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Gene: TIMP1 (TIMP metallopeptidase inhibitor 1) Chlorocebus sabaeus

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Symbol:

TIMP1

Name:

TIMP metallopeptidase inhibitor 1

RGD ID:

18631323

Description:

ENCODES a protein that exhibits protease binding (ortholog); INVOLVED IN cartilage development (ortholog); cellular response to acetaldehyde (ortholog); cellular response to peptide (ortholog); PARTICIPATES IN interleukin-6 signaling pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); adult respiratory distress syndrome (ortholog); alcoholic liver cirrhosis (ortholog); FOUND IN basement membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC103231892; LOC119623212; metalloproteinase inhibitor 1; metalloproteinase inhibitor 1-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	44,759,412 - 44,763,243 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	44,760,531 - 44,765,571 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666566	24,012 - 27,843 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

adult respiratory distress syndrome (ISO)

alcoholic liver cirrhosis (ISO)

Animal Disease Models (ISO)

aortic valve insufficiency (ISO)

atherosclerosis (ISO)

autoimmune disease (ISO)

Brain Injuries (ISO)

breast cancer (ISO)

CAKUT2 (ISO)

calcinosis (ISO)

cholangitis (ISO)

cholestasis (ISO)

chronic obstructive pulmonary disease (ISO)

congestive heart failure (ISO)

COVID-19 (ISO)

cystic fibrosis (ISO)

degenerative disc disease (ISO)

diabetes mellitus (ISO)

Down syndrome (ISO)

Emphysema (ISO)

endometrial carcinoma (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

extrahepatic cholestasis (ISO)

Female Urogenital Diseases (ISO)

gastric ulcer (ISO)

heart disease (ISO)

heart valve disease (ISO)

Hemorrhagic Shock (ISO)

hyperhomocysteinemia (ISO)

Hyperoxia (ISO)

hypertension (ISO)

IgA glomerulonephritis (ISO)

Inflammation (ISO)

intracranial aneurysm (ISO)

Kawasaki disease (ISO)

Lymphatic Metastasis (ISO)

metabolic dysfunction-associated steatohepatitis (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

obesity (ISO)

oral submucous fibrosis (ISO)

ovarian cancer (ISO)

pre-eclampsia (ISO)

preretinal fibrosis (ISO)

pulmonary fibrosis (ISO)

relapsing-remitting multiple sclerosis (ISO)

renal cell carcinoma (ISO)

stroke (ISO)

thoracic aortic aneurysm (ISO)

transitional cell carcinoma (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

varicose veins (ISO)

vascular disease (ISO)

Wilson disease (ISO)

Wounds and Injuries (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cartilage development (ISO)

cellular response to acetaldehyde (ISO)

cellular response to peptide (ISO)

cellular response to UV-A (IEA)

connective tissue replacement involved in inflammatory response wound healing (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of catalytic activity (ISO)

negative regulation of endopeptidase activity (ISO)

negative regulation of membrane protein ectodomain proteolysis (IEA)

negative regulation of metallopeptidase activity (ISO)

negative regulation of proteolysis (IEA)

negative regulation of trophoblast cell migration (IEA)

positive regulation of cell population proliferation (IEA)

regulation of integrin-mediated signaling pathway (IEA)

response to cytokine (IEA,ISO)

response to hormone (IEA)

response to peptide hormone (ISO)

signal transduction (IEA)

Cellular Component

basement membrane (IEA,ISO)

extracellular matrix (IEA)

extracellular region (IEA)

extracellular space (IEA)

secretory granule lumen (IEA)

Molecular Function

cytokine activity (IEA)

enzyme inhibitor activity (IEA)

growth factor activity (IEA)

metal ion binding (IEA)

metalloendopeptidase inhibitor activity (IEA)

peptidase inhibitor activity (IEA)

protease binding (IEA,ISO)

protein binding (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-6 signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

TIMP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	44,759,412 - 44,763,243 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	44,760,531 - 44,765,571 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666566	24,012 - 27,843 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TIMP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	47,582,436 - 47,586,789 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	47,582,408 - 47,586,789 (+)	Ensembl			hg38	GRCh38
GRCh37	X	47,441,835 - 47,446,188 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	47,326,634 - 47,331,134 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	X	47,198,084 - 47,202,441	NCBI
Celera	X	51,636,947 - 51,641,447 (+)	NCBI		Celera
Cytogenetic Map	X	p11.3	NCBI
HuRef	X	45,154,211 - 45,158,632 (+)	NCBI		HuRef
CHM1_1	X	47,472,792 - 47,477,292 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	46,992,326 - 46,996,679 (+)	NCBI		T2T-CHM13v2.0

Timp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	20,736,524 - 20,740,972 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	20,736,405 - 20,740,974 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	X	20,870,166 - 20,874,737 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	20,870,166 - 20,874,735 (+)	Ensembl			mm10	GRCm38
MGSCv37	X	20,447,292 - 20,451,863 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	X	20,027,998 - 20,031,591 (+)	NCBI		MGSCv36	mm8
Celera	X	19,001,307 - 19,005,878 (+)	NCBI		Celera
Cytogenetic Map	X	A1.3	NCBI
cM Map	X	16.38	NCBI

Timp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	3,766,509 - 3,772,578 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	X	3,766,510 - 3,771,135 (-)	Ensembl				GRCr8
mRatBN7.2	X	1,212,969 - 1,217,714 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	1,212,972 - 1,217,664 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	X	1,241,133 - 1,245,729 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	4,716,824 - 4,721,420 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	1,037,983 - 1,042,580 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	1,364,771 - 1,369,451 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	1,364,786 - 1,369,384 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	X	2,179,962 - 2,184,814 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	X	12,542,496 - 12,547,094 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	X	1,780,586 - 1,785,184 (-)	NCBI		Celera
RGSC_v3.1	X	12,548,051 - 12,552,650 (-)	NCBI
Cytogenetic Map	X	q11	NCBI

Timp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955516	505,789 - 512,118 (-)	Ensembl
ChiLan1.0	NW_004955516	507,113 - 511,360 (-)	NCBI	ChiLan1.0	ChiLan1.0

TIMP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	49,208,573 - 49,213,215 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	49,212,076 - 49,216,587 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	40,018,190 - 40,022,636 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	47,914,906 - 47,919,419 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	47,914,906 - 47,919,419 (+)	Ensembl			panPan2	panpan1.1

TIMP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	41,201,623 - 41,205,314 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	41,201,638 - 41,205,310 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	15,576,764 - 15,580,333 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	41,335,929 - 41,339,499 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	41,335,826 - 41,339,498 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	41,323,532 - 41,327,103 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	41,311,800 - 41,315,371 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	41,404,449 - 41,408,018 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Timp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	33,505,193 - 33,509,420 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936502	13,345,832 - 13,350,248 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936502	13,345,936 - 13,350,170 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TIMP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	42,102,172 - 42,106,296 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	X	42,103,251 - 42,106,289 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	47,372,604 - 47,375,643 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	X	p	NCBI

Timp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624978	121,803 - 124,912 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624978	120,723 - 125,006 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Timp1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	X	2,777,611 - 2,782,506 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in TIMP1
49 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007991541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JBLKOC010000030	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000011711 ⟹ ENSCSAP00000009775

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	X	44,760,531 - 44,765,571 (+)	Ensembl

RefSeq Acc Id:

XM_007991541 ⟹ XP_007989732

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	X	44,759,412 - 44,763,243 (+)	NCBI
Vero_WHO_p1.0	NW_023666566	24,012 - 27,843 (-)	NCBI

Sequence:

show sequence

TCGGCCCGCCCCTTGGCTTCTGCACTGATGGTGGGTGGATGAGTAATGCATCCAGGAAGCCTGG
AGGCCTGTGGTTTCCGCACCCGCTGCCACCCCCGCCCCTAGCGTGGACATTTATCCTCTAGCGC
TCAGGCCCTGCCGCCATCGCCGCAGATCCAGTGCCCAGAGAGACACGAGAGAACCCACCATGGC
CCCCTTTGAGCCCCTCGCTTCCGGCATCCTGTTGTTGCTGTGGCTGATAGCCCCCAGCAGGGCC
TGCACCTGTGTCCCACCCCACCCACAGACGGCCTTCTGCAATTCCGACCTCGTCATCAGGGCCA
AGTTCGTGGGGACACCAGAAGTCAACCAGACCACCTTATACCAGCGTTATGAGATCAAGATGAC
CAAGATGTATAAAGGGTTCCAGGCCTTAGGGGATGCCGCTGACATCCGGTTCGTCTACACCCCC
GCCATGGAGAGTGTCTGCGGATACTTCCACAGGTCCCAGAACCGCAGCGAGGAGTTTCTCATTG
CTGGAAAACTGCAGGACGGACTCTTGCACATCACCACCTGCAGTTTCGTGGCTCCCTGGAACAG
TCTGAGCTTAGCTCAGCGCCGGGGCTTCACCAAGACCTACACTGTTGGCTGTGAGGAATGCACA
GTGTTTCCCTGTTTATCCATCCCCTGCAAACTGCAGAGTGGCACTCATTGCTTGTGGACGGACC
AGCTCCTCCAAGGCTCTGAAAAGGGCTTCCAGGCCCGTCACCTTGCCTGCCTGCCTCGGGAGCC
AGGGCTGTGCACCTGGCAGTCCCTGCGGACCCGGATAGCCTGAATCCTGCCGGAGTGGAAGCTG
AAGCCTGCGCAGTGTCCACCCTGTTCCCACTCCCATCTTTCTTCTAGACAATGAAATAAAGAGT
TACCACCCAGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007989732	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009775
	ENSCSAP00000009775.1

RefSeq Acc Id:	XP_007989732 ⟸ XM_007991541
- UniProtKB:	A0A0D9RMD6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000009775 ⟸ ENSCSAT00000011711

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000013611	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011711.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.120	UniProtKB/TrEMBL
	3.90.370.10	UniProtKB/TrEMBL
InterPro	Netrin_domain	UniProtKB/TrEMBL
	TIMP	UniProtKB/TrEMBL
	TIMP-like_OB-fold	UniProtKB/TrEMBL
	TIMP_C	UniProtKB/TrEMBL
	TIMP_CS	UniProtKB/TrEMBL
KEGG Report	csab:103231892	UniProtKB/TrEMBL
NCBI Gene	TIMP1	ENTREZGENE
PANTHER	PTHR11844	UniProtKB/TrEMBL
	PTHR11844:SF20	UniProtKB/TrEMBL
Pfam	TIMP	UniProtKB/TrEMBL
PROSITE	NTR	UniProtKB/TrEMBL
	TIMP	UniProtKB/TrEMBL
SMART	NTR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50242	UniProtKB/TrEMBL
UniProt	A0A0D9RMD6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-04-17	TIMP1	TIMP metallopeptidase inhibitor 1	LOC119623212	metalloproteinase inhibitor 1-like	Data Merged	737654	PROVISIONAL
2025-04-15	TIMP1	TIMP metallopeptidase inhibitor 1	LOC103231892	metalloproteinase inhibitor 1	Symbol and/or name change	5135510	APPROVED
2020-12-08	LOC103231892	metalloproteinase inhibitor 1	TIMP1	TIMP metallopeptidase inhibitor 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)