SRSF6 (serine and arginine rich splicing factor 6) - Rat Genome Database

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Gene: SRSF6 (serine and arginine rich splicing factor 6) Chlorocebus sabaeus
Analyze
Symbol: SRSF6
Name: serine and arginine rich splicing factor 6
RGD ID: 18789354
Description: ENCODES a protein that exhibits mRNA binding (inferred); pre-mRNA binding (inferred); RNA binding (inferred); INVOLVED IN negative regulation of gene expression (ortholog); negative regulation of type B pancreatic cell apoptotic process (ortholog); positive regulation of epithelial cell proliferation involved in lung morphogenesis (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH clear cell renal cell carcinoma (ortholog); colon adenocarcinoma (ortholog); Epidermal Hyperplasia (ortholog); FOUND IN cytoplasm (inferred); nuclear speck (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/arginine-rich splicing factor 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1220,340,163 - 20,345,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl220,342,681 - 20,346,122 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605069,083,496 - 69,089,235 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nuclear speck  (IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SRSF6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1220,340,163 - 20,345,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl220,342,681 - 20,346,122 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605069,083,496 - 69,089,235 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SRSF6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382043,457,896 - 43,464,243 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2043,457,893 - 43,466,046 (+)EnsemblGRCh38hg38GRCh38
GRCh372042,086,536 - 42,092,883 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362041,519,932 - 41,525,655 (+)NCBINCBI36Build 36hg18NCBI36
Build 342041,519,931 - 41,525,655NCBI
Celera2038,793,993 - 38,799,734 (+)NCBICelera
Cytogenetic Map20q13.11NCBI
HuRef2038,822,762 - 38,828,474 (+)NCBIHuRef
CHM1_12041,990,350 - 41,996,091 (+)NCBICHM1_1
T2T-CHM13v2.02045,191,165 - 45,197,503 (+)NCBIT2T-CHM13v2.0
Srsf6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392162,773,428 - 162,779,041 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2162,773,448 - 162,779,041 (+)EnsemblGRCm39 Ensembl
GRCm382162,931,508 - 162,937,121 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2162,931,528 - 162,937,121 (+)EnsemblGRCm38mm10GRCm38
MGSCv372162,757,244 - 162,762,857 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362162,622,982 - 162,628,562 (+)NCBIMGSCv36mm8
Celera2168,878,554 - 168,884,169 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map283.87NCBI
Srsf6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,009,072 - 172,014,395 (+)NCBIGRCr8
mRatBN7.23151,589,546 - 151,594,869 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3151,589,535 - 151,594,860 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3155,397,888 - 155,403,214 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03163,896,848 - 163,902,174 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03161,640,441 - 161,645,767 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03159,305,345 - 159,310,668 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,305,345 - 159,310,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03165,502,385 - 165,507,708 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43153,795,483 - 153,799,026 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13153,701,518 - 153,705,060 (+)NCBI
Celera3150,247,637 - 150,252,960 (+)NCBICelera
Cytogenetic Map3q42NCBI
Srsf6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544513,661,209 - 13,669,102 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544513,663,474 - 13,669,102 (-)NCBIChiLan1.0ChiLan1.0
SRSF6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22149,193,875 - 49,203,175 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12049,186,976 - 49,196,276 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02039,795,659 - 39,801,864 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12040,888,396 - 40,892,152 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2040,888,560 - 40,891,853 (+)Ensemblpanpan1.1panPan2
SRSF6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12431,217,190 - 31,222,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2431,217,184 - 31,218,618 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2430,860,739 - 30,866,500 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02431,924,806 - 31,930,549 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2431,924,822 - 31,930,549 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12431,188,536 - 31,194,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02431,299,944 - 31,305,686 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02431,840,352 - 31,846,095 (+)NCBIUU_Cfam_GSD_1.0
Srsf6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640180,213,648 - 180,219,277 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365303,086,680 - 3,092,828 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365303,086,944 - 3,092,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRSF6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1746,119,409 - 46,125,126 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11746,119,612 - 46,122,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21751,513,133 - 51,516,063 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Srsf6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479010,812,013 - 10,817,833 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479010,812,013 - 10,817,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 60
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008016978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000012116   ⟹   ENSCSAP00000010161
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl220,342,681 - 20,346,122 (-)Ensembl
RefSeq Acc Id: XM_008016978   ⟹   XP_008015169
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1220,340,163 - 20,345,873 (-)NCBI
Vero_WHO_p1.0NW_02366605069,083,496 - 69,089,235 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008015169 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010161
  ENSCSAP00000010161.1
Reference Protein Sequences
RefSeq Acc Id: XP_008015169   ⟸   XM_008016978
- UniProtKB: A0A0D9RNH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010161   ⟸   ENSCSAT00000012116


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014022 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012116.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/TrEMBL
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  SRSF6_RRM1 UniProtKB/TrEMBL
KEGG Report csab:103245801 UniProtKB/TrEMBL
NCBI Gene SRSF6 ENTREZGENE
PANTHER RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  SERINE/ARGININE-RICH SPLICING FACTOR 6 UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/TrEMBL
PROSITE RRM UniProtKB/TrEMBL
SMART RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF54928 UniProtKB/TrEMBL
UniProt A0A0D9RNH2 ENTREZGENE, UniProtKB/TrEMBL