Pdcd10 (programmed cell death 10)

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Gene: Pdcd10 (programmed cell death 10) Mus musculus

Analyze

Symbol:

Pdcd10

Name:

programmed cell death 10

RGD ID:

1550654

MGI Page

MGI

Description:

Predicted to enable protein homodimerization activity and protein kinase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytosol. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to colocalize with Golgi apparatus. Is expressed in several structures, including cardiovascular system; central nervous system; gut; retina layer; and umbilical artery. Used to study cerebral cavernous malformation 3. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

2410003B13Rik; Ccm3; MGC102058; programmed cell death protein 10; TF-1 cell apoptosis related protein-15; TF-1 cell apoptosis-related protein 15; Tfa1; Tfa15; Tfar15

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDCD10 (programmed cell death 10)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Pdcd10 (programmed cell death 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pdcd10 (programmed cell death 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDCD10 (programmed cell death 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDCD10 (programmed cell death 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pdcd10 (programmed cell death 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDCD10 (programmed cell death 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDCD10 (programmed cell death 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pdcd10 (programmed cell death 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PDCD10 (programmed cell death 10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Pdcd10 (programmed cell death 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pdcd10b (programmed cell death 10b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|ZFIN)
Danio rerio (zebrafish):	pdcd10a (programmed cell death 10a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	ccm-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Ccm3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pdcd10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Related Pseudogenes:

Gm14253

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	75,423,797 - 75,464,159 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	75,423,797 - 75,464,163 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	75,516,490 - 75,556,852 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	75,516,490 - 75,556,856 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	75,320,412 - 75,360,721 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	75,602,416 - 75,642,726 (-)	NCBI		MGSCv36	mm8
Celera	3	75,581,629 - 75,621,940 (-)	NCBI		Celera
Cytogenetic Map	3	E3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arteriovenous malformations of the brain (ISO)

cerebral cavernous malformation (ISO)

cerebral cavernous malformation 1 (ISO)

cerebral cavernous malformation 3 (IAGP,ISO)

familial encephalopathy with neuroserpin inclusion bodies (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

4,4'-diaminodiphenylmethane (EXP)

acetylsalicylic acid (ISO)

aflatoxin B1 (ISO)

amiodarone (ISO)

amphetamine (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (EXP,ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

cis-caffeic acid (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

epoxiconazole (EXP)

ethanol (EXP)

fenthion (EXP)

flutamide (ISO)

folic acid (EXP)

indometacin (ISO)

inulin (EXP)

ivermectin (ISO)

maneb (EXP)

methidathion (EXP)

ochratoxin A (ISO)

oxidopamine (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanoic acid (ISO)

phenobarbital (EXP)

potassium chromate (ISO)

pyrogallol (EXP)

resveratrol (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

T-2 toxin (ISO)

thalidomide (EXP)

thapsigargin (ISO)

thioacetamide (ISO)

trans-caffeic acid (ISO)

tungsten (EXP)

tunicamycin (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (IEA)

apoptotic process (IEA)

cellular response to leukemia inhibitory factor (IEP)

endothelium development (NAS)

establishment of Golgi localization (ISO)

Golgi reassembly (ISO)

intrinsic apoptotic signaling pathway in response to hydrogen peroxide (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis (ISO)

negative regulation of cell migration involved in sprouting angiogenesis (ISO)

negative regulation of gene expression (ISO)

positive regulation of cell migration (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of gene expression (ISO)

positive regulation of intracellular protein transport (ISO)

positive regulation of MAP kinase activity (IBA,ISO)

positive regulation of Notch signaling pathway (ISO)

positive regulation of peptidyl-serine phosphorylation (ISO)

positive regulation of protein serine/threonine kinase activity (ISO)

positive regulation of stress-activated MAPK cascade (ISO)

protein stabilization (ISO)

regulation of angiogenesis (NAS)

regulation of Golgi organization (IBA)

regulation of Rho protein signal transduction (ISO)

stress fiber assembly (ISO)

stress-activated protein kinase signaling cascade (ISO)

wound healing, spreading of cells (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

FAR/SIN/STRIPAK complex (IBA)

Golgi apparatus (ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

protein binding (IPI)

protein homodimerization activity (ISO)

protein kinase binding (IBA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal angiogenesis (IAGP)

abnormal astrocyte morphology (IAGP)

abnormal brain morphology (IAGP)

abnormal brain vasculature morphology (IAGP)

abnormal cardiac jelly morphology (IAGP)

abnormal cardinal vein morphology (IAGP)

abnormal developmental vascular remodeling (IAGP)

abnormal dorsal aorta morphology (IAGP)

abnormal endocardium morphology (IAGP)

abnormal gait (IAGP)

abnormal intersomitic vessel morphology (IAGP)

abnormal myocardium layer morphology (IAGP)

abnormal neutrophil morphology (IAGP)

abnormal neutrophil physiology (IAGP)

abnormal pericyte morphology (IAGP)

abnormal retina vasculature morphology (IAGP)

abnormal vascular branching morphogenesis (IAGP)

abnormal vascular endothelial cell migration (IAGP)

abnormal vasculogenesis (IAGP)

abnormal vitelline vascular remodeling (IAGP)

abnormal vitelline vasculature morphology (IAGP)

anemia (IAGP)

astrocytosis (IAGP)

circling (IAGP)

CNS inflammation (IAGP)

decreased body weight (IAGP)

decreased embryo size (IAGP)

dilated brain ventricle (IAGP)

dilated dorsal aorta (IAGP)

dilated vasculature (IAGP)

embryonic growth arrest (IAGP)

embryonic lethality between somite formation and embryo turning, complete penetrance (IAGP)

embryonic lethality between somite formation and embryo turning, incomplete penetrance (IAGP)

embryonic lethality during organogenesis, complete penetrance (IAGP)

enlarged pericardium (IAGP)

hydrocephaly (IAGP)

impaired hematopoiesis (IAGP)

increased brain size (IAGP)

increased circulating creatinine level (IAGP)

increased hemangioma incidence (IAGP)

lethality throughout fetal growth and development, complete penetrance (IAGP)

microcephaly (IAGP)

myocardial trabeculae hypoplasia (IAGP)

no abnormal phenotype detected (IAGP)

pallor (IAGP)

postnatal growth retardation (IAGP)

postnatal lethality (IAGP)

postnatal lethality, complete penetrance (IAGP)

postnatal lethality, incomplete penetrance (IAGP)

premature death (IAGP)

prenatal lethality, incomplete penetrance (IAGP)

renal tubular necrosis (IAGP)

thin myocardium (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:10725249	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11544199	PMID:12477932	PMID:14610273	PMID:15489334	PMID:16141072	PMID:16141073
PMID:16455310	PMID:17657516	PMID:18799693	PMID:20371769	PMID:20439489	PMID:21321212	PMID:21490399	PMID:21677750	PMID:21859843	PMID:21873635	PMID:22898778	PMID:23748444
PMID:24176643	PMID:24595293	PMID:25122144	PMID:25625206	PMID:25737280	PMID:26109568	PMID:26386873	PMID:26417067	PMID:26612856	PMID:27113764	PMID:27548575	PMID:28500274
PMID:29295866	PMID:30442679	PMID:30728328	PMID:31040226	PMID:31235698	PMID:31426861	PMID:31776290	PMID:32325033	PMID:32640906	PMID:32648916	PMID:32968282	PMID:33495460
PMID:34156031	PMID:34226698	PMID:35741725

Genomics

Comparative Map Data

Pdcd10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	75,423,797 - 75,464,159 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	75,423,797 - 75,464,163 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	75,516,490 - 75,556,852 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	75,516,490 - 75,556,856 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	75,320,412 - 75,360,721 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	75,602,416 - 75,642,726 (-)	NCBI		MGSCv36	mm8
Celera	3	75,581,629 - 75,621,940 (-)	NCBI		Celera
Cytogenetic Map	3	E3	NCBI

PDCD10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	167,683,298 - 167,734,892 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	3	167,683,298 - 167,734,939 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	167,401,086 - 167,452,680 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	168,884,388 - 168,935,345 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	168,884,398 - 168,935,332	NCBI
Celera	3	165,800,144 - 165,851,087 (-)	NCBI		Celera
Cytogenetic Map	3	q26.1	NCBI
HuRef	3	164,771,770 - 164,822,713 (-)	NCBI		HuRef
CHM1_1	3	167,364,579 - 167,415,523 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	170,467,195 - 170,518,819 (-)	NCBI		T2T-CHM13v2.0

Pdcd10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	160,303,465 - 160,346,086 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	160,303,449 - 160,346,018 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	167,476,398 - 167,518,511 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	165,480,684 - 165,522,792 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	160,113,470 - 160,155,584 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	173,966,701 - 174,012,730 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	173,967,080 - 174,012,676 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	193,304,862 - 193,348,032 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	166,402,652 - 166,445,015 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	166,352,757 - 166,395,121 (-)	NCBI
Celera	2	154,499,050 - 154,540,946 (-)	NCBI		Celera
Cytogenetic Map	2	q32	NCBI

Pdcd10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955448	16,864,031 - 16,887,626 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955448	16,866,577 - 16,887,215 (-)	NCBI	ChiLan1.0	ChiLan1.0

PDCD10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	3	165,588,664 - 165,639,889 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	164,703,909 - 164,755,085 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	172,760,923 - 172,811,900 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	172,760,923 - 172,811,430 (-)	Ensembl	panpan1.1		panPan2

PDCD10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	34	32,512,109 - 32,553,524 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	34	32,512,112 - 32,553,445 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	34	41,592,572 - 41,634,550 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	34	32,590,535 - 32,632,534 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	34	32,584,275 - 32,632,464 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	34	32,535,691 - 32,577,676 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	34	32,496,175 - 32,538,163 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	34	32,767,820 - 32,809,818 (-)	NCBI		UU_Cfam_GSD_1.0

Pdcd10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	98,930,028 - 98,971,364 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936593	4,651,114 - 4,692,534 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936593	4,650,624 - 4,693,387 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDCD10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	106,517,432 - 106,558,895 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	106,517,408 - 106,558,959 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	115,080,081 - 115,120,768 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDCD10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	21,697,366 - 21,748,760 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	21,706,675 - 21,749,470 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	30,541,167 - 30,592,646 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pdcd10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	45,654,022 - 45,678,745 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	45,653,470 - 45,698,461 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pdcd10
1599 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	708
Count of miRNA genes:	398
Interacting mature miRNAs:	454
Transcripts:	ENSMUST00000029424, ENSMUST00000159217, ENSMUST00000159519, ENSMUST00000160196, ENSMUST00000161137, ENSMUST00000162138
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
26884436	Zlq3_m	zygomatic length QTL 3, 10 week (mouse)					3	3265060	142405761	Mouse
4142399	Aec1_m	autoimmune exocrinopathy 1 (mouse)			Not determined			7586174	102690034	Mouse
4141116	Lgaq4_m	late growth adjusted QTL 4 (mouse)			Not determined			10249221	83184946	Mouse
4141255	W10q3_m	weight 10 weeks QTL 3 (mouse)			Not determined			10249221	83184946	Mouse
4141563	Lgq3_m	late growth QTL 3 (mouse)			Not determined			10249221	83184946	Mouse
39128206	Lwq18_m	liver weight QTL 18 (mouse)					3	10249221	83184946	Mouse
1357584	Splq6_m	spleen weight QTL 6 (mouse)			Not determined		3	10249221	83184946	Mouse
1357440	Hrtpq1_m	heart weight percentage QTL 1 (mouse)			Not determined		3	10249221	83184946	Mouse
26884427	Cvht4_m	cranial vault height 4, 10 week (mouse)					3	16054164	109707316	Mouse
13207570	Tcq12_m	total cholesterol QTL 12 (mouse)					3	16504164	130163649	Mouse
26884422	Cvht7_m	cranial vault height 7, 16 week (mouse)					3	28954149	118893649	Mouse
1302056	Orgwq4_m	organ weight QTL 4 (mouse)			Not determined		3	30067588	147304689	Mouse
1301705	Sles3_m	systemic lupus erythmatosus suppressor 3 (mouse)			Not determined		3	37174862	143353183	Mouse
13208566	Bmiq5_m	body mass index QTL 5 (mouse)					3	40954435	115793649	Mouse
26884380	Skwq1_m	skull length QTL 1, 5 week (mouse)					3	43954435	101607316	Mouse
4141079	Ath23_m	atherosclerosis 23 (mouse)			Not determined			49357581	83357581	Mouse
1300895	Hdl5_m	HDL level 5 (mouse)			Not determined		3	49495005	83495118	Mouse
1301824	Susp_m	suppressor of superoxide production (mouse)			Not determined		3	49495005	83495118	Mouse
26884378	Skwq6_m	skull length QTL 6, 10 week (mouse)					3	51907421	102307316	Mouse
26884382	Bzwq1_m	bi-zygomatic width QTL 1, 5 week (mouse)					3	52207421	137205761	Mouse
1357585	Manln3_m	mandible length 3 (mouse)			Not determined		3	52625509	86625745	Mouse
1301917	Tshp4_m	tooth shape 4 (mouse)			Not determined		3	52625509	86625745	Mouse
1300593	Skull4_m	skull morphology 4 (mouse)			Not determined		3	52625509	86625745	Mouse
13464139	Nhdlq17_m	non-HDL QTL 17 (mouse)					3	52923183	86923183	Mouse
11039519	Ltpr3_m	Leishmania tropica response 3 (mouse)					3	56704102	100464137	Mouse
12880419	V125Dq4_m	vitamin D active form serum level QTL 4 (mouse)					3	58907307	92907307	Mouse
4141294	Bmd24_m	bone mineral density 24 (mouse)			Not determined		3	61740061	95740241	Mouse
1301971	Cia5_m	collagen induced arthritis QTL 5 (mouse)			Not determined		3	66046658	100046795	Mouse
25314313	Syncl1_m	synaptonemal complex length 1 (mouse)					3	67907333	128393649	Mouse
11251721	Ewc3_m	ethanol withdrawal and consumption 3 (mouse)					3	69568554	103568554	Mouse
1301791	Char4_m	P. chabaudi malaria resistance QTL 4 (mouse)			Not determined		3	69625509	100655290	Mouse
1301422	Sle11_m	systematic lupus erythematosus susceptibility 11 (mouse)			Not determined		3	70208904	104209042	Mouse
11049572	Lmr11c_m	leishmaniasis resistance 11c (mouse)					3	72139967	106140094	Mouse
1300982	Lmr11_m	leishmaniasis resistance 11 (mouse)			Not determined		3	72139967	106140094	Mouse
1300595	Tmevd2_m	Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)			Not determined		3	75463302	109463549	Mouse

Markers in Region

RH124808

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	3	75,521,450 - 75,521,748	UniSTS	GRCm38
MGSCv37	3	75,325,372 - 75,325,670	UniSTS	GRCm37
Celera	3	75,586,589 - 75,586,887	UniSTS
Cytogenetic Map	3	E3	UniSTS

UniSTS:234579

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	156,347,203 - 156,347,368	UniSTS	GRCm38
MGSCv37	2	156,172,939 - 156,173,104	UniSTS	GRCm37
Celera	2	162,283,667 - 162,283,832	UniSTS
Cytogenetic Map	3	E3	UniSTS
Cytogenetic Map	2	H1	UniSTS
Cytogenetic Map	2	H2	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC140430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC163624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC168120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF159368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK005594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK075926	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK077308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK137198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK149182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK160234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK168857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK169689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC019650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY091056	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000029424 ⟹ ENSMUSP00000029424

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	3	75,424,768 - 75,464,118 (-)	Ensembl
GRCm38.p6 Ensembl	3	75,517,461 - 75,556,811 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000159217

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	3	75,440,692 - 75,464,144 (-)	Ensembl
GRCm38.p6 Ensembl	3	75,533,385 - 75,556,837 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000159519

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	3	75,424,583 - 75,428,337 (-)	Ensembl
GRCm38.p6 Ensembl	3	75,517,276 - 75,521,030 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000160196

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	3	75,424,835 - 75,428,877 (-)	Ensembl
GRCm38.p6 Ensembl	3	75,517,528 - 75,521,570 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000161137 ⟹ ENSMUSP00000125752

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	3	75,423,797 - 75,464,163 (-)	Ensembl
GRCm38.p6 Ensembl	3	75,516,490 - 75,556,856 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000162138 ⟹ ENSMUSP00000124421

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	3	75,436,186 - 75,464,066 (-)	Ensembl
GRCm38.p6 Ensembl	3	75,528,879 - 75,556,759 (-)	Ensembl

RefSeq Acc Id:

NM_019745 ⟹ NP_062719

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	3	75,423,797 - 75,464,159 (-)	NCBI
GRCm38	3	75,516,490 - 75,556,852 (-)	NCBI
MGSCv37	3	75,320,412 - 75,360,721 (-)	RGD
Celera	3	75,581,629 - 75,621,993 (-)	NCBI
cM Map	3		ENTREZGENE

Sequence:

show sequence

GACTCCTGCTGGGCAGGATTCCGGACAACGCCTGGTTCCTTTCGGGTCCTTCCGGCGTCGCCGG
AGTGAATTGATCCGGGAGTTGAAGAGGGCTCCAAAGGTGGGAAGTGAAGTCCGTGCCTCAGTTG
CCGATTGCTGTTCTTCTTTGTGTACCAGTCTTTATCACATACACATAAAAAAGGGAAGAAATTC
GGCAGTGAATGAAGATTCCTCTGCATTTTAGCATTGCTTTTTCTACTGTAGTTGGCTTTTGAAT
GAGGATGACAATGGAAGAGATGAAGAATGAAGCTGAGACCACTTCCATGGTTTCTATGCCTCTC
TATGCAGTCATGTATCCTGTGTTTAATGAGCTAGAACGAGTAAATTTGTCTGCAGCTCAGACTC
TGAGAGCCGCTTTCATTAAGGCTGAAAAGGAAAATCCAGGCCTCACACAAGACATCATTATGAA
AATATTAGAGAAAAAAAGTGTAGAAGTTAACTTCACCGAGTCCCTCCTTCGTATGGCAGCTGAT
GACGTAGAAGAGTACATGATTGAGCGGCCAGAGCCAGAATTCCAGGACCTAAATGAAAAGGCAC
GGGCACTTAAACAGATTCTCAGTAAGATTCCTGATGAGATCAATGACAGAGTGAGGTTTCTGCA
GACAATCAAGGATATAGCTAGTGCAATAAAAGAACTACTTGATACAGTGAATAATGTCTTCAAA
AAATATCAGTACCAGAACCGCAGGGCACTTGAACACCAAAAGAAAGAATTTGTAAAATACTCCA
AAAGTTTCAGTGACACTCTGAAGACTTATTTTAAAGATGGCAAGGCAATAAATGTGTTCATAAG
TGCCAACCGGCTAATTCATCAAACCAACTTGATACTTCAGACCTTCAAAACTGTGGCCTGAAAG
TTGTATATGTTAAGAGATGTACTTCTCAGTGGCAGTATTAAACTGCATTTATCTGTAAATTTTA
AAGTTTGACTGTATAAATTATCAGTCCCTCCGGAGGGACCTAATCCAGGATGTTGAATGGGATT
ATTGCCATCTTACACCATATTTTTGTAAAATGTAGCTTAATCATAATCTCACAATGAAGATTTT
GCATCACTTTTGCTATTATCATTCTTTTAAGAATTATAAGCCAAAAGAATTTACGCCTTAATGT
GTCATTATATAACATTCCTTACAAGAACTGTAAATATTGGTGTTTGTTTCTGACATTTTAACTT
GAAAGCGATATGCTGCAAGATAATGTATTTAACAATATTTGGTGGCAAATATTCAATAAATAGT
TTACATCTGTTAAACATTTCTTTACTTGAAAAAAGATGCATATATATATGTGTGTGTGTATATA
TGATCAGAAGACCAAGACAACTTGGTATAATGTTAAAGATCTTCTAATGGGAGCTTACTAGCAG
TTTATCAAATAATAAAGGAACAAGAATTCCTATTTTTTGTCCTTAATCACTTTGAGCAAAATGT
AGTCAGTTAAAATACTTTTGTTAGTTGTTACATATCAAGAACTGGATATTTTTTCACTATTTCC
AATCTTTATAGACCTGAGAAGAGAGATGAAGCTACGGGGTCTTCGTACTGTAGTAACACTTCAG
GTTCATGACGCTTTCTGAGTGGTAGATGCGGCTCCACGAAATTACTTCTGCTATACTAGGCCCT
AATAAGCTTTGCACATTGTCCCCAGAGTAATCACAATTTAAAAAAAAAAAATTCTAATAGTTGT
ATTGAGATTTTTATCAGTGTTAATATAATATATACTCTTTAAATATGTATAGTTTGTTTCACAC
TAGAGAAGTTATAAGAAAACTATGTATCGGTATTCATGTTGAGTGATTTGAGTTTTTAATTATA
AAATAAAGGGAAAATCAGGTTTTGTTCATGTTTTATAAAGAAATGAAATATTAAAATTTGTTGA
CAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_062719	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD44335	(Get FASTA)	NCBI Sequence Viewer
	AAH19650	(Get FASTA)	NCBI Sequence Viewer
	AAH86778	(Get FASTA)	NCBI Sequence Viewer
	BAB24143	(Get FASTA)	NCBI Sequence Viewer
	BAC36058	(Get FASTA)	NCBI Sequence Viewer
	BAC36742	(Get FASTA)	NCBI Sequence Viewer
	BAE23263	(Get FASTA)	NCBI Sequence Viewer
	BAE35705	(Get FASTA)	NCBI Sequence Viewer
	BAE40678	(Get FASTA)	NCBI Sequence Viewer
	BAE41306	(Get FASTA)	NCBI Sequence Viewer
	EDL15475	(Get FASTA)	NCBI Sequence Viewer
	Q8VE70	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_062719 ⟸ NM_019745

- UniProtKB:

Q9WV43 (UniProtKB/Swiss-Prot), Q8VE70 (UniProtKB/Swiss-Prot), A0A6P5PDF5 (UniProtKB/TrEMBL), A0A8C6HUQ9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIM
KILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFL
QTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFI
SANRLIHQTNLILQTFKTVA

hide sequence

RefSeq Acc Id:

ENSMUSP00000029424 ⟸ ENSMUST00000029424

RefSeq Acc Id:

ENSMUSP00000124421 ⟸ ENSMUST00000162138

RefSeq Acc Id:

ENSMUSP00000125752 ⟸ ENSMUST00000161137

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8VE70-F1-model_v2	AlphaFold	Q8VE70	1-212	view protein structure

Promoters

RGD ID:

6834196

Promoter ID:

MM_KWN:34609

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_2Hour, BoneMarrow_4Hour

Transcripts:

OTTMUST00000076919, OTTMUST00000076920

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	3	75,325,341 - 75,326,382 (-)	MPROMDB

RGD ID:

6834198

Promoter ID:

MM_KWN:34610

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day3, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

OTTMUST00000076917, OTTMUST00000076918, OTTMUST00000081074, OTTMUST00000081075

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	3	75,360,681 - 75,361,452 (-)	MPROMDB

RGD ID:

6880900

Promoter ID:

EPDNEW_M3901

Type:

initiation region

Name:

Pdcd10_1

Description:

Mus musculus programmed cell death 10 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	3	75,556,809 - 75,556,869	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1928396	AgrOrtholog
Ensembl Genes	ENSMUSG00000027835	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000029424.7	UniProtKB/TrEMBL
	ENSMUSP00000124421.2	UniProtKB/TrEMBL
	ENSMUSP00000125752	ENTREZGENE
	ENSMUSP00000125752.2	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000029424.12	UniProtKB/TrEMBL
	ENSMUST00000161137	ENTREZGENE
	ENSMUST00000161137.8	UniProtKB/Swiss-Prot
	ENSMUST00000162138.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.12.70	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.20.120.1950	UniProtKB/TrEMBL
	Nucleotidyltransferases domain 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	PDC10_dimerisation_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDCD10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:56426	UniProtKB/Swiss-Prot
MGD	MGI:1928396	ENTREZGENE
NCBI Gene	56426	ENTREZGENE
PANTHER	PROGRAMMED CELL DEATH PROTEIN 10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR13250	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DUF1241	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pdcd10	PhenoGen
UniProt	A0A6P5PDF5	ENTREZGENE
	A0A8C6HUQ9	ENTREZGENE
	E0CY82_MOUSE	UniProtKB/TrEMBL
	F8WI55_MOUSE	UniProtKB/TrEMBL
	PDC10_MOUSE	UniProtKB/Swiss-Prot
	Q3TVB4_MOUSE	UniProtKB/TrEMBL
	Q8VE70	ENTREZGENE
	Q9WV43	ENTREZGENE
UniProt Secondary	Q9DAR3	UniProtKB/Swiss-Prot
	Q9WV43	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype

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