Srsf6 (serine and arginine rich splicing factor 6)

Gene: Srsf6 (serine and arginine rich splicing factor 6) Rattus norvegicus

Analyze

Symbol:

Srsf6

Name:

serine and arginine rich splicing factor 6

RGD ID:

1359241

Description:

Predicted to enable mRNA binding activity and pre-mRNA binding activity. Involved in negative regulation of gene expression; negative regulation of type B pancreatic cell apoptotic process; and response to insulin. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to human SRSF6 (serine and arginine rich splicing factor 6); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aconitine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC362264; pre-mRNA-splicing factor SRP55; serine/arginine-rich splicing factor 6; Sfrs6; similar to dJ862K6.2.2 (splicing factor, arginine/serine-rich 6 (SRP55-2)(isoform 2)); splicing factor, arginine/serine-rich 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Related Pseudogenes:

Srsf6-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	172,009,072 - 172,014,395 (+)	NCBI		GRCr8
mRatBN7.2	3	151,589,546 - 151,594,869 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	151,589,535 - 151,594,860 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	155,397,888 - 155,403,214 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	163,896,848 - 163,902,174 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	161,640,441 - 161,645,767 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	159,305,345 - 159,310,668 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	159,305,345 - 159,310,668 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	165,502,385 - 165,507,708 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	153,795,483 - 153,799,026 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	153,701,518 - 153,705,060 (+)	NCBI
Celera	3	150,247,637 - 150,252,960 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

clear cell renal cell carcinoma (ISO)

colon adenocarcinoma (ISO)

Epidermal Hyperplasia (ISO)

focal epilepsy (ISO)

Huntington's disease (ISO)

lung cancer (ISO)

Neoplasm Metastasis (ISO)

proliferative diabetic retinopathy (ISO)

skin cancer (ISO)

spermatogenic failure 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3',5'-cyclic UMP (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

aconitine (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

atrazine (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

calyculin a (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

coumarin (ISO)

crocidolite asbestos (ISO)

curcumin (ISO)

cyclosporin A (ISO)

dibenzo[a,l]pyrene (ISO)

dorsomorphin (ISO)

ethanol (ISO)

fenthion (ISO)

folic acid (ISO)

FR900359 (ISO)

GSK690693 (ISO)

indometacin (ISO)

iron dichloride (ISO)

ivermectin (ISO)

leflunomide (ISO)

methylparaben (ISO)

N-methyl-4-phenylpyridinium (ISO)

niclosamide (ISO)

ozone (ISO)

paraquat (ISO)

PCB138 (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

progesterone (ISO)

quercetin (EXP)

rotenone (EXP)

SB 431542 (ISO)

sodium fluoride (ISO)

testosterone enanthate (ISO)

Tributyltin oxide (ISO)

trichloroethene (EXP)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

alternative mRNA splicing, via spliceosome (ISO,ISS)

mRNA splice site recognition (ISO,ISS)

negative regulation of gene expression (IMP)

negative regulation of keratinocyte differentiation (ISO,ISS)

negative regulation of mRNA splicing, via spliceosome (ISO)

negative regulation of type B pancreatic cell apoptotic process (IMP)

positive regulation of epithelial cell proliferation involved in lung morphogenesis (ISO)

regulation of alternative mRNA splicing, via spliceosome (ISO,ISS)

regulation of keratinocyte proliferation (ISO,ISS)

regulation of wound healing (ISO,ISS)

response to insulin (IEP)

Cellular Component

cytoplasm (IBA)

nuclear speck (ISO,ISS)

nucleus (IBA)

ribonucleoprotein complex (IBA)

Molecular Function

mRNA binding (IBA)

pre-mRNA binding (ISO,ISS)

protein binding (ISO)

RNA binding (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Splicing factor polymorphisms, the control of VEGF isoforms and association with angiogenic eye disease.	Carter JG, etal., Curr Eye Res. 2011 Apr;36(4):328-35. doi: 10.3109/02713683.2010.548892. Epub 2011 Feb 10.
2.	Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.	Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
3.	The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers.	Cohen-Eliav M, etal., J Pathol. 2013 Mar;229(4):630-9. doi: 10.1002/path.4129.
4.	Huntington's disease is a four-repeat tauopathy with tau nuclear rods.	Fernandez-Nogales M, etal., Nat Med. 2014 Aug;20(8):881-5. doi: 10.1038/nm.3617. Epub 2014 Jul 20.
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Altered expression of heterogenous nuclear ribonucleoproteins and SR factors in human colon adenocarcinomas.	Ghigna C, etal., Cancer Res. 1998 Dec 15;58(24):5818-24.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Alterations in expression pattern of splicing factors in epithelial ovarian cancer and its clinical impact.	Iborra S, etal., Int J Gynecol Cancer. 2013 Jul;23(6):990-6. doi: 10.1097/IGC.0b013e31829783e3.
9.	Splicing factor SRSF6 promotes hyperplasia of sensitized skin.	Jensen MA, etal., Nat Struct Mol Biol. 2014 Feb;21(2):189-97. doi: 10.1038/nsmb.2756. Epub 2014 Jan 19.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Genetic variants in Ser-Arg protein-coding genes are associated with the risk of nonobstructive azoospermia in Chinese men.	Ni B, etal., Fertil Steril. 2014 Jun;101(6):1711-7.e1-2. doi: 10.1016/j.fertnstert.2014.02.033. Epub 2014 Mar 21.
12.	GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.	Nogueira TC, etal., PLoS Genet. 2013 May;9(5):e1003532. doi: 10.1371/journal.pgen.1003532. Epub 2013 May 30.
13.	Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells.	Patel NA, etal., J Biol Chem. 2001 Jun 22;276(25):22648-54. Epub 2001 Mar 30.
14.	Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors.	Piekielko-Witkowska A, etal., PLoS One. 2010 Oct 27;5(10):e13690. doi: 10.1371/journal.pone.0013690.
15.	GOA pipeline	RGD automated data pipeline
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Comprehensive gene review and curation	RGD comprehensive gene curation
18.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19.	The spliceosome: design principles of a dynamic RNP machine.	Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
20.	Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.	Walsh CM, etal., J Biol Chem. 2013 Jan 25;288(4):2816-28. doi: 10.1074/jbc.M112.410803. Epub 2012 Dec 11.

Additional References at PubMed

PMID:12549914	PMID:15009664	PMID:22658674	PMID:22681889	PMID:22767602	PMID:29476059	PMID:30361391	PMID:31505169

Genomics

Comparative Map Data

Srsf6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	172,009,072 - 172,014,395 (+)	NCBI		GRCr8
mRatBN7.2	3	151,589,546 - 151,594,869 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	151,589,535 - 151,594,860 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	155,397,888 - 155,403,214 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	163,896,848 - 163,902,174 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	161,640,441 - 161,645,767 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	159,305,345 - 159,310,668 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	159,305,345 - 159,310,668 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	165,502,385 - 165,507,708 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	153,795,483 - 153,799,026 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	153,701,518 - 153,705,060 (+)	NCBI
Celera	3	150,247,637 - 150,252,960 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

SRSF6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	43,457,896 - 43,464,243 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	43,457,893 - 43,466,046 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	42,086,536 - 42,092,883 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	41,519,932 - 41,525,655 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	41,519,931 - 41,525,655	NCBI
Celera	20	38,793,993 - 38,799,734 (+)	NCBI		Celera
Cytogenetic Map	20	q13.11	NCBI
HuRef	20	38,822,762 - 38,828,474 (+)	NCBI		HuRef
CHM1_1	20	41,990,350 - 41,996,091 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	45,191,165 - 45,197,503 (+)	NCBI		T2T-CHM13v2.0

Srsf6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	162,773,428 - 162,779,041 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	162,773,448 - 162,779,041 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	162,931,508 - 162,937,121 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	162,931,528 - 162,937,121 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	162,757,244 - 162,762,857 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	162,622,982 - 162,628,562 (+)	NCBI		MGSCv36	mm8
Celera	2	168,878,554 - 168,884,169 (+)	NCBI		Celera
Cytogenetic Map	2	H2	NCBI
cM Map	2	83.87	NCBI

Srsf6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	13,661,209 - 13,669,102 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	13,663,474 - 13,669,102 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRSF6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	49,193,875 - 49,203,175 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	49,186,976 - 49,196,276 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	39,795,659 - 39,801,864 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	40,888,396 - 40,892,152 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	40,888,560 - 40,891,853 (+)	Ensembl	panpan1.1		panPan2

SRSF6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	31,217,190 - 31,222,852 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	31,217,184 - 31,218,618 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	30,860,739 - 30,866,500 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	31,924,806 - 31,930,549 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	31,924,822 - 31,930,549 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	31,188,536 - 31,194,277 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	31,299,944 - 31,305,686 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	31,840,352 - 31,846,095 (+)	NCBI		UU_Cfam_GSD_1.0

Srsf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	180,213,648 - 180,219,277 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936530	3,086,680 - 3,092,828 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936530	3,086,944 - 3,092,780 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRSF6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	46,119,409 - 46,125,126 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	46,119,612 - 46,122,540 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	51,513,133 - 51,516,063 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRSF6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	20,340,163 - 20,345,873 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	20,342,681 - 20,346,122 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	69,083,496 - 69,089,235 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srsf6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	10,812,013 - 10,817,833 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624790	10,812,013 - 10,817,414 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Srsf6
6 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1074
Count of miRNA genes:	340
Interacting mature miRNAs:	462
Transcripts:	ENSRNOT00000008427
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
12879871	Am7	Aortic mass QTL 7		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	145925360	166177555	Rat
12879872	Cm97	Cardiac mass QTL 97		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	145925360	166177555	Rat
12879873	Cm96	Cardiac mass QTL 96		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	145925360	166177555	Rat
12879874	Cm98	Cardiac mass QTL 98		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	145925360	166177555	Rat
12879875	Kidm64	Kidney mass QTL 64		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	145925360	166177555	Rat
12879876	Bw182	Body weight QTL 182		0.003	body mass (VT:0001259)	body weight (CMO:0000012)	3	145925360	166177555	Rat
2301411	Bp320	Blood pressure QTL 320		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145925360	166177555	Rat
1300113	Bp176	Blood pressure QTL 176	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	145956084	157309487	Rat
1598854	Memor10	Memory QTL 10	2		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	3	145956084	161299569	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
1578666	Vnigr1	Vascular neointimal growth QTL 1	4.6		artery morphology trait (VT:0002191)	artery lumen area (CMO:0001409)	3	149040888	168026850	Rat

Markers in Region

AW146126

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	151,594,680 - 151,594,786 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	159,310,480 - 159,310,585	NCBI	Rnor6.0
Rnor_5.0	3	165,507,520 - 165,507,625	UniSTS	Rnor5.0
RGSC_v3.4	3	153,800,609 - 153,800,714	UniSTS	RGSC3.4
Celera	3	150,252,772 - 150,252,877	UniSTS
Cytogenetic Map	3	q42	UniSTS

RH131453

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	151,589,307 - 151,589,523 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	159,305,107 - 159,305,322	NCBI	Rnor6.0
Rnor_5.0	3	165,502,147 - 165,502,362	UniSTS	Rnor5.0
RGSC_v3.4	3	153,795,236 - 153,795,451	UniSTS	RGSC3.4
Celera	3	150,247,399 - 150,247,614	UniSTS
RH 3.4 Map	3	1391.0	UniSTS
Cytogenetic Map	3	q42	UniSTS

AA874922

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	151,592,459 - 151,592,647 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	159,308,259 - 159,308,446	NCBI	Rnor6.0
Rnor_5.0	3	165,505,299 - 165,505,486	UniSTS	Rnor5.0
RGSC_v3.4	3	153,798,388 - 153,798,575	UniSTS	RGSC3.4
Celera	3	150,250,551 - 150,250,738	UniSTS
RH 3.4 Map	3	1387.9	UniSTS
Cytogenetic Map	3	q42	UniSTS

RH139802

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	151,594,171 - 151,594,351 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	159,309,971 - 159,310,150	NCBI	Rnor6.0
Rnor_5.0	3	165,507,011 - 165,507,190	UniSTS	Rnor5.0
RGSC_v3.4	3	153,800,100 - 153,800,279	UniSTS	RGSC3.4
Celera	3	150,252,263 - 150,252,442	UniSTS
RH 3.4 Map	3	1387.9	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	10	74	35	41	11	8
Low								1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM060375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM081417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223381	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227426	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000008427 ⟹ ENSRNOP00000008427

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	151,589,535 - 151,594,860 (+)	Ensembl
Rnor_6.0 Ensembl	3	159,305,345 - 159,310,668 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117899 ⟹ ENSRNOP00000086011

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	151,589,542 - 151,592,959 (+)	Ensembl

RefSeq Acc Id:

NM_001014185 ⟹ NP_001014207

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	172,009,072 - 172,014,395 (+)	NCBI
mRatBN7.2	3	151,589,546 - 151,594,869 (+)	NCBI
Rnor_6.0	3	159,305,345 - 159,310,668 (+)	NCBI
Rnor_5.0	3	165,502,385 - 165,507,708 (+)	NCBI
RGSC_v3.4	3	153,795,483 - 153,799,026 (+)	RGD
Celera	3	150,247,637 - 150,252,960 (+)	NCBI

Sequence:

show sequence

GCTGACTCGGCCGCAGCTGCGGTGTGAGGCGCGTGTTCGGGCCTTCGCCGTCCCCGCACCCGCA
CCGCAGCCCCTGCCCCGCGGCCCGCCGCACCTCAGCTAGCCTCCGGGAGAACACCCACCACGGC
CATGCCGCGCGTCTACATAGGACGCCTGAGCTACAACGTCCGCGAGAAGGACATCCAGCGCTTT
TTCAGCGGCTACGGCCGCCTCCTCGAAATCGACCTCAAAAATGGGTACGGTTTCGTGGAGTTCG
AGGACTCCCGTGATGCGGACGACGCCGTTTACGAGCTGAACAGCAAGGAGCTGTGCGGCGAGCG
CGTGATCGTAGAGCACGCCCGGGGCCCGCGCCGGGACCGCGATGGCTACAGCTACGGAAGCCGC
AGTGGTGGAGGTGGATACAGCAGTCGGAGAACTTCTGGCAGAGACAAATATGGACCACCTGTTC
GTACAGAATACAGGCTTATTGTAGAAAATCTATCTAGTCGTTGCAGTTGGCAAGACTTAAAGGA
TTTCATGCGGCAAGCAGGAGAGGTGACTTATGCAGATGCTCACAAAGAACGAACAAATGAGGGT
GTAATTGAATTTAGATCCTACTCTGACATGAAGCGTGCTTTGGATAAACTGGATGGCACAGAAA
TAAATGGCAGGAATATACGGCTTATTGAAGATAAGCCACGAACAAGCCATAGGCGCTCTTACTC
TGGAAGTAGATCCAGATCACGGTCTAGAAGAAGATCTCGGAGTAGGAGTCGCAGAAGCAGCCGC
AGTAGATCTCGAAGTATCTCAAAAAGTCGCTCGCGATCTAGGTCTCGGAGCAAAGGTCGATCCC
GATCCCGCTCAAAGGGCAGGAAATCCAGATCAAAGAGCAAATCTAAGCCCAAGTCTGATCGGGG
TTCCCATTCACATTCAAGAAGCAGATCTAAGGATAAGTATGGGAAGTCACGAAGTAGGTCACGT
TCTCGGTCCCCCAAAGAAAATGGAAAAGGAGATATAAAGTCAAAATCCAGATCCCGGAGCCAGT
CTCGATCCCATTCGCCTCTGCCTGCTCCACCCTCAAAGGCTCGGTCCATGTCCCCTCCGCCAAA
AAGAGCTTCAAGGTCCCGTTCTAGATCTCGTTCCAGGTCCAGATCAAGTTCCAGAGATTAGCCC
TGAACTCTACGTTCTTTGCACACTATGACGGAACTCTTTCCTACTTGCCTAGGCAGTCACTCTT
CCGAGTTCGTACTCGGCCTCTTCTTCAAGAGGATTTCCTGAAAAGGGAACACAGGAATTTGATT
TGTGGCCAAATTTAATGAGAAAAGATGAGGTTCTAAAATGGTGGTATGAAGCCCTCTCCCTTCT
TTGTAGAATTAAGATAATTTTGATTTTGTAGCCTTTGAGCTAAAATAACTTTTGTAAAGATTAA
GCTCACTTAGATTTTTTTTAAAGTATTGCAGCGGGATCTGCTGCAGGGTTCTGTTGTTTTGTTT
TGCTTATTTTTAAATTAACTGTTCAAGCTTTTGGATACTGCAGGCTTTAGAGGGAGAACCCAAA
TTTTCAATTATGTTGGCTTTTTATAAAGCTTGAGTTATGTAAGATTTAAATAAAAGTTTGCTAC
CAAGATGATTGCCTTATTGAATAGGTCACTCCTAAGGCCCTTTAAGTGTTGATACCTGCCATTG
GTGGAGACAGTGTAAATTCTACAGAAGTGTAAAACAAGGCAAGCCTCAGACCAGCAATAAATTA
TTCAGTTTGGCTAACCTTATTTTGTGCTGTTAATCAAATCTACCAAAGTCTTTTGTCTACCCCT
TTTATAAGTTGAGTTAAAAGTAAAAGGGACTTTGTAGTTAGTGCCACATGATAAATAAAAGAAA
CTAAAGGATTACAATTTGAACTCTTCAAGAAGTAGGTCCTAGTACTTGGGATCTTGTTATCCTG
TGCTCTGGAAGTGGTCAGCATAATTAGTGTTAATGTATGATTTGGTGGTCTTTAATGTTTGAAA
AACAGAAGTAACCTTTAATTAGAGATTTAGTTATTTTTATTCAAAGTTGAAAAGCATATACACT
GCATTTTCTGCTGAAAGATGAATCTGTTTAACAGGTGCTTAGCAGACTATTGATAAGATTTGCT
GGTTAAAATTCAATCAGTCCCCTTTGTATTGGTGGGGCTTTTGTGGTTAGTTTAAAAAACAGTG
ACATGGTTAAACTAAAATGCTTCATACTTTTAAGCATTAGGAATGCTGTGGAAACCCAAGTTAA
AATAAATAGTGCAAATGTGTAGGAATAACTAGATTTGCAGTTTCTATACATCCCAAAGCCCAGT
CAGTTGAGACTGCGATCAATTGTTACTTAACAACCTTTCCATTATTCAGACGTGTGTAAAGTCA
TTTCATCTAAGTGCTTAACCTCATTCTTTAGTAAAGGTGTAGATGGATTGGGTGAGGTTTAATT
CCTTCCTCAGCTGTTGTATAATCTAGCAAAAGTTGGATTAGAGATTATAAGGTAGAGTTTGTTT
GTAGGGTTAAATAATCAGGACATGCAATAAAGTCAGGCTGAGTGGAAAAAGATTCAAGGGCCTA
GGTAGGTGTCAGTAAGTGGGAATACTTGGAAAAACAGGGAAAGGGGAATGTTTTCAAGACATTT
ATCCTGCTCAAAATCTTAGAGACTGACTTTAGGAATAAAGTGTCAGATACAGCTGCTGCTTTAG
TCGTCTTTTCTTTGATGCTTTGTTTAGATGTTTATAAGAAATAGGTTTATTTTTCCAGTGTAAA
TTTCAGAATTTAAAGAAAATTGTGTCTGGTTATAGTTTACTATTTTACCTACTTAAAAACAAAT
GTGATGGCTCTTTAAGAATTGGATTTGACCAAAGTTCTCTTTGTTTTCAGGGAAAACTATATAA
AAGCTTTCTGAGCCACAGCCTTTTAAAGGGGGAAAGGCTAATAGTAAAATTTGACTTTCTGACT
GCATGCAACTTTGAGCTGGGCTTGCCTTCTGTGGTAATACATGACAGAGGCATTAGACTTTTTT
AGCTGCCCTAATAAGTATATGATGAATAAATAAATGCCAATACCCATAACAATTTTTCTAGTGG
GGACAAAGGTCATTTGATTAATCTAGGTTTTCATACCGACCCGATTATTAAATGCACTTAAAAA
AAAACTGCATTTAAAGCATTGGCCTTAGCAGAATTGACTGACTTAGTTCCTTACTGGTGAGTGA
ATTCAGTTCCCTACCAACTAATGCGCAGAATCTAAGAATCCCATCCTGCACACATTGGTTGGAG
CCCTGAGTGGAGTATCAGCAGCACCAACTGATAAGAGCACAAGAGAAGTGGGGAACATCTGGAG
TCCTGTTGGACGTGACAGTGTTTCTTGATATGTATGCCACAGTGCCTTGGTGGCCAGCTTGAGT
CCTACCTACTCAGCCTTTGTCCCCACTCCTCCTGTGTTAGCTTTCATCTTGCATATTCTTTTTT
TTCTACTTTGTTAACCTACTTTATGCTTTATCTCAATAAAATGCTTACCAAGGGAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001014207	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87121	(Get FASTA)	NCBI Sequence Viewer
	EDL96600	(Get FASTA)	NCBI Sequence Viewer
	EDL96601	(Get FASTA)	NCBI Sequence Viewer
	EDL96602	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000008427
	ENSRNOP00000008427.5
	ENSRNOP00000086011.1
	ENSRNOP00055005766
	ENSRNOP00060001104
	ENSRNOP00065035206
GenBank Protein	G3V6S8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001014207 ⟸ NM_001014185

- UniProtKB:

Q5PQM1 (UniProtKB/Swiss-Prot), G3V6S8 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPRVYIGRLSYNVREKDIQRFFSGYGRLLEIDLKNGYGFVEFEDSRDADDAVYELNSKELCGER
VIVEHARGPRRDRDGYSYGSRSGGGGYSSRRTSGRDKYGPPVRTEYRLIVENLSSRCSWQDLKD
FMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDKPRTSHRRSYS
GSRSRSRSRRRSRSRSRRSSRSRSRSISKSRSRSRSRSKGRSRSRSKGRKSRSKSKSKPKSDRG
SHSHSRSRSKDKYGKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSHSPLPAPPSKARSMSPPPK
RASRSRSRSRSRSRSSSRD

hide sequence

RefSeq Acc Id:

ENSRNOP00000008427 ⟸ ENSRNOT00000008427

RefSeq Acc Id:

ENSRNOP00000086011 ⟸ ENSRNOT00000117899

Protein Domains

RRM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V6S8-F1-model_v2	AlphaFold	G3V6S8	1-339	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692631

Promoter ID:

EPDNEW_R3154

Type:

multiple initiation site

Name:

Srsf6_1

Description:

serine and arginine rich splicing factor 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	159,305,334 - 159,305,394	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359241	AgrOrtholog
BioCyc Gene	G2FUF-46928	BioCyc
Ensembl Genes	ENSRNOG00000006380	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055004796	UniProtKB/Swiss-Prot
	ENSRNOG00060001308	UniProtKB/Swiss-Prot
	ENSRNOG00065025011	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000008427	ENTREZGENE
	ENSRNOT00000008427.7	UniProtKB/Swiss-Prot
	ENSRNOT00000117899.1	UniProtKB/TrEMBL
	ENSRNOT00055007647	UniProtKB/Swiss-Prot
	ENSRNOT00060001896	UniProtKB/Swiss-Prot
	ENSRNOT00065043007	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.70.330	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7106749	IMAGE-MGC_LOAD
InterPro	Nucleotide-bd_a/b_plait_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RRM_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:362264	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94786	IMAGE-MGC_LOAD
NCBI Gene	362264	ENTREZGENE
PANTHER	RIBONUCLEOPROTEIN RB97D	UniProtKB/TrEMBL
	RIBONUCLEOPROTEIN RB97D	UniProtKB/TrEMBL
	RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN	UniProtKB/Swiss-Prot
	SERINE/ARGININE-RICH SPLICING FACTOR 6	UniProtKB/Swiss-Prot
Pfam	RRM_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Srsf6	PhenoGen
PROSITE	RRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006380	RatGTEx
	ENSRNOG00055004796	RatGTEx
	ENSRNOG00060001308	RatGTEx
	ENSRNOG00065025011	RatGTEx
SMART	RRM	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF54928	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A2U9_RAT	UniProtKB/TrEMBL
	G3V6S8	ENTREZGENE
	Q5PQM1	ENTREZGENE
	SRSF6_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q5PQM1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-15	Srsf6	serine and arginine rich splicing factor 6	Srsf6	serine/arginine-rich splicing factor 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-01	Srsf6	serine/arginine-rich splicing factor 6	Sfrs6	splicing factor, arginine/serine-rich 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-22	Sfrs6	splicing factor, arginine/serine-rich 6	Srsf6	serine/arginine-rich splicing factor 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-13	Srsf6	serine/arginine-rich splicing factor 6	Sfrs6	splicing factor, arginine/serine-rich 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-09-20	Sfrs6	splicing factor, arginine/serine-rich 6	Srsf6	serine/arginine-rich splicing factor 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-09-14	Srsf6	serine/arginine-rich splicing factor 6	Sfrs6	splicing factor, arginine/serine-rich 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Sfrs6	splicing factor, arginine/serine-rich 6	LOC362264	similar to dJ862K6.2.2 (splicing factor, arginine/serine-rich 6 (SRP55-2)(isoform 2))	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations