Cygb (cytoglobin) - Rat Genome Database

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Gene: Cygb (cytoglobin) Rattus norvegicus
Analyze
Symbol: Cygb
Name: cytoglobin
RGD ID: 69415
Description: Enables heme binding activity; nitric oxide dioxygenase activity, heme protein as donor; and peroxidase activity. Involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of hepatic stellate cell activation; and nitric oxide catabolic process. Located in cytoplasm. Used to study liver cirrhosis and renal fibrosis. Biomarker of kidney disease and liver cirrhosis. Orthologous to human CYGB (cytoglobin); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glnf; globin f; HGb; histoglobin; MGC95105; nitric oxygen dioxygenase CYGB; nitrite reductase CYGB; pseudoperoxidase CYGB; Staap; Stap; stellate cell activation associated protein; stellate cell activation-associated protein; superoxide dismutase CYGB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,376,506 - 102,386,272 (-)NCBIGRCr8
mRatBN7.210101,877,675 - 101,887,442 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,877,676 - 101,887,442 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,934,815 - 106,944,558 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,397,907 - 106,407,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,798,546 - 101,808,312 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,618,325 - 105,628,091 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,618,326 - 105,628,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,280,904 - 105,290,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,759,885 - 106,769,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,774,389 - 106,784,155 (-)NCBI
Celera10100,448,536 - 100,458,302 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CygbRatChronic Pancreatitis  IEP 9685173 RGD 
CygbRatkidney disease  IEP 9685173 RGD 
CygbRatliver cirrhosis  IMP 9685176 RGD 
CygbRatliver cirrhosis  IEP 68672 RGD 
CygbRatrenal fibrosis treatmentIMP 9685174 RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CygbRatfundus dystrophy  ISORGD:13451838554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:16199547|PMID:16938425|PMID:20507925|PMID:23661369|PMID:23805042|PMID:25741868|PMID:26497376|PMID:26806561|PMID:28181551|PMID:28492532|PMID:29785639|PMID:31213501|PMID:31456290|PMID:31589614|PMID:31964843|PMID:34426522|PMID:36819107
CygbRatgenetic disease  ISORGD:13451838554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
CygbRatretinitis pigmentosa  ISORGD:13451838554872ClinVar Annotator: match by term: Retinitis Pigmentosa, Recessive | ClinVar Annotator: match by term: Retinitis more ...ClinVarPMID:16938425|PMID:17576681|PMID:20507925|PMID:23661369|PMID:23805042|PMID:25741868|PMID:26806561|PMID:28181551|PMID:28492532|PMID:29785639|PMID:9536098
CygbRatretinitis pigmentosa  ISORGD:13451838554872ClinVar Annotator: match by term: Retinitis Pigmentosa, Recessive | ClinVar Annotator: match by term: Retinitis more ...ClinVarPMID:16199547|PMID:16938425|PMID:17576681|PMID:20507925|PMID:23661369|PMID:23805042|PMID:25741868|PMID:26497376|PMID:26806561|PMID:28181551|PMID:28492532|PMID:29785639|PMID:31213501|PMID:31456290|PMID:31589614|PMID:31964843|PMID:32036094|PMID:34426522|PMID:36819107|PMID:36909829|PMID:9536098
CygbRatretinitis pigmentosa 36  ISORGD:13451838554872ClinVar Annotator: match by term: Retinitis pigmentosa 36ClinVarPMID:16938425|PMID:20507925|PMID:23661369|PMID:23805042|PMID:24992209|PMID:25741868|PMID:26497376|PMID:28181551|PMID:28492532|PMID:29785639|PMID:31213501|PMID:31456290|PMID:31589614|PMID:31964843|PMID:34426522|PMID:36819107
Object Symbol
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Original Reference(s)
CygbRatExperimental Liver Cirrhosis  ISORGD:134518311554173CTD Direct Evidence: therapeuticCTDPMID:16581302
CygbRatextrahepatic cholestasis  ISORGD:134518311554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
CygbRatHepatic Insufficiency  ISORGD:134518311554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
CygbRatHepatomegaly  ISORGD:134518311554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
CygbRatNervous System Heredodegenerative Disorders  ISORGD:134518311554173CTD Direct Evidence: marker/mechanismCTDPMID:16825958
CygbRatprimary biliary cholangitis  ISORGD:134518311554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087

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Object Symbol
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Original Reference(s)
CygbRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of CYGB mRNA]CTDPMID:31150632
CygbRat(-)-epigallocatechin 3-gallate decreases expressionISORGD:13451836480464epigallocatechin gallate results in decreased expression of CYGB mRNACTDPMID:20706672
CygbRat17alpha-ethynylestradiol increases expressionISORGD:7336346480464Ethinyl Estradiol results in increased expression of CYGB mRNACTDPMID:17942748
CygbRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of CYGB mRNACTDPMID:17557909
CygbRat17alpha-ethynylestradiol multiple interactionsISORGD:7336346480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYGB mRNACTDPMID:17942748
CygbRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464estradiol 3-benzoate promotes the reaction [Thioacetamide results in increased expression of CYGB mRNA]CTDPMID:15716488
CygbRat2,2',5,5'-tetrachlorobiphenyl increases expressionISORGD:134518364804642,5,2',5'-tetrachlorobiphenyl analog results in increased expression of CYGB mRNACTDPMID:36804509
CygbRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:7336346480464Tetrachlorodibenzodioxin results in increased expression of CYGB mRNACTDPMID:19933214|PMID:28213091
CygbRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of CYGB mRNACTDPMID:34747641
CygbRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:13451836480464Tetrachlorodibenzodioxin results in increased expression of CYGB mRNACTDPMID:20106945|PMID:21632981
CygbRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:7336346480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYGB mRNACTDPMID:17942748
CygbRat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionISORGD:134518364804642,2',4,4',5-brominated diphenyl ether results in increased expression of CYGB mRNACTDPMID:26705709
CygbRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISORGD:73363464804642,2',4,4',5-brominated diphenyl ether affects the expression of CYGB mRNACTDPMID:38648751
CygbRat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYGB mRNACTDPMID:32119087
CygbRat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of CYGB mRNA; alpha-Chlorohydrin results in increased expression of CYGB more ...CTDPMID:28522335|PMID:34915118
CygbRat4,4'-sulfonyldiphenol increases expressionISORGD:7336346480464bisphenol S results in increased expression of CYGB mRNACTDPMID:30951980|PMID:39298647
CygbRat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of more ...CTDPMID:36041667
CygbRat4,4'-sulfonyldiphenol increases methylationISORGD:7336346480464bisphenol S results in increased methylation of CYGB exonCTDPMID:33297965
CygbRat4-hydroxyphenyl retinamide increases expressionISORGD:7336346480464Fenretinide results in increased expression of CYGB mRNACTDPMID:28973697
CygbRat5-aza-2'-deoxycytidine increases expressionISORGD:13451836480464Decitabine results in increased expression of CYGB mRNACTDPMID:25781201

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Biological Process
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Object Symbol
Species
Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
CygbRatfatty acid oxidation  IDA 68672 RGD 
CygbRatnegative regulation of collagen biosynthetic process  IDA 9685174 RGD 
CygbRatnegative regulation of fibroblast migration  IDA 9685173 RGD 
CygbRatnegative regulation of hepatic stellate cell activation  IDA 9685176 RGD 
CygbRatnitric oxide catabolic process involved_inISORGD:7336341624291 PMID:28393874, PMID:33334890RGDPMID:28393874|PMID:33334890
CygbRatnitric oxide catabolic process involved_inIEAUniProtKB:Q9CX80|ensembl:ENSMUSP000000211661600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatnitric oxide catabolic process involved_inIEAUniProtKB:Q8WWM9|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatnitric oxide catabolic process involved_inISSUniProtKB:Q8WWM91600115GO_REF:0000024UniProtGO_REF:0000024
CygbRatnitric oxide catabolic process involved_inISORGD:13451831624291 PMID:28671819RGDPMID:28671819
CygbRatnitric oxide catabolic process involved_inIMP 401901230PMID:28393874UniProt 
CygbRatoxygen transport involved_inIEAInterPro:IPR0133141600115GO_REF:0000002InterProGO_REF:0000002
CygbRatremoval of superoxide radicals involved_inIEAUniProtKB:Q8WWM9|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatremoval of superoxide radicals involved_inISORGD:7336341624291 PMID:34930834RGDPMID:34930834
CygbRatremoval of superoxide radicals involved_inISSUniProtKB:Q8WWM91600115GO_REF:0000024UniProtGO_REF:0000024
CygbRatremoval of superoxide radicals involved_inISORGD:13451831624291 PMID:34930834RGDPMID:34930834
CygbRatremoval of superoxide radicals involved_inIEAUniProtKB:Q9CX80|ensembl:ENSMUSP000000211661600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatresponse to hypoxia  IEP 9685175 RGD 
CygbRatresponse to oxidative stress involved_inIDA 68672PMID:11320098UniProt 
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Cellular Component
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Object Symbol
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Original Reference(s)
CygbRatcytoplasm located_inISORGD:7336341624291 PMID:14660570RGDPMID:14660570
CygbRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
CygbRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
CygbRatcytoplasm located_inIEAUniProtKB:Q9CX80|ensembl:ENSMUSP000000211661600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatcytoplasm is_active_inISORGD:13451831624291 PMID:34930834RGDPMID:34930834
CygbRatcytoplasm is_active_inISORGD:7336341624291 PMID:34930834RGDPMID:34930834
CygbRatcytoplasm located_inISORGD:13451831624291 PMID:14660570RGDPMID:14660570
CygbRatcytoplasm located_inIEAUniProtKB:Q8WWM9|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatcytoplasm located_inNAS 68672PMID:11320098UniProt 
CygbRatcytoplasm located_inIDA 9685173PMID:14647402UniProt 
CygbRatcytosol located_inIEAUniProtKB:A0A1K0FUB6|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatcytosol located_inISORGD:13451831624291 RGDGO_REF:0000052
CygbRatcytosol located_inIEAUniProtKB:Q8WWM9|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatneuron projection located_inISORGD:7336341624291 PMID:14660570RGDPMID:14660570
CygbRatneuron projection located_inIEAUniProtKB:Q9CX80|ensembl:ENSMUSP000000211661600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatneuronal cell body located_inISORGD:7336341624291 PMID:14660570RGDPMID:14660570
CygbRatneuronal cell body located_inIEAUniProtKB:Q9CX80|ensembl:ENSMUSP000000211661600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatnuclear speck located_inIEAUniProtKB:A0A1K0FUB6|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatnuclear speck located_inISORGD:13451831624291 RGDGO_REF:0000052
CygbRatnuclear speck located_inIEAUniProtKB:Q8WWM9|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Object Symbol
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Original Reference(s)
CygbRatcarbon monoxide binding enablesISORGD:13451831624291 PMID:11893755RGDPMID:11893755
CygbRatcarbon monoxide binding enablesIEAUniProtKB:Q8WWM9|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatcatalase activity  IDA 68672 RGD 
CygbRatfatty acid peroxidase activity  IDA 68672 RGD 
CygbRatheme binding  IDA 68672 RGD 
CygbRatheme binding enablesIEAInterPro:IPR000971|InterPro:IPR012292|InterPro:IPR0133141600115GO_REF:0000002InterProGO_REF:0000002
CygbRatheme binding enablesIBAPANTHER:PTN005321088|RGD:694151600115GO_REF:0000033GO_CentralGO_REF:0000033
CygbRatiron ion binding enablesIEAInterPro:IPR0133141600115GO_REF:0000002InterProGO_REF:0000002
CygbRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
CygbRatnitric oxide dioxygenase activity, heme protein as donor enablesISORGD:7336341624291 PMID:33334890RGDPMID:33334890
CygbRatnitric oxide dioxygenase activity, heme protein as donor enablesIEAUniProtKB:Q9CX80|ensembl:ENSMUSP000000211661600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatnitric oxide dioxygenase activity, heme protein as donor enablesIDA 401901230PMID:28393874UniProt 
CygbRatnitric oxide dioxygenase activity, heme protein as donor enablesIEAUniProtKB:Q8WWM9|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatnitric oxide dioxygenase activity, heme protein as donor enablesISORGD:13451831624291 PMID:20511233, PMID:28393874, PMID:28671819RGDPMID:20511233|PMID:28393874|PMID:28671819
CygbRatnitrite reductase activity enablesISORGD:13451831624291 PMID:29128400RGDPMID:29128400
CygbRatnitrite reductase activity enablesIEAUniProtKB:Q8WWM9|ensembl:ENSP000002932301600115GO_REF:0000107EnsemblGO_REF:0000107
CygbRatnitrite reductase activity enablesISSUniProtKB:Q8WWM91600115GO_REF:0000024UniProtGO_REF:0000024
CygbRatoxidoreductase activity enablesIBAMGI:2149481|PANTHER:PTN005321088|RGD:69415|UniProtKB:Q8WWM9|ZFIN:ZDB-GENE-020513-1|ZFIN:ZDB-GENE-060920-11600115GO_REF:0000033GO_CentralGO_REF:0000033
CygbRatoxidoreductase activity enablesIEAARBA:ARBA000287471600115GO_REF:0000117UniProtGO_REF:0000117
CygbRatoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. Kawada N, etal., J Biol Chem 2001 Jul 6;276(27):25318-23.
3. Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall. Liu X, etal., Nat Commun. 2017 Apr 10;8:14807. doi: 10.1038/ncomms14807.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Cytoglobin, a novel globin, plays an antifibrotic role in the kidney. Mimura I, etal., Am J Physiol Renal Physiol. 2010 Nov;299(5):F1120-33. doi: 10.1152/ajprenal.00145.2010. Epub 2010 Aug 18.
6. Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis. Nakatani K, etal., Lab Invest. 2004 Jan;84(1):91-101.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia. Schmidt M, etal., J Biol Chem. 2004 Feb 27;279(9):8063-9. Epub 2003 Dec 3.
12. Cytoglobin overexpression protects against damage-induced fibrosis. Xu R, etal., Mol Ther. 2006 Jun;13(6):1093-100. Epub 2006 Apr 3.
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PMID:11919282   PMID:12477932   PMID:15489334   PMID:16750520   PMID:19147491   PMID:20230802   PMID:20511233   PMID:21084849   PMID:21224051   PMID:23306842   PMID:23585565   PMID:26312997  



Cygb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,376,506 - 102,386,272 (-)NCBIGRCr8
mRatBN7.210101,877,675 - 101,887,442 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,877,676 - 101,887,442 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,934,815 - 106,944,558 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,397,907 - 106,407,650 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,798,546 - 101,808,312 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,618,325 - 105,628,091 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,618,326 - 105,628,091 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,280,904 - 105,290,670 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,759,885 - 106,769,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,774,389 - 106,784,155 (-)NCBI
Celera10100,448,536 - 100,458,302 (-)NCBICelera
Cytogenetic Map10q32.2NCBI
CYGB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,527,356 - 76,551,193 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,527,356 - 76,551,175 (-)EnsemblGRCh38hg38GRCh38
GRCh371774,523,438 - 74,533,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361772,035,035 - 72,045,377 (-)NCBINCBI36Build 36hg18NCBI36
Build 341772,035,034 - 72,045,377NCBI
Celera1771,115,779 - 71,126,119 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,951,063 - 69,961,627 (-)NCBIHuRef
CHM1_11774,588,377 - 74,598,946 (-)NCBICHM1_1
T2T-CHM13v2.01777,424,099 - 77,449,394 (-)NCBIT2T-CHM13v2.0
Cygb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,536,421 - 116,544,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,536,421 - 116,545,139 (-)EnsemblGRCm39 Ensembl
GRCm3811116,645,595 - 116,654,504 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,645,595 - 116,654,313 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711116,506,909 - 116,515,627 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,461,685 - 116,470,403 (-)NCBIMGSCv36mm8
Celera11128,416,859 - 128,425,516 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.45NCBI
Cygb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,766,006 - 5,775,784 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555065,766,006 - 5,775,722 (+)NCBIChiLan1.0ChiLan1.0
CYGB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,570,565 - 92,601,134 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,395,777 - 97,406,085 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,475,651 - 70,485,987 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11776,167,003 - 76,178,247 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1776,167,947 - 76,179,412 (-)Ensemblpanpan1.1panPan2
CYGB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,191,114 - 4,201,438 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,184,959 - 4,200,164 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,872,569 - 4,881,413 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,867,061 - 4,877,257 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,867,055 - 4,875,983 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,892,392 - 4,901,203 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,012,299 - 5,021,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,093,431 - 5,102,251 (+)NCBIUU_Cfam_GSD_1.0
Cygb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,798,176 - 4,809,539 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,604,710 - 1,613,783 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,602,436 - 1,613,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYGB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1124,977,245 - 4,988,283 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,829,817 - 4,840,005 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYGB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,140,130 - 45,151,068 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,140,284 - 45,151,082 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607715,877,603 - 15,891,518 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cygb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,384,213 - 6,395,979 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248016,385,771 - 6,395,705 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cygb
27 total Variants

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:143
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000016067
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 59 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat

1 to 10 of 59 rows
RH133332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,877,700 - 101,877,883 (+)MAPPERmRatBN7.2
Rnor_6.010105,618,351 - 105,618,533NCBIRnor6.0
Rnor_5.010105,280,930 - 105,281,112UniSTSRnor5.0
RGSC_v3.410106,759,911 - 106,760,093UniSTSRGSC3.4
Celera10100,448,562 - 100,448,744UniSTS
Cytogenetic Map10q32.3UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000016067   ⟹   ENSRNOP00000016067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,877,676 - 101,887,442 (-)Ensembl
Rnor_6.0 Ensembl10105,618,326 - 105,628,091 (-)Ensembl
RefSeq Acc Id: NM_130744   ⟹   NP_570100
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,376,506 - 102,386,272 (-)NCBI
mRatBN7.210101,877,675 - 101,887,442 (-)NCBI
Rnor_6.010105,618,325 - 105,628,091 (-)NCBI
Rnor_5.010105,280,904 - 105,290,670 (-)NCBI
RGSC_v3.410106,759,885 - 106,769,651 (-)RGD
Celera10100,448,536 - 100,458,302 (-)RGD
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_570100 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88455 (Get FASTA)   NCBI Sequence Viewer  
  CAC59827 (Get FASTA)   NCBI Sequence Viewer  
  EDM06685 (Get FASTA)   NCBI Sequence Viewer  
  EDM06686 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016067
  ENSRNOP00000016067.4
GenBank Protein Q921A4 (Get FASTA)   NCBI Sequence Viewer  
  SAI82220 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_570100   ⟸   NM_130744
- UniProtKB: Q921A4 (UniProtKB/Swiss-Prot),   A0A1K0GY57 (UniProtKB/TrEMBL),   A6HKY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016067   ⟸   ENSRNOT00000016067
GLOBIN

Name Modeler Protein Id AA Range Protein Structure
AF-Q921A4-F1-model_v2 AlphaFold Q921A4 1-190 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697920
Promoter ID:EPDNEW_R8445
Type:single initiation site
Name:Cygb_1
Description:cytoglobin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010105,628,101 - 105,628,161EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22592 BioCyc
Ensembl Genes ENSRNOG00000011541 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000016067 ENTREZGENE
  ENSRNOT00000016067.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.490.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7127197 IMAGE-MGC_LOAD
InterPro Globin UniProtKB/Swiss-Prot
  Globin-like_sf UniProtKB/Swiss-Prot
  Globin/Proto UniProtKB/Swiss-Prot
  Globin_lamprey/hagfish UniProtKB/Swiss-Prot
KEGG Report rno:170520 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95105 IMAGE-MGC_LOAD
NCBI Gene 170520 ENTREZGENE
PANTHER CYTOGLOBIN UniProtKB/Swiss-Prot
  PTHR46783 UniProtKB/Swiss-Prot
Pfam Globin UniProtKB/Swiss-Prot
PhenoGen Cygb PhenoGen
PRINTS FISHGLOBIN UniProtKB/Swiss-Prot
PROSITE GLOBIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011541 RatGTEx
Superfamily-SCOP SSF46458 UniProtKB/Swiss-Prot
UniProt A0A1K0GY57 ENTREZGENE, UniProtKB/TrEMBL
  A6HKY0 ENTREZGENE, UniProtKB/TrEMBL
  CYGB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Cygb  cytoglobin  Staap  stellate cell activation associated protein  Symbol and Name updated 1299863 APPROVED
2002-06-10 Staap  stellate cell activation associated protein      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease increased expression in fibrotic liver tissues is induced by thioacetamide (TAA) administration; functions in the development of liver fibrosis 68672
gene_function peroxidase that catabolizes hydrogen peroxide and lipid hydroperoxides 68672
gene_process may play a role as an antifibrotic scavenger of peroxides in the liver 68672
gene_protein 190 amino acids 68672
gene_regulation expression dramatically increased in fibrotic liver tissues induced by thioacetamide (TAA) administration 68672
gene_regulation heavily up-regulated both in in vitro and in vivo activated stellate cells 68672