SF3B1 (splicing factor 3b subunit 1)

Gene: SF3B1 (splicing factor 3b subunit 1) Homo sapiens

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Symbol:

SF3B1

Name:

splicing factor 3b subunit 1

Description:

Exhibits RNA binding activity and splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Localizes to the nucleus. Implicated in myelodysplastic syndrome.

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

Hsh155; MDS; pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; pre-mRNA-splicing factor SF3b 155 kDa subunit; PRP10; PRPF10; SAP 155; SAP155; SF3b155; spliceosome associated protein 155; spliceosome-associated protein 155; splicing factor 3b, subunit 1, 155kD; splicing factor 3b, subunit 1, 155kDa

Orthologs:

Mus musculus (house mouse) : Sf3b1 (splicing factor 3b, subunit 1) MGI Alliance
Rattus norvegicus (Norway rat) : Sf3b1 (splicing factor 3b, subunit 1) Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sf3b1 (splicing factor 3b subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SF3B1 (splicing factor 3b subunit 1)
Canis lupus familiaris (dog) : SF3B1 (splicing factor 3b subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sf3b1 (splicing factor 3b subunit 1)
Sus scrofa (pig) : SF3B1 (splicing factor 3b subunit 1)
Chlorocebus sabaeus (African green monkey) : SF3B1 (splicing factor 3b subunit 1)
Heterocephalus glaber (naked mole-rat) : Sf3b1 (splicing factor 3b subunit 1)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Sf3b1 (splicing factor 3b, subunit 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Sf3b1 (splicing factor 3b, subunit 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Sf3b1 (splicing factor 3b subunit 1)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	SF3B1 (splicing factor 3b subunit 1)	NCBI	Ortholog
Canis lupus familiaris (dog):	SF3B1 (splicing factor 3b subunit 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sf3b1 (splicing factor 3b subunit 1)	NCBI	Ortholog
Sus scrofa (pig):	SF3B1 (splicing factor 3b subunit 1)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (African green monkey):	SF3B1 (splicing factor 3b subunit 1)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Sf3b1 (splicing factor 3b subunit 1)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Sf3b1 (splicing factor 3b, subunit 1)	Alliance	DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Mus musculus (house mouse):	Sf3b1 (splicing factor 3b, subunit 1)	Alliance	DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):	sf3b1 (splicing factor 3b, subunit 1)	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, ZFIN)
Saccharomyces cerevisiae (baker's yeast):	HSH155	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):	Sf3b1	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):	sftb-1	Alliance	DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38 Ensembl	2	197,388,515 - 197,435,091 (-)	Ensembl
GRCh38	2	197,389,784 - 197,435,093 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	198,256,698 - 198,299,815 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	197,964,943 - 198,008,016 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	198,082,205 - 198,125,277	NCBI
Celera	2	192,012,574 - 192,055,648 (-)	NCBI
Cytogenetic Map	2	q33.1	NCBI
HuRef	2	190,109,104 - 190,152,365 (-)	NCBI		HuRef
CHM1_1	2	198,262,509 - 198,305,651 (-)	NCBI		CHM1_1

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Genomics

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miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences

Protein Sequences

Promoters

Clinical Variants

Additional Information

External Database Links

Nomenclature History

More on SF3B1
	Alliance Gene
	NCBI Gene
	Ensembl Gene
	JBrowse: hg19 hg38
	HGNC Report
	NCBI Genome Data Viewer

RGD Object Information
RGD ID:	1346641
Created:	2005-03-08
Species:	Homo sapiens
Last Modified:	2020-02-11
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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Imported Annotations - ClinVar

Imported Annotations - CTD

Imported Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)