Nckap1l (NCK associated protein 1 like) - Rat Genome Database

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Gene: Nckap1l (NCK associated protein 1 like) Mus musculus
Analyze
Symbol: Nckap1l
Name: NCK associated protein 1 like
RGD ID: 1619908
MGI Page MGI
Description: Predicted to enable GTPase activator activity; TORC2 complex binding activity; and protein kinase activator activity. Involved in several processes, including lymphocyte homeostasis; negative regulation of cytokine production; and positive regulation of lymphocyte activation. Part of SCAR complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and musculature. Human ortholog(s) of this gene implicated in immunodeficiency 72. Orthologous to human NCKAP1L (NCK associated protein 1 like); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 4930568P13Rik; AI463083; Hem1; hematopoietic protein 1; Hemp1; nck-associated protein 1-like
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915103,362,219 - 103,411,288 (+)NCBIGRCm39mm39
GRCm39 Ensembl15103,362,221 - 103,407,237 (+)Ensembl
GRCm3815103,453,783 - 103,502,860 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15103,453,794 - 103,498,810 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715103,284,256 - 103,329,231 (+)NCBIGRCm37mm9NCBIm37
MGSCv3615103,281,859 - 103,326,834 (+)NCBImm8
Celera15105,611,951 - 105,656,787 (+)NCBICelera
Cytogenetic Map15F3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin polymerization-dependent cell motility  (ISO)
B cell homeostasis  (IMP)
B cell receptor signaling pathway  (ISO)
cell migration  (IBA)
cell morphogenesis  (IBA)
cell projection assembly  (IBA)
chemotaxis  (ISO)
cortical actin cytoskeleton organization  (IBA,IMP,ISO)
erythrocyte development  (ISO)
erythrocyte homeostasis  (IMP)
maintenance of cell polarity  (ISO)
myeloid cell homeostasis  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cytotoxic T cell degranulation  (ISO)
negative regulation of interleukin-17 production  (IMP)
negative regulation of interleukin-6 production  (IMP)
negative regulation of myosin-light-chain-phosphatase activity  (ISO)
neuron projection morphogenesis  (IBA)
neutrophil chemotaxis  (ISO)
positive regulation of actin filament polymerization  (IMP,ISO)
positive regulation of B cell differentiation  (IMP)
positive regulation of B cell proliferation  (ISO)
positive regulation of CD4-positive, alpha-beta T cell differentiation  (IMP)
positive regulation of CD8-positive, alpha-beta T cell differentiation  (IMP)
positive regulation of cell adhesion mediated by integrin  (IMP)
positive regulation of erythrocyte differentiation  (IMP)
positive regulation of gamma-delta T cell differentiation  (IMP)
positive regulation of leukocyte migration  (ISO)
positive regulation of lymphocyte differentiation  (IMP)
positive regulation of neutrophil chemotaxis  (IMP)
positive regulation of neutrophil migration  (ISO)
positive regulation of phagocytosis, engulfment  (IMP)
positive regulation of phosphorylation  (ISO)
positive regulation of T cell proliferation  (IMP,ISO)
positive regulation of TORC2 signaling  (ISO)
protein-containing complex assembly  (IMP)
response to xenobiotic stimulus  (ISO)
T cell homeostasis  (IMP)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal CD4-positive T cell differentiation  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal epididymis morphology  (IAGP)
abnormal erythroid progenitor cell morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal regulatory T cell number  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal thoracic cavity morphology  (IAGP)
abnormal thymus lobule morphology  (IAGP)
acanthocytosis  (IAGP)
amyloidosis  (IAGP)
cardiac fibrosis  (IAGP)
dacryocytosis  (IAGP)
decreased alpha-beta T cell number  (IEA)
decreased B cell number  (IEA)
decreased body weight  (IEA)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased central memory CD8 positive, alpha-beta T cell number  (IEA)
decreased double-positive T cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased mature gamma-delta T cell number  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased NK cell number  (IEA)
decreased T cell proliferation  (IAGP)
extramedullary hematopoiesis  (IAGP)
heart inflammation  (IAGP)
hypochromic microcytic anemia  (IAGP)
impaired macrophage phagocytosis  (IAGP)
impaired neutrophil chemotaxis  (IAGP)
impaired neutrophil phagocytosis  (IAGP)
increased alpha-beta T cell number  (IEA)
increased CD8-positive, alpha-beta T cell number  (IEA)
increased circulating interleukin-17 level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased double-negative T cell number  (IAGP)
increased effector memory CD4-positive, alpha-beta T cell number  (IEA)
increased effector memory CD8-positive, alpha-beta T cell number  (IEA)
increased erythrocyte osmotic fragility  (IAGP)
increased interleukin-17 secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
lymph node hypoplasia  (IAGP)
poikilocytosis  (IAGP)
reticulocytosis  (IAGP)
schistocytosis  (IAGP)
spleen hyperplasia  (IAGP)
thymus hypoplasia  (IAGP)
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18287559   PMID:19015308  
PMID:20697350   PMID:21267068   PMID:21308776   PMID:21677750   PMID:21873635   PMID:22922362   PMID:23424621   PMID:26975831   PMID:27775702   PMID:28378742   PMID:28892060   PMID:29915352  
PMID:30333137   PMID:32646852  


Genomics

Comparative Map Data
Nckap1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915103,362,219 - 103,411,288 (+)NCBIGRCm39mm39
GRCm39 Ensembl15103,362,221 - 103,407,237 (+)Ensembl
GRCm3815103,453,783 - 103,502,860 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15103,453,794 - 103,498,810 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715103,284,256 - 103,329,231 (+)NCBIGRCm37mm9NCBIm37
MGSCv3615103,281,859 - 103,326,834 (+)NCBImm8
Celera15105,611,951 - 105,656,787 (+)NCBICelera
Cytogenetic Map15F3NCBI
NCKAP1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1254,497,752 - 54,548,243 (+)EnsemblGRCh38hg38GRCh38
GRCh381254,497,752 - 54,548,243 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371254,891,536 - 54,942,027 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361253,177,762 - 53,223,166 (+)NCBINCBI36hg18NCBI36
Build 341253,177,779 - 53,223,160NCBI
Celera1254,543,329 - 54,588,759 (+)NCBI
Cytogenetic Map12q13.13-q13.2NCBI
HuRef1251,930,257 - 51,975,669 (+)NCBIHuRef
CHM1_11254,858,206 - 54,903,614 (+)NCBICHM1_1
Nckap1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27134,577,443 - 134,622,934 (+)NCBI
Rnor_6.0 Ensembl7145,068,286 - 145,113,507 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07145,068,239 - 145,113,507 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07142,849,455 - 142,894,585 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47142,351,954 - 142,397,045 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17142,432,180 - 142,475,970 (+)NCBI
Celera7131,001,894 - 131,046,866 (+)NCBICelera
Cytogenetic Map7q36NCBI
Nckap1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554581,733,883 - 1,784,182 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554581,733,799 - 1,785,591 (+)NCBIChiLan1.0ChiLan1.0
NCKAP1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11234,932,470 - 34,977,881 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1234,932,470 - 34,977,881 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01234,200,102 - 34,249,873 (-)NCBIMhudiblu_PPA_v0panPan3
NCKAP1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.127805,274 - 858,901 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27805,310 - 843,439 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2745,396,099 - 45,449,340 (+)NCBI
ROS_Cfam_1.027802,738 - 856,041 (-)NCBI
UMICH_Zoey_3.127795,107 - 848,346 (-)NCBI
UNSW_CanFamBas_1.027803,528 - 857,308 (-)NCBI
UU_Cfam_GSD_1.02745,799,997 - 45,853,537 (+)NCBI
Nckap1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494561,430,392 - 61,521,726 (-)NCBI
SpeTri2.0NW_00493651211,683,330 - 11,734,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCKAP1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl519,677,875 - 19,723,132 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1519,677,613 - 19,720,550 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NCKAP1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11150,611,193 - 50,658,800 (+)NCBI
Vero_WHO_p1.0NW_023666037195,373,507 - 195,426,134 (-)NCBI
Nckap1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249042,508,576 - 2,575,505 (+)NCBI

Position Markers
D15Mit79  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815103,472,156 - 103,472,268UniSTSGRCm38
MGSCv3715103,302,587 - 103,302,699UniSTSGRCm37
Celera15105,630,278 - 105,630,386UniSTS
Cytogenetic Map15F3UniSTS
cM Map1566.2UniSTS
Whitehead Genetic1563.4UniSTS
Whitehead/MRC_RH15914.29UniSTS
AI463083  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3815103,497,585 - 103,497,684UniSTSGRCm38
MGSCv3715103,328,016 - 103,328,115UniSTSGRCm37
Celera15105,655,572 - 105,655,671UniSTS
Cytogenetic Map15F3UniSTS
Whitehead/MRC_RH15914.29UniSTS
Nckap1l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15F3UniSTS
cM Map15 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556323312103517472Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564434485103517472Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570461452104043685Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570465070104043685Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570465070104043685Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572498466104043685Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573545941104043685Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577629711104043685Mouse
14928306Manh79_mmandible shape 79 (mouse)1578949676104043685Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1579000000104043685Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579265530104043685Mouse
4141897Imrfq2_mimmune response to Factor IX QTL 2 (mouse)Not determined80011059104043685Mouse
1301284Cosz3_mcocaine seizure 3 (mouse)Not determined1580415753104043685Mouse
4141902Cia37_mcollagen induced arthritis 37 (mouse)Not determined1580987052104043685Mouse
1300974Pgia9_mproteoglycan induced arthritis 9 (mouse)Not determined1580987052104043685Mouse
4141511Gdcr1_mglycerolphosphate dehydrogenase regulator 1 (mouse)Not determined82717593104043685Mouse
1357614Bmca_mbile mucin accumulation (mouse)Not determined1585988005104043685Mouse
11530037Sluc34a_msusceptibility to lung cancer 34a (mouse)1585988005104043685Mouse
11530038Sluc34b_msusceptibility to lung cancer 34b (mouse)1585988005104043685Mouse
1301918Skull22_mskull morphology 22 (mouse)Not determined1585993114104043685Mouse
1301764Chab4_mcholesterol absorption 4 (mouse)Not determined1586751919104043685Mouse
4141581Dshv1_mdorsal hippocampal volume 1 (mouse)Not determined92890759103517472Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:479
Count of miRNA genes:324
Interacting mature miRNAs:384
Transcripts:ENSMUST00000047405
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000047405   ⟹   ENSMUSP00000035400
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl15103,453,827 - 103,498,810 (+)Ensembl
RefSeq Acc Id: ENSMUST00000229127   ⟹   ENSMUSP00000154960
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl15103,453,799 - 103,498,206 (+)Ensembl
RefSeq Acc Id: ENSMUST00000229468
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl15103,453,794 - 103,498,801 (+)Ensembl
RefSeq Acc Id: ENSMUST00000229835
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl15103,479,135 - 103,497,938 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230276
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl15103,479,148 - 103,498,809 (+)Ensembl
RefSeq Acc Id: NM_153505   ⟹   NP_705725
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915103,362,252 - 103,407,227 (+)NCBI
GRCm3815103,453,825 - 103,498,800 (+)NCBI
MGSCv3715103,284,256 - 103,329,231 (+)RGD
Celera15105,611,951 - 105,656,787 (+)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006520255   ⟹   XP_006520318
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3915103,362,219 - 103,411,288 (+)NCBI
GRCm3815103,453,783 - 103,502,860 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_705725   ⟸   NM_153505
- UniProtKB: Q8K1X4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006520318   ⟸   XM_006520255
- Peptide Label: isoform X1
- UniProtKB: Q8K1X4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035400   ⟸   ENSMUST00000047405
RefSeq Acc Id: ENSMUSP00000154960   ⟸   ENSMUST00000229127

Promoters
RGD ID:6826261
Promoter ID:MM_KWN:19912
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Spleen
Transcripts:NM_153505
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615103,283,951 - 103,284,451 (+)MPROMDB
RGD ID:6826262
Promoter ID:MM_KWN:19913
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour
Transcripts:UC007XYG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3615103,308,951 - 103,309,537 (+)MPROMDB
RGD ID:8685282
Promoter ID:EPDNEW_M20672
Type:initiation region
Name:Nckap1l_1
Description:Mus musculus NCK associated protein 1 like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20673  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815103,453,846 - 103,453,906EPDNEW
RGD ID:8685286
Promoter ID:EPDNEW_M20673
Type:multiple initiation site
Name:Nckap1l_2
Description:Mus musculus NCK associated protein 1 like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M20672  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3815103,461,055 - 103,461,115EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1926063 AgrOrtholog
Ensembl Genes ENSMUSG00000022488 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035400 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000154960 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000047405 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000229127 UniProtKB/TrEMBL
InterPro Nck-associated_protein-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:105855 UniProtKB/Swiss-Prot
MGD MGI:1926063 ENTREZGENE
NCBI Gene 105855 ENTREZGENE
PANTHER PTHR12093 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Nckap1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nckap1l PhenoGen
UniProt A0A2R8VHC4_MOUSE UniProtKB/TrEMBL
  NCKPL_MOUSE UniProtKB/Swiss-Prot
  Q3UDY0_MOUSE UniProtKB/TrEMBL
  Q8BVQ3_MOUSE UniProtKB/TrEMBL
  Q8K1X4 ENTREZGENE