| 61939 | Nckap1 | NCK-associated protein 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN apical protein localization (ortholog); basal protein localization (ortholog); cell migration involved in gastrulation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathw ay; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN glutamatergic synapse; postsynaptic density; filamentous actin (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil | 3 | 85824333 | 85898748 | Rat | 167 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62232 | Nckap1 | NCK-associated protein 1 | Predicted to contribute to small GTPase binding activity. Involved in positive regulation of actin filament polymerization and positive regulation of lamellipodium assembly. Acts upstream of or within several processes, including apical protein localization; embryonic morphogenesis; and segmentation . Located in lamellipodium and ruffle. Part of filamentous actin. Is active in postsynapse. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Orthologous to human NCKAP1 (NCK associated protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 80330856 | 80411526 | Mouse | 187 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 732467 | NCKAP1 | NCK associated protein 1 | Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular exosome and focal adhesion. Part of SCAR complex. [provided by Allia nce of Genome Resources, Jul 2025] | 2 | 182909115 | 183038457 | Human | 177 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 8901654 | Nckap1 | NCK associated protein 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN apical protein localization (ortholog); basal protein localization (ortholog); cell migration involved in gastrulation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathw ay; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN filamentous actin (ortholog); glutamatergic synapse (ortholog); lamellipodium (ortholog) | NW_004955403 | 14476689 | 14554380 | Chinchilla | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11995242 | NCKAP1 | NCK associated protein 1 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN apical protein localization (ortholog); basal protein localization (ortholog); cell migration involved in gastrulation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathw ay; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | 2B | 70193950 | 70308442 | Bonobo | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12178898 | NCKAP1 | NCK associated protein 1 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN apical protein localization (ortholog); basal protein localization (ortholog); cell migration involved in gastrulation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathw ay; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | 36 | 25965243 | 26054775 | Dog | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12555039 | Nckap1 | NCK associated protein 1 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN apical protein localization (ortholog); basal protein localization (ortholog); cell migration involved in gastrulation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathw ay; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | NW_004936509 | 11525764 | 11624833 | Squirrel | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14256374 | NCKAP1 | NCK associated protein 1 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN apical protein localization (ortholog); basal protein localization (ortholog); cell migration involved in gastrulation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathw ay; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | | | | Pig | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18695900 | NCKAP1 | NCK associated protein 1 | ENCODES a protein that exhibits small GTPase binding (inferred); INVOLVED IN apical protein localization (ortholog); basal protein localization (ortholog); cell migration involved in gastrulation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathw ay; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density (ortholog) | | | | Green Monkey | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18912668 | Nckap1 | NCK associated protein 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN apical protein localization (ortholog); basal protein localization (ortholog); cell migration involved in gastrulation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathw ay; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN filamentous actin (ortholog); glutamatergic synapse (ortholog); lamellipodium (ortholog) | | | | Naked Mole-Rat | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236160 | nckap1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625947436 | Nckap1 | NCK associated protein 1 | ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN apical protein localization (ortholog); basal protein localization (ortholog); cell migration involved in gastrulation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathw ay; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN filamentous actin (ortholog); glutamatergic synapse (ortholog); lamellipodium (ortholog) | | | | Black Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250326 | nckap1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243751 | nckap1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 27375846 | NCKAP1P1 | NCKAP1 pseudogene 1 | | X | 97906647 | 97908083 | Human | | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1312032 | Nckap1l | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase activator activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin polymerization-dependent cell motility (ortholog); B cell homeostasis (ortholog); B cell receptor signaling pathway (or tholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 72 (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); SCAR complex (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 136455900 | 136501384 | Rat | 156 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323803 | NCKAP1L | NCK associated protein 1 like | This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] | 12 | 54497752 | 54548243 | Human | 174 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1619908 | Nckap1l | NCK associated protein 1 like | Predicted to enable GTPase activator activity; TORC2 complex binding activity; and protein kinase activator activity. Involved in several processes, including lymphocyte homeostasis; negative regulation of cytokine production; and positive regulation of lymphocyte activation. Part of SCAR complex. I s expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and musculature. Human ortholog(s) of this gene implicated in immunodeficiency 72. Orthologous to human NCKAP1L (NCK associated protein 1 like). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 103362219 | 103411288 | Mouse | 226 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8713235 | Nckap1l | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase activator activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin polymerization-dependent cell motility (ortholog); B cell homeostasis (ortholog); B cell receptor signaling pathway (or tholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 72 (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); SCAR complex (ortholog) | NW_004955458 | 1733799 | 1785591 | Chinchilla | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11764008 | NCKAP1L | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (inferred); protein kinase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN actin polymerization-dependent cell motility (inferred); B cell homeostasis (inferred); B cell receptor signaling pathway (in ferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 72 (ortholog); FOUND IN cytosol (inferred); plasma membrane (inferred); SCAR complex (inferred) | 12 | 34200102 | 34249873 | Bonobo | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12225132 | NCKAP1L | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (inferred); protein kinase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN actin polymerization-dependent cell motility (inferred); B cell homeostasis (inferred); B cell receptor signaling pathway (in ferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 72 (ortholog); FOUND IN cytosol (inferred); plasma membrane (inferred); SCAR complex (inferred) | 27 | 805274 | 858901 | Dog | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12496177 | Nckap1l | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (inferred); protein kinase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN actin polymerization-dependent cell motility (inferred); B cell homeostasis (inferred); B cell receptor signaling pathway (in ferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 72 (ortholog); FOUND IN cytosol (inferred); plasma membrane (inferred); SCAR complex (inferred) | NW_004936512 | 11683330 | 11734423 | Squirrel | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13886230 | NCKAP1L | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (inferred); protein kinase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN actin polymerization-dependent cell motility (inferred); B cell homeostasis (inferred); B cell receptor signaling pathway (in ferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 72 (ortholog); FOUND IN cytosol (inferred); plasma membrane (inferred); SCAR complex (inferred) | | | | Pig | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18532025 | NCKAP1L | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase activator activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin polymerization-dependent cell motility (ortholog); B cell homeostasis (ortholog); B cell receptor signaling pathway (or tholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 72 (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); SCAR complex (ortholog) | | | | Green Monkey | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910641 | Nckap1l | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (inferred); protein kinase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN actin polymerization-dependent cell motility (inferred); B cell homeostasis (inferred); B cell receptor signaling pathway (in ferred); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 72 (ortholog); FOUND IN cytosol (inferred); plasma membrane (inferred); SCAR complex (inferred) | | | | Naked Mole-Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866133 | NCKAP1L | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (inferred); protein kinase activator activity (inferred); protein-containing complex binding (inferred); INVOLVED IN actin polymerization-dependent cell motility (inferred); B cell homeostasis (inferred); B cell receptor signaling pathway (in ferred); FOUND IN cytosol (inferred); plasma membrane (inferred); SCAR complex (inferred) | | | | Green Monkey | 45 | symbol | gene, protein-coding |
| 155232155 | nckap1l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626033979 | Nckap1l | NCK associated protein 1 like | ENCODES a protein that exhibits GTPase activator activity (ortholog); protein kinase activator activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN actin polymerization-dependent cell motility (ortholog); B cell homeostasis (ortholog); B cell receptor signaling pathway (or tholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); immunodeficiency 72 (ortholog); FOUND IN cytosol (ortholog); plasma membrane (ortholog); SCAR complex (ortholog) | | | | Black Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232156 | nckap1l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 16561439 | AC068789.1 | novel transcript, antisense to NCKAP1L | | | | | Human | | name | gene, lncrna |
| 1314711 | ANKRD26 | ankyrin repeat domain 26 | This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] | 10 | 26947582 | 27100494 | Human | 171 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |