Mir19a (microRNA 19a) - Rat Genome Database

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Gene: Mir19a (microRNA 19a) Rattus norvegicus
Analyze
Symbol: Mir19a
Name: microRNA 19a
RGD ID: 2325462
Description: Enables mRNA base-pairing post-transcriptional repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing. Located in extracellular exosome. Orthologous to human MIR19A (microRNA 19a); INTERACTS WITH 2-methoxyethanol; aflatoxin B1; atrazine.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-19a; rno-mir-19a
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,588,131 - 98,588,212 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1598,588,131 - 98,588,212 (+)EnsemblGRCr8
mRatBN7.21592,180,912 - 92,180,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,912 - 92,180,993 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1596,087,701 - 96,087,782 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,567 - 97,220,648 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,973 - 94,128,054 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1597,666,918 - 97,666,999 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1596,752,834 - 96,752,915 (+)NCBILyon_Normotensive
Lyon_Hypertensive1597,544,428 - 97,544,509 (+)NCBILyon_Hypertensive
F344_StmMcwi1595,566,984 - 95,567,065 (+)NCBIF344_StmMcwi
Rnor_6.015100,180,162 - 100,180,243 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,162 - 100,180,243 (+)Ensemblrn6Rnor6.0
Rnor_5.015103,641,185 - 103,641,266 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1591,045,592 - 91,045,673 (+)NCBICelera
Cytogenetic Map15q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. LncRNA H19 Aggravates Cerebral Ischemia/Reperfusion Injury by Functioning as a ceRNA for miR-19a-3p to Target PTEN. Gao N, etal., Neuroscience. 2020 Jun 15;437:117-129. doi: 10.1016/j.neuroscience.2020.04.020. Epub 2020 Apr 24.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Exosomal miRNA-19a and miRNA-614 Induced by Air Pollutants Promote Proinflammatory M1 Macrophage Polarization via Regulation of RORα Expression in Human Respiratory Mucosal Microenvironment. Shin CH, etal., J Immunol. 2020 Dec 1;205(11):3179-3190. doi: 10.4049/jimmunol.2000456. Epub 2020 Oct 28.
4. MicroRNA Microarray-Based Identification of Involvement of miR-155 and miR-19a in Development of Oral Lichen Planus (OLP) by Modulating Th1/Th2 Balance via Targeting eNOS and Toll-Like Receptor 2 (TLR2). Wang L, etal., Med Sci Monit. 2018 May 29;24:3591-3603. doi: 10.12659/MSM.907497.
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:18329372   PMID:20403161   PMID:21338882   PMID:24117217   PMID:25590961   PMID:25858512   PMID:26381867   PMID:26617805   PMID:27220268   PMID:31168302  
PMID:31573047   PMID:31633225   PMID:31924121   PMID:32096186   PMID:32271450   PMID:34051800   PMID:36334791   PMID:36539014   PMID:37218372   PMID:37393018  


Genomics

Comparative Map Data
Mir19a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81598,588,131 - 98,588,212 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1598,588,131 - 98,588,212 (+)EnsemblGRCr8
mRatBN7.21592,180,912 - 92,180,993 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1592,180,912 - 92,180,993 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1596,087,701 - 96,087,782 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01597,220,567 - 97,220,648 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01594,127,973 - 94,128,054 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1597,666,918 - 97,666,999 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1596,752,834 - 96,752,915 (+)NCBILyon_Normotensive
Lyon_Hypertensive1597,544,428 - 97,544,509 (+)NCBILyon_Hypertensive
F344_StmMcwi1595,566,984 - 95,567,065 (+)NCBIF344_StmMcwi
Rnor_6.015100,180,162 - 100,180,243 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15100,180,162 - 100,180,243 (+)Ensemblrn6Rnor6.0
Rnor_5.015103,641,185 - 103,641,266 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1591,045,592 - 91,045,673 (+)NCBICelera
Cytogenetic Map15q23NCBI
MIR19A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381391,350,891 - 91,350,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1391,350,891 - 91,350,972 (+)Ensemblhg38GRCh38
GRCh371392,003,145 - 92,003,226 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361390,801,145 - 90,801,226 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1372,850,116 - 72,850,197 (+)NCBICelera
Cytogenetic Map13q31.3NCBI
HuRef1372,598,980 - 72,599,061 (+)NCBIHuRef
CHM1_11391,971,785 - 91,971,866 (+)NCBICHM1_1
T2T-CHM13v2.01390,553,467 - 90,553,548 (+)NCBIT2T-CHM13v2.0
Mir19a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914115,281,432 - 115,281,513 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14115,281,432 - 115,281,513 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3814115,044,000 - 115,044,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14115,044,000 - 115,044,081 (+)Ensemblmm10GRCm38
MGSCv3714115,443,222 - 115,443,303 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera14113,634,568 - 113,634,649 (+)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1459.4NCBI
MIR19A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12242,478,298 - 42,478,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2242,478,285 - 42,478,366 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2242,333,986 - 42,334,043 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02242,879,547 - 42,879,604 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2242,879,534 - 42,879,615 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12242,562,020 - 42,562,077 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02242,616,399 - 42,616,456 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02242,617,462 - 42,617,519 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MIR19A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1160,734,939 - 60,735,020 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11160,734,939 - 60,735,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21166,610,343 - 66,610,424 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mir19a
1 total Variants
miRNA Target Status (No longer updated)

Predicted Targets
Summary Value
Count of predictions:9049
Count of gene targets:5542
Count of transcripts:5932
Interacting mature miRNAs:rno-miR-19a-3p, rno-miR-19a-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1560213984105213984Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1582194914108192169Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1588677086104695021Rat
1358354Srcrt5Stress Responsive Cort QTL 53.38blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1582503470108192169Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)1572716871101425383Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1582714037106778197Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)1588677086104695021Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
7411646Foco21Food consumption QTL 2123.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1584278281108192169Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1572716871101425383Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1581519Cm59Cardiac mass QTL 592.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1595260808102247606Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1575928947101425383Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)1583700787108192169Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1559257087104257087Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1582194914108192169Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 5 9 26 28 28 12 17 12 60 34 18 8 25 16 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1598,588,131 - 98,588,212 (+)Ensembl
mRatBN7.2 Ensembl1592,180,912 - 92,180,993 (+)Ensembl
Rnor_6.0 Ensembl15100,180,162 - 100,180,243 (+)Ensembl
RefSeq Acc Id: NR_031822
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81598,588,131 - 98,588,212 (+)NCBI
mRatBN7.21592,180,912 - 92,180,993 (+)NCBI
Dahl_SR_JrHsd1597,666,918 - 97,666,999 (+)NCBI
Lyon_Normotensive1596,752,834 - 96,752,915 (+)NCBI
Lyon_Hypertensive1597,544,428 - 97,544,509 (+)NCBI
F344_StmMcwi1595,566,984 - 95,567,065 (+)NCBI
Rnor_6.015100,180,162 - 100,180,243 (+)NCBI
Rnor_5.015103,641,185 - 103,641,266 (+)NCBI
Celera1591,045,592 - 91,045,673 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325462 AgrOrtholog
BioCyc Gene G2FUF-12492 BioCyc
Ensembl Genes ENSRNOG00000035578 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053701 ENTREZGENE
miRBase MI0000849 ENTREZGENE
NCBI Gene 100314151 ENTREZGENE
PhenoGen Mir19a PhenoGen
RatGTEx ENSRNOG00000035578 RatGTEx
RNAcentral URS000006FDD4 RNACentral
  URS000075E9A5 RNACentral
  URS000075EB4E RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir19a  microRNA 19a  Mir19a  microRNA mir-19a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir19a  microRNA mir-19a      Symbol and Name status set to provisional 70820 PROVISIONAL