| 737393 | Pdc | phosducin | Predicted to be involved in regulation of G protein-coupled receptor signaling pathway and visual perception. Located in photoreceptor outer segment. Is expressed in several structures, including central nervous system; foot; skeleton; and spinal nerve plexus. Orthologous to human PDC weight:700;'>PDC (phosducin). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 150195168 | 150209657 | Mouse | 44 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1323232 | Pdcd1 | programmed cell death 1 | Predicted to enable signaling receptor activity. Involved in negative regulation of immune response. Acts upstream of or within negative regulation of B cell apoptotic process; negative regulation of tolerance induction; and positive regulation of T cell apoptotic process. Located in external side o f plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 93966027 | 93980278 | Mouse | 270 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735274 | Dlat | dihydrolipoamide S-acetyltransferase | Enables acetyltransferase activity. Involved in pyruvate catabolic process and pyruvate decarboxylation to acetyl-CoA. Located in mitochondrion and myelin sheath. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 50545933 | 50571080 | Mouse | 228 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735515 | Pdcl | phosducin-like | Involved in positive regulation of smoothened signaling pathway. Acts upstream of or within heterotrimeric G-protein complex assembly and visual perception. Predicted to be located in cilium. Predicted to be active in cytoplasm. Orthologous to human PDCL (phosdu cin like). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 37240086 | 37249832 | Mouse | 84 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 62180 | Pdcd2 | programmed cell death 2 | Predicted to enable enzyme binding activity. Predicted to be involved in positive regulation of apoptotic process; positive regulation of hematopoietic stem cell proliferation; and regulation of hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm. Predicted to be acti ve in nucleus. Is expressed in cranial ganglion; cranial nerve; and dorsal root ganglion. Orthologous to human PDCD2 (programmed cell death 2). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 15739472 | 15747560 | Mouse | 114 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 732160 | Pdcd4 | programmed cell death 4 | Predicted to enable RNA binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of cytokine production involved in inflammatory response; and positive regulation of inflammatory response. Predicted to be located in cytoplasm. Predicted to be active in cytosol and n ucleus. Is expressed in several structures, including brain; early conceptus; epithelium; oocyte; and thymus primordium. Orthologous to human PDCD4 (programmed cell death 4). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 53880662 | 53926024 | Mouse | 315 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1321537 | Pdcd5 | programmed cell death 5 | Predicted to enable acetyltransferase activator activity; beta-tubulin binding activity; and heparin binding activity. Predicted to be involved in several processes, including cellular response to transforming growth factor beta stimulus; negative regulation of chaperone-mediated protein folding; an d regulation of mitochondrion organization. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PDCD5 (programmed cell death 5). [provided by Alliance of Genome Resources, Apr 2025] | 7 | 35341410 | 35346907 | Mouse | 108 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1322593 | Pdcd6 | programmed cell death 6 | Enables calcium-dependent protein binding activity; metal ion binding activity; and protein homodimerization activity. Involved in response to calcium ion. Acts upstream of or within apoptotic process. Located in cytoplasm. Orthologous to human PDCD6 (programmed cell death 6). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 74451240 | 74465445 | Mouse | 204 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1319040 | Pdcd7 | programmed cell death 7 | Involved in response to glucocorticoid. Acts upstream of or within RNA splicing; positive regulation of T cell apoptotic process; and positive regulation of apoptotic signaling pathway. Part of U2AF complex and spliceosomal complex. Is expressed in several structures, including brain ventricular lay er; chondrocranium; jaw; submandibular gland primordium; and vibrissa. Orthologous to human PDCD7 (programmed cell death 7). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 65253350 | 65266925 | Mouse | 88 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1558552 | Pdcl2 | phosducin-like 2 | Involved in acrosome assembly. Acts upstream of or within sperm axoneme assembly. Located in endoplasmic reticulum. Orthologous to human PDCL2 (phosducin like 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 76459963 | 76479003 | Mouse | 40 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1320125 | Pdcl3 | phosducin-like 3 | Enables vascular endothelial growth factor receptor 2 binding activity. Involved in angiogenesis and positive regulation of gene expression. Located in cytoplasm. Part of protein-containing complex. Orthologous to human PDCL3 (phosducin like 3). [provided by All iance of Genome Resources, Jul 2025] | 1 | 39026895 | 39036317 | Mouse | 126 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550654 | Pdcd10 | programmed cell death 10 | Predicted to enable protein homodimerization activity and protein kinase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in Golgi membrane; cell periphery; and cytosol. Predicted to be part of FAR/SIN/STRIPAK complex. Is expressed in several structures, including cardiovascular system; central nervous system; gonad; gut; and retina layer. Used to study cerebral cavernous malformation 3. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 75423797 | 75464159 | Mouse | 237 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1312660 | Pdcd11 | programmed cell death 11 | Predicted to enable NF-kappaB binding activity and RNA binding activity. Predicted to be involved in rRNA processing. Located in cytosol. Is expressed in several structures, including blastocyst; brain; early embryo; olfactory epithelium; and thymus primordium. Orthologous to human PDC -weight:700;'>PDCD11 (programmed cell death 11). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 47079183 | 47119585 | Mouse | 99 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1332227 | Pdcd2l | programmed cell death 2-like | Predicted to be involved in apoptotic process. Predicted to be located in cytoplasm. Orthologous to human PDCD2L (programmed cell death 2 like). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 33883922 | 33896154 | Mouse | 62 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 68506 | Pdcd6ip | programmed cell death 6 interacting protein | Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including actomyosin contractile ring assembly; bicellular tight junction assembly; and maintenance of epithelial cell apical/basal polarity. Located in actomyosin; cytosol; and extracellular exosome. Is expressed in several structures, including branchial arch; facial prominence; gut; limb bud; and neural fold. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 29. Orthologous to human PDCD6IP (programmed cell death 6 interacting protein). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 113480812 | 113537457 | Mouse | 218 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552436 | Pdcd1lg2 | programmed cell death 1 ligand 2 | Acts upstream of or within negative regulation of T cell proliferation and positive regulation of T cell proliferation. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system epithelium; forebrain; nose; retina; and skin. Orthologous to human PDCD1LG2 (programmed cell death 1 ligand 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 29388319 | 29450327 | Mouse | 110 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 2299652 | Pdcd5-ps | programmed cell death 5, pseudogene | Predicted to enable acetyltransferase activator activity; beta-tubulin binding activity; and heparin binding activity. Predicted to be involved in several processes, including cellular response to transforming growth factor beta stimulus; negative regulation of chaperone-mediated protein folding; an d regulation of mitochondrion organization. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2025] | 1 | 189009519 | 189010044 | Mouse | 1 | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 731381 | Aifm1 | apoptosis-inducing factor, mitochondrion-associated 1 | Enables several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and poly-ADP-D-ribose binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of necroptotic pro cess; and protein import into mitochondrial intermembrane space. Acts upstream of or within neuron apoptotic process and regulation of apoptotic DNA fragmentation. Located in cytosol and mitochondrion. Is active in nucleus. Is expressed in several structures, including cerebral cortex; early embryo; long bone epiphyseal plate; retina; and submandibular gland primordium epithelium. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1). [provided by Alliance of Genome Resources, Jul 2025] | X | 47563821 | 47602440 | Mouse | 601 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1320180 | Mrps30 | mitochondrial ribosomal protein S30 | Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; genitourinary system; liver; and peripheral nervous system ganglion. Orthologous to human MRPS3 0 (mitochondrial ribosomal protein S30). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 118516646 | 118523788 | Mouse | 82 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732449 | Nphs2 | nephrosis 2, podocin | Acts upstream of or within gene expression. Located in cytoplasmic side of plasma membrane. Is active in cell periphery. Colocalizes with slit diaphragm. Is expressed in liver; metanephros; and ureter. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 2. Orthologous to human NPHS2 (NPHS2 stomatin family member, podocin). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 156138105 | 156155605 | Mouse | 222 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 11042 | P2rx1 | purinergic receptor P2X, ligand-gated ion channel, 1 | Enables monoatomic cation channel activity and purinergic nucleotide receptor activity. Acts upstream of or within several processes, including platelet activation; regulation of monoatomic ion transport; and serotonin secretion by platelet. Located in external side of plasma membrane and postsynapt ic membrane. Is expressed in several structures, including bladder; foregut-midgut junction; heart; liver lobe; and midgut. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 72889882 | 72906026 | Mouse | 182 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1553554 | Cd274 | CD274 antigen | The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domai ns. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015] | 19 | 29339428 | 29365495 | Mouse | 404 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1322853 | A530064D06Rik | RIKEN cDNA A530064D06 gene | INTERACTS WITH 17beta-estradiol (ortholog); benzo[a]pyrene (ortholog); Cuprizon (ortholog) | 17 | 48459064 | 48474425 | Mouse | 17 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1617462 | Pgcka1 | PDCD10 and GCKIII kinases associated 1 | Is expressed in brain; gut; respiratory system; submandibular gland primordium; and urinary system. Orthologous to human PGCKA1 (PDCD10 and GCKIII kinases associated 1). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 63969833 | 64056968 | Mouse | 64 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |