| 1304890 | Ufm1 | ubiquitin-fold modifier 1 | INVOLVED IN negative regulation of apoptotic process; regulation of insulin secretion involved in cellular response to glucose stimulus; brain development (ortholog); ASSOCIATED WITH hypomyelinating leukodystrophy 14 (ortholog); long QT syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aconitine; bisphenol A | 2 | 140119722 | 140127866 | Rat | 144 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1344837 | UFM1 | ubiquitin fold modifier 1 | UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008] | 13 | 38349851 | 38363619 | Human | 147 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1550713 | Ufm1 | ubiquitin-fold modifier 1 | Involved in protein ufmylation and response to endoplasmic reticulum stress. Located in endoplasmic reticulum and nucleus. Is expressed in embryo and pancreas epithelium. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 14. Orthologous to human UFM1 ;'>UFM1 (ubiquitin fold modifier 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 53760797 | 53771228 | Mouse | 143 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8960833 | Ufm1 | ubiquitin fold modifier 1 | INVOLVED IN brain development (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of protein import into nucleus (ortholog); ASSOCIATED WITH hypomyelinating leukodystrophy 14 (ortholog); long QT syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulu m (ortholog); nucleus (ortholog) | NW_004955431 | 7860706 | 7872972 | Chinchilla | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11894641 | UFM1 | ubiquitin fold modifier 1 | INVOLVED IN brain development (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of protein import into nucleus (ortholog); ASSOCIATED WITH hypomyelinating leukodystrophy 14 (ortholog); long QT syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulu m (ortholog); nucleus (ortholog) | 13 | 19571114 | 19584259 | Bonobo | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12130196 | UFM1 | ubiquitin fold modifier 1 | INVOLVED IN brain development (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of protein import into nucleus (ortholog); ASSOCIATED WITH hypomyelinating leukodystrophy 14 (ortholog); long QT syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulu m (ortholog); nucleus (ortholog) | 25 | 2427521 | 2547449 | Dog | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12444829 | Ufm1 | ubiquitin fold modifier 1 | INVOLVED IN negative regulation of apoptotic process (ortholog); regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); response to endoplasmic reticulum stress (ortholog); ASSOCIATED WITH hypomyelinating leukodystrophy 14 (ortholog); long QT syndrome (ortholog ); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | NW_004937057 | 143001 | 153873 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14077309 | UFM1 | ubiquitin fold modifier 1 | INVOLVED IN negative regulation of apoptotic process (ortholog); regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); response to endoplasmic reticulum stress (ortholog); ASSOCIATED WITH hypomyelinating leukodystrophy 14 (ortholog); long QT syndrome (ortholog ); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14388942 | Ufm1 | | | | | | Fly | | symbol | gene, null |
| 18524470 | UFM1 | ubiquitin fold modifier 1 | INVOLVED IN negative regulation of apoptotic process (ortholog); regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); response to endoplasmic reticulum stress (ortholog); ASSOCIATED WITH hypomyelinating leukodystrophy 14 (ortholog); long QT syndrome (ortholog ); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18906010 | Ufm1 | ubiquitin fold modifier 1 | INVOLVED IN brain development (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of protein import into nucleus (ortholog); ASSOCIATED WITH hypomyelinating leukodystrophy 14 (ortholog); long QT syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulu m (ortholog); nucleus (ortholog) | | | | Naked Mole-Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243119 | ufm1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625836359 | Ufm1 | ubiquitin fold modifier 1 | INVOLVED IN brain development (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of protein import into nucleus (ortholog); ASSOCIATED WITH hypomyelinating leukodystrophy 14 (ortholog); long QT syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulu m (ortholog); nucleus (ortholog) | | | | Black Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254413 | ufm1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243118 | ufm1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16565636 | UFM1P1 | UFM1 pseudogene 1 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 36049837 | UFM1P1 | UFM1 pseudogene 1 | | X | 145768026 | 145769950 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 36049840 | UFM1P2 | UFM1 pseudogene 2 | | 17 | 35375236 | 35377746 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16559684 | UFM1P3 | UFM1 pseudogene 3 | | | | | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, processed_pseudogene |
| 36049819 | UFM1P3 | UFM1 pseudogene 3 | | 8 | 100164330 | 100165543 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1309308 | Ufl1 | Ufm1-specific ligase 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); UFM1 ligase activity (ortholog); INVOLVED IN negative regulation of apoptotic process; DNA damage checkpoint signaling (ortholog); DNA damage response (ortholog); ASSOCIATED WITH hereditary breas t ovarian cancer syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 5 | 43759271 | 43791682 | Rat | 178 | old_gene_name , name , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1319587 | UFL1 | UFM1 specific ligase 1 | Enables UFM1 ligase activity and protein kinase binding activity. Involved in several processes, including positive regulation of reticulophagy; regulation of intracellular signal transduction; and regulation of primary metabolic process. Acts upstream of or wit hin several processes, including positive regulation of cell population proliferation; regulation of proteasomal ubiquitin-dependent protein catabolic process; and response to endoplasmic reticulum stress. Located in cytoplasm; nucleus; and site of double-strand break. Part of protein-containing complex. Is active in endoplasmic reticulum membrane and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 96521806 | 96555276 | Human | 136 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1319588 | Ufl1 | UFM1 specific ligase 1 | Predicted to enable UFM1 ligase activity and protein kinase binding activity. Involved in several processes, including hemopoiesis; negative regulation of T cell activation; and positive regulation of autophagy. Acts upstream of or within positive regulation of glial cell proliferation; regulation of gene expression; and response to L-glutamate. Located in cytoplasm and neuron projection. Is expressed in cerebellum; cerebral cortex; embryo; and liver. Orthologous to human UFL1 (UFM1 specific ligase 1). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 25247149 | 25281821 | Mouse | 211 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8842557 | Ufl1 | UFM1 specific ligase 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); UFM1 ligase activity (ortholog); INVOLVED IN DNA damage checkpoint signaling (ortholog); DNA damage response (ortholog); erythrocyte differentiation (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004955411 | 22548139 | 22577287 | Chinchilla | 56 | old_gene_name , name , description | gene, protein-coding, MODEL [RefSeq] |
| 11764072 | UFL1 | UFM1 specific ligase 1 | ENCODES a protein that exhibits protein kinase binding (inferred); UFM1 ligase activity (inferred); UFM1 transferase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation o f cell population proliferation (ortholog); positive regulation of glial cell proliferation (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | 6 | 94356440 | 94389920 | Bonobo | 57 | old_gene_name , name , description | gene, protein-coding, MODEL [RefSeq] |
| 12235750 | UFL1 | UFM1 specific ligase 1 | ENCODES a protein that exhibits protein kinase binding (inferred); transferase activity (inferred); UFM1 ligase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of glial cell proliferation (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN endoplasmic reticulum (ortholog) | 12 | 54988200 | 55023414 | Dog | 56 | old_gene_name , name , description | gene, protein-coding, MODEL [RefSeq] |
| 12653861 | Ufl1 | UFM1 specific ligase 1 | ENCODES a protein that exhibits protein kinase binding (inferred); transferase activity (inferred); UFM1 ligase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of glial cell proliferation (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004936699 | 1131385 | 1163310 | Squirrel | 58 | old_gene_name , name , description | gene, protein-coding, MODEL [RefSeq] |
| 13912629 | UFL1 | UFM1 specific ligase 1 | ENCODES a protein that exhibits ligase activity (inferred); protein kinase binding (inferred); transferase activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of cell population proliferation (ortholog); positive regulation of glial cell prolifer ation (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN endoplasmic reticulum (ortholog) | | | | Pig | 57 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 18494381 | UFL1 | UFM1 specific ligase 1 | ENCODES a protein that exhibits protein kinase binding (inferred); transferase activity (inferred); UFM1 ligase activity (inferred); INVOLVED IN erythrocyte differentiation (ortholog); hematopoietic stem cell differentiation (ortholog); negative regulation of ap optotic process (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); neuron projection (ortholog) | | | | Green Monkey | 57 | old_gene_name , name , description | gene, protein-coding, MODEL [RefSeq] |
| 18918350 | Ufl1 | UFM1 specific ligase 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN DNA damage checkpoint signaling (ortholog); DNA damage response (ortholog); erythrocyte differentiation (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cytoplasm (ortholog); endo plasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 57 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625976557 | Ufl1 | UFM1 specific ligase 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); UFM1 ligase activity (ortholog); INVOLVED IN DNA damage checkpoint signaling (ortholog); DNA damage response (ortholog); erythrocyte differentiation (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 56 | old_gene_name , name , description | gene, protein-coding, MODEL [RefSeq] |
| 1604425 | UFSP1 | UFM1 specific peptidase 1 | This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an a ctive form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009] | 7 | 100888721 | 100889715 | Human | 47 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1623958 | Ufsp1 | UFM1-specific peptidase 1 | Enables deUFMylase activity. Predicted to be involved in protein maturation. Predicted to be active in cytosol. Is expressed in several structures, including diaphragm; limb segment; nervous system; skeletal musculature; and thymus primordium. Orthologous to human UFSP1 (UFM1 ;'>UFM1 specific peptidase 1). [provided by Alliance of Genome Resources, Apr 2025] | 5 | 137292931 | 137293926 | Mouse | 53 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 7536909 | Ufsp1 | UFM1-specific peptidase 1 | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); deUFMylase activity (ortholog); INVOLVED IN protein maturation (ortholog); protein ufmylation (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; cadmium dichloride | 12 | 25042882 | 25043896 | Rat | 43 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 8933515 | Ufsp1 | UFM1 specific peptidase 1 | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); deUFMylase activity (ortholog); INVOLVED IN protein maturation (ortholog); protein ufmylation (ortholog); FOUND IN cytosol (ortholog) | NW_004955573 | 85799 | 86917 | Chinchilla | 8 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11828445 | UFSP1 | UFM1 specific peptidase 1 | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); INVOLVED IN protein maturation (ortholog); protein ufmylation (ortholog); FOUND IN cytosol (ortholog) | 7 | 92913749 | 92914766 | Bonobo | 8 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12118169 | UFSP1 | UFM1 specific peptidase 1 | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); deUFMylase activity (ortholog); INVOLVED IN protein maturation (ortholog); protein ufmylation (ortholog); FOUND IN cytosol (ortholog) | 6 | 8880072 | 8881126 | Dog | 8 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12544873 | Ufsp1 | UFM1 specific peptidase 1 | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); INVOLVED IN protein maturation (ortholog); protein ufmylation (ortholog); FOUND IN cytosol (ortholog) | NW_004936543 | 855550 | 856607 | Squirrel | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13858936 | UFSP1 | UFM1 specific peptidase 1 | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); INVOLVED IN protein maturation (ortholog); protein ufmylation (ortholog); FOUND IN cytosol (ortholog) | | | | Pig | 8 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18796456 | UFSP1 | UFM1 specific peptidase 1 | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); INVOLVED IN protein maturation (ortholog); protein ufmylation (ortholog); FOUND IN cytosol (ortholog) | | | | Green Monkey | 8 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18906312 | Ufsp1 | UFM1 specific peptidase 1 | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); INVOLVED IN protein maturation (ortholog); protein ufmylation (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 10 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 625976545 | Ufsp1 | UFM1 specific peptidase 1 | ENCODES a protein that exhibits cysteine-type peptidase activity (ortholog); deUFMylase activity (ortholog); INVOLVED IN protein maturation (ortholog); protein ufmylation (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 8 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1311161 | Ufsp2 | UFM1-specific peptidase 2 | ENCODES a protein that exhibits deUFMylase activity (ortholog); INVOLVED IN negative regulation of proteolysis involved in protein catabolic process (ortholog); proteolysis (ortholog); regulation of intracellular estrogen receptor signaling pathway (ortholog); ASSOCIATED WITH Beukes hip dysplasia (o rtholog); Desbuquois dysplasia (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A | 16 | 53004590 | 53023640 | Rat | 102 | old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1322473 | Ufsp2 | UFM1-specific peptidase 2 | Enables deUFMylase activity. Involved in regulation of type II interferon production. Located in endoplasmic reticulum and nucleus. Is expressed in liver; orbito-sphenoid; pancreas epithelium; and turbinate bone primordium. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and develo pmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 46428551 | 46449995 | Mouse | 98 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605068 | UFSP2 | UFM1 specific peptidase 2 | This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows in teraction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] | 4 | 185399537 | 185425964 | Human | 185 | old_gene_name , name | gene, protein-coding, REVIEWED [RefSeq] |
| 8804680 | Ufsp2 | UFM1 specific peptidase 2 | ENCODES a protein that exhibits deUFMylase activity (ortholog); INVOLVED IN negative regulation of proteolysis involved in protein catabolic process (ortholog); proteolysis (ortholog); regulation of intracellular estrogen receptor signaling pathway (ortholog); ASSOCIATED WITH Beukes hip dysplasia (o rtholog); Desbuquois dysplasia (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); nucleus (ortholog) | NW_004955403 | 23634967 | 23655429 | Chinchilla | 24 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11829046 | UFSP2 | UFM1 specific peptidase 2 | ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); deUFMylase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of proteolysis involved in protein catabolic process (inferred); proteolysis (inferred); regulation of intracellular estrogen re ceptor signaling pathway (inferred); ASSOCIATED WITH Beukes hip dysplasia (ortholog); Desbuquois dysplasia (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); nucleus (inferred) | 4 | 177562642 | 177589312 | Bonobo | 30 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12314822 | UFSP2 | UFM1 specific peptidase 2 | ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); deUFMylase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of proteolysis involved in protein catabolic process (inferred); proteolysis (inferred); regulation of intracellular estrogen re ceptor signaling pathway (inferred); ASSOCIATED WITH Beukes hip dysplasia (ortholog); Desbuquois dysplasia (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); nucleus (inferred) | 16 | 45208741 | 45230041 | Dog | 30 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12617767 | Ufsp2 | UFM1 specific peptidase 2 | ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); deUFMylase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of proteolysis involved in protein catabolic process (inferred); proteolysis (inferred); regulation of intracellular estrogen re ceptor signaling pathway (inferred); ASSOCIATED WITH Beukes hip dysplasia (ortholog); Desbuquois dysplasia (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); nucleus (inferred) | NW_004936554 | 3926046 | 3945575 | Squirrel | 30 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14063982 | UFSP2 | UFM1 specific peptidase 2 | ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); deUFMylase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of proteolysis involved in protein catabolic process (inferred); proteolysis (inferred); regulation of intracellular estrogen re ceptor signaling pathway (inferred); ASSOCIATED WITH Beukes hip dysplasia (ortholog); Desbuquois dysplasia (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); nucleus (inferred) | | | | Pig | 30 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18770563 | UFSP2 | UFM1 specific peptidase 2 | ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); deUFMylase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of proteolysis involved in protein catabolic process (inferred); proteolysis (inferred); regulation of intracellular estrogen re ceptor signaling pathway (inferred); ASSOCIATED WITH Beukes hip dysplasia (ortholog); Desbuquois dysplasia (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); nucleus (inferred) | | | | Green Monkey | 30 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18927288 | Ufsp2 | UFM1 specific peptidase 2 | ENCODES a protein that exhibits cysteine-type peptidase activity (inferred); deUFMylase activity (inferred); hydrolase activity (inferred); INVOLVED IN negative regulation of proteolysis involved in protein catabolic process (ortholog); regulation of intracellular estrogen receptor signaling pathway (ortholog); regulation of type II interferon production (ortholog); ASSOCIATED WITH Beukes hip dysplasia (ortholog); Desbuquois dysplasia (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog) | | | | Naked Mole-Rat | 26 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626073293 | Ufsp2 | UFM1 specific peptidase 2 | ENCODES a protein that exhibits deUFMylase activity (ortholog); INVOLVED IN negative regulation of proteolysis involved in protein catabolic process (ortholog); proteolysis (ortholog); regulation of intracellular estrogen receptor signaling pathway (ortholog); ASSOCIATED WITH Beukes hip dysplasia (o rtholog); Desbuquois dysplasia (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); nucleus (ortholog) | | | | Black Rat | 24 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12280148 | LOC100682866 | E3 UFM1-protein ligase 1-like | | 2 | 16625121 | 16632918 | Dog | | name | gene, pseudo, MODEL [RefSeq] |
| 16555811 | AC007969.1 | ubiquitin-fold modifier 1 (UFM1) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1311702 | Uba5 | ubiquitin-like modifier activating enzyme 5 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); UFM1 activating enzyme activity (ortholog); zinc ion binding (ortholog); INVOLVED IN erythrocyte differentiation (ortholog); megakaryocyte differentiation (ortholog); neuromuscular pro cess (ortholog); ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 24 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17beta-estradiol | 8 | 113544037 | 113559711 | Rat | 165 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1323296 | UBA5 | ubiquitin like modifier activating enzyme 5 | This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Alternative splicing results in multiple transcript variants. A pse udogene of this gene has been identified on chromosome 1. [provided by RefSeq, Feb 2016] | 3 | 132654430 | 132679794 | Human | 224 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1323297 | Uba5 | ubiquitin-like modifier activating enzyme 5 | Enables UFM1 activating enzyme activity. Involved in myeloid cell differentiation; protein ufmylation; and regulation of type II interferon production. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 24 and developmental and epileptic encephalopathy 44. Orthologous to human UBA5 (ubiquitin like modifier activating enzyme 5). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 103923786 | 103940767 | Mouse | 160 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1303313 | Ufc1 | ubiquitin-fold modifier conjugating enzyme 1 | ENCODES a protein that exhibits UFM1 conjugating enzyme activity (ortholog); INVOLVED IN brain development (ortholog); protein K69-linked ufmylation (ortholog); protein ufmylation (ortholog); ASSOCIATED WITH neurodevelopmental disorder with spasticity and poor g rowth (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acrylamide | 13 | 86241779 | 86280513 | Rat | 82 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1604819 | UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008] | 1 | 161153978 | 161158856 | Human | 146 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615128 | Ufc1 | ubiquitin-fold modifier conjugating enzyme 1 | Enables UFM1 conjugating enzyme activity. Involved in protein ufmylation and regulation of type II interferon production. Is expressed in chondrocranium and liver. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spasticity and poor growth. Orthologous to human UFC1 (ubiquitin-fold modifier conjugating enzyme 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 171116137 | 171122575 | Mouse | 77 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 18933562 | Ufc1 | ubiquitin-fold modifier conjugating enzyme 1 | ENCODES a protein that exhibits UFM1 conjugating enzyme activity (inferred); UFM1 transferase activity (inferred); INVOLVED IN brain development (ortholog); protein ufmylation (ortholog); regulation of type II interferon pro duction (ortholog); ASSOCIATED WITH neurodevelopmental disorder with spasticity and poor growth (ortholog); FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 18 | old_gene_name , description | gene, protein-coding, MODEL [RefSeq] |
| 1320614 | DDRGK1 | DDRGK domain containing 1 | The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity. [provided by RefSeq, Dec 2015] | 20 | 3190350 | 3204682 | Human | 209 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1557559 | Ddrgk1 | DDRGK domain containing 1 | Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; UFM1-modified protein reader activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including negative regulation of endoplasm ic reticulum unfolded protein response; positive regulation of plasma cell differentiation; and positive regulation of protein localization to endoplasmic reticulum. Is active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver and biliary system; and nervous system. Orthologous to human DDRGK1 (DDRGK domain containing 1). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 130495955 | 130506549 | Mouse | 166 | old_gene_name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1307672 | Zup1 | zinc finger containing ubiquitin peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 3H-1,2-dithiole-3-thione; bisphenol A; Butylbenzyl phthalate | 20 | 31327939 | 31358088 | Rat | 73 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1316997 | ZUP1 | zinc finger containing ubiquitin peptidase 1 | This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing th e terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018] | 6 | 116635618 | 116668766 | Human | 74 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1316998 | Zup1 | zinc finger containing ubiquitin peptidase 1 | Predicted to enable cysteine-type deubiquitinase activity and zinc ion binding activity. Predicted to be located in cytosol and nucleoplasm. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZUP1 (zinc finger containing ubiquitin peptidase 1). [provided by Alliance o f Genome Resources, Jul 2025] | 10 | 33795138 | 33827316 | Mouse | 79 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 8800379 | Zup1 | zinc finger containing ubiquitin peptidase 1 | FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | NW_004955436 | 1001 | 28469 | Chinchilla | 4 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11852691 | ZUP1 | zinc finger containing ubiquitin peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 6 | 114443844 | 114477220 | Bonobo | 10 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12236930 | ZUP1 | zinc finger containing ubiquitin peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | 1 | 57076730 | 57108527 | Dog | 14 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12517600 | Zup1 | zinc finger containing ubiquitin peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | NW_004937068 | 21312 | 42266 | Squirrel | 10 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14083221 | ZUP1 | zinc finger containing ubiquitin peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Pig | 14 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18384227 | ZUP1 | zinc finger containing ubiquitin peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred) | | | | Green Monkey | 10 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18914276 | Zup1 | zinc finger containing ubiquitin peptidase 1 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); FOUND IN cytosol (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 10 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11937499 | UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | ENCODES a protein that exhibits UFM1 conjugating enzyme activity (inferred); UFM1 transferase activity (inferred); INVOLVED IN protein ufmylation (ortholog); response to endoplasmic reticulum stress (ortholog); ASSOCIATED WI TH neurodevelopmental disorder with spasticity and poor growth (ortholog); FOUND IN cytoplasm (inferred) | 1 | 136545095 | 136571327 | Bonobo | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 12542936 | Ufc1 | ubiquitin-fold modifier conjugating enzyme 1 | ENCODES a protein that exhibits UFM1 conjugating enzyme activity (inferred); UFM1 transferase activity (inferred); INVOLVED IN protein ufmylation (ortholog); response to endoplasmic reticulum stress (ortholog); ASSOCIATED WI TH neurodevelopmental disorder with spasticity and poor growth (ortholog); FOUND IN cytoplasm (inferred) | NW_004936903 | 449042 | 462727 | Squirrel | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 18390394 | UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | ENCODES a protein that exhibits UFM1 conjugating enzyme activity (inferred); UFM1 transferase activity (inferred); INVOLVED IN brain development (ortholog); protein ufmylation (ortholog); regulation of type II interferon pro duction (ortholog); ASSOCIATED WITH neurodevelopmental disorder with spasticity and poor growth (ortholog); FOUND IN cytoplasm (inferred) | | | | Green Monkey | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 1309979 | Ddrgk1 | DDRGK domain containing 1 | ENCODES a protein that exhibits ubiquitin-like protein ligase binding (ortholog); UFM1-modified protein reader activity (ortholog); INVOLVED IN negative regulation of apoptotic process; regulation of insulin secretion involved in cellular response to glucose sti mulus; cartilage development (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); Spondyloepimetaphyseal Dysplasia, Shohat Type (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; leflunomide | 3 | 138315006 | 138336691 | Rat | 128 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8960241 | Ddrgk1 | DDRGK domain containing 1 | ENCODES a protein that exhibits ubiquitin-like protein ligase binding (ortholog); UFM1-modified protein reader activity (ortholog); INVOLVED IN cartilage development (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of gene exp ression (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); Spondyloepimetaphyseal Dysplasia, Shohat Type (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004955415 | 14085404 | 14098220 | Chinchilla | 53 | description | gene, protein-coding, MODEL [RefSeq] |
| 11893601 | DDRGK1 | DDRGK domain containing 1 | ENCODES a protein that exhibits ubiquitin-like protein ligase binding (inferred); UFM1-modified protein reader activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of I-kappaB phosphorylation (ortholog); regul ation of insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); Spondyloepimetaphyseal Dysplasia, Shohat Type (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | 20 | 3276292 | 3290433 | Bonobo | 56 | description | gene, protein-coding, MODEL [RefSeq] |
| 12326443 | DDRGK1 | DDRGK domain containing 1 | ENCODES a protein that exhibits ubiquitin-like protein ligase binding (inferred); UFM1-modified protein reader activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of I-kappaB phosphorylation (ortholog); regul ation of insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); Spondyloepimetaphyseal Dysplasia, Shohat Type (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH bisphenol A | 24 | 18085865 | 18098868 | Dog | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 12715654 | Ddrgk1 | DDRGK domain containing 1 | ENCODES a protein that exhibits ubiquitin-like protein ligase binding (inferred); UFM1-modified protein reader activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of I-kappaB phosphorylation (ortholog); regul ation of insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); Spondyloepimetaphyseal Dysplasia, Shohat Type (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004936485 | 15516348 | 15526380 | Squirrel | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 14063073 | DDRGK1 | DDRGK domain containing 1 | ENCODES a protein that exhibits ubiquitin-like protein ligase binding (inferred); UFM1-modified protein reader activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of I-kappaB phosphorylation (ortholog); regul ation of insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); Spondyloepimetaphyseal Dysplasia, Shohat Type (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Pig | 55 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18553921 | DDRGK1 | DDRGK domain containing 1 | ENCODES a protein that exhibits ubiquitin-like protein ligase binding (inferred); UFM1-modified protein reader activity (inferred); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of I-kappaB phosphorylation (ortholog); regul ation of insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); Spondyloepimetaphyseal Dysplasia, Shohat Type (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Green Monkey | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 18905031 | Ddrgk1 | DDRGK domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); negative regulation of gene expression (ortholog); negative regulation of PERK-mediated unfolded protein response ( ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); Spondyloepimetaphyseal Dysplasia, Shohat Type (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Naked Mole-Rat | 53 | description | gene, protein-coding, MODEL [RefSeq] |
| 625935498 | Ddrgk1 | DDRGK domain containing 1 | ENCODES a protein that exhibits ubiquitin-like protein ligase binding (ortholog); UFM1-modified protein reader activity (ortholog); INVOLVED IN cartilage development (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of gene exp ression (ortholog); ASSOCIATED WITH Desbuquois dysplasia (ortholog); genetic disease (ortholog); Spondyloepimetaphyseal Dysplasia, Shohat Type (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 53 | description | gene, protein-coding, MODEL [RefSeq] |
| 1310877 | Saysd1 | SAYSVFN motif domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (ortholog); INVOLVED IN protein quality control for misfolded or incompletely synthesized proteins (ortholog); rescue of stalled cytosolic ribosome (ortholog); FOUND IN endoplasmic reticulum ( ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate | 15 | 4273302 | 4278971 | Rat | 34 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1322030 | SAYSD1 | SAYSVFN motif domain containing 1 | Enables UFM1-modified protein reader activity. Involved in protein quality control for misfolded or incompletely synthesized proteins and rescue of stalled ribosome. Located in intracellular membrane-bounded organelle. Is active in endoplasmic reticulum. [provid ed by Alliance of Genome Resources, Apr 2025] | 6 | 39104063 | 39115186 | Human | 41 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1614357 | Saysd1 | SAYSVFN motif domain containing 1 | Predicted to enable UFM1-modified protein reader activity. Predicted to be involved in protein quality control for misfolded or incompletely synthesized proteins and rescue of stalled ribosome. Is active in endoplasmic reticulum. Orthologous to human SAYSD1 (SAY SVFN motif domain containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 20125704 | 20133240 | Mouse | 55 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8986239 | Saysd1 | SAYSVFN motif domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (ortholog); INVOLVED IN protein quality control for misfolded or incompletely synthesized proteins (ortholog); rescue of stalled cytosolic ribosome (ortholog); FOUND IN endoplasmic reticulum ( ortholog) | NW_004955437 | 4369140 | 4375405 | Chinchilla | 5 | description | gene, protein-coding, MODEL [RefSeq] |
| 11839596 | SAYSD1 | SAYSVFN motif domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (inferred); INVOLVED IN protein quality control for misfolded or incompletely synthesized proteins (inferred); rescue of stalled cytosolic ribosome (inferred); FOUND IN endoplasmic reticulum ( inferred) | 6 | 38693198 | 38704321 | Bonobo | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 12089664 | SAYSD1 | SAYSVFN motif domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (inferred); INVOLVED IN protein quality control for misfolded or incompletely synthesized proteins (inferred); rescue of stalled cytosolic ribosome (inferred); FOUND IN endoplasmic reticulum ( inferred) | 12 | 8044811 | 8051239 | Dog | 8 | description | gene, protein-coding, MODEL [RefSeq] |
| 12658285 | Saysd1 | SAYSVFN motif domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (inferred); INVOLVED IN protein quality control for misfolded or incompletely synthesized proteins (inferred); rescue of stalled cytosolic ribosome (inferred); FOUND IN endoplasmic reticulum ( inferred) | NW_004936476 | 20513238 | 20520825 | Squirrel | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 14001291 | SAYSD1 | SAYSVFN motif domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (inferred); INVOLVED IN protein quality control for misfolded or incompletely synthesized proteins (inferred); rescue of stalled cytosolic ribosome (inferred); FOUND IN endoplasmic reticulum ( inferred) | | | | Pig | 8 | description | gene, protein-coding, MODEL [RefSeq] |
| 18552338 | SAYSD1 | SAYSVFN motif domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (inferred); INVOLVED IN protein quality control for misfolded or incompletely synthesized proteins (inferred); rescue of stalled cytosolic ribosome (inferred); FOUND IN endoplasmic reticulum ( inferred) | | | | Green Monkey | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 18931240 | Saysd1 | SAYSVFN motif domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (inferred); INVOLVED IN protein quality control for misfolded or incompletely synthesized proteins (inferred); rescue of stalled cytosolic ribosome (inferred); FOUND IN endoplasmic reticulum ( inferred) | | | | Naked Mole-Rat | 4 | description | gene, protein-coding, MODEL [RefSeq] |
| 625976981 | Saysd1 | SAYSVFN motif domain containing 1 | ENCODES a protein that exhibits UFM1-modified protein reader activity (ortholog); INVOLVED IN protein quality control for misfolded or incompletely synthesized proteins (ortholog); rescue of stalled cytosolic ribosome (ortholog); FOUND IN endoplasmic reticulum ( ortholog) | | | | Black Rat | 5 | description | gene, protein-coding, MODEL [RefSeq] |
| 1319807 | Stk38 | serine/threonine kinase 38 | Predicted to enable several functions, including ATP binding activity; UFM1-modified protein reader activity; and magnesium ion binding activity. Predicted to be involved in several processes, including DNA damage checkpoint signaling; negative regulation of MAP kinase activity; and protein phosphorylation. Predicted to be located in cytosol and nucleus. Predicted to be active in glutamatergic synapse and site of double-strand break. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and nose. Orthologous to human STK38 (serine/threonine kinase 38). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 29189854 | 29226979 | Mouse | 194 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8795352 | Uba5 | ubiquitin like modifier activating enzyme 5 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); UFM1 activating enzyme activity (ortholog); zinc ion binding (ortholog); INVOLVED IN erythrocyte differentiation (ortholog); megakaryocyte differentiation (ortholog); neuromuscular pro cess (ortholog); ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 24 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum membrane (ortholog) | NW_004955501 | 5841516 | 5864304 | Chinchilla | 38 | description | gene, protein-coding, MODEL [RefSeq] |
| 625910368 | Uba5 | ubiquitin like modifier activating enzyme 5 | ENCODES a protein that exhibits protein homodimerization activity (ortholog); UFM1 activating enzyme activity (ortholog); zinc ion binding (ortholog); INVOLVED IN erythrocyte differentiation (ortholog); megakaryocyte differentiation (ortholog); neuromuscular pro cess (ortholog); ASSOCIATED WITH autosomal recessive spinocerebellar ataxia 24 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum membrane (ortholog) | | | | Black Rat | 38 | description | gene, protein-coding, MODEL [RefSeq] |
| 8998538 | Ufc1 | ubiquitin-fold modifier conjugating enzyme 1 | ENCODES a protein that exhibits UFM1 conjugating enzyme activity (ortholog); INVOLVED IN brain development (ortholog); protein K69-linked ufmylation (ortholog); protein ufmylation (ortholog); ASSOCIATED WITH neurodevelopmental disorder with spasticity and poor g rowth (ortholog) | NW_004955468 | 12919031 | 12922740 | Chinchilla | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 12338997 | UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | ENCODES a protein that exhibits UFM1 conjugating enzyme activity (inferred); INVOLVED IN protein ufmylation (ortholog); response to endoplasmic reticulum stress (ortholog); ASSOCIATED WITH neurodevelopmental disorder with spasticity and poor growth (ortholog) | 38 | 21319039 | 21339524 | Dog | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 13895833 | UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | ENCODES a protein that exhibits UFM1 conjugating enzyme activity (inferred); INVOLVED IN protein ufmylation (ortholog); response to endoplasmic reticulum stress (ortholog); ASSOCIATED WITH neurodevelopmental disorder with spasticity and poor growth (ortholog) | | | | Pig | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 625981093 | Ufc1 | ubiquitin-fold modifier conjugating enzyme 1 | ENCODES a protein that exhibits UFM1 conjugating enzyme activity (ortholog); INVOLVED IN brain development (ortholog); protein K69-linked ufmylation (ortholog); protein ufmylation (ortholog); ASSOCIATED WITH neurodevelopmental disorder with spasticity and poor g rowth (ortholog) | | | | Black Rat | 18 | description | gene, protein-coding, MODEL [RefSeq] |
