Smarcb1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1) - Rat Genome Database

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Gene: Smarcb1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1) Rattus norvegicus
Analyze
Symbol: Smarcb1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
RGD ID: 1308761
Description: Predicted to enable several functions, including Tat protein binding activity; p53 binding activity; and transcription coactivator activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in several processes, including nucleosome disassembly; positive regulation by host of viral transcription; and positive regulation of macromolecule biosynthetic process. Predicted to act upstream of or within several processes, including blastocyst hatching; hepatocyte differentiation; and single stranded viral RNA replication via double stranded DNA intermediate. Part of chromatin. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; central nervous system cancer (multiple); rhabdoid cancer; and schwannomatosis (multiple). Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1); PARTICIPATES IN SWI/SNF family mediated chromatin remodeling pathway; INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC103694876; LOC361825; MGC116367; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,740,105 - 12,763,054 (+)NCBIGRCr8
mRatBN7.22012,741,164 - 12,763,616 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,741,477 - 12,763,620 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,448,137 - 13,470,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,809,058 - 12,831,162 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,280,851 - 13,302,955 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,679,955 - 13,702,821 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,680,716 - 13,704,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,836,242 - 15,858,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,140,331 - 13,162,437 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,140,557 - 13,162,664 (+)NCBI
Celera2014,232,795 - 14,254,901 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A mosaic pattern of INI1/SMARCB1 protein expression distinguishes Schwannomatosis and NF2-associated peripheral schwannomas from solitary peripheral schwannomas and NF2-associated vestibular schwannomas. Caltabiano R, etal., Childs Nerv Syst. 2017 Jun;33(6):933-940. doi: 10.1007/s00381-017-3340-2. Epub 2017 Apr 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Hargreaves DC and Crabtree GR, Cell Res. 2011 Mar;21(3):396-420. doi: 10.1038/cr.2011.32. Epub 2011 Mar 1.
5. Loss of INI1 expression is characteristic of both conventional and proximal-type epithelioid sarcoma. Hornick JL, etal., Am J Surg Pathol. 2009 Apr;33(4):542-50. doi: 10.1097/PAS.0b013e3181882c54.
6. The diagnostic utility of reduced immunohistochemical expression of SMARCB1 in synovial sarcomas: a validation study. Ito J, etal., Hum Pathol. 2016 Jan;47(1):32-7. doi: 10.1016/j.humpath.2015.09.010. Epub 2015 Sep 25.
7. Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Kadoch C and Crabtree GR, Cell. 2013 Mar 28;153(1):71-85. doi: 10.1016/j.cell.2013.02.036.
8. SMARCB1 (INI1)-deficient sinonasal carcinoma: a series of 13 cases with assessment of histologic patterns. Kakkar A, etal., Hum Pathol. 2019 Jan;83:59-67. doi: 10.1016/j.humpath.2018.08.008. Epub 2018 Aug 16.
9. High Frequency of Ovarian Cyst Development in Vhl2B/+;Snf5+/- Mice. Kuwahara Y, etal., Am J Pathol. 2018 Jul;188(7):1510-1516. doi: 10.1016/j.ajpath.2018.03.010. Epub 2018 Apr 22.
10. Targeted next-generation sequencing for differential diagnosis of neurofibromatosis type 2, schwannomatosis, and meningiomatosis. Louvrier C, etal., Neuro Oncol. 2018 Jun 18;20(7):917-929. doi: 10.1093/neuonc/noy009.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Evaluation of the role of downregulation of SNF5/INI1 core subunit of SWI/SNF complex in clear cell renal cell carcinoma development. Sarnowska E, etal., Am J Cancer Res. 2017 Nov 1;7(11):2275-2289. eCollection 2017.
18. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. Shain AH and Pollack JR, PLoS One. 2013;8(1):e55119. doi: 10.1371/journal.pone.0055119. Epub 2013 Jan 23.
19. Absence of expression of SMARCB1/INI1 in malignant rhabdoid tumors of the central nervous system, kidneys and soft tissue: an immunohistochemical study with implications for diagnosis. Sigauke E, etal., Mod Pathol. 2006 May;19(5):717-25. doi: 10.1038/modpathol.3800581.
20. SNF5 is Involved in Suppression of Hepatocellular Carcinoma Progression via TGF-Beta 1 Signaling. Sun H, etal., Anat Rec (Hoboken). 2016 Jul;299(7):869-77. doi: 10.1002/ar.23357. Epub 2016 May 10.
21. Germline SMARCB1 mutation predisposes to multiple meningiomas and schwannomas with preferential location of cranial meningiomas at the falx cerebri. van den Munckhof P, etal., Neurogenetics. 2012 Feb;13(1):1-7. doi: 10.1007/s10048-011-0300-y. Epub 2011 Oct 26.
22. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Versteege I, etal., Nature. 1998 Jul 9;394(6689):203-6.
23. Loss of INI1 expression in colorectal carcinoma is associated with high tumor grade, poor survival, BRAFV600E mutation, and mismatch repair deficiency. Wang J, etal., Hum Pathol. 2016 Sep;55:83-90. doi: 10.1016/j.humpath.2016.04.018. Epub 2016 May 14.
24. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. Wang W, etal., EMBO J. 1996 Oct 1;15(19):5370-82.
25. The role of Snf5 in the osteogenic differentiation potential during replicative senescence of rat mesenchymal stromal cells. Wu S, etal., Mech Ageing Dev. 2018 Apr;171:1-6. doi: 10.1016/j.mad.2018.01.003. Epub 2018 Feb 2.
Additional References at PubMed
PMID:8804307   PMID:11078522   PMID:11095756   PMID:11263494   PMID:11313485   PMID:11430827   PMID:11726552   PMID:11950834   PMID:12368262   PMID:12477932   PMID:14963118   PMID:16138077  
PMID:16217013   PMID:16287714   PMID:16687403   PMID:16787967   PMID:17640523   PMID:22368283   PMID:24335282   PMID:26073604  


Genomics

Comparative Map Data
Smarcb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,740,105 - 12,763,054 (+)NCBIGRCr8
mRatBN7.22012,741,164 - 12,763,616 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,741,477 - 12,763,620 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,448,137 - 13,470,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,809,058 - 12,831,162 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,280,851 - 13,302,955 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,679,955 - 13,702,821 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,680,716 - 13,704,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,836,242 - 15,858,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,140,331 - 13,162,437 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,140,557 - 13,162,664 (+)NCBI
Celera2014,232,795 - 14,254,901 (+)NCBICelera
Cytogenetic Map20p12NCBI
SMARCB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,786,966 - 23,838,009 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,786,931 - 23,838,009 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,129,153 - 24,180,196 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,459,150 - 22,506,705 (+)NCBINCBI36Build 36hg18NCBI36
Build 342222,453,703 - 22,501,258NCBI
Celera227,968,247 - 8,015,764 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,117,207 - 7,164,626 (+)NCBIHuRef
CHM1_12224,141,393 - 24,188,920 (+)NCBICHM1_1
T2T-CHM13v2.02224,234,168 - 24,285,193 (+)NCBIT2T-CHM13v2.0
Smarcb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,732,603 - 75,757,448 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,732,603 - 75,757,451 (-)EnsemblGRCm39 Ensembl
GRCm381075,896,769 - 75,921,614 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,896,769 - 75,921,617 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,359,514 - 75,384,359 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,340,491 - 75,365,304 (-)NCBIMGSCv36mm8
Celera1076,941,458 - 76,966,299 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.61NCBI
Smarcb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,415,839 - 8,457,097 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,420,263 - 8,457,105 (-)NCBIChiLan1.0ChiLan1.0
SMARCB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22333,515,250 - 33,565,294 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,255,101 - 36,301,814 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0224,542,764 - 4,589,461 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,627,950 - 22,673,921 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,627,982 - 22,673,921 (+)Ensemblpanpan1.1panPan2
SMARCB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,692,610 - 28,728,778 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,692,899 - 28,728,783 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,765,925 - 27,802,103 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,097,586 - 30,133,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,097,586 - 30,134,047 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,178,905 - 28,215,089 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,796,839 - 27,833,022 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,784,702 - 28,820,890 (-)NCBIUU_Cfam_GSD_1.0
Smarcb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,445,150 - 141,477,819 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,275,362 - 1,308,913 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366191,276,239 - 1,308,945 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMARCB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,874,984 - 49,906,048 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,874,981 - 49,906,043 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,317,251 - 53,348,336 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SMARCB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,902,985 - 6,945,111 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl196,902,951 - 6,944,784 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666100428,050 - 470,045 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smarcb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,361,260 - 10,396,719 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,362,149 - 10,396,580 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smarcb1
93 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:57
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000029458
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
mesenchyme
mesoderm
nervous system
reproductive system
1 1 20 2 1 20 2

Sequence


Ensembl Acc Id: ENSRNOT00000029458   ⟹   ENSRNOP00000034916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,741,477 - 12,763,615 (+)Ensembl
Rnor_6.0 Ensembl2013,680,716 - 13,704,931 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111650   ⟹   ENSRNOP00000097025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,743,322 - 12,763,620 (+)Ensembl
RefSeq Acc Id: NM_001025728   ⟹   NP_001020899
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,740,948 - 12,763,054 (+)NCBI
mRatBN7.22012,741,510 - 12,763,616 (+)NCBI
Rnor_6.02013,680,715 - 13,702,821 (+)NCBI
Rnor_5.02015,836,242 - 15,858,384 (+)NCBI
RGSC_v3.42013,140,331 - 13,162,437 (+)RGD
Celera2014,232,795 - 14,254,901 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256318   ⟹   XP_006256380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,740,105 - 12,763,054 (+)NCBI
mRatBN7.22012,741,164 - 12,763,616 (+)NCBI
Rnor_6.02013,679,955 - 13,702,821 (+)NCBI
Rnor_5.02015,836,242 - 15,858,384 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279245   ⟹   XP_063135315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,740,105 - 12,763,054 (+)NCBI
RefSeq Acc Id: NP_001020899   ⟸   NM_001025728
- UniProtKB: Q4KLI0 (UniProtKB/TrEMBL),   G3V935 (UniProtKB/TrEMBL),   A0A8J8YH81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256380   ⟸   XM_006256318
- Peptide Label: isoform X1
- UniProtKB: A6JKF4 (UniProtKB/TrEMBL),   A0A8J8YH81 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034916   ⟸   ENSRNOT00000029458
Ensembl Acc Id: ENSRNOP00000097025   ⟸   ENSRNOT00000111650
RefSeq Acc Id: XP_063135315   ⟸   XM_063279245
- Peptide Label: isoform X2
- UniProtKB: A0A8J8YH81 (UniProtKB/TrEMBL)
Protein Domains
SWI/SNF Subunit INI1 DNA binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLI0-F1-model_v2 AlphaFold Q4KLI0 1-376 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701529
Promoter ID:EPDNEW_R12053
Type:initiation region
Name:Smarcb1_1
Description:SWI/SNF related, matrix associated, actin dependent regulatorof chromatin, subfamily b, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,680,728 - 13,680,788EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308761 AgrOrtholog
BioCyc Gene G2FUF-4165 BioCyc
Ensembl Genes ENSRNOG00000028302 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029458.7 UniProtKB/TrEMBL
  ENSRNOT00000111650.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7383650 IMAGE-MGC_LOAD
InterPro INI1_DNA-bd UniProtKB/TrEMBL
  SNF5 UniProtKB/TrEMBL
  SWI_SNF_chromatin_remodel_cplx UniProtKB/TrEMBL
KEGG Report rno:361825 UniProtKB/TrEMBL
MGC_CLONE MGC:116367 IMAGE-MGC_LOAD
NCBI Gene 361825 ENTREZGENE
PANTHER SNF5 UniProtKB/TrEMBL
  SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY B MEMBER 1 UniProtKB/TrEMBL
Pfam INI1_DNA-bd UniProtKB/TrEMBL
  SNF5 UniProtKB/TrEMBL
PhenoGen Smarcb1 PhenoGen
PIRSF SWI_SNF UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028302 RatGTEx
UniProt A0A8I6AVW5_RAT UniProtKB/TrEMBL
  A0A8J8YH81 ENTREZGENE, UniProtKB/TrEMBL
  A6JKF4 ENTREZGENE, UniProtKB/TrEMBL
  A6JKF6_RAT UniProtKB/TrEMBL
  G3V935 ENTREZGENE
  Q4KLI0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary G3V935 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Smarcb1  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1  LOC103694876  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1  Data merged from RGD:9203817 737654 PROVISIONAL
2014-08-25 LOC103694876  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Smarcb1  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1  Smarcb1_predicted  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Smarcb1_predicted  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED