CTD | PMID:30157460 | Grik1 | Rat | benzoates | multiple interactions | ISO | GRIK1 (Homo sapiens) | 6480464 | Benzoates analog binds to and results in decreased activity of GRIK1 protein | CTD | PMID:14667236 | Grik1 | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA | CTD | PMID:25607892 | Grik1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of GRIK1 mRNA | CTD | PMID:26496021 | Grik1 | Rat | bisphenol A | increases expression | ISO | Grik1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of GRIK1 mRNA | CTD | PMID:32156529 | Grik1 | Rat | bisphenol A | affects methylation | ISO | GRIK1 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of GRIK1 gene | CTD | PMID:31601247 | Grik1 | Rat | bisphenol A | multiple interactions | ISO | GRIK1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of GRIK1 gene | CTD | PMID:31601247 | Grik1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GRIK1 mRNA | CTD | PMID:34947998 | Grik1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GRIK1 mRNA | CTD | PMID:30816183 and PMID:32528016 | Grik1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of GRIK1 mRNA | CTD | PMID:25181051 | Grik1 | Rat | bisphenol F | decreases expression | ISO | Grik1 (Mus musculus) | 6480464 | bisphenol F results in decreased expression of GRIK1 mRNA | CTD | PMID:30951980 | Grik1 | Rat | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of GRIK1 mRNA | CTD | PMID:19167457 | Grik1 | Rat | celecoxib | multiple interactions | ISO | Grik1 (Mus musculus) | 6480464 | Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA] | CTD | PMID:21589914 | Grik1 | Rat | CGP 52608 | multiple interactions | ISO | GRIK1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to GRIK1 gene] | CTD | PMID:28238834 | Grik1 | Rat | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of GRIK1 mRNA and Cocaine affects the expression of GRIK1 protein | CTD | PMID:12358776 and PMID:15140200 | Grik1 | Rat | DDE | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA | CTD | PMID:25607892 | Grik1 | Rat | Dibutyl phosphate | affects expression | ISO | GRIK1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of GRIK1 mRNA | CTD | PMID:37042841 | Grik1 | Rat | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA | CTD | PMID:25607892 | Grik1 | Rat | disodium selenite | increases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of GRIK1 mRNA | CTD | PMID:18514395 | Grik1 | Rat | epoxiconazole | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA | CTD | PMID:25607892 | Grik1 | Rat | ethanol | decreases expression | EXP | | 6480464 | Ethanol results in decreased expression of GRIK1 mRNA | CTD | PMID:20655511 | Grik1 | Rat | ethanol | multiple interactions | EXP | | 6480464 | N-methyl-N-(6-methoxy-1-phenyl-1 more ... | CTD | PMID:20655511 | Grik1 | Rat | folic acid | decreases expression | ISO | Grik1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of GRIK1 mRNA | CTD | PMID:25629700 | Grik1 | Rat | fulvestrant | multiple interactions | ISO | GRIK1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of GRIK1 gene | CTD | PMID:31601247 | Grik1 | Rat | kainic acid | multiple interactions | ISO | Grik1 (Mus musculus) | 6480464 | Celecoxib promotes the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA] and PTGS2 affects the reaction [Kainic Acid results in decreased expression of GRIK1 mRNA] | CTD | PMID:21589914 | Grik1 | Rat | kainic acid | increases expression | ISO | Grik1 (Mus musculus) | 6480464 | Kainic Acid results in increased expression of GRIK1 mRNA | CTD | PMID:29208536 | Grik1 | Rat | kainic acid | decreases expression | ISO | Grik1 (Mus musculus) | 6480464 | Kainic Acid results in decreased expression of GRIK1 mRNA | CTD | PMID:21589914 | Grik1 | Rat | lead diacetate | decreases expression | ISO | Grik1 (Mus musculus) | 6480464 | lead acetate results in decreased expression of GRIK1 mRNA | CTD | PMID:24260418 | Grik1 | Rat | lead diacetate | increases expression | ISO | Grik1 (Mus musculus) | 6480464 | lead acetate results in increased expression of GRIK1 mRNA | CTD | PMID:24260418 | Grik1 | Rat | linuron | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA | CTD | PMID:25607892 | Grik1 | Rat | methapyrilene | increases methylation | ISO | GRIK1 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of GRIK1 intron | CTD | PMID:30157460 | Grik1 | Rat | methotrexate | affects expression | ISO | Grik1 (Mus musculus) | 6480464 | Methotrexate affects the expression of GRIK1 mRNA | CTD | PMID:18502557 | Grik1 | Rat | morphine | multiple interactions | ISO | Grik1 (Mus musculus) | 6480464 | GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein] and GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form] | CTD | PMID:20359526 | Grik1 | Rat | morphine | affects response to substance | ISO | Grik1 (Mus musculus) | 6480464 | GRIK1 protein affects the susceptibility to Morphine | CTD | PMID:20359526 | Grik1 | Rat | N-ethyl-N-nitrosourea | increases mutagenesis | EXP | | 6480464 | Ethylnitrosourea results in increased mutagenesis of GRIK1 gene | CTD | PMID:16495775 | Grik1 | Rat | prochloraz | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA | CTD | PMID:25607892 | Grik1 | Rat | procymidone | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA | CTD | PMID:25607892 | Grik1 | Rat | rac-lactic acid | increases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of GRIK1 mRNA | CTD | PMID:30851411 | Grik1 | Rat | Se-methyl-L-selenocysteine | increases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | selenomethylselenocysteine results in increased expression of GRIK1 mRNA | CTD | PMID:18514395 | Grik1 | Rat | Se-methylselenocysteine | increases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | selenomethylselenocysteine results in increased expression of GRIK1 mRNA | CTD | PMID:18514395 | Grik1 | Rat | topiramate | affects response to substance | ISO | GRIK1 (Homo sapiens) | 6480464 | GRIK1 gene SNP affects the susceptibility to topiramate | CTD | PMID:19331489 | Grik1 | Rat | topiramate | affects binding | EXP | | 731146 | topiramate binds to Grik1 protein | RGD | | Grik1 | Rat | triclosan | decreases expression | ISO | GRIK1 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of GRIK1 mRNA | CTD | PMID:30510588 | Grik1 | Rat | triphenyl phosphate | affects expression | ISO | GRIK1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of GRIK1 mRNA | CTD | PMID:37042841 | Grik1 | Rat | vinclozolin | multiple interactions | EXP | | 6480464 | [Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of GRIK1 mRNA | CTD | PMID:25607892 | |