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Gene: NCKAP1 (NCK associated protein 1) Homo sapiens
Symbol: NCKAP1
Name: NCK associated protein 1
Description: Contributes to Rac GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Localizes to the SCAR complex; PARTICIPATES IN E-cadherin signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH aflatoxin B1; arsenous acid; artesunate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ11291; HEM2; KIAA0587; membrane-associated protein HEM-2; MGC8981; NAP 1; NAP1; NAP125; nck-associated protein 1; p125Nap1
Mus musculus (house mouse) : Nckap1 (NCK-associated protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nckap1 (NCK-associated protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nckap1 (NCK associated protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NCKAP1 (NCK associated protein 1)
Canis lupus familiaris (dog) : NCKAP1 (NCK associated protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nckap1 (NCK associated protein 1)
Sus scrofa (pig) : NCKAP1 (NCK associated protein 1)
Chlorocebus sabaeus (African green monkey) : NCKAP1 (NCK associated protein 1)
Heterocephalus glaber (naked mole-rat) : Nckap1 (NCK associated protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2182,909,115 - 183,038,858 (-)Ensembl
GRCh382182,909,115 - 183,038,457 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372183,789,579 - 183,903,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362183,497,850 - 183,611,474 (-)NCBINCBI36hg18NCBI36
Build 342183,615,110 - 183,728,735NCBI
Celera2177,385,839 - 177,499,386 (-)NCBI
Cytogenetic Map2q32.1NCBI
HuRef2175,647,499 - 175,761,404 (-)NCBIHuRef
CHM1_12183,795,489 - 183,909,486 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NCKAP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732467
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.