Kcne3 (potassium voltage-gated channel subfamily E regulatory subunit 3) - Rat Genome Database

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Gene: Kcne3 (potassium voltage-gated channel subfamily E regulatory subunit 3) Rattus norvegicus
Analyze
Symbol: Kcne3
Name: potassium voltage-gated channel subfamily E regulatory subunit 3
RGD ID: 621384
Description: Enables potassium channel regulator activity and transmembrane transporter binding activity. Involved in negative regulation of delayed rectifier potassium channel activity and positive regulation of voltage-gated calcium channel activity. Located in plasma membrane. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 6 and hypokalemic periodic paralysis. Orthologous to human KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; all-trans-retinoic acid.
Type: protein-coding (Ensembl: lncRNA)
RefSeq Status: PROVISIONAL
Previously known as: MGC105432; minimum potassium ion channel-related peptide 2; mink-related peptide 2; MiRP2; potassium channel subunit beta MiRP2; potassium channel, voltage gated subfamily E regulatory beta subunit 3; potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 3; potassium voltage-gated channel subfamily E member 3; potassium voltage-gated channel, Isk-related family, member 3; potassium voltage-gated channel, Isk-related subfamily, gene 3; potassium voltage-gated channel, Isk-related subfamily, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,936,035 - 163,942,998 (+)NCBIGRCr8
mRatBN7.21154,523,903 - 154,530,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,523,830 - 154,532,020 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,518,249 - 162,525,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,698,347 - 169,705,304 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,571,923 - 162,578,879 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,189,934 - 165,196,949 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,189,985 - 165,196,948 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,390,138 - 171,397,804 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,558,044 - 157,565,008 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,636,337 - 157,643,300 (+)NCBI
Celera1152,607,926 - 152,614,889 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Kcne3Rathypokalemic periodic paralysis  ISOKCNE3 (Homo sapiens)1600040 RGD 
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Kcne3Rat3-methylglutaconic aciduria type 7b  ISOKCNE3 (Homo sapiens)8554872ClinVar Annotator: match by term: 3-methylglutaconic aciduria and type VIIBClinVarPMID:28492532
Kcne3RatBrugada syndrome  ISOKCNE3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:19122847 more ...
Kcne3RatBrugada syndrome 6  ISOKCNE3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11207363 more ...
Kcne3Ratcardiomyopathy  ISOKCNE3 (Homo sapiens)8554872ClinVar Annotator: match by term: CardiomyopathiesClinVarPMID:11207363 more ...
Kcne3Ratintellectual disability  ISOKCNE3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Kcne3Ratlong QT syndrome  ISOKCNE3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
Kcne3RatNeonatal Severe Encephalopathy with Lactic Acidosis and Brain Abnormalities  ISOKCNE3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11207363 more ...
Kcne3RatSudden Unexpected Nocturnal Death Syndrome  ISOKCNE3 (Homo sapiens)8554872ClinVar Annotator: match by term: Sudden unexpected nocturnal death syndromeClinVarPMID:19122847 more ...
Kcne3RatSyncope  ISOKCNE3 (Homo sapiens)8554872ClinVar Annotator: match by term: SyncopeClinVarPMID:11207363 more ...
Kcne3RatVentricular Fibrillation  ISOKCNE3 (Homo sapiens)8554872ClinVar Annotator: match by term: Ventricular fibrillationClinVarPMID:11207363 more ...
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Kcne3RatBrugada syndrome 6  ISOKCNE3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Kcne3RatBrugada syndrome 6  ISOKCNE3 (Homo sapiens)7240710 OMIM 

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Kcne3Rat(1->4)-beta-D-glucan multiple interactionsISOKcne3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of KCNE3 mRNACTDPMID:36331819
Kcne3Rat1,1-dichloroethene increases expressionISOKcne3 (Mus musculus)6480464vinylidene chloride results in increased expression of KCNE3 mRNACTDPMID:26682919
Kcne3Rat1,2-dichloroethane decreases expressionISOKcne3 (Mus musculus)6480464ethylene dichloride results in decreased expression of KCNE3 mRNACTDPMID:28960355
Kcne3Rat1,2-dimethylhydrazine multiple interactionsISOKcne3 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KCNE3 mRNACTDPMID:22206623
Kcne3Rat1,2-dimethylhydrazine decreases expressionISOKcne3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of KCNE3 mRNACTDPMID:22206623
Kcne3Rat17beta-estradiol multiple interactionsISOKCNE3 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in decreased expression of KCNE3 mRNACTDPMID:20660070
Kcne3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of KCNE3 mRNACTDPMID:19490992
Kcne3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOKCNE3 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of KCNE3 mRNACTDPMID:21632981
Kcne3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOKcne3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of KCNE3 mRNACTDPMID:16467188
Kcne3Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOKcne3 (Mus musculus)64804642 more ...CTDPMID:38648751
Kcne3Rat4,4'-sulfonyldiphenol increases expressionISOKcne3 (Mus musculus)6480464bisphenol S results in increased expression of KCNE3 mRNACTDPMID:30951980
Kcne3Rat4,4'-sulfonyldiphenol affects methylationISOKcne3 (Mus musculus)6480464bisphenol S affects the methylation of KCNE3 geneCTDPMID:31683443
Kcne3Rat4,4'-sulfonyldiphenol increases methylationISOKcne3 (Mus musculus)6480464bisphenol S results in increased methylation of KCNE3 exon and bisphenol S results in increased methylation of KCNE3 promoterCTDPMID:33297965
Kcne3Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of KCNE3 mRNACTDPMID:30047161
Kcne3Rataflatoxin B1 increases methylationISOKCNE3 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of KCNE3 geneCTDPMID:27153756
Kcne3Ratall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of KCNE3 mRNACTDPMID:20488242
Kcne3Ratall-trans-retinoic acid increases expressionISOKCNE3 (Homo sapiens)6480464Tretinoin results in increased expression of KCNE3 mRNACTDPMID:33167477
Kcne3Ratamiodarone increases expressionISOKcne3 (Mus musculus)6480464Amiodarone results in increased expression of KCNE3 mRNACTDPMID:15520326
Kcne3Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of KCNE3 mRNACTDPMID:30047161
Kcne3Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of KCNE3 mRNACTDPMID:16483693

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Biological Process
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Kcne3Ratintracellular chloride ion homeostasis involved_inISOKcne3 (Mus musculus)1624291 PMID:11527966RGDPMID:11527966
Kcne3Ratintracellular chloride ion homeostasis involved_inIEAUniProtKB:Q9WTW2 and ensembl:ENSMUSP000001366161600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratmembrane repolarization during action potential involved_inIBAPANTHER:PTN001445835 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcne3Ratmembrane repolarization during ventricular cardiac muscle cell action potential involved_inIEAGO:19022821600115GO_REF:0000108GOCGO_REF:0000108
Kcne3Ratmonoatomic ion transport involved_inIEAInterPro:IPR0003691600115GO_REF:0000002InterProGO_REF:0000002
Kcne3Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
Kcne3Ratnegative regulation of delayed rectifier potassium channel activity involved_inIDA 10047250PMID:12954870UniProt 
Kcne3Ratnegative regulation of delayed rectifier potassium channel activity involved_inISOKCNE3 (Homo sapiens)1624291 PMID:12954870RGDPMID:12954870
Kcne3Ratnegative regulation of membrane repolarization during ventricular cardiac muscle cell action potential involved_inISOKCNE3 (Homo sapiens)1624291 PMID:22987075RGDPMID:22987075
Kcne3Ratnegative regulation of membrane repolarization during ventricular cardiac muscle cell action potential involved_inIEAUniProtKB:Q9Y6H6 and ensembl:ENSP000003105571600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratnegative regulation of potassium ion export across plasma membrane involved_inISOKCNE3 (Homo sapiens)1624291 PMID:22987075RGDPMID:22987075
Kcne3Ratnegative regulation of potassium ion export across plasma membrane involved_inIEAUniProtKB:Q9Y6H6 and ensembl:ENSP000003105571600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratnegative regulation of voltage-gated potassium channel activity  IDA 7243967 RGD 
Kcne3Ratpositive regulation of voltage-gated calcium channel activity  IDA 7243967 RGD 
Kcne3Ratpotassium ion export across plasma membrane involved_inIBAPANTHER:PTN001445835 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcne3Ratpotassium ion transmembrane transport involved_inISOKcne3 (Mus musculus)1624291 PMID:11527966RGDPMID:11527966
Kcne3Ratpotassium ion transmembrane transport involved_inIEAUniProtKB:Q9WTW2 and ensembl:ENSMUSP000001366161600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratpotassium ion transport involved_inIEAUniProtKB-KW:KW-06331600115GO_REF:0000043UniProtGO_REF:0000043
Kcne3Ratpotassium ion transport involved_inIEAInterPro:IPR0054261600115GO_REF:0000002InterProGO_REF:0000002
Kcne3Ratregulation of heart rate by cardiac conduction involved_inISOKCNE3 (Homo sapiens)1624291 PMID:22987075RGDPMID:22987075
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Cellular Component
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Kcne3Ratbasolateral part of cell is_active_inISOKcne3 (Mus musculus)1624291 PMID:11527966RGDPMID:11527966
Kcne3Ratbasolateral part of cell is_active_inIEAUniProtKB:Q9WTW2 and ensembl:ENSMUSP000001366161600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Kcne3Ratcytoplasm located_inISSUniProtKB:Q9Y6H61600115GO_REF:0000024UniProtGO_REF:0000024
Kcne3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Kcne3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Kcne3Ratcytoplasm located_inIEAUniProtKB:Q9Y6H6 and ensembl:ENSP000003105571600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratcytoplasm located_inISOKCNE3 (Homo sapiens)1624291 PMID:12954870RGDPMID:12954870
Kcne3Ratdendrite located_inISSUniProtKB:Q9Y6H61600115GO_REF:0000024UniProtGO_REF:0000024
Kcne3Ratdendrite located_inIEAUniProtKB:Q9Y6H6 and ensembl:ENSP000003105571600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratdendrite located_inIEAUniProtKB-SubCell:SL-02831600115GO_REF:0000044UniProtGO_REF:0000044
Kcne3Ratdendrite located_inISOKCNE3 (Homo sapiens)1624291 PMID:12954870RGDPMID:12954870
Kcne3Ratmembrane located_inIEAInterPro:IPR000369 and InterPro:IPR0054261600115GO_REF:0000002InterProGO_REF:0000002
Kcne3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Kcne3Ratmembrane raft located_inISOKCNE3 (Homo sapiens)1624291 PMID:20533308RGDPMID:20533308
Kcne3Ratmembrane raft located_inIEAUniProtKB-SubCell:SL-03701600115GO_REF:0000044UniProtGO_REF:0000044
Kcne3Ratmembrane raft located_inIEAUniProtKB:Q9Y6H6 and ensembl:ENSP000003105571600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratneuronal cell body membrane located_inISSUniProtKB:Q9Y6H61600115GO_REF:0000024UniProtGO_REF:0000024
Kcne3Ratneuronal cell body membrane located_inIEAUniProtKB:Q9Y6H6 and ensembl:ENSP000003105571600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratneuronal cell body membrane located_inISOKCNE3 (Homo sapiens)1624291 PMID:12954870RGDPMID:12954870
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Molecular Function
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Original Reference(s)
Kcne3Ratdelayed rectifier potassium channel activity contributes_toIBAPANTHER:PTN001445835 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcne3Ratpotassium channel regulator activity  TAS 633042 RGD 
Kcne3Ratpotassium channel regulator activity enablesIBAMGI:96673 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcne3Ratpotassium channel regulator activity enablesIEAUniProtKB:Q9Y6H6 and ensembl:ENSP000003105571600115GO_REF:0000107EnsemblGO_REF:0000107
Kcne3Ratpotassium channel regulator activity enablesISOKCNE3 (Homo sapiens)1624291 PMID:12954870RGDPMID:12954870
Kcne3Ratpotassium channel regulator activity enablesIDA 10047250PMID:12954870UniProt 
Kcne3Ratpotassium channel regulator activity  IDA 633042 RGD 
Kcne3Ratprotein binding enablesISOKcne3 (Mus musculus)1624291UniProtKB:Q9WVJ0 and PMID:19623261RGDPMID:19623261
Kcne3Ratprotein binding enablesISOKCNE3 (Homo sapiens)1624291UniProtKB:P51787 and PMID:20533308RGDPMID:20533308
Kcne3Ratprotein binding enablesIPIUniProtKB:Q9Z0N710412297PMID:21911611UniProt 
Kcne3Rattransmembrane transporter binding enablesIPIUniProtKB:P1538710047250PMID:12954870UniProt 
Kcne3Rattransmembrane transporter binding enablesIBAPANTHER:PTN001445835 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Kcne3Rattransmembrane transporter binding enablesIPIUniProtKB:P2512210047250PMID:12954870UniProt 
Kcne3Ratvoltage-gated potassium channel activity enablesIEAInterPro:IPR000369 and InterPro:IPR0054261600115GO_REF:0000002InterProGO_REF:0000002
Kcne3Ratvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization contributes_toIBAPANTHER:PTN001445835 and UniProtKB:P153821600115GO_REF:0000033GO_CentralGO_REF:0000033
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Reference Title
Reference Citation
1. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Abbott GW, etal., Cell. 2001 Jan 26;104(2):217-31.
2. Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K(+) channels. Alzamora R, etal., J Physiol. 2011 Nov 1;589(Pt 21):5091-107. doi: 10.1113/jphysiol.2011.215772. Epub 2011 Sep 12.
3. Regulation and properties of KCNQ1 (K(V)LQT1) and impact of the cystic fibrosis transmembrane conductance regulator. Boucherot A, etal., J Membr Biol 2001 Jul 1;182(1):39-47.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. Lewis A, etal., J Biol Chem. 2004 Feb 27;279(9):7884-92. Epub 2003 Dec 16.
6. MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. McCrossan ZA, etal., J Neurosci. 2003 Sep 3;23(22):8077-91.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
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PMID:10646604   PMID:11220365   PMID:12477932   PMID:15489334   PMID:20533308   PMID:22987075  



Kcne3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,936,035 - 163,942,998 (+)NCBIGRCr8
mRatBN7.21154,523,903 - 154,530,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,523,830 - 154,532,020 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,518,249 - 162,525,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,698,347 - 169,705,304 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,571,923 - 162,578,879 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,189,934 - 165,196,949 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,189,985 - 165,196,948 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,390,138 - 171,397,804 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,558,044 - 157,565,008 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,636,337 - 157,643,300 (+)NCBI
Celera1152,607,926 - 152,614,889 (+)NCBICelera
Cytogenetic Map1q32NCBI
KCNE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381174,454,841 - 74,467,549 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1174,454,841 - 74,467,729 (-)EnsemblGRCh38hg38GRCh38
GRCh371174,165,886 - 74,178,594 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,843,534 - 73,856,248 (-)NCBINCBI36Build 36hg18NCBI36
Build 341173,843,805 - 73,850,798NCBI
Celera1171,472,396 - 71,485,109 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1170,461,201 - 70,473,937 (-)NCBIHuRef
CHM1_11174,049,426 - 74,062,143 (-)NCBICHM1_1
T2T-CHM13v2.01174,384,260 - 74,396,980 (-)NCBIT2T-CHM13v2.0
Kcne3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,825,714 - 99,834,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl799,825,709 - 99,834,076 (+)EnsemblGRCm39 Ensembl
GRCm387100,176,507 - 100,184,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,176,502 - 100,184,869 (+)EnsemblGRCm38mm10GRCm38
MGSCv377107,327,207 - 107,333,374 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,052,780 - 100,058,947 (+)NCBIMGSCv36mm8
Celera7100,513,245 - 100,519,198 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.33NCBI
Kcne3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541417,166,546 - 17,200,353 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541417,166,537 - 17,200,385 (+)NCBIChiLan1.0ChiLan1.0
KCNE3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2975,396,558 - 75,409,080 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11176,440,593 - 76,453,426 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01169,527,663 - 69,540,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,832,858 - 72,845,399 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,835,048 - 72,835,359 (-)Ensemblpanpan1.1panPan2
KCNE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,860,727 - 23,872,194 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,871,648 - 23,871,947 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2123,625,823 - 23,638,780 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02124,063,194 - 24,076,168 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2124,074,135 - 24,074,434 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12123,860,571 - 23,873,532 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02124,057,896 - 24,070,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,975,487 - 23,988,456 (+)NCBIUU_Cfam_GSD_1.0
Kcne3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494761,876,838 - 61,888,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364983,478,039 - 3,478,350 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364983,477,313 - 3,487,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl98,810,720 - 8,822,494 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.198,810,716 - 8,822,191 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.299,649,248 - 9,660,859 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1165,699,558 - 65,710,305 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl165,700,156 - 65,700,467 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604360,150,565 - 60,161,017 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcne3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248172,513,539 - 2,606,682 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248172,593,649 - 2,607,462 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Kcne3
34 total Variants

Predicted Target Of
Summary Value
Count of predictions:322
Count of miRNA genes:202
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000048437
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 70 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat

1 to 10 of 70 rows
AW533943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21154,526,740 - 154,526,896 (+)MAPPERmRatBN7.2
Rnor_6.01165,192,825 - 165,192,980NCBIRnor6.0
Rnor_5.01171,393,680 - 171,393,835UniSTSRnor5.0
RGSC_v3.41157,560,884 - 157,561,039UniSTSRGSC3.4
Celera1152,610,765 - 152,610,920UniSTS
RH 3.4 Map11255.2UniSTS
Cytogenetic Map1q32UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 90 89 58 25 58 6 217 97 91 45 56 31



Ensembl Acc Id: ENSRNOT00000048437   ⟹   ENSRNOP00000044706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1154,523,830 - 154,532,020 (+)Ensembl
Rnor_6.0 Ensembl1165,189,985 - 165,196,948 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1154,523,876 - 154,532,020 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1154,523,830 - 154,532,020 (+)Ensembl
RefSeq Acc Id: NM_022235   ⟹   NP_071571
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,936,035 - 163,942,998 (+)NCBI
mRatBN7.21154,523,903 - 154,530,865 (+)NCBI
Rnor_6.01165,189,985 - 165,196,949 (+)NCBI
Rnor_5.01171,390,138 - 171,397,804 (+)NCBI
RGSC_v3.41157,558,044 - 157,565,008 (+)RGD
Celera1152,607,926 - 152,614,889 (+)RGD
Sequence:
Protein RefSeqs NP_071571 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86406 (Get FASTA)   NCBI Sequence Viewer  
  CAB72139 (Get FASTA)   NCBI Sequence Viewer  
  EDM18361 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000098796
GenBank Protein Q9JJV7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071571   ⟸   NM_022235
- UniProtKB: Q9JJV7 (UniProtKB/Swiss-Prot),   A6I6L9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044706   ⟸   ENSRNOT00000048437

Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJV7-F1-model_v2 AlphaFold Q9JJV7 1-107 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690238
Promoter ID:EPDNEW_R761
Type:multiple initiation site
Name:Kcne3_1
Description:potassium voltage-gated channel subfamily E regulatory subunit3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,189,970 - 165,190,030EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58342 BioCyc
Ensembl Genes ENSRNOG00000017054 Ensembl
  ENSRNOG00000063050 ENTREZGENE
Ensembl Transcript ENSRNOT00000155651 ENTREZGENE
IMAGE_CLONE IMAGE:7306835 IMAGE-MGC_LOAD
InterPro K_chnl_KCNE UniProtKB/Swiss-Prot
  K_chnl_volt-dep_bsu_KCNE3 UniProtKB/Swiss-Prot
KEGG Report rno:63883 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105432 IMAGE-MGC_LOAD
NCBI Gene 63883 ENTREZGENE
PANTHER PTHR15282 UniProtKB/Swiss-Prot
  PTHR15282:SF6 UniProtKB/Swiss-Prot
Pfam ISK_Channel UniProtKB/Swiss-Prot
PharmGKB KCNE3 RGD
PhenoGen Kcne3 PhenoGen
PRINTS KCNE3CHANNEL UniProtKB/Swiss-Prot
  KCNECHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017054 RatGTEx
  ENSRNOG00000063050 RatGTEx
RNAcentral URS00022AFD56 RNACentral
  URS00022B0438 RNACentral
  URS00022B6E8C RNACentral
UniProt A6I6L9 ENTREZGENE, UniProtKB/TrEMBL
  KCNE3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcne3  potassium voltage-gated channel subfamily E regulatory subunit 3  Kcne3  potassium channel, voltage gated subfamily E regulatory beta subunit 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Kcne3  potassium channel, voltage gated subfamily E regulatory beta subunit 3  Kcne3  potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcne3  potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 3  Kcne3  potassium voltage-gated channel, Isk-related family, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-29 Kcne3  potassium voltage-gated channel, Isk-related family, member 3  Kcne3  potassium voltage-gated channel, Isk-related subfamily, gene 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Kcne3  potassium voltage-gated channel, Isk-related subfamily, gene 3  Kcne3  potassium voltage-gated channel, Isk-related subfamily, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Kcne3  potassium voltage-gated channel, Isk-related subfamily, member 3    mink-related peptide 2  Name updated 1299863 APPROVED
2002-08-07 Kcne3  mink-related peptide 2      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_process coexpression activates K+ currents 633042