RGD Reference Report - Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. - Rat Genome Database

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Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia.

Authors: Shibata, H  Joo, A  Fujii, Y  Tani, A  Makino, C  Hirata, N  Kikuta, R  Ninomiya, H  Tashiro, N  Fukumaki, Y 
Citation: Shibata H, etal., Psychiatr Genet. 2001 Sep;11(3):139-44.
RGD ID: 1642476
Pubmed: PMID:11702055   (View Abstract at PubMed)

The glutamatergic dysfunction hypothesis suggests genes involved in glutamatergic transmission as candidates for schizophrenia susceptibility genes. We screened single nucleotide polymorphisms (SNPs) in the entire coding sequence of the GluR5 kainate receptor gene, GRIK1, by polymerase chain reaction-single strand conformation polymorphism and direct sequencing. We identified six SNPs including three known ones, 522A/C (174T, synonymous), 1173C/T (391D, synonymous), and 2705C/T (902L/S), as well as three novel ones, 995C/T (332A/V), 2400C/T (800L, synonymous), and 2585A/G (862R/Q). We genotyped Japanese samples of schizophrenia (n = 193-203) and healthy controls (n = 199-215) for three SNPs those were commonly observed in our samples, 522A/C, 1173C/T, and 2705C/T. We observed no significant associations of the SNPs and their haplotypes with schizophrenia. Therefore, we conclude that GRIK1 does not play a major role in schizophrenia pathogenesis in the Japanese population.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GRIK1Humanschizophrenia no_associationIAGP DNA:SNPs:three known and three novel:Japanese populationRGD 
Grik1Ratschizophrenia no_associationISOGRIK1 (Homo sapiens) RGD 
Grik1Mouseschizophrenia no_associationISOGRIK1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grik1  (glutamate ionotropic receptor kainate type subunit 1)

Genes (Mus musculus)
Grik1  (glutamate receptor, ionotropic, kainate 1)

Genes (Homo sapiens)
GRIK1  (glutamate ionotropic receptor kainate type subunit 1)


Additional Information