Atg3 (autophagy related 3) - Rat Genome Database

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Gene: Atg3 (autophagy related 3) Rattus norvegicus
Analyze
Symbol: Atg3
Name: autophagy related 3
RGD ID: 708464
Description: Enables Atg8-family conjugating enzyme activity. Involved in autophagy. Predicted to be part of Atg12-Atg5-Atg16 complex. Predicted to be active in cytosol and phagophore assembly site. Orthologous to human ATG3 (autophagy related 3); PARTICIPATES IN autophagy pathway; INTERACTS WITH 3,3',5,5'-tetrabromobisphenol A; 4-nonylphenol; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: APG3 autophagy 3-like; APG3 autophagy 3-like (S. cerevisiae); APG3-like; Apg3l; ATG3 autophagy related 3 homolog; ATG3 autophagy related 3 homolog (S. cerevisiae); autophagy-related 3; autophagy-related 3 (yeast); autophagy-related protein 3; PIG-1; Pig1; preconditioning-inducible gene 1 protein; ubiquitin-like-conjugating enzyme ATG3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,130,948 - 69,159,280 (-)NCBIGRCr8
mRatBN7.21155,624,914 - 55,653,249 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,624,917 - 55,653,224 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,438,596 - 64,466,930 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,100,453 - 57,128,787 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,170,970 - 56,199,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,585,192 - 60,613,706 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,585,171 - 60,613,718 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,687,322 - 64,715,836 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,162,205 - 57,190,568 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,219,793 - 57,248,157 (-)NCBI
Celera1155,191,074 - 55,219,238 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Atg3Ratalcoholic cardiomyopathy treatmentISORGD:1557224407532638 RGD 
Atg3Ratalcoholic hepatitis treatmentISORGD:1557224407532639 RGD 

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Original Reference(s)
Atg3Rat1,2-dimethylhydrazine multiple interactionsISORGD:15572246480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of ATG3 mRNACTDPMID:22206623
Atg3Rat17beta-estradiol decreases expressionISORGD:15572246480464Estradiol results in decreased expression of ATG3 mRNACTDPMID:39298647
Atg3Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISORGD:135341664804642,2',4,4'-tetrabromodiphenyl ether results in decreased expression of ATG3 proteinCTDPMID:31675489
Atg3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:15572246480464Tetrachlorodibenzodioxin affects the expression of ATG3 mRNACTDPMID:21570461
Atg3Rat2,4,6-tribromophenol decreases expressionISORGD:135341664804642,4,6-tribromophenol results in decreased expression of ATG3 mRNACTDPMID:31675489
Atg3Rat2-bromohexadecanoic acid multiple interactionsISORGD:135341664804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ...CTDPMID:38195004
Atg3Rat2-deoxy-D-glucose multiple interactionsISORGD:13534166480464Deoxyglucose affects the reaction [demycarosyl-3D-digitoxosylmithramycin SK affects the expression of ATG3 mRNA]CTDPMID:26079942
Atg3Rat3,3',5,5'-tetrabromobisphenol A decreases expressionEXP 6480464tetrabromobisphenol A results in decreased expression of ATG3 mRNACTDPMID:28970181
Atg3Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISORGD:13534166480464tetrabromobisphenol A results in decreased expression of ATG3 proteinCTDPMID:31675489
Atg3Rat4,4'-sulfonyldiphenol decreases expressionISORGD:15572246480464bisphenol S results in decreased expression of ATG3 mRNACTDPMID:29741722
Atg3Rat4,4'-sulfonyldiphenol increases expressionISORGD:13534166480464bisphenol S results in increased expression of ATG3 proteinCTDPMID:34186270
Atg3Rat4-nonylphenol increases expressionEXP 64804644-nonylphenol results in increased expression of ATG3 mRNACTDPMID:28041982
Atg3Rat4-phenylbutyric acid multiple interactionsISORGD:135341664804644-phenylbutyric acid inhibits the reaction [Cantharidin results in increased expression of ATG3 protein]CTDPMID:35398186
Atg3Ratacrylamide increases expressionISORGD:15572246480464Acrylamide results in increased expression of ATG3 mRNACTDPMID:34569336
Atg3Rataldehydo-D-glucose increases expressionEXP 6480464Glucose results in increased expression of ATG3 mRNACTDPMID:38444079
Atg3Rataldehydo-D-glucose decreases expressionEXP 6480464Glucose results in decreased expression of ATG3 proteinCTDPMID:39127087
Atg3Rataldehydo-D-glucose multiple interactionsEXP 6480464Berberine inhibits the reaction [Glucose results in decreased expression of ATG3 protein]CTDPMID:39127087
Atg3Ratall-trans-retinoic acid multiple interactionsISORGD:13534166480464SPI1 protein affects the reaction [Tretinoin results in increased expression of ATG3 mRNA]CTDPMID:29743969
Atg3Ratall-trans-retinoic acid increases expressionISORGD:13534166480464Tretinoin results in increased expression of ATG3 mRNACTDPMID:29743969
Atg3Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of ATG3 mRNACTDPMID:16483693

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Biological Process
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Original Reference(s)
Atg3Ratautophagosome assembly involved_inISORGD:15572241624291 PMID:20723759, PMID:24747438RGDPMID:20723759|PMID:24747438
Atg3Ratautophagosome assembly acts_upstream_of_or_withinISORGD:15572241624291 PMID:21220506RGDPMID:21220506
Atg3Ratautophagosome assembly involved_inIBAFB:FBgn0036813|MGI:1915091|PANTHER:PTN000305307|SGD:S000005290|UniProtKB:Q9NT621600115GO_REF:0000033GO_CentralGO_REF:0000033
Atg3Ratautophagosome assembly involved_inIEAUniProtKB:Q9NT62|ensembl:ENSP000002832901600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratautophagosome assembly involved_inISORGD:13534161624291 PMID:33446636RGDPMID:33446636
Atg3Ratautophagosome assembly involved_inIEAUniProtKB:Q9CPX6|ensembl:ENSMUSP000000233431600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratautophagosome assembly involved_inISSUniProtKB:Q9CPX61600115GO_REF:0000024UniProtGO_REF:0000024
Atg3Ratautophagy  IEP 1643237 RGD 
Atg3Ratautophagy involved_inIEAUniProtKB-KW:KW-00721600115GO_REF:0000043UniProtGO_REF:0000043
Atg3Ratautophagy involved_inIEAUniProtKB:Q9CPX6|ensembl:ENSMUSP000000233431600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratautophagy involved_inISSUniProtKB:Q9CPX61600115GO_REF:0000024UniProtGO_REF:0000024
Atg3Ratautophagy involved_inISORGD:15572241624291 PMID:18768753RGDPMID:18768753
Atg3Ratautophagy involved_inIEAARBA:ARBA000277571600115GO_REF:0000117UniProtGO_REF:0000117
Atg3Ratautophagy of mitochondrion involved_inIBAPANTHER:PTN000305308|SGD:S0000052901600115GO_REF:0000033GO_CentralGO_REF:0000033
Atg3Ratglycophagy involved_inIBAFB:FBgn0036813|PANTHER:PTN0003053071600115GO_REF:0000033GO_CentralGO_REF:0000033
Atg3Ratmacroautophagy acts_upstream_of_or_withinISORGD:15572241624291 PMID:24035364RGDPMID:24035364
Atg3Ratmacroautophagy acts_upstream_of_or_withinIEAUniProtKB:Q9CPX6|ensembl:ENSMUSP000000233431600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratmitochondrial fragmentation involved in apoptotic process involved_inISSUniProtKB:Q9CPX61600115GO_REF:0000024UniProtGO_REF:0000024
Atg3Ratmitochondrial fragmentation involved in apoptotic process involved_inISORGD:15572241624291 PMID:20723759RGDPMID:20723759
Atg3Ratmitochondrial fragmentation involved in apoptotic process involved_inIEAUniProtKB:Q9CPX6|ensembl:ENSMUSP000000233431600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Atg3RatAtg12-Atg5-Atg16 complex part_ofISORGD:13534161624291 PMID:24186333, PMID:24191030, PMID:37252361RGDPMID:24186333|PMID:24191030|PMID:37252361
Atg3RatAtg12-Atg5-Atg16 complex part_ofIEAUniProtKB:Q9NT62|ensembl:ENSP000002832901600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratcytoplasm is_active_inISORGD:13534161624291 PMID:11825910RGDPMID:11825910
Atg3Ratcytoplasm is_active_inIEAUniProtKB:Q9NT62|ensembl:ENSP000002832901600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Atg3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Atg3Ratcytosol located_inIEAUniProtKB:Q9NT62|ensembl:ENSP000002832901600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratcytosol is_active_inIBAFB:FBgn0036813|PANTHER:PTN000305308|UniProtKB:Q9NT621600115GO_REF:0000033GO_CentralGO_REF:0000033
Atg3Ratcytosol located_inISORGD:13534161624291 PMID:11825910RGDPMID:11825910
Atg3Ratphagophore assembly site is_active_inIBAPANTHER:PTN000305307|SGD:S0000052901600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Original Reference(s)
Atg3RatAtg12 transferase activity enablesISSUniProtKB:Q9CPX61600115GO_REF:0000024UniProtGO_REF:0000024
Atg3RatAtg12 transferase activity enablesISORGD:15572241624291 PMID:20723759RGDPMID:20723759
Atg3RatAtg12 transferase activity enablesIEAUniProtKB:Q9CPX6|ensembl:ENSMUSP000000233431600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3RatAtg8-family conjugating enzyme activity enablesIEAUniProtKB:Q9NT62|ensembl:ENSP000002832901600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3RatAtg8-family conjugating enzyme activity enablesISORGD:13534161624291 PMID:12207896, PMID:24186333, PMID:24191030, PMID:33446636, PMID:37252361RGDPMID:12207896|PMID:24186333|PMID:24191030|PMID:33446636|PMID:37252361
Atg3RatAtg8-family conjugating enzyme activity enablesIMP 401901225PMID:24747438UniProt 
Atg3RatAtg8-family conjugating enzyme activity enablesIBAPANTHER:PTN000305308|RGD:708464|UniProtKB:Q9NT621600115GO_REF:0000033GO_CentralGO_REF:0000033
Atg3RatAtg8-family conjugating enzyme activity enablesISSUniProtKB:Q9NT621600115GO_REF:0000024UniProtGO_REF:0000024
Atg3RatAtg8-family ligase activity enablesISSUniProtKB:Q9CPX61600115GO_REF:0000024UniProtGO_REF:0000024
Atg3RatAtg8-family ligase activity enablesISORGD:15572241624291 PMID:20723759RGDPMID:20723759
Atg3RatAtg8-family ligase activity enablesIEAUniProtKB:Q9CPX6|ensembl:ENSMUSP000000233431600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratenzyme binding enablesIEAUniProtKB:Q9NT62|ensembl:ENSP000002832901600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratenzyme binding enablesISORGD:13534161624291UniProtKB:O95352 PMID:11825910RGDPMID:11825910
Atg3Ratprotein binding enablesISORGD:13534161624291UniProtKB:O94817|UniProtKB:O95166|UniProtKB:O95352|UniProtKB:P60520|UniProtKB:P62879|UniProtKB:Q676U5|UniProtKB:Q70IA6|UniProtKB:Q7Z6L1|UniProtKB:Q9GZQ8|UniProtKB:Q9H0R8|UniProtKB:Q9H1Y0|UniProtKB:Q9H492 PMID:11825910, PMID:12890687, PMID:15355958, PMID:16303767, PMID:18083104, PMID:20562859, PMID:23202584, PMID:24186333, PMID:24191030, PMID:26043688, PMID:32296183, PMID:32814053, PMID:33961781, more ...RGDPMID:11825910|PMID:12890687|PMID:15355958|PMID:16303767|PMID:18083104|PMID:20562859|PMID:23202584|PMID:24186333|PMID:24191030|PMID:26043688|PMID:32296183|PMID:32814053|PMID:33961781|PMID:35271311|PMID:37252361
Atg3Ratprotein binding enablesISORGD:15572241624291UniProtKB:Q9CQY1 PMID:18321988, PMID:20723759, PMID:25686249RGDPMID:18321988|PMID:20723759|PMID:25686249
Atg3Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
Atg3Ratubiquitin-like protein transferase activity enablesISORGD:13534161624291 PMID:11825910RGDPMID:11825910
Atg3Ratubiquitin-like protein transferase activity enablesIEAUniProtKB:Q9NT62|ensembl:ENSP000002832901600115GO_REF:0000107EnsemblGO_REF:0000107
Atg3Ratubiquitin-like protein transferase activity enablesIEAInterPro:IPR0071351600115GO_REF:0000002InterProGO_REF:0000002
Atg3Ratubiquitin-like protein transferase activity enablesIEAARBA:ARBA000273631600115GO_REF:0000117UniProtGO_REF:0000117
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RGD Manual Annotations


  
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Original Reference(s)
Atg3Ratautophagy pathway   ISORGD:13534161643329 RGD 
Atg3Ratautophagy pathway   ISORGD:13534164889529 RGD 
Atg3Ratautophagy pathway   IEP 1643237 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Atg3Ratautophagy pathway   IEA 6907045 KEGGrno:04140

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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy. Liang B, etal., Int J Mol Med. 2017 Dec;40(6):1781-1791. doi: 10.3892/ijmm.2017.3191. Epub 2017 Oct 16.
4. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nath S, etal., Nat Cell Biol. 2014 May;16(5):415-24. doi: 10.1038/ncb2940. Epub 2014 Apr 20.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
10. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
11. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. Tanida I, etal., J Biol Chem 2002 Apr 19;277(16):13739-44. Epub 2002 Feb 1.
12. The rat Apg3p/Aut1p homolog is upregulated by ischemic preconditioning in the retina. Wu BX, etal., Mol Vis. 2006 Oct 26;12:1292-302.
13. Mammalian autophagy: core molecular machinery and signaling regulation. Yang Z and Klionsky DJ, Curr Opin Cell Biol. 2010 Apr;22(2):124-31. Epub 2009 Dec 23.
14. The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway. Zhang XX, etal., Biomed Microdevices. 2022 Oct 29;24(4):37. doi: 10.1007/s10544-022-00622-2.
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PMID:15489334   PMID:18321988   PMID:20723759   PMID:21220506   PMID:24035364   PMID:24089205   PMID:26061804   PMID:29311554  



Atg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,130,948 - 69,159,280 (-)NCBIGRCr8
mRatBN7.21155,624,914 - 55,653,249 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1155,624,917 - 55,653,224 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,438,596 - 64,466,930 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01157,100,453 - 57,128,787 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01156,170,970 - 56,199,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01160,585,192 - 60,613,706 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1160,585,171 - 60,613,718 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01164,687,322 - 64,715,836 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,162,205 - 57,190,568 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,219,793 - 57,248,157 (-)NCBI
Celera1155,191,074 - 55,219,238 (-)NCBICelera
Cytogenetic Map11q21NCBI
ATG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383112,532,510 - 112,561,962 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3112,532,510 - 112,562,046 (-)EnsemblGRCh38hg38GRCh38
GRCh373112,251,357 - 112,280,809 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363113,734,049 - 113,763,175 (-)NCBINCBI36Build 36hg18NCBI36
Build 343113,734,049 - 113,763,175NCBI
Celera3110,660,041 - 110,689,158 (-)NCBICelera
Cytogenetic Map3q13.2NCBI
HuRef3109,635,431 - 109,664,875 (-)NCBIHuRef
CHM1_13112,215,286 - 112,244,741 (-)NCBICHM1_1
T2T-CHM13v2.03115,253,546 - 115,282,997 (-)NCBIT2T-CHM13v2.0
Atg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391644,979,192 - 45,008,901 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1644,979,148 - 45,008,901 (+)EnsemblGRCm39 Ensembl
GRCm381645,158,829 - 45,188,538 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1645,158,785 - 45,188,538 (+)EnsemblGRCm38mm10GRCm38
MGSCv371645,158,942 - 45,188,651 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361645,078,161 - 45,107,870 (+)NCBIMGSCv36mm8
Celera1645,552,434 - 45,582,081 (+)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1629.45NCBI
Atg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542712,881,454 - 12,906,399 (-)NCBIChiLan1.0ChiLan1.0
ATG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22110,535,875 - 110,564,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13110,539,768 - 110,569,070 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03109,681,163 - 109,710,835 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13116,606,467 - 116,635,209 (-)NCBIpanpan1.1PanPan1.1panPan2
ATG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13317,046,951 - 17,073,203 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3317,046,973 - 17,073,150 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3317,150,094 - 17,176,355 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03317,290,643 - 17,316,985 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3317,290,665 - 17,316,925 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13317,095,504 - 17,121,791 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03317,142,968 - 17,169,265 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03317,692,507 - 17,718,820 (-)NCBIUU_Cfam_GSD_1.0
Atg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602137,263,965 - 137,289,577 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936536232,192 - 257,954 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936536232,343 - 257,949 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13147,279,437 - 147,309,590 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113147,279,110 - 147,309,597 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213156,876,859 - 156,907,063 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12268,227,772 - 68,256,555 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2268,228,203 - 68,257,503 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604198,205,946 - 98,234,553 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atg3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473135,978,595 - 36,004,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Atg3
81 total Variants

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:24
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000002906
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat

1 to 10 of 21 rows
WI-22015  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21155,625,023 - 55,625,154 (+)MAPPERmRatBN7.2
Rnor_6.01160,585,281 - 60,585,411NCBIRnor6.0
Rnor_5.01164,687,411 - 64,687,541UniSTSRnor5.0
RGSC_v3.41157,162,294 - 57,162,424UniSTSRGSC3.4
Celera1155,191,163 - 55,191,293UniSTS
Cytogenetic Map11q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000002906   ⟹   ENSRNOP00000002906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,624,935 - 55,653,224 (-)Ensembl
Rnor_6.0 Ensembl1160,585,185 - 60,613,718 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,624,917 - 55,653,054 (-)Ensembl
Rnor_6.0 Ensembl1160,585,171 - 60,586,048 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1160,594,412 - 60,597,961 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094798   ⟹   ENSRNOP00000084764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1155,624,935 - 55,652,930 (-)Ensembl
RefSeq Acc Id: NM_134394   ⟹   NP_599221
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,130,948 - 69,159,280 (-)NCBI
mRatBN7.21155,624,914 - 55,653,249 (-)NCBI
Rnor_6.01160,585,192 - 60,613,706 (-)NCBI
Rnor_5.01164,687,322 - 64,715,836 (-)NCBI
RGSC_v3.41157,162,205 - 57,190,568 (-)RGD
Celera1155,191,074 - 55,219,238 (-)RGD
Sequence:
RefSeq Acc Id: XM_039087948   ⟹   XP_038943876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,130,982 - 69,158,923 (-)NCBI
mRatBN7.21155,624,928 - 55,652,943 (-)NCBI
RefSeq Acc Id: XM_063270263   ⟹   XP_063126333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81169,130,982 - 69,143,332 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_599221 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943876 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126333 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG09182 (Get FASTA)   NCBI Sequence Viewer  
  AAH78743 (Get FASTA)   NCBI Sequence Viewer  
  EDM11145 (Get FASTA)   NCBI Sequence Viewer  
  EDM11146 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002906
  ENSRNOP00000002906.3
GenBank Protein Q6AZ50 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_599221   ⟸   NM_134394
- UniProtKB: Q6AZ50 (UniProtKB/Swiss-Prot),   Q9ESH2 (UniProtKB/Swiss-Prot),   A6IQZ2 (UniProtKB/TrEMBL),   A0A8I6GAZ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002906   ⟸   ENSRNOT00000002906
RefSeq Acc Id: XP_038943876   ⟸   XM_039087948
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000084764   ⟸   ENSRNOT00000094798
RefSeq Acc Id: XP_063126333   ⟸   XM_063270263
- Peptide Label: isoform X2
- UniProtKB: A6IQZ3 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-Q6AZ50-F1-model_v2 AlphaFold Q6AZ50 1-314 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698141
Promoter ID:EPDNEW_R8665
Type:initiation region
Name:Atg3_1
Description:autophagy related 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8666  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01160,613,460 - 60,613,520EPDNEW
RGD ID:13698142
Promoter ID:EPDNEW_R8666
Type:initiation region
Name:Atg3_2
Description:autophagy related 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8665  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01160,613,687 - 60,613,747EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-21374 BioCyc
Ensembl Genes ENSRNOG00000002094 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002906 ENTREZGENE
  ENSRNOT00000002906.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1460.50 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112937 IMAGE-MGC_LOAD
InterPro Autophagy-rel_prot_3 UniProtKB/Swiss-Prot
KEGG Report rno:171415 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93202 IMAGE-MGC_LOAD
NCBI Gene 171415 ENTREZGENE
PANTHER PTHR12866 UniProtKB/Swiss-Prot
  UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3 UniProtKB/Swiss-Prot
Pfam Autophagy_act_C UniProtKB/Swiss-Prot
PhenoGen Atg3 PhenoGen
RatGTEx ENSRNOG00000002094 RatGTEx
UniProt A0A8I6G762_RAT UniProtKB/TrEMBL
  A0A8I6GAZ4 ENTREZGENE, UniProtKB/TrEMBL
  A6IQZ2 ENTREZGENE, UniProtKB/TrEMBL
  A6IQZ3 ENTREZGENE, UniProtKB/TrEMBL
  ATG3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9ESH2 ENTREZGENE
UniProt Secondary Q9ESH2 UniProtKB/Swiss-Prot
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-06-07 Atg3  autophagy related 3  Atg3  ATG3 autophagy related 3 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atg3  ATG3 autophagy related 3 homolog (S. cerevisiae)  Atg3  autophagy-related 3 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-12-21 Atg3  autophagy-related 3 (yeast)  Apg3l  APG3 autophagy 3-like (S. cerevisiae)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Apg3l  APG3 autophagy 3-like (S. cerevisiae)  Pig1  preconditioning-inducible gene 1 protein  Symbol and Name updated 1299863 APPROVED