| 61318 | Cd69 | Cd69 molecule | ENCODES a protein that exhibits calcium ion binding; identical protein binding (ortholog); molecular sequestering activity (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of T cell migration (or tholog); ASSOCIATED WITH arthritis (ortholog); Experimental Arthritis (ortholog); Spontaneous Abortions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; acetamide | 4 | 164411485 | 164419403 | Rat | 165 | symbol , old_gene_name , PhenoGen , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735248 | Cd69 | CD69 antigen | Predicted to enable calcium ion binding activity and identical protein binding activity. Involved in cellular response to xenobiotic stimulus. Located in external side of plasma membrane. Orthologous to human CD69 (CD69 mole cule). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 129244287 | 129252332 | Mouse | 190 | symbol , old_gene_name , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1351395 | CD69 | CD69 molecule | This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011] | 12 | 9752486 | 9760901 | Human | 165 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8961508 | Cd69 | CD69 molecule | ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); molecular sequestering activity (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of T cell mi gration (ortholog); ASSOCIATED WITH arthritis (ortholog); Experimental Arthritis (ortholog); Spontaneous Abortions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog) | NW_004955413 | 5579037 | 5586238 | Chinchilla | 19 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11863847 | CD69 | CD69 molecule | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH arthritis (ortholog); Experimental Arthritis (ortholog); Spontaneous Abortions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membra ne (ortholog) | 12 | 9800446 | 9808874 | Bonobo | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12186075 | CD69 | CD69 molecule | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH arthritis (ortholog); Experimental Arthritis (ortholog); Spontaneous Abortions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membra ne (ortholog) | 27 | 36197202 | 36205045 | Dog | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14092966 | CD69 | CD69 molecule | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (inferred); negative regulation of inflammatory response (inferred); negative regulation of T cell migration (inferred); ASSOCIATED WITH arthritis (ortholog); Experimental Arthritis ( ortholog); Spontaneous Abortions (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); plasma membrane (inferred) | | | | Pig | 21 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18528951 | CD69 | CD69 molecule | ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cellular response to xenobiotic stimulus (ortholog); ASSOCIATED WITH arthritis (ortholog); Experimental Arthritis (ortholog); Spontaneous Abortions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membra ne (ortholog) | | | | Green Monkey | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18901677 | Cd69 | CD69 molecule | ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); molecular sequestering activity (ortholog); INVOLVED IN negative regulation of inflammatory response (ortholog); negative regulation of T cell migration (ortholog); negative regulation of T-helper 1 7 cell lineage commitment (ortholog); ASSOCIATED WITH arthritis (ortholog); Experimental Arthritis (ortholog); Spontaneous Abortions (ortholog); FOUND IN plasma membrane (ortholog); protein-containing complex (ortholog) | | | | Naked Mole-Rat | 21 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626174659 | cd69 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626177420 | cd69 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626178949 | cd69 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626179682 | cd69 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626182988 | cd69 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626188567 | cd69 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626188814 | cd69 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626150174 | LOC116904568 | early activation antigen CD69-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 625896310 | LOC116904569 | early activation antigen CD69-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 1565373 | Clec2l | C-type lectin domain family 2, member L | ENCODES a protein that exhibits carbohydrate binding (inferred); FOUND IN membrane (inferred); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 4 | 68359021 | 68381431 | Rat | 31 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1564770 | Clec2m | C-type lectin domain family 2, member M | ENCODES a protein that exhibits carbohydrate binding (inferred); ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); Behcet's disease (ortholog); FOUND IN membrane (inferred); INTERACTS WITH bisphenol A; DDT; vinclozolin | 4 | 164455031 | 164465936 | Rat | 17 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 737541 | ADH7 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The e nzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] | 4 | 99412263 | 99435342 | Human | 172 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1345853 | AMY1C | amylase alpha 1C | Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. [provided by RefSeq, Jul 2008] | 1 | 103749654 | 103758692 | Human | 36 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1607057 | ANKRD17 | ankyrin repeat domain 17 | The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear locali zation signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] | 4 | 73073376 | 73258798 | Human | 163 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1351716 | ARHGAP25 | Rho GTPase activating protein 25 | ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008] | 2 | 68710544 | 68826833 | Human | 83 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1601723 | BCDIN3D | BCDIN3 domain containing RNA methyltransferase | This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group dono r, S-adenosylmethionine. This gene is overexpressed in breast cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast cancer. The encoded protein is thought to promote the cellular invasion of breast cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017] | 12 | 49836043 | 49843106 | Human | 72 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1343435 | BPIFB1 | BPI fold containing family B member 1 | The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluste r on chromosome 20. [provided by RefSeq, Jul 2008] | 20 | 33283214 | 33309871 | Human | 60 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1315346 | CARMIL1 | capping protein regulator and myosin 1 linker 1 | Involved in several processes, including actin filament network formation; plasma membrane bounded cell projection organization; and positive regulation of cellular component organization. Located in several cellular components, including lamellipodium; macropinosome; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 25279374 | 25620530 | Human | 154 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1604061 | CCL5 | C-C motif chemokine ligand 5 | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residu es of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] | 17 | 35871491 | 35880360 | Human | 920 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1318406 | CCR6 | C-C motif chemokine receptor 6 | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] | 6 | 167111795 | 167139141 | Human | 233 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 10305 | CD2 | CD2 molecule | The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene. [provided by R efSeq, Jun 2016] | 1 | 116754430 | 116769229 | Human | 129 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1603569 | CFAP57 | cilia and flagella associated protein 57 | This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member is thought to function in craniofacial development, possibly in the fusion of lip and palate. A missense mutation in this gene is associated with Van der Woude syndrome 2. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] | 1 | 43172330 | 43254358 | Human | 39 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1347509 | CFLAR | CASP8 and FADD like apoptosis regulator | The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011] | 2 | 201116164 | 201176687 | Human | 451 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1315278 | CLIC2 | chloride intracellular channel 2 | This gene encodes a chloride intracellular channel protein. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Th is protein plays a role in inhibiting the function of ryanodine receptor 2. A mutation in this gene is the cause of an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017] | X | 155276211 | 155334614 | Human | 131 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1349263 | CNTN4 | contactin 4 | This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in t he formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011] | 3 | 2098866 | 3057959 | Human | 98 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1345570 | COPS4 | COP9 signalosome subunit 4 | This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 sig nalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] | 4 | 83035183 | 83075818 | Human | 117 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1322237 | CRADD | CARD and death domain containing adaptor protein | This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 12 | 93677375 | 93894840 | Human | 154 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1316588 | DAZAP2 | DAZ associated protein 2 | This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eu karyotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] | 12 | 51238826 | 51246717 | Human | 106 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 735779 | DIO2 | iodothyronine deiodinase 2 | The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the conversion of prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4) to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by outer ring 5'-deiodination. This gene is widely expressed, includi ng in thyroid and brain. It is thought to be responsible for the 'local' production of T3, and thus important in influencing thyroid hormone action in these tissues. It has also been reported to be highly expressed in thyroids of patients with Graves disease, and in follicular adenomas. The intrathyroidal T4 to T3 conversion by this enzyme may contribute significantly to the relative increase in thyroidal T3 production in these patients. This protein is a selenoprotein containing the non-standard amino acid, selenocysteine (Sec), which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Unlike the other two members (DIO1 and DIO3) of this enzyme family, the mRNA for this gene contains an additional in-frame UGA codon that has been reported (in human) to function either as a Sec or a stop codon, which can result in two isoforms with one or two Sec residues; however, only the upstream Sec (conserved with the single Sec residue found at the active site in DIO1 and DIO3) was shown to be essential for enzyme activity (PMID:10403186). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2018] | 14 | 80197526 | 80231057 | Human | 317 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1345008 | DRC9 | dynein regulatory complex subunit 9 | Enables Hsp70 protein binding activity and calmodulin binding activity. Predicted to be involved in sperm axoneme assembly. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 197889077 | 197960177 | Human | 99 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 14700608 | EML4-AS1 | EML4 antisense RNA 1 | | 2 | 42142435 | 42170231 | Human | | GenBank Nucleotide | gene, ncrna, VALIDATED [RefSeq] |
| 1605898 | FAAP24 | FA core complex associated protein 24 | FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008] | 19 | 32972242 | 32978229 | Human | 49 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1604549 | FCRL3 | Fc receptor like 3 | This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmi c domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 1 | 157676481 | 157700956 | Human | 37 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1318329 | FOLR2 | folate receptor beta | The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolat e to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | 11 | 72216794 | 72221950 | Human | 118 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1603714 | FYB1 | FYN binding protein 1 | The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provid ed by RefSeq, Jul 2011] | 5 | 39105252 | 39274528 | Human | 145 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 12904515 | HTD2 | hydroxyacyl-thioester dehydratase type 2 | This gene encodes a protein that localizes to the mitochondria and can function as a 3-hydroxyacyl thioester dehydratase. This gene is located just downstream of the gene for ribonuclease P/MRP subunit p14 (RPP14) in a genomic context that is conserved among animals. The upstream RPP14 gene is thoug ht to be co-transcribed with this gene, and bicistronic transcripts may include open reading frames for both proteins. [provided by RefSeq, May 2017] | 3 | 58306245 | 58320193 | Human | 19 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1346818 | IDO1 | indoleamine 2,3-dioxygenase 1 | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotoni n. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011] | 8 | 39913891 | 39928790 | Human | 250 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 6893148 | LINC00649 | long intergenic non-protein coding RNA 649 | INTERACTS WITH 4,4'-sulfonyldiphenol; clothianidin; DDE | 21 | 33931122 | 33971186 | Human | 6 | GenBank Nucleotide | gene, ncrna, VALIDATED [RefSeq] |
| 7251771 | LINC00892 | long intergenic non-protein coding RNA 892 | INTERACTS WITH cadmium atom; cadmium dichloride; diuron | X | 136639543 | 136642429 | Human | 4 | GenBank Nucleotide | gene, ncrna, VALIDATED [RefSeq] |
| 1321494 | LPP | LIM domain containing preferred translocation partner in lipoma | This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This prot ein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] | 3 | 188153021 | 188890671 | Human | 187 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1320546 | LY86 | lymphocyte antigen 86 | Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 6588720 | 6654982 | Human | 117 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1323750 | MS4A1 | membrane spanning 4-domains A1 | This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene enc odes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008] | 11 | 60455847 | 60470752 | Human | 132 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1342584 | NDUFS4 | NADH:ubiquinone oxidoreductase subunit S4 | This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitoch ondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] | 5 | 53560639 | 53683338 | Human | 342 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1352493 | NINJ2 | ninjurin 2 | The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after ner ve injury. [provided by RefSeq, Oct 2011] | 12 | 564296 | 663445 | Human | 87 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 7244909 | NRAV | negative regulator of antiviral response | INTERACTS WITH aflatoxin B1; avobenzone; benzo[a]pyrene | 12 | 120490338 | 120495946 | Human | 11 | GenBank Nucleotide | gene, ncrna, VALIDATED [RefSeq] |
| 1605656 | PBRM1 | polybromo 1 | This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primar y clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012] | 3 | 52545367 | 52685913 | Human | 154 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1603975 | PCNP | PEST proteolytic signal containing nuclear protein | Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 101574094 | 101594465 | Human | 86 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1605683 | PHF20 | PHD finger protein 20 | Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nuclear membrane; and nucleoplasm. Part of MLL1 complex and NSL complex. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 35772015 | 35950370 | Human | 73 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1322769 | PHPT1 | phosphohistidine phosphatase 1 | This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternativ e splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] | 9 | 136849409 | 136851024 | Human | 108 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1322218 | PITRM1 | pitrilysin metallopeptidase 1 | The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016] | 10 | 3137727 | 3172841 | Human | 120 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1313510 | PRPF8 | pre-mRNA processing factor 8 | Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein- protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008] | 17 | 1650629 | 1684867 | Human | 529 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1604500 | PRR14L | proline rich 14 like | INTERACTS WITH 17beta-estradiol; 2-hydroxypropanoic acid; aflatoxin B1 | 22 | 31681347 | 31750132 | Human | 55 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1351950 | PSMD6 | proteasome 26S subunit, non-ATPase 6 | This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provide d by RefSeq, Nov 2012] | 3 | 64010551 | 64024007 | Human | 126 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1317504 | PTPN22 | protein tyrosine phosphatase non-receptor type 22 | This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell recep tor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009] | 1 | 113813811 | 113871759 | Human | 470 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1350281 | SCFD1 | sec1 family domain containing 1 | Predicted to enable syntaxin binding activity. Involved in negative regulation of autophagosome assembly; regulation of protein transport; and response to toxic substance. Located in cis-Golgi network. [provided by Alliance of Genome Resources, Jul 2025] | 14 | 30622254 | 30735850 | Human | 108 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 731355 | SCLT1 | sodium channel and clathrin linker 1 | This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is neces sary for ciliogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] | 4 | 128873241 | 129093539 | Human | 198 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1346641 | SF3B1 | splicing factor 3b subunit 1 | This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 2 | 197389784 | 197435093 | Human | 284 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1313532 | SFR1 | SWI5 dependent homologous recombination repair protein 1 | Enables transcription coactivator activity. Involved in cellular response to estrogen stimulus; double-strand break repair via homologous recombination; and positive regulation of DNA-templated transcription. Located in centrosome; nucleolus; and nucleoplasm. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 104120166 | 104126383 | Human | 81 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1606148 | SHLD1 | shieldin complex subunit 1 | Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in site of double-strand break. [provided by Alliance of Genome Resources , Jul 2025] | 20 | 5750193 | 5864395 | Human | 64 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1352815 | SOCS2 | suppressor of cytokine signaling 2 | This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] | 12 | 93569969 | 93626236 | Human | 320 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1603042 | TMX2 | thioredoxin related transmembrane protein 2 | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane do main and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017] | 11 | 57712593 | 57740973 | Human | 88 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1351958 | TNFSF8 | TNF superfamily member 8 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] | 9 | 114893343 | 114930595 | Human | 121 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 2937319 | TRANK1 | tetratricopeptide repeat and ankyrin repeat containing 1 | ASSOCIATED WITH Abnormal brain FDG positron emission tomography; Abnormal eating behavior; Abnormal speech pattern; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; acrolein | 3 | 36826819 | 36945744 | Human | 125 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1350228 | TRAPPC2 | trafficking protein particle complex subunit 2 | The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010] | X | 13712245 | 13734620 | Human | 208 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1318085 | UBE2L3 | ubiquitin conjugating enzyme E2 L3 | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein liga ses (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009] | 22 | 21549447 | 21624034 | Human | 204 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1347936 | VWF | von Willebrand factor | This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mu tations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015] | 12 | 5948877 | 6124670 | Human | 963 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
| 1349966 | ZNF200 | zinc finger protein 200 | Predicted to enable zinc ion binding activity. Involved in protein localization to nucleus. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 3222325 | 3235158 | Human | 43 | GenBank Nucleotide | gene, protein-coding, VALIDATED [RefSeq] |
| 1352355 | ZNF382 | zinc finger protein 382 | This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signalin g and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] | 19 | 36605313 | 36634114 | Human | 69 | GenBank Nucleotide | gene, protein-coding, REVIEWED [RefSeq] |
