Ino80c (INO80 complex subunit C) - Rat Genome Database

Name: Ino80c
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ino80c (INO80 complex subunit C) Rattus norvegicus

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Symbol:

Ino80c

Name:

INO80 complex subunit C

RGD ID:

1310199

Description:

Predicted to be involved in several processes, including regulation of embryonic development; regulation of nucleobase-containing compound metabolic process; and telomere maintenance. Predicted to be part of Ino80 complex and MLL1 complex. Orthologous to human INO80C (INO80 complex subunit C); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; INTERACTS WITH bisphenol A; caffeine; flutamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC291737; MGC109171; RGD1310199; similar to RIKEN cDNA D030070L09

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	INO80C (INO80 complex subunit C)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ino80c (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ino80c (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	INO80C (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	INO80C (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ino80c (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	INO80C (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	INO80C (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ino80c (INO80 complex subunit C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TSC22D1 (TSC22 domain family member 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	INO80C (INO80 complex subunit C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ino80c (INO80 complex subunit C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ino80c (INO80 complex subunit C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12659	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IES6	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	15,653,508 - 15,752,455 (-)	NCBI		GRCr8
mRatBN7.2	18	15,378,764 - 15,398,574 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	15,378,770 - 15,393,403 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	15,565,979 - 15,580,823 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	16,348,684 - 16,363,528 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	15,638,515 - 15,653,207 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	15,995,005 - 16,009,639 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	15,995,000 - 16,009,710 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	15,757,172 - 15,771,806 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	15,863,573 - 15,878,207 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	15,890,219 - 15,904,853 (-)	NCBI
Celera	18	15,326,724 - 15,341,400 (-)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

caffeine (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

ethanol (ISO)

flutamide (EXP)

FR900359 (ISO)

fulvestrant (ISO)

genistein (EXP)

gentamycin (EXP)

indometacin (ISO)

isobutanol (ISO)

ketamine (EXP)

leflunomide (EXP)

methidathion (ISO)

methoxyacetic acid (EXP)

methylmercury chloride (EXP)

Monobutylphthalate (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

quercitrin (ISO)

rac-lactic acid (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin remodeling (IBA,IEA,ISO)

DNA recombination (IEA)

DNA repair (IEA)

positive regulation of DNA repair (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of telomere maintenance in response to DNA damage (ISO)

regulation of cell cycle (ISO)

regulation of chromosome organization (ISO)

regulation of DNA repair (ISO)

regulation of DNA replication (ISO)

regulation of DNA strand elongation (ISO)

regulation of embryonic development (ISO)

telomere maintenance (ISO)

Cellular Component

Ino80 complex (IBA,IEA,ISO)

MLL1 complex (ISO,ISS)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

INO80 family mediated chromatin remodeling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	Comprehensive gene review and curation	RGD comprehensive gene curation
4.	The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics.	Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:15960975	PMID:21303910

Genomics

Comparative Map Data

Ino80c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	15,653,508 - 15,752,455 (-)	NCBI		GRCr8
mRatBN7.2	18	15,378,764 - 15,398,574 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	15,378,770 - 15,393,403 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	15,565,979 - 15,580,823 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	16,348,684 - 16,363,528 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	15,638,515 - 15,653,207 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	15,995,005 - 16,009,639 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	15,995,000 - 16,009,710 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	15,757,172 - 15,771,806 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	15,863,573 - 15,878,207 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	15,890,219 - 15,904,853 (-)	NCBI
Celera	18	15,326,724 - 15,341,400 (-)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

INO80C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	35,468,333 - 35,497,960 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	35,452,230 - 35,497,979 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	33,048,297 - 33,077,924 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	31,302,289 - 31,331,953 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	31,302,295 - 31,331,953	NCBI
Celera	18	29,856,143 - 29,885,819 (-)	NCBI		Celera
Cytogenetic Map	18	q12.2	NCBI
HuRef	18	29,908,353 - 29,937,720 (-)	NCBI		HuRef
CHM1_1	18	32,975,385 - 33,005,073 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	35,659,720 - 35,689,378 (-)	NCBI		T2T-CHM13v2.0

Ino80c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	24,237,818 - 24,254,876 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	24,237,814 - 24,255,010 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	24,104,761 - 24,121,819 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	24,104,757 - 24,121,953 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	24,263,262 - 24,280,320 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	24,247,771 - 24,264,829 (-)	NCBI		MGSCv36	mm8
Celera	18	24,594,754 - 24,611,292 (-)	NCBI		Celera
Cytogenetic Map	18	A2	NCBI
cM Map	18	12.74	NCBI

Ino80c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	22,189,943 - 22,210,658 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	22,189,943 - 22,210,315 (-)	NCBI	ChiLan1.0	ChiLan1.0

INO80C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	52,856,561 - 52,886,393 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	38,549,152 - 38,578,976 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	28,686,112 - 28,715,946 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	32,274,331 - 32,319,177 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	32,260,924 - 32,304,152 (-)	Ensembl	panpan1.1		panPan2

INO80C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	54,569,954 - 54,586,902 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	54,569,972 - 54,586,782 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	53,994,976 - 54,012,142 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	54,540,829 - 54,558,010 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	54,540,845 - 54,557,893 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	54,223,695 - 54,240,872 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	54,246,861 - 54,264,015 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	54,540,279 - 54,557,460 (+)	NCBI		UU_Cfam_GSD_1.0

Ino80c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	50,305,491 - 50,322,123 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936517	9,632,870 - 9,649,527 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936517	9,632,870 - 9,649,525 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

INO80C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	119,262,227 - 119,285,779 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	119,262,488 - 119,285,852 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	111,721,259 - 111,744,557 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

INO80C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	45,282,846 - 45,311,885 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	45,282,812 - 45,311,870 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	19,780,493 - 19,809,933 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ino80c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624779	9,843,065 - 9,862,137 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624779	9,843,068 - 9,861,959 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ino80c
92 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	257
Count of miRNA genes:	168
Interacting mature miRNAs:	208
Transcripts:	ENSRNOT00000022169
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301410	Bp317	Blood pressure QTL 317		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944273	26548295	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	11944299	59330563	Rat
61382	Bp46	Blood pressure QTL 46	18.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11941791	31393320	Rat
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	25758124	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
1331781	Scl28	Serum cholesterol level QTL 28	3.995		blood HDL cholesterol amount (VT:0000184)	serum high density lipoprotein cholesterol level (CMO:0000361)	18	11944299	24797117	Rat
6903359	Bp355	Blood pressure QTL 355	3.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944544	59796478	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	14951337	59951337	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
1331766	Bp236	Blood pressure QTL 236	3.022		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	11944299	31359530	Rat
631264	Scl22	Serum cholesterol level QTL 22	6.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	18	11941791	31393320	Rat
12904680	Bw189	Body weight QTL 189		0.019	body mass (VT:0001259)	body weight (CMO:0000012)	18	11944273	26548295	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	11791518	63636873	Rat
1641910	Colcr3	Colorectal carcinoma resistance QTL 3	5.02	0.000007	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	2249477	22066430	Rat
12904693	Am20	Aortic mass QTL 20		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	11944273	26548295	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
12904695	Kidm73	Kidney mass QTL 73		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	11944273	26548295	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
12904689	Cm128	Cardiac mass QTL 128		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	11944273	26548295	Rat
12904690	Cm129	Cardiac mass QTL 129		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	11944273	26548295	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
12904691	Cm130	Cardiac mass QTL 130		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	11944273	26548295	Rat
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	25758124	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	11944299	52293055	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	11944299	41122201	Rat

Markers in Region

RH133170

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	15,380,454 - 15,380,641 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	15,996,691 - 15,996,877	NCBI	Rnor6.0
Rnor_5.0	18	15,758,858 - 15,759,044	UniSTS	Rnor5.0
RGSC_v3.4	18	15,865,259 - 15,865,445	UniSTS	RGSC3.4
Celera	18	15,328,410 - 15,328,596	UniSTS
RH 3.4 Map	18	192.4	UniSTS
Cytogenetic Map	18	p12	UniSTS

RH130469

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	15,378,874 - 15,379,055 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	15,995,111 - 15,995,291	NCBI	Rnor6.0
Rnor_5.0	18	15,757,278 - 15,757,458	UniSTS	Rnor5.0
RGSC_v3.4	18	15,863,679 - 15,863,859	UniSTS	RGSC3.4
Celera	18	15,326,830 - 15,327,010	UniSTS
RH 3.4 Map	18	181.4	UniSTS
Cytogenetic Map	18	p12	UniSTS

RH138450

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	15,383,934 - 15,384,175 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	16,000,171 - 16,000,411	NCBI	Rnor6.0
Rnor_5.0	18	15,762,338 - 15,762,578	UniSTS	Rnor5.0
RGSC_v3.4	18	15,868,739 - 15,868,979	UniSTS	RGSC3.4
Celera	18	15,331,888 - 15,332,128	UniSTS
RH 3.4 Map	18	182.4	UniSTS
Cytogenetic Map	18	p12	UniSTS

MARC_13470-13471:1002300368:2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	15,385,059 - 15,386,080 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	16,001,296 - 16,002,316	NCBI	Rnor6.0
Rnor_5.0	18	15,763,463 - 15,764,483	UniSTS	Rnor5.0
RGSC_v3.4	18	15,869,864 - 15,870,884	UniSTS	RGSC3.4
Celera	18	15,333,013 - 15,334,033	UniSTS
Cytogenetic Map	18	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001017446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001428709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096736	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022169 ⟹ ENSRNOP00000022169

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	15,378,770 - 15,393,403 (-)	Ensembl
Rnor_6.0 Ensembl	18	15,995,000 - 16,009,710 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118512 ⟹ ENSRNOP00000093588

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	15,378,770 - 15,393,311 (-)	Ensembl

RefSeq Acc Id:

NM_001017446 ⟹ NP_001017446

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	15,653,510 - 15,668,144 (-)	NCBI
mRatBN7.2	18	15,378,769 - 15,393,403 (-)	NCBI
Rnor_6.0	18	15,995,005 - 16,009,639 (-)	NCBI
Rnor_5.0	18	15,757,172 - 15,771,806 (-)	NCBI
RGSC_v3.4	18	15,863,573 - 15,878,207 (-)	RGD
Celera	18	15,326,724 - 15,341,400 (-)	RGD

Sequence:

show sequence

GGAGTTTCCTGGCATCAACACGGAAGTAACATCTAGCCGGAAGTTTTAGGGCTCGCCTTGGGAG
GGGTGGGGGCGGGGAGCCGCAGGCCGACTGCGGGCAGAATGGCGGCTCAAATTCCAATCGTGGC
TGCTACCTCTACTCCCACCGTAGCTAGGAACAGCAAGAAGAGGCCGGCTAGCCCTTCTCACAAC
AGCAGCGGAGGGGGATATGGTGCTAGTAAGAAGAAAAAACTGTCGGCCTCCGGCTTTGCTCAGG
GTGTCAGCATTGAAGCCATGAGTGAGAGTAAAATGGCATCCTCTGAGTTAAGCTCAGGGCCTGT
GGAGAAAGCTGCCAAGCCTTTGCCATTTAAAGATCCCAACTTTGTGCACTCTGGCCATGGCGGT
GCAGTAGCTGGCAAGAAGAATAGAACCTGGAAGAACCTCAAACAGATCCTCGCTGCTGAAAGGG
CGTTGCCATGGCAACTGAACGATCCTAACTACTTTAGTATTGATGCTCCTCCATCCTTTAAGCC
AGCTAAGAAGTATTCTGATGTTTCTGGCCTTCTTGCCAACTACACAGACCCTCAGAGCAAGTTG
CGGTTCAGCACTGTTGAGGAATTCTCCTACATTCGCAGGCTGCCATCAGATGTGGTCACAGGTT
ACCTGACACTGAGGAAAGCCACAAGCATCGTCCCCTGAGTCTCGAAAATGGCGATGGGATGGGA
ACAGCCTCGAAAGCGGACTGCACTTGTGACTTTGTTTCATGGAAACAAACATTTCTACTGAAAG
TCTGAAAATGTCAACTCTGGGCTTTGGGAAGAACGCCTGGCTTTCCTGTGAGGAGTTTTTCGTT
TGTTTTCTTCCTCTCCAAGTGCGACCTTCCTAGTTGAATGAAATCATACTTCAGTTGTTGCCTT
ATGTAAAAATTGTTTGATAAGAACATGTAGTAAAATTATGCATTTAAATTAACCCAAGCAAGTC
CCTGAATTTTGTTTGCAAGTTGTGAACTCTCCTCTAACGTTTTCAAAGAATGTGCAGTGAAGAC
ACACAGGCCTGGGTTGTTCTGGAGCCTAACAAGCATGCTGGTCTTTCCGTGGGTCAGAAGCTTC
TGTGTGTTTTCTGCTGTGCAGTTGAATGACTTTACCCATCATGGCCTGCCTGCTGGTGACTTAT
TTGTCTCTGCTGTATGGTGAATTGTGACATTGGCTTCCAGGGGCCAAAGGAGAGATTCAGCTCT
CAAAAGGAAAAGTATTTAGCTAGGTTGAAGAAAACAGATTTTTGGAGACTTAGCCTTTAAGACC
ACTCATTGCTTTTGCAGGGGACCCAGGCTTGGTTCCCAGCACTCACATGGTGACCCACAGCTAT
CTCTAACACCAGTTCCAAGGCATCCAATACCCCCTTCTGACTTCACCAGGCGAGTACATAAATA
CACACAGGCAAACTCTCATATATACAAAAATAATATAATTTTTAAAAATTGTATTTTTTTCTTA
CGAGCACACTGATATCAAGACTGCTCTGAGGTGAGTCCTTCTGATACCTGCTGCATGTCTTCCC
CATAAGAGAGAAGCTTCGAGGTGTACCTTAAAGTGACCAGAATGTTAGAGATTCCTCACCTTGC
AGAGCTGGGGTGAGGAAGAGTTTCTTGCCACTGTGGTTACTTTTCATGCAGTGACCAAATGCCC
ATCAAAAAGGAATACATGCCCATCTCTGTGGGGACTCATGACGGCAGGAGTGGGAGGCAGCTGG
CTGAACTGTATCCACCGCTATGACACAGAACAGACAAGTAAGACTGGACGGTAACACCTCGAGG
CCTCCCTCCAGTGACCCACTCCCTCCAGAAAGGGTCTACCATTGCAACAACCTTCCAACCTGCC
ACCCACACCGGGCACCAATTGTTCCAACATATTTTACATTCAGATCACTACACCATGTCTCCCG
AGTTAAAGCACGTATCCACCCAGACTTCAAATGTGCTTTGTAACTGTTGATGGCACCTTACAAA
GGGCCAAAGTGTTTCCCATCAGATAGCACTTTTCTGAACCCACGCCTCTTGGGAAGAGATCACA
GGGCTTGACCCATCATCAGATAGGCTCAGGTGGCCTATGGAGAGGTCACAATGATGGCTTCCTA
CATGAAACAGTCAAGTCAATTTCCCATAATGCTCTCATCTGAGAGAATGCATGAACCTTATTTG
AATCCTGGTTCAAACAGAAAGCTTACAGTATGTATGAGACAGTTATGAACCTGACAGACTTTGC
TGTGTGAAGATATTTATGAACATTTTCAGTCAGAATGCTGGTATCATCCTGTTAAGGGAAGGGG
TCATATATTAGAGACAAAGGCTGAAACATTTGTGCACAGAGCGATATGATATCTGGGATTTGTT
TTAGGATGATGTGGGAGGGAGGAAATGGATGGAAGTGGTGTTGAGACAATATTGGCCATGAGTC
AGCTATTGTGTGCTAAGAAGTTCCTCACACCAGTCTACTCTGTATGTGTTTGAATTTCTCCACA
ATAAACTTAACAAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039096736 ⟹ XP_038952664

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	15,653,508 - 15,752,455 (-)	NCBI
mRatBN7.2	18	15,378,764 - 15,398,574 (-)	NCBI

RefSeq Acc Id:

XM_063277257 ⟹ XP_063133327

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	15,653,508 - 15,752,455 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001017446	(Get FASTA)	NCBI Sequence Viewer
	NP_001415638	(Get FASTA)	NCBI Sequence Viewer
	XP_038952664	(Get FASTA)	NCBI Sequence Viewer
	XP_063133327	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91281	(Get FASTA)	NCBI Sequence Viewer
	EDL76130	(Get FASTA)	NCBI Sequence Viewer
	EDL76131	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022169.5
	ENSRNOP00000093588.1
	ENSRNOP00065019608
GenBank Protein	Q5BJY3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001017446 ⟸ NM_001017446
- UniProtKB:	Q5BJY3 (UniProtKB/Swiss-Prot), A6J2J9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAQIPIVAATSTPTVARNSKKRPASPSHNSSGGGYGASKKKKLSASGFAQGVSIEAMSESKMA SSELSSGPVEKAAKPLPFKDPNFVHSGHGGAVAGKKNRTWKNLKQILAAERALPWQLNDPNYFS IDAPPSFKPAKKYSDVSGLLANYTDPQSKLRFSTVEEFSYIRRLPSDVVTGYLTLRKATSIVP hide sequence

Ensembl Acc Id:

ENSRNOP00000022169 ⟸ ENSRNOT00000022169

RefSeq Acc Id:	XP_038952664 ⟸ XM_039096736
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000093588 ⟸ ENSRNOT00000118512

RefSeq Acc Id:	XP_063133327 ⟸ XM_063277257
- Peptide Label:	isoform X2

Protein Domains

Vps72/YL1 C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5BJY3-F1-model_v2	AlphaFold	Q5BJY3	1-191	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310199	AgrOrtholog
BioCyc Gene	G2FUF-8163	BioCyc
Ensembl Genes	ENSRNOG00000016532	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00065015129	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000022169.7	UniProtKB/Swiss-Prot
	ENSRNOT00000118512.1	UniProtKB/TrEMBL
	ENSRNOT00065025051	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7097077	IMAGE-MGC_LOAD
	IMAGE:7192011	IMAGE-MGC_LOAD
InterPro	INO80C/Ies6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Vps72/YL1_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:291737	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:109171	IMAGE-MGC_LOAD
	MGC:94762	IMAGE-MGC_LOAD
NCBI Gene	291737	ENTREZGENE
PANTHER	INO80 COMPLEX SUBUNIT C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR31200	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	YL1_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ino80c	PhenoGen
RatGTEx	ENSRNOG00000016532	RatGTEx
	ENSRNOG00065015129	RatGTEx
SMART	YL1_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AX91_RAT	UniProtKB/TrEMBL
	A6J2J9	ENTREZGENE, UniProtKB/TrEMBL
	IN80C_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-09	Ino80c	INO80 complex subunit C	RGD1310199	similar to RIKEN cDNA D030070L09	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1310199	similar to RIKEN cDNA D030070L09	RGD1310199_predicted	similar to RIKEN cDNA D030070L09 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1310199_predicted	similar to RIKEN cDNA D030070L09 (predicted)	LOC291737_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC291737_predicted	similar to RIKEN cDNA D030070L09 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations