RGD Reference Report - Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia.

Authors: Shibata, H  Joo, A  Fujii, Y  Tani, A  Makino, C  Hirata, N  Kikuta, R  Ninomiya, H  Tashiro, N  Fukumaki, Y 
Citation: Shibata H, etal., Psychiatr Genet. 2001 Sep;11(3):139-44.
RGD ID: 1642476
Pubmed: PMID:11702055   (View Abstract at PubMed)

The glutamatergic dysfunction hypothesis suggests genes involved in glutamatergic transmission as candidates for schizophrenia susceptibility genes. We screened single nucleotide polymorphisms (SNPs) in the entire coding sequence of the GluR5 kainate receptor gene, GRIK1, by polymerase chain reaction-single strand conformation polymorphism and direct sequencing. We identified six SNPs including three known ones, 522A/C (174T, synonymous), 1173C/T (391D, synonymous), and 2705C/T (902L/S), as well as three novel ones, 995C/T (332A/V), 2400C/T (800L, synonymous), and 2585A/G (862R/Q). We genotyped Japanese samples of schizophrenia (n = 193-203) and healthy controls (n = 199-215) for three SNPs those were commonly observed in our samples, 522A/C, 1173C/T, and 2705C/T. We observed no significant associations of the SNPs and their haplotypes with schizophrenia. Therefore, we conclude that GRIK1 does not play a major role in schizophrenia pathogenesis in the Japanese population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
schizophrenia no_associationIAGP 1642476DNA:SNPs:three known and three novel:Japanese populationRGD 
schizophrenia no_associationISOGRIK1 (Homo sapiens)1642476; 1642476 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Grik1  (glutamate ionotropic receptor kainate type subunit 1)

Genes (Mus musculus)
Grik1  (glutamate receptor, ionotropic, kainate 1)

Genes (Homo sapiens)
GRIK1  (glutamate ionotropic receptor kainate type subunit 1)


Additional Information