| 621319 | Fgr | FGR proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity; Fc-gamma receptor I complex binding (ortholog); immunoglobulin receptor binding (ortholog); INVOLVED IN myoblast proliferation; bone mineralization (ortholog); defense response to Gram-positive bacterium (ortholog); PARTICIPATES IN ei cosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (ortholog); cytoskeleton (ortholog); plasma membrane (ortholog); INTERACTS WITH (R)-noradrenaline; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 150473767 | 150503524 | Rat | 191 | symbol , old_gene_name , PhenoGen , name , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733253 | FGR | FGR proto-oncogene, Src family tyrosine kinase | This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and prolin e-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] | 1 | 27612064 | 27635185 | Human | 208 | symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733254 | Fgr | FGR proto-oncogene, Src family tyrosine kinase | Enables several functions, including immunoglobulin receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including integrin-mediated signaling pathway; negative regulation of natural killer cel l activation; and regulation of vesicle-mediated transport. Acts upstream of or within bone mineralization and skeletal system morphogenesis. Located in plasma membrane. Colocalizes with actin cytoskeleton and ruffle membrane. Is expressed in 2-cell stage embryo; blastocyst; metanephros; nervous system; and neural ectoderm. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 132701406 | 132729204 | Mouse | 210 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8939400 | Fgr | FGR proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits Fc-gamma receptor I complex binding (ortholog); immunoglobulin receptor binding (ortholog); non-membrane spanning protein tyrosine kinase activity (ortholog); INVOLVED IN bone mineralization (ortholog); defense response to Gram-positive bacterium (ortholog); integrin- mediated signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (ortholog); cytoskeleton (ortholog); plasma membrane (ortholog) | NW_004955452 | 6840274 | 6863460 | Chinchilla | 48 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11790089 | FGR | FGR proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN bone mineralization (ortholog); defense response to Gram-positive bacterium (ortholog); myoblast proliferation (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional sig naling axis; glypican signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (inferred); cytoskeleton (inferred); cytosol (inferred) | 1 | 26872781 | 26895751 | Bonobo | 61 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12376828 | FGR | FGR proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN bone mineralization (ortholog); defense response to Gram-positive bacterium (ortholog); myoblast proliferation (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional sig naling axis; glypican signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (inferred); cytoskeleton (inferred); plasma membrane (inferred) | 2 | 72678858 | 72692417 | Dog | 60 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12584903 | Fgr | FGR proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN bone mineralization (ortholog); defense response to Gram-positive bacterium (ortholog); myoblast proliferation (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional sig naling axis; glypican signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred) | NW_004936474 | 11897998 | 11919153 | Squirrel | 57 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 13914915 | FGR | FGR proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN bone mineralization (ortholog); defense response to Gram-positive bacterium (ortholog); myoblast proliferation (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional sig naling axis; glypican signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (inferred); cytoskeleton (inferred); plasma membrane (inferred); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 63 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18503499 | FGR | FGR proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN bone mineralization (ortholog); defense response to Gram-positive bacterium (ortholog); myoblast proliferation (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional sig naling axis; glypican signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (inferred); cytoskeleton (inferred); cytosol (inferred) | | | | Green Monkey | 60 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18920644 | Fgr | FGR proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits Fc-gamma receptor I complex binding (ortholog); immunoglobulin receptor binding (ortholog); non-membrane spanning protein tyrosine kinase activity (ortholog); INVOLVED IN bone mineralization (ortholog); defense response to Gram-positive bacterium (ortholog); integrin- mediated signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (ortholog); plasma membrane (ortholog); ruffle membrane (ortholog) | | | | Naked Mole-Rat | 65 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155240369 | fgr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625890791 | Fgr | FGR proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits Fc-gamma receptor I complex binding (ortholog); immunoglobulin receptor binding (ortholog); non-membrane spanning protein tyrosine kinase activity (ortholog); INVOLVED IN bone mineralization (ortholog); defense response to Gram-positive bacterium (ortholog); integrin- mediated signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (ortholog); cytoskeleton (ortholog); plasma membrane (ortholog) | | | | Black Rat | 48 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 155254727 | fgr.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155245507 | fgr.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 620713 | Fgfr1 | Fibroblast growth factor receptor 1 | ENCODES a protein that exhibits cell adhesion molecule binding; protein-containing complex binding; signaling receptor binding; INVOLVED IN cellular response to histamine; cellular response to lipopolysaccharide; cellular response to nerve growth factor stimulus; PARTICIPATES IN cerium oxide nanopar ticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; ASSOCIATED WITH Burns; Experimental Liver Cirrhosis; Experimental Seizures; FOUND IN perinuclear region of cytoplasm; glutamatergic synapse (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2-amino-2-deoxy-D-glucopyranose; 3,3',5-triiodo-L-thyronine | 16 | 73194631 | 73249855 | Rat | 539 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732291 | Fgfr1 | fibroblast growth factor receptor 1 | Enables SH2 domain binding activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor activity. Involved in several processes, including cementum mineralization; diphosphate metabolic process; and forebrain development. Acts upstream of or within several processes, in cluding ear development; positive regulation of cell population proliferation; and regulation of animal organ morphogenesis. Located in plasma membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Pfeiffer syndrome; atopic dermatitis; and otitis media. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); carcinoma (multiple); hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 26008808 | 26067819 | Mouse | 985 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 6893411 | Fynem1Mcwi | FYN oncogene related to SRC, FGR, YES; zinc finger nuclease induced mutant 1, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting mutation is a 7-bp deletion in exon 4 (del 383-389) | | | | Rat | | name | gene, allele |
| 6893380 | Fynem6Mcwi | FYN oncogene related to SRC, FGR, YES; zinc finger nuclease induced mutant 6, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting mutation is an 8-bp deletion in exon 4 (del 385-392) | | | | Rat | | name | gene, allele |
| 732290 | FGFR1 | fibroblast growth factor receptor 1 | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length r epresentative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] | 8 | 38411143 | 38468635 | Human | 1343 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 2641 | Fyn | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding; CD8 receptor binding; enzyme binding; INVOLVED IN cellular response to glycine; cellular response to growth factor stimulus; cellular response to hydrogen peroxide; PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; e icosanoid signaling pathway; ASSOCIATED WITH Burns; Sepsis; temporal lobe epilepsy; FOUND IN dendrite; glutamatergic synapse; mitochondrion; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 20 | 44322635 | 44514498 | Rat | 493 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731929 | FYN | FYN proto-oncogene, Src family tyrosine kinase | This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alte rnatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008] | 6 | 111660332 | 111873452 | Human | 557 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 9064220 | Fyn | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits alpha-tubulin binding (ortholog); CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN actin filament (ortholog); cell body (ortholog); cell periphery (ortholog) | NW_004955411 | 36403156 | 36597660 | Chinchilla | 247 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11825903 | FYN | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Ree lin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog) | 6 | 109469750 | 109684086 | Bonobo | 252 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12067709 | FYN | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Ree lin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog) | 12 | 68105060 | 68316630 | Dog | 264 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12566780 | Fyn | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Ree lin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog) | NW_004936679 | 388500 | 588518 | Squirrel | 247 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18917612 | Fyn | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits alpha-tubulin binding (ortholog); CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN altered Reelin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN actin filament (ortholog); cell body (ortholog); cell periphery (ortholog) | | | | Naked Mole-Rat | 252 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14050710 | FYN | FYN proto-oncogene, Src family tyrosine kinase | ENCODES a protein that exhibits CD4 receptor binding (ortholog); CD8 receptor binding (ortholog); enzyme binding (ortholog); INVOLVED IN activated T cell proliferation (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to glycine (ortholog); PARTICIPATES IN altered Ree lin signaling pathway; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); alcohol dependence (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); membrane raft (ortholog); mitochondrion (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 268 | old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550101 | Akr1b8 | aldo-keto reductase family 1, member B8 | Predicted to enable several functions, including NADP binding activity; geranylgeranyl reductase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be located in extracellular region and lysosome. Predicted to be active in cytosol and mi tochondrion. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and respiratory system. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 34331081 | 34345396 | Mouse | 76 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
