Ddrgk1 (DDRGK domain containing 1)

Gene: Ddrgk1 (DDRGK domain containing 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Ddrgk1

Name:

DDRGK domain containing 1

RGD ID:

12715654

Description:

ENCODES a protein that exhibits UFM1-modified protein reader activity (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); positive regulation of reticulophagy (ortholog); regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH genetic disease (ortholog); Huntington's disease-like 1 (ortholog); Inosine Triphosphatase Deficiency (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DDRGK domain-containing protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	167,084,969 - 167,095,016 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	15,516,302 - 15,526,376 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	15,516,348 - 15,526,380 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Huntington's disease-like 1 (ISO)

Inosine Triphosphatase Deficiency (ISO)

pantothenate kinase-associated neurodegeneration (ISO)

Spondyloepimetaphyseal Dysplasia, Shohat Type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cartilage development (IEA)

negative regulation of apoptotic process (ISO)

negative regulation of gene expression (IEA)

negative regulation of IRE1-mediated unfolded protein response (IEA)

negative regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA)

positive regulation of cell migration (IEA)

positive regulation of cell population proliferation (IEA)

positive regulation of gene expression (IEA)

positive regulation of I-kappaB phosphorylation (IEA)

positive regulation of proteasomal protein catabolic process (IEA)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA)

positive regulation of protein localization to endoplasmic reticulum (IEA)

positive regulation of reticulophagy (ISO)

positive regulation of transcription by RNA polymerase II (IEA)

protein localization to endoplasmic reticulum (IEA)

protein ufmylation (IEA)

regulation of insulin secretion involved in cellular response to glucose stimulus (ISO)

regulation of intracellular estrogen receptor signaling pathway (IEA)

regulation of protein stability (IEA)

rescue of stalled ribosome (ISO)

response to endoplasmic reticulum stress (IEA)

reticulophagy (IEA)

ribosome disassembly (ISO)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA,ISO)

nucleolus (IEA)

Molecular Function

protein binding (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

ubiquitin-like protein ligase binding (IEA)

UFM1-modified protein reader activity (ISO)

References

Genomics

Comparative Map Data

Ddrgk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	167,084,969 - 167,095,016 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	15,516,302 - 15,526,376 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	15,516,348 - 15,526,380 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DDRGK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	3,190,350 - 3,204,682 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	3,190,350 - 3,204,685 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	3,170,996 - 3,185,328 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	3,119,012 - 3,133,295 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	3,119,012 - 3,133,295	NCBI
Celera	20	3,232,967 - 3,247,257 (-)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	3,118,864 - 3,133,155 (-)	NCBI		HuRef
CHM1_1	20	3,171,069 - 3,185,357 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	3,221,281 - 3,235,633 (-)	NCBI		T2T-CHM13v2.0

Ddrgk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	130,495,955 - 130,506,549 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	130,495,880 - 130,506,579 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	130,654,033 - 130,664,654 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	130,653,960 - 130,664,659 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	130,479,819 - 130,490,381 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	130,345,072 - 130,356,100 (-)	NCBI		MGSCv36	mm8
Celera	2	131,878,895 - 131,889,451 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	63.24	NCBI

Ddrgk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	138,315,006 - 138,336,691 (-)	NCBI		GRCr8
mRatBN7.2	3	117,861,916 - 117,882,680 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	117,861,653 - 117,882,680 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	121,765,667 - 121,776,915 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	130,363,251 - 130,374,520 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	128,021,802 - 128,033,050 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	123,195,580 - 123,206,828 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	123,195,580 - 123,206,828 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	129,693,708 - 129,704,956 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	118,284,299 - 118,295,547 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	118,188,916 - 118,200,762 (-)	NCBI
Celera	3	116,682,282 - 116,693,534 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Ddrgk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	14,085,404 - 14,098,856 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	14,085,404 - 14,098,220 (-)	NCBI	ChiLan1.0	ChiLan1.0

DDRGK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	4,157,301 - 4,171,449 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	4,154,126 - 4,168,261 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	3,276,292 - 3,290,433 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	3,038,779 - 3,052,789 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	3,038,779 - 3,052,789 (-)	Ensembl	panpan1.1		panPan2

DDRGK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	18,085,865 - 18,098,868 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	18,084,725 - 18,097,157 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	17,914,255 - 17,927,262 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	18,504,362 - 18,517,360 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	18,504,223 - 18,517,432 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	18,098,065 - 18,111,061 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	18,210,878 - 18,223,902 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	18,538,034 - 18,551,030 (+)	NCBI		UU_Cfam_GSD_1.0

DDRGK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	32,479,977 - 32,491,396 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	32,479,981 - 32,491,401 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	36,851,089 - 36,862,509 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DDRGK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	33,846,591 - 33,879,770 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	33,860,439 - 33,880,101 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	10,639,095 - 10,652,062 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ddrgk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	4,292,256 - 4,305,504 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	4,292,256 - 4,305,424 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005320527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000006430 ⟹ ENSSTOP00000005747

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936485	15,516,302 - 15,526,376 (+)	Ensembl

RefSeq Acc Id:

XM_005320527 ⟹ XP_005320584

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	167,084,969 - 167,095,016 (+)	NCBI
SpeTri2.0	NW_004936485	15,516,348 - 15,526,380 (+)	NCBI

Sequence:

show sequence

CGGGGCCTGGGTGATACGGGCCTCATCGTGGACGCGCTGGTTCTGCTGGGAAGTCGTCGTCATG
GTGGCGCCCGTGGTGTATCTGGTGGCAGCGGCTCTGCTTGTCTGCCTTATACTCTTCCTCACTC
GCAGTCGTGGCAGAGCGGTAGCAGCTGGTCCAGAGTCACTGCACAATGAAGAGGATCCAATAAT
AGCAGACCAGGTGGCCCAGTCTCGGCCTCTGCAGCCTGAGGAACAGAGGGCTGGAGGCAGGCCC
CGGCGCAGGAGGGACCTGGGCAGCCGCCTGCAGGCCCAGCGTCGAGCCCAAAGGATAGCCTGGA
CAGAAGTGGATGAGAATGAGGAGGAAGCTGTCATCCCAGCCCAGGAGGAAGAAGACATTGAGAA
GCCAGTGGAAACTCATCTGACAGGGAAAATTGGAGCCAAGAAACTACGGAAGTTAGAGGAGAAA
CAAGCTCGAAAAGCCCAGCGTGAGGCAGAGGAGGCTGAACGTGAAGAGCGGAAACGCCTAGAGT
CCCAACGTGAGGCTGAGTGGAAGAAGGAGGAGGAGCGGCTTCGCTTGGAGGAGGAACAGAAGGA
GGAGGAAGAGAGAAAGGCCCAGGAAGAACAGGCCCGGCGGGAGCATGAGGAGTACCTGAAACTG
AAGGAAGCCTTTGTGGTGGAGGAGGAGGGTGTGGGTGAGACCATGACTGAGGAGCAGTCCCACA
GCTTCCTGACAGAATTTATCAACTACATTAAGCAATCCAAGGTTGTACTCTTGGAAGATTTGGC
TTCCCAGGTGGGCCTACGGACTCAGGACACTATCAACCGCATCCAGGACCTGCTGGCTGATGGG
ACTCTAACAGGTGTGATTGACGACCGGGGCAAGTTCATCTACATAACCCCAGAGGAACTGGCTG
CTGTGGCCAACTTCATCCGACAGCGGGGCCGGGTGTCCATCACTGAGCTTGCCCAGGCCAGCAA
CTCCCTCATCGCCTGGGGCTAGGAGCCCCCACAACCCTGCCAGCCTGACCTCAGCCCTGCCTAC
TTGGACTCAGAGCTGGTGTGGCCTACCTGGTAGTACATCTTCATCTCTCCTCACCATCCTGAGG
CAGTGATGGAGTGTGGCCAGGAAGTTGTAGATTAAAGGCCTGTGAGCACTGCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005320584	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000005747.3

RefSeq Acc Id:

XP_005320584 ⟸ XM_005320527

- UniProtKB:

I3M7W8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVAPVVYLVAAALLVCLILFLTRSRGRAVAAGPESLHNEEDPIIADQVAQSRPLQPEEQRAGGR
PRRRRDLGSRLQAQRRAQRIAWTEVDENEEEAVIPAQEEEDIEKPVETHLTGKIGAKKLRKLEE
KQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAQEEQARREHEEYLK
LKEAFVVEEEGVGETMTEEQSHSFLTEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAD
GTLTGVIDDRGKFIYITPEELAAVANFIRQRGRVSITELAQASNSLIAWG

hide sequence

RefSeq Acc Id:

ENSSTOP00000005747 ⟸ ENSSTOT00000006430

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006435	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006430.3	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
InterPro	DDRGK_dom-contain	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	Ddrgk1	ENTREZGENE
PANTHER	DDRGK DOMAIN-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
	DDRGK DOMAIN-CONTAINING PROTEIN 1	UniProtKB/TrEMBL
Pfam	DDRGK	UniProtKB/TrEMBL
SMART	DDRGK	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
UniProt	I3M7W8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM