Kcne3 (potassium voltage-gated channel subfamily E regulatory subunit 3) - Rat Genome Database

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Gene: Kcne3 (potassium voltage-gated channel subfamily E regulatory subunit 3) Chinchilla lanigera
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Symbol: Kcne3
Name: potassium voltage-gated channel subfamily E regulatory subunit 3
RGD ID: 8968662
Description: ENCODES a protein that exhibits potassium channel regulator activity (ortholog); transmembrane transporter binding (ortholog); INVOLVED IN intracellular chloride ion homeostasis (ortholog); negative regulation of delayed rectifier potassium channel activity (ortholog); negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential (ortholog); ASSOCIATED WITH 3-methylglutaconic aciduria type 7b (ortholog); Brugada syndrome (ortholog); Brugada syndrome 6 (ortholog); FOUND IN basolateral part of cell (ortholog); cytoplasm (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium channel, voltage gated subfamily E regulatory beta subunit 3; potassium voltage-gated channel subfamily E member 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541417,166,546 - 17,200,353 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541417,166,537 - 17,200,385 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Kcne3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541417,166,546 - 17,200,353 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541417,166,537 - 17,200,385 (+)NCBIChiLan1.0ChiLan1.0
KCNE3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381174,454,841 - 74,467,549 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1174,454,841 - 74,467,729 (-)EnsemblGRCh38hg38GRCh38
GRCh371174,165,886 - 74,178,594 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,843,534 - 73,856,248 (-)NCBINCBI36Build 36hg18NCBI36
Build 341173,843,805 - 73,850,798NCBI
Celera1171,472,396 - 71,485,109 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1170,461,201 - 70,473,937 (-)NCBIHuRef
CHM1_11174,049,426 - 74,062,143 (-)NCBICHM1_1
T2T-CHM13v2.01174,384,260 - 74,396,980 (-)NCBIT2T-CHM13v2.0
Kcne3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,825,714 - 99,834,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl799,825,709 - 99,834,076 (+)EnsemblGRCm39 Ensembl
GRCm387100,176,507 - 100,184,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,176,502 - 100,184,869 (+)EnsemblGRCm38mm10GRCm38
MGSCv377107,327,207 - 107,333,374 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,052,780 - 100,058,947 (+)NCBIMGSCv36mm8
Celera7100,513,245 - 100,519,198 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.33NCBI
Kcne3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,936,035 - 163,942,998 (+)NCBIGRCr8
mRatBN7.21154,523,903 - 154,530,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,523,830 - 154,532,020 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,518,249 - 162,525,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,698,347 - 169,705,304 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,571,923 - 162,578,879 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,189,934 - 165,196,949 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,189,985 - 165,196,948 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,390,138 - 171,397,804 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,558,044 - 157,565,008 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,636,337 - 157,643,300 (+)NCBI
Celera1152,607,926 - 152,614,889 (+)NCBICelera
Cytogenetic Map1q32NCBI
KCNE3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2975,396,558 - 75,409,080 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11176,440,593 - 76,453,426 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01169,527,663 - 69,540,236 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,832,858 - 72,845,399 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,835,048 - 72,835,359 (-)Ensemblpanpan1.1panPan2
KCNE3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,860,727 - 23,872,194 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,871,648 - 23,871,947 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2123,625,823 - 23,638,780 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02124,063,194 - 24,076,168 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2124,074,135 - 24,074,434 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12123,860,571 - 23,873,532 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02124,057,896 - 24,070,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,975,487 - 23,988,456 (+)NCBIUU_Cfam_GSD_1.0
Kcne3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494761,876,838 - 61,888,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364983,478,039 - 3,478,350 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364983,477,313 - 3,487,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNE3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl98,810,720 - 8,822,494 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.198,810,716 - 8,822,191 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.299,649,248 - 9,660,859 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNE3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1165,699,558 - 65,710,305 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl165,700,156 - 65,700,467 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604360,150,565 - 60,161,017 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcne3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248172,513,539 - 2,606,682 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248172,593,649 - 2,607,462 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000023870   ⟹   ENSCLAP00000023645
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541417,166,546 - 17,200,353 (+)Ensembl
RefSeq Acc Id: XM_005379918   ⟹   XP_005379975
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541417,166,546 - 17,200,353 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005379919   ⟹   XP_005379976
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541417,189,418 - 17,200,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005379920   ⟹   XP_005379977
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541417,189,416 - 17,200,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005379922   ⟹   XP_005379979
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541417,168,151 - 17,200,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005379923   ⟹   XP_005379980
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541417,172,286 - 17,200,385 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013511942   ⟹   XP_013367396
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541417,168,151 - 17,200,385 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001233141
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541417,166,537 - 17,168,720 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005379975   ⟸   XM_005379918
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005379979   ⟸   XM_005379922
- Peptide Label: isoform X5
- UniProtKB: A0A8C2W165 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005379980   ⟸   XM_005379923
- Peptide Label: isoform X5
- UniProtKB: A0A8C2W165 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005379976   ⟸   XM_005379919
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005379977   ⟸   XM_005379920
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013367396   ⟸   XM_013511942
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCLAP00000023645   ⟸   ENSCLAT00000023870


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016222 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023870 ENTREZGENE
  ENSCLAT00000023870.1 UniProtKB/TrEMBL
InterPro K_chnl_KCNE UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNE3 UniProtKB/TrEMBL
NCBI Gene LOC102007421 ENTREZGENE
PANTHER PTHR15282 UniProtKB/TrEMBL
  PTHR15282:SF6 UniProtKB/TrEMBL
Pfam ISK_Channel UniProtKB/TrEMBL
PRINTS KCNE3CHANNEL UniProtKB/TrEMBL
  KCNECHANNEL UniProtKB/TrEMBL
UniProt A0A8C2W165 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Kcne3  potassium voltage-gated channel subfamily E regulatory subunit 3    potassium channel, voltage gated subfamily E regulatory beta subunit 3  Symbol and/or name change 5135510 APPROVED
2015-08-25 Kcne3  potassium channel, voltage gated subfamily E regulatory beta subunit 3  LOC102007421  potassium voltage-gated channel subfamily E member 3-like  Symbol and/or name change 5135510 APPROVED