Ddrgk1 (DDRGK domain containing 1) - Rat Genome Database

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Gene: Ddrgk1 (DDRGK domain containing 1) Mus musculus
Analyze
Symbol: Ddrgk1
Name: DDRGK domain containing 1
RGD ID: 1557559
MGI Page MGI
Description: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin-like protein ligase binding activity. Involved in several processes, including cartilage development; negative regulation of IRE1-mediated unfolded protein response; and positive regulation of protein localization to endoplasmic reticulum. Located in endoplasmic reticulum. Is expressed in central nervous system; genitourinary system; heart; and liver. Orthologous to human DDRGK1 (DDRGK domain containing 1); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; propiconazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1110001I20Rik; 2600009E05Rik; AI326138; DDRGK domain-containing protein 1; RP23-100C5.9; Ufbp1; UFM1-binding and PCI domain-containing protein 1; UFM1-binding protein 1 containing a PCI domain
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,495,955 - 130,506,565 (-)NCBIGRCm39mm39
GRCm39 Ensembl2130,495,880 - 130,506,579 (-)Ensembl
GRCm382130,654,033 - 130,664,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,653,960 - 130,664,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv372130,479,819 - 130,490,381 (-)NCBIGRCm37mm9NCBIm37
MGSCv362130,345,072 - 130,356,100 (-)NCBImm8
Celera2131,878,895 - 131,889,451 (-)NCBICelera
Cytogenetic Map2F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821  
PMID:17967808   PMID:20228063   PMID:21267068   PMID:21494687   PMID:21873635   PMID:24194600   PMID:25219498   PMID:26544067   PMID:28128204   PMID:28263186   PMID:30196744   PMID:30635284  
PMID:30701081   PMID:30842412  


Genomics

Comparative Map Data
Ddrgk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,495,955 - 130,506,565 (-)NCBIGRCm39mm39
GRCm39 Ensembl2130,495,880 - 130,506,579 (-)Ensembl
GRCm382130,654,033 - 130,664,654 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,653,960 - 130,664,659 (-)EnsemblGRCm38mm10GRCm38
MGSCv372130,479,819 - 130,490,381 (-)NCBIGRCm37mm9NCBIm37
MGSCv362130,345,072 - 130,356,100 (-)NCBImm8
Celera2131,878,895 - 131,889,451 (-)NCBICelera
Cytogenetic Map2F1NCBI
DDRGK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl203,190,350 - 3,204,685 (-)EnsemblGRCh38hg38GRCh38
GRCh38203,190,350 - 3,204,682 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37203,170,996 - 3,185,328 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,119,012 - 3,133,295 (-)NCBINCBI36hg18NCBI36
Build 34203,119,012 - 3,133,295NCBI
Celera203,232,967 - 3,247,257 (-)NCBI
Cytogenetic Map20p13NCBI
HuRef203,118,864 - 3,133,155 (-)NCBIHuRef
CHM1_1203,171,069 - 3,185,357 (-)NCBICHM1_1
Ddrgk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23117,861,916 - 117,882,680 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl3123,195,580 - 123,206,828 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03123,195,580 - 123,206,828 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03129,693,708 - 129,704,956 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,284,299 - 118,295,547 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13118,188,916 - 118,200,762 (-)NCBI
Celera3116,682,282 - 116,693,534 (-)NCBICelera
Cytogenetic Map3q36NCBI
Ddrgk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,085,404 - 14,098,856 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,085,404 - 14,098,220 (-)NCBIChiLan1.0ChiLan1.0
DDRGK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1203,038,779 - 3,052,789 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,038,779 - 3,052,789 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0203,276,292 - 3,290,433 (-)NCBIMhudiblu_PPA_v0panPan3
DDRGK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,085,865 - 18,098,868 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,084,725 - 18,097,157 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,914,255 - 17,927,262 (+)NCBI
ROS_Cfam_1.02418,504,362 - 18,517,360 (+)NCBI
UMICH_Zoey_3.12418,098,065 - 18,111,061 (+)NCBI
UNSW_CanFamBas_1.02418,210,878 - 18,223,902 (+)NCBI
UU_Cfam_GSD_1.02418,538,034 - 18,551,030 (+)NCBI
Ddrgk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640167,084,969 - 167,095,016 (+)NCBI
SpeTri2.0NW_00493648515,516,348 - 15,526,380 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDRGK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,479,976 - 32,491,400 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,479,981 - 32,491,401 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,851,089 - 36,862,509 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDRGK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,846,591 - 33,879,770 (-)NCBI
ChlSab1.1 Ensembl233,860,439 - 33,880,101 (-)Ensembl
Vero_WHO_p1.0NW_02366607110,639,095 - 10,652,062 (+)NCBI
Ddrgk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247414,292,256 - 4,305,424 (-)NCBI

Position Markers
AI326138  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382130,654,041 - 130,654,311UniSTSGRCm38
MGSCv372130,479,777 - 130,480,047UniSTSGRCm37
Celera2131,878,853 - 131,879,123UniSTS
Cytogenetic Map2F3UniSTS
Whitehead/MRC_RH21638.13UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294400000154400000Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297292889131293051Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297292889131293051Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297379883131379883Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297379883131379883Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100993579134993788Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2101112449135112609Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2101112449135112609Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2101112449135112609Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102800000160100000Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106391660140391809Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107413756141413756Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110647738144647887Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111331784145331901Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111331784145331901Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111331784145331901Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111331784145331901Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111709108145709243Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111781466145781606Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112370826146371085Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112370826146371085Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112370826146371085Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114457594132872237Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115370937149371074Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115370937149371074Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116235703150235821Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116464410150464554Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118758772160769245Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118758772160769245Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118758772160769245Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118758772160769245Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122376665142690215Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2123041095157041211Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123390053148858457Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2124095391158095504Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126200000135600000Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127822099161822198Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127822099161822198Mouse
1558989Gnf4_mgrowth and fatness 4 (mouse)Not determined2128331784132872237Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129500000163500000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:895
Count of miRNA genes:471
Interacting mature miRNAs:568
Transcripts:ENSMUST00000089559, ENSMUST00000124559, ENSMUST00000134044, ENSMUST00000135072, ENSMUST00000135167, ENSMUST00000153271
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000089559   ⟹   ENSMUSP00000086988
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2130,653,960 - 130,664,659 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124559
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2130,655,199 - 130,663,819 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134044   ⟹   ENSMUSP00000114535
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2130,654,291 - 130,661,741 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135072   ⟹   ENSMUSP00000121190
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2130,658,686 - 130,664,165 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135167
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2130,654,195 - 130,657,357 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153271
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2130,654,035 - 130,654,777 (-)Ensembl
RefSeq Acc Id: NM_029832   ⟹   NP_084108
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392130,496,003 - 130,506,565 (-)NCBI
GRCm382130,654,083 - 130,664,645 (-)NCBI
MGSCv372130,479,819 - 130,490,381 (-)RGD
Celera2131,878,895 - 131,889,451 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_001783204
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392130,495,955 - 130,506,549 (-)NCBI
GRCm382130,654,033 - 130,664,654 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940771
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392130,495,955 - 130,506,549 (-)NCBI
RefSeq Acc Id: XR_004940772
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392130,495,955 - 130,506,549 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_084108   ⟸   NM_029832
- Peptide Label: precursor
- UniProtKB: Q80WW9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000121190   ⟸   ENSMUST00000135072
RefSeq Acc Id: ENSMUSP00000086988   ⟸   ENSMUST00000089559
RefSeq Acc Id: ENSMUSP00000114535   ⟸   ENSMUST00000134044
Protein Domains
PCI

Promoters
RGD ID:6831144
Promoter ID:MM_KWN:31753
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000077879
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362130,483,301 - 130,483,801 (-)MPROMDB
RGD ID:6831142
Promoter ID:MM_KWN:31755
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000036835,   OTTMUST00000077876,   OTTMUST00000077878
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362130,489,751 - 130,490,462 (-)MPROMDB
RGD ID:6878770
Promoter ID:EPDNEW_M2836
Type:initiation region
Name:Ddrgk1_1
Description:Mus musculus DDRGK domain containing 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382130,664,620 - 130,664,680EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1924256 AgrOrtholog
Ensembl Genes ENSMUSG00000068290 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000086988 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000114535 UniProtKB/TrEMBL
  ENSMUSP00000121190 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000089559 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000134044 UniProtKB/TrEMBL
  ENSMUST00000135072 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro DDRGK_dom-contain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:77006 UniProtKB/Swiss-Prot
MGD MGI:1924256 ENTREZGENE
NCBI Gene 77006 ENTREZGENE
Pfam DDRGK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ddrgk1 PhenoGen
SMART DDRGK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt B0R015_MOUSE UniProtKB/TrEMBL
  DDRGK_MOUSE UniProtKB/Swiss-Prot
  F7AIJ1_MOUSE UniProtKB/TrEMBL
  Q80WW9 ENTREZGENE
UniProt Secondary Q14BT4 UniProtKB/Swiss-Prot
  Q9CT52 UniProtKB/Swiss-Prot