Symbol:
Cyba
Name:
cytochrome b-245 alpha chain
RGD ID:
620573
Description:
Contributes to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to L-glutamine; cellular response to gamma radiation; and positive regulation of cell population proliferation. Located in several cellular components, including focal adhesion; perinuclear endoplasmic reticulum; and stress fiber. Part of NADPH oxidase complex. Used to study hypertension and pulmonary hypertension. Biomarker of diabetic retinopathy; end stage renal disease; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain); PARTICIPATES IN thyroid hormone biosynthetic pathway; Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH (R)-lipoic acid; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
alpha-subunit p22; cytochrome b(558) alpha chain; cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; cytochrome b558 alpha-subunit; cytochrome b558 subunit alpha; neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Phox; superoxide-generating NADPH oxidase light chain subunit
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CYBA (cytochrome b-245 alpha chain) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):
Cyba (cytochrome b-245, alpha polypeptide) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
LOC102004641 (cytochrome b-245 light chain) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
LOC100986914 (cytochrome b-245 light chain) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CYBA (cytochrome b-245 alpha chain) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
LOC101967032 (cytochrome b-245 light chain) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CYBA (cytochrome b-245 alpha chain) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
CYBA (cytochrome b-245 alpha chain) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
LOC101717043 (cytochrome b-245 light chain) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
RPP14 (ribonuclease P/MRP subunit p14) HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
CYBA (cytochrome b-245 alpha chain)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Cyba (cytochrome b-245, alpha polypeptide)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
cyba (cytochrome b-245, alpha polypeptide)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
cyba
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Allele / Splice:
Cybaem1Mcwi ;
CybamesSdi
Genetic Models:
SS-Cybaem1Mcwi
Candidate Gene For:
Eau8
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 19 67,396,143 - 67,404,214 (-) NCBI GRCr8 mRatBN7.2 19 50,487,598 - 50,495,669 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 19 50,487,597 - 50,495,721 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 19 57,282,778 - 57,290,847 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 19 57,962,531 - 57,970,602 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 19 60,181,396 - 60,189,465 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 19 55,249,634 - 55,257,824 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 55,249,616 - 55,257,876 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 19 65,959,818 - 65,967,224 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 52,713,150 - 52,721,609 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 19 52,718,030 - 52,726,490 (-) NCBI Celera 19 49,727,142 - 49,735,154 (-) NCBI Celera Cytogenetic Map 19 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Cyba Rat acute lymphoblastic leukemia ISO RGD:734174 11040545 mRNA:increased expression:peripheral blood mononuclear cell: RGD Cyba Rat asthma susceptibility ISO RGD:734174 4311041 DNA:polymorphism: :-930A>G (human) RGD Cyba Rat asthma susceptibility ISO RGD:734174 4772770 DNA:SNPs: :-930A>G, 242C>T, 640A>G (human) RGD Cyba Rat chronic granulomatous disease ISO RGD:734174 11040541 DNA:nonsense,missense mutations:exons:35C>T, 98G>A,(p.Q3X,G24R)(human) RGD Cyba Rat chronic granulomatous disease ISO RGD:734174 1600791 autosomal recessive cytochrome b-negative CGD, OMIM:233690;DNA:missense mutation: :p.R90Q (human) RGD Cyba Rat chronic granulomatous disease ISO RGD:734174 734861 DNA:mutations:multiple (human) RGD Cyba Rat chronic obstructive pulmonary disease susceptibility ISO RGD:734174 4304108 DNA:polymorphism: :p.H72Y (human) RGD Cyba Rat chronic obstructive pulmonary disease susceptibility ISO RGD:734174 4293707 DNA:polymorphisms: :-930A>G, 242C>T (human) RGD Cyba Rat coronary artery disease ISO RGD:734174 1578443 RGD Cyba Rat Coronary Disease ISO RGD:734174 1580275 RGD Cyba Rat Diabetic Nephropathies ISO RGD:734174 8695982 associated with Diabetes Mellitus, Type 2;DNA:SNP: :242C>T (human) RGD Cyba Rat diabetic retinopathy IEP 2317854 associated with Diabetes Mellitus, Experimental RGD Cyba Rat end stage renal disease IEP 2306994 RGD Cyba Rat Eosinophilia IAGP 11040542 DNA:deletion:splice junction: RGD Cyba Rat Experimental Diabetes Mellitus IEP 11040693 mRNA:increased expression:pancreas: RGD Cyba Rat Experimental Diabetes Mellitus IEP 2317852 mRNA, protein:increased expression:aorta RGD Cyba Rat hypertension ISO RGD:734174 1580276 RGD Cyba Rat hypertension IEP 2317853 protein:increased expression:kidney cortex RGD Cyba Rat hypertension IDA 4775206 RGD Cyba Rat Metabolic Syndrome IEP 2317864 RGD Cyba Rat myocardial infarction IEP 1599690 mRNA:increase expression:ventricle myocardium: RGD Cyba Rat myocardial infarction IEP 2317860 mRNA:increased expression:myocardium RGD Cyba Rat obstructive sleep apnea severity ISO RGD:734174 4266589 mRNA, protein:increased expression:sputum, macrophage, neutrophil RGD Cyba Rat phagocyte bactericidal dysfunction ISO RGD:734174 4779762 DNA:mutations: :multiple (human) RGD Cyba Rat pulmonary hypertension ISO RGD:734175 4762683 associated with Anoxia;mRNA, protein:increased expression:lung RGD Cyba Rat pulmonary hypertension IDA 4773907 RGD Cyba Rat pulmonary sarcoidosis no_association ISO RGD:734174 4780358 DNA:SNPs:exons:214C>T (rs4673), 521C>T (rs17845095) (human) RGD Cyba Rat pulmonary tuberculosis no_association ISO RGD:734174 4780358 DNA:SNPs:exons:214C>T (rs4673), 521C>T (rs17845095) (human) RGD Cyba Rat Reperfusion Injury IEP 1599683 RGD Cyba Rat Spinal Cord Injuries IEP 1599510 mRNA:increased expression:spinal cord RGD
Cyba Rat 16Q24.3 Microdeletion Syndrome ISO RGD:734174 8554872 ClinVar Annotator: match by term: 16q24.3 microdeletion syndrome ClinVar Cyba Rat autoimmune polyendocrine syndrome type 1 ISO RGD:734174 8554872 ClinVar Annotator: match by term: Polyglandular autoimmune syndrome, type 1 ClinVar PMID:10914676|PMID:18546332|PMID:22924696|PMID:23910690|PMID:25741868|PMID:28492532|PMID:28941186|PMID:30470980|PMID:35140711|PMID:36606663 Cyba Rat autosomal recessive chronic granulomatous disease 4 ISO RGD:734174 8554872 ClinVar Annotator: match by term: Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative ClinVar PMID:10440830|PMID:10759707|PMID:10910929|PMID:10914676|PMID:12073015|PMID:1415254|PMID:16199547|PMID:16937026|PMID:17576681|PMID:1763037|PMID:18422995|PMID:18546332|PMID:19292887|PMID:19388116|PMID:19949658|PMID:20167518|PMID:20674832|PMID:21190454|PMID:22336310|PMID:2243141|PMID:22562447|PMID:22876374|PMID:22924696|PMID:23002911|PMID:23910690|PMID:25741868|PMID:26185101|PMID:26915675|PMID:26936803|PMID:27537055|PMID:27701760|PMID:27980538|PMID:28251166|PMID:28341171|PMID:28492532|PMID:28941186|PMID:29454792|PMID:29560547|PMID:30470980|PMID:30709874|PMID:30716179|PMID:31364312|PMID:31375816|PMID:31456102|PMID:31813112|PMID:32040803|PMID:32081864|PMID:33629196|PMID:3368442|PMID:33717137|PMID:34547651|PMID:35140711|PMID:3571224|PMID:35960392|PMID:36241643|PMID:36606663|PMID:4384563|PMID:8168815|PMID:9445163|PMID:9536098 Cyba Rat chronic granulomatous disease ISO RGD:734174 8554872 ClinVar Annotator: match by term: Chronic granulomatous disease ClinVar PMID:10440830|PMID:10759707|PMID:10910929|PMID:10914676|PMID:1415254|PMID:16199547|PMID:17576681|PMID:1763037|PMID:18546332|PMID:19292887|PMID:19388116|PMID:19949658|PMID:20167518|PMID:20674832|PMID:21190454|PMID:22336310|PMID:2243141|PMID:22876374|PMID:22924696|PMID:23910690|PMID:25741868|PMID:26185101|PMID:26936803|PMID:27537055|PMID:27701760|PMID:28341171|PMID:28492532|PMID:28941186|PMID:29454792|PMID:30470980|PMID:30709874|PMID:31456102|PMID:31813112|PMID:31847883|PMID:32040803|PMID:32081864|PMID:3368442|PMID:33717137|PMID:34547651|PMID:35140711|PMID:35960392|PMID:36606663|PMID:8168815|PMID:9445163|PMID:9536098 Cyba Rat Fanconi anemia ISO RGD:734174 8554872 ClinVar Annotator: match by term: Fanconi anemia ClinVar PMID:28492532 Cyba Rat genetic disease ISO RGD:734174 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:28492532 Cyba Rat inflammatory bowel disease ISO RGD:734174 8554872 ClinVar Annotator: match by term: Very early onset inflammatory bowel disease ClinVar PMID:10440830|PMID:19388116|PMID:25741868|PMID:28492532|PMID:30709874|PMID:3368442|PMID:9445163 Cyba Rat KBG syndrome ISO RGD:734174 8554872 ClinVar Annotator: match by term: KBG syndrome ClinVar PMID:21782149|PMID:25125236|PMID:25413698|PMID:25652421|PMID:28492532|PMID:31602316|PMID:31690835 Cyba Rat primary ciliary dyskinesia 33 ISO RGD:734174 8554872 ClinVar Annotator: match by term: Primary ciliary dyskinesia 33 ClinVar PMID:28492532 Cyba Rat spermatogenic failure 31 ISO RGD:734174 8554872 ClinVar Annotator: match by term: CYBA DEFICIENCY ClinVar PMID:10440830|PMID:10910929|PMID:19388116|PMID:20167518|PMID:2243141|PMID:25741868|PMID:26185101|PMID:28492532|PMID:30709874|PMID:31364312|PMID:3368442|PMID:3571224|PMID:9445163 Cyba Rat X-linked chronic granulomatous disease ISO RGD:734174 8554872 ClinVar Annotator: match by term: Granulomatous disease, chronic, X-linked ClinVar PMID:28492532
Only show annotations with direct experimental evidence (0 objects hidden)
Cyba Rat (1->4)-beta-D-glucan multiple interactions ISO RGD:734175 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYBA mRNA CTD PMID:36331819 Cyba Rat (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results more ... CTD PMID:33111558 Cyba Rat (R)-lipoic acid multiple interactions ISO RGD:734175 6480464 Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA] CTD PMID:35187969 Cyba Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression EXP 6480464 o,p'-DDT results in increased expression of CYBA mRNA CTD PMID:24096037 Cyba Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactions ISO RGD:734174 6480464 Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CYBA mRNA] CTD PMID:35122929 Cyba Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO RGD:734174 6480464 o,p'-DDT results in increased expression of CYBA mRNA CTD PMID:35122929 Cyba Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO RGD:734175 6480464 o,p'-DDT results in increased expression of CYBA mRNA CTD PMID:24096037 Cyba Rat 1,2-dimethylhydrazine increases expression EXP 6480464 1,2-Dimethylhydrazine results in increased expression of CYBA mRNA CTD PMID:32387197 Cyba Rat 1,2-dimethylhydrazine increases expression ISO RGD:734175 6480464 1,2-Dimethylhydrazine results in increased expression of CYBA mRNA CTD PMID:22206623 Cyba Rat 1-naphthyl isothiocyanate decreases expression EXP 6480464 1-Naphthylisothiocyanate results in decreased expression of CYBA mRNA CTD PMID:25380136 Cyba Rat 11-deoxycorticosterone increases expression EXP 6480464 Desoxycorticosterone results in increased expression of CYBA mRNA; Desoxycorticosterone results in increased expression of CYBA more ... CTD PMID:16271043 Cyba Rat 11-deoxycorticosterone multiple interactions EXP 6480464 [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of CYBA protein CTD PMID:22431579 Cyba Rat 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of CYBA mRNA CTD PMID:17557909|PMID:24096037 Cyba Rat 17alpha-ethynylestradiol increases expression ISO RGD:734175 6480464 Ethinyl Estradiol results in increased expression of CYBA mRNA CTD PMID:17555576|PMID:17942748|PMID:24096037 Cyba Rat 17beta-estradiol affects expression ISO RGD:734175 6480464 Estradiol affects the expression of CYBA mRNA CTD PMID:16195479|PMID:16684588 Cyba Rat 17beta-estradiol decreases expression ISO RGD:734175 6480464 Estradiol results in decreased expression of CYBA mRNA CTD PMID:39298647 Cyba Rat 17beta-estradiol multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CYBA mRNA CTD PMID:32741896 Cyba Rat 17beta-estradiol increases expression ISO RGD:734174 6480464 Estradiol results in increased expression of CYBA mRNA CTD PMID:17121429|PMID:19167446 Cyba Rat 17beta-estradiol 3-benzoate multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CYBA mRNA CTD PMID:32741896 Cyba Rat 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) multiple interactions ISO RGD:734174 6480464 [CYP3A4 protein affects the susceptibility to 2,2'-methylenebis(4-methyl-6-tert-butylphenol)] which affects the expression of CYBA mRNA CTD PMID:38160208 Cyba Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:734175 6480464 Tetrachlorodibenzodioxin results in increased expression of CYBA mRNA CTD PMID:23864506|PMID:28213091 Cyba Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CYBA mRNA CTD PMID:34747641 Cyba Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:734175 6480464 Tetrachlorodibenzodioxin affects the expression of CYBA mRNA CTD PMID:26377647 Cyba Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CYBA mRNA CTD PMID:20959002 Cyba Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:734174 6480464 Tetrachlorodibenzodioxin results in increased expression of CYBA mRNA CTD PMID:16051281|PMID:20106945|PMID:21632981 Cyba Rat 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:734175 6480464 [Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of CYBA protein; ONO more ... CTD PMID:28887131 Cyba Rat 2-amino-2-deoxy-D-glucopyranose decreases expression ISO RGD:734174 6480464 Glucosamine results in decreased expression of CYBA mRNA CTD PMID:18077487 Cyba Rat 2-aminobiphenyl multiple interactions ISO RGD:734174 6480464 CYBA mutant form inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein] CTD PMID:22288910 Cyba Rat 2-aminobiphenyl increases expression ISO RGD:734174 6480464 2-aminodiphenyl results in increased expression of CYBA protein CTD PMID:22288910 Cyba Rat 2-hydroxypropanoic acid decreases expression ISO RGD:734174 6480464 Lactic Acid results in decreased expression of CYBA mRNA CTD PMID:30851411 Cyba Rat 3-chloropropane-1,2-diol affects expression EXP 6480464 alpha-Chlorohydrin affects the expression of CYBA mRNA CTD PMID:28522335 Cyba Rat 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1,2-dithiol-3-thione results in decreased expression of CYBA mRNA CTD PMID:19162173 Cyba Rat 4,4'-diaminodiphenylmethane decreases expression EXP 6480464 4,4'-diaminodiphenylmethane results in decreased expression of CYBA mRNA CTD PMID:25380136 Cyba Rat 4,4'-sulfonyldiphenol multiple interactions ISO RGD:734175 6480464 [bisphenol S co-treated with Tretinoin] results in decreased expression of CYBA mRNA CTD PMID:30951980 Cyba Rat 4,4'-sulfonyldiphenol increases methylation ISO RGD:734175 6480464 bisphenol S results in increased methylation of CYBA exon CTD PMID:33297965 Cyba Rat 4-hydroxy-TEMPO decreases expression EXP 6480464 tempol results in decreased expression of CYBA mRNA CTD PMID:16685210 Cyba Rat 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:734175 6480464 CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 Cyba Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of CYBA mRNA CTD PMID:31881176 Cyba Rat aflatoxin B1 increases expression ISO RGD:734174 6480464 Aflatoxin B1 results in increased expression of CYBA mRNA CTD PMID:27153756 Cyba Rat aflatoxin B1 decreases expression ISO RGD:734174 6480464 Aflatoxin B1 results in decreased expression of CYBA mRNA CTD PMID:32234424|PMID:35690182 Cyba Rat AICA ribonucleotide multiple interactions EXP 6480464 AICA ribonucleotide inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein] CTD PMID:21195169 Cyba Rat aldehydo-D-glucosamine decreases expression ISO RGD:734174 6480464 Glucosamine results in decreased expression of CYBA mRNA CTD PMID:18077487 Cyba Rat aldehydo-D-glucose increases expression ISO RGD:734174 6480464 Glucose results in increased expression of CYBA protein CTD PMID:17916771|PMID:18088078 Cyba Rat aldehydo-D-glucose decreases expression ISO RGD:734174 6480464 Glucose results in decreased expression of CYBA mRNA CTD PMID:32942007 Cyba Rat aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of CYBA mRNA; Glucose results in increased expression of CYBA more ... CTD PMID:22245600|PMID:31838053 Cyba Rat aldehydo-D-glucose multiple interactions EXP 6480464 [[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression more ... CTD PMID:22245600|PMID:31838053 Cyba Rat aldehydo-D-glucose multiple interactions ISO RGD:734174 6480464 dorsomorphin inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA more ... CTD PMID:17916771|PMID:18088078 Cyba Rat all-trans-retinoic acid increases expression ISO RGD:734174 6480464 Tretinoin results in increased expression of CYBA mRNA CTD PMID:15498508|PMID:16054129|PMID:17218384|PMID:33167477 Cyba Rat all-trans-retinoic acid multiple interactions ISO RGD:734175 6480464 [bisphenol A co-treated with Tretinoin] results in decreased expression of CYBA mRNA; [bisphenol F co-treated more ... CTD PMID:30951980 Cyba Rat aminoguanidine multiple interactions EXP 6480464 pimagedine inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA] CTD PMID:18594475 Cyba Rat amlodipine multiple interactions EXP 6480464 Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA] CTD PMID:21107329 Cyba Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CYBA mRNA CTD PMID:16483693 Cyba Rat anagliptin multiple interactions ISO RGD:734174 6480464 anagliptin inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA] CTD PMID:31586451 Cyba Rat anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Glucose results in increased expression of CYBA protein] CTD PMID:22245600 Cyba Rat antirheumatic drug decreases expression ISO RGD:734174 6480464 Antirheumatic Agents results in decreased expression of CYBA mRNA CTD PMID:24449571 Cyba Rat apocynin multiple interactions EXP 6480464 acetovanillone inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]; acetovanillone inhibits more ... CTD PMID:23270704 Cyba Rat apocynin multiple interactions ISO RGD:734175 6480464 acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of more ... CTD PMID:29037473 Cyba Rat aristolochic acid A decreases expression ISO RGD:734174 6480464 aristolochic acid I results in decreased expression of CYBA protein CTD PMID:33212167 Cyba Rat Aroclor 1254 increases expression ISO RGD:734175 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of CYBA mRNA CTD PMID:23650126 Cyba Rat arsane affects response to substance ISO RGD:734174 6480464 CYBA gene polymorphism affects the susceptibility to Arsenic; CYBA gene SNP affects the susceptibility to more ... CTD PMID:16076760|PMID:26220686 Cyba Rat arsenic atom affects response to substance ISO RGD:734174 6480464 CYBA gene polymorphism affects the susceptibility to Arsenic; CYBA gene SNP affects the susceptibility to more ... CTD PMID:16076760|PMID:26220686 Cyba Rat arsenite(3-) increases expression ISO RGD:734174 6480464 arsenite results in increased expression of CYBA mRNA CTD PMID:10720412 Cyba Rat arsenite(3-) multiple interactions ISO RGD:734174 6480464 CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides] CTD PMID:10720412 Cyba Rat arsenous acid increases expression ISO RGD:734174 6480464 Arsenic Trioxide results in increased expression of CYBA mRNA CTD PMID:15070760|PMID:27750169 Cyba Rat atorvastatin calcium multiple interactions EXP 6480464 Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of CYBA mRNA] CTD PMID:25218292 Cyba Rat benzo[a]pyrene multiple interactions ISO RGD:734175 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to CYBA promoter] CTD PMID:19654925 Cyba Rat benzo[a]pyrene decreases expression ISO RGD:734174 6480464 Benzo(a)pyrene results in decreased expression of CYBA mRNA CTD PMID:32234424|PMID:35690182 Cyba Rat benzo[a]pyrene increases methylation ISO RGD:734174 6480464 Benzo(a)pyrene results in increased methylation of CYBA exon CTD PMID:27901495 Cyba Rat benzo[a]pyrene affects methylation ISO RGD:734174 6480464 Benzo(a)pyrene affects the methylation of CYBA promoter CTD PMID:27901495 Cyba Rat benzo[a]pyrene decreases expression ISO RGD:734175 6480464 Benzo(a)pyrene results in decreased expression of CYBA mRNA CTD PMID:19770486|PMID:22641617 Cyba Rat benzo[a]pyrene increases expression ISO RGD:734175 6480464 Benzo(a)pyrene results in increased expression of CYBA mRNA CTD PMID:22228805|PMID:35567930 Cyba Rat beta-D-glucosamine decreases expression ISO RGD:734174 6480464 Glucosamine results in decreased expression of CYBA mRNA CTD PMID:18077487 Cyba Rat bezafibrate multiple interactions ISO RGD:734174 6480464 Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA] CTD PMID:11172467 Cyba Rat bezafibrate multiple interactions EXP 6480464 Bezafibrate inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA] CTD PMID:12967931 Cyba Rat bezafibrate decreases expression ISO RGD:734174 6480464 Bezafibrate results in decreased expression of CYBA mRNA CTD PMID:11172467 Cyba Rat bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:734174 6480464 CYBA protein affects the reaction [Diethylhexyl Phthalate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 more ... CTD PMID:28673093 Cyba Rat bis(2-ethylhexyl) phthalate increases expression ISO RGD:734175 6480464 Diethylhexyl Phthalate results in increased expression of CYBA mRNA CTD PMID:33754040 Cyba Rat bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:734175 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated more ... CTD PMID:35739755 Cyba Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CYBA mRNA CTD PMID:25181051 Cyba Rat bisphenol A increases expression ISO RGD:734175 6480464 bisphenol A results in increased expression of CYBA mRNA CTD PMID:32156529|PMID:36633214 Cyba Rat bisphenol A multiple interactions ISO RGD:734175 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated more ... CTD PMID:30951980|PMID:35739755|PMID:36633214 Cyba Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CYBA mRNA CTD PMID:30816183|PMID:34947998 Cyba Rat bisphenol A decreases methylation ISO RGD:734175 6480464 bisphenol A results in decreased methylation of CYBA promoter CTD PMID:27312807 Cyba Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Dietary Fats] results in increased expression of CYBA mRNA CTD PMID:25112833 Cyba Rat bisphenol F multiple interactions ISO RGD:734175 6480464 [bisphenol F co-treated with Tretinoin] results in decreased expression of CYBA mRNA CTD PMID:30951980 Cyba Rat bleomycin A2 increases expression ISO RGD:734175 6480464 Bleomycin results in increased expression of CYBA mRNA CTD PMID:35187969 Cyba Rat bleomycin A2 multiple interactions ISO RGD:734175 6480464 Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA] CTD PMID:35187969 Cyba Rat bortezomib decreases expression ISO RGD:734174 6480464 Bortezomib results in decreased expression of CYBA mRNA CTD PMID:20977926 Cyba Rat butan-1-ol multiple interactions ISO RGD:734174 6480464 [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ... CTD PMID:29432896 Cyba Rat Butylbenzyl phthalate multiple interactions ISO RGD:734175 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated more ... CTD PMID:35739755 Cyba Rat Butylparaben increases expression ISO RGD:734174 6480464 butylparaben results in increased expression of CYBA mRNA CTD PMID:17121429 Cyba Rat C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of CYBA mRNA CTD PMID:19167457 Cyba Rat cadmium dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]; AICA ribonucleotide more ... CTD PMID:21195169 Cyba Rat cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of CYBA protein CTD PMID:21195169 Cyba Rat cadmium dichloride increases expression ISO RGD:734174 6480464 Cadmium Chloride results in increased expression of CYBA protein CTD PMID:21195169 Cyba Rat caffeine increases phosphorylation ISO RGD:734174 6480464 Caffeine results in increased phosphorylation of CYBA protein CTD PMID:35688186 Cyba Rat calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of CYBA mRNA; Calcitriol results in decreased expression of CYBA more ... CTD PMID:32147540 Cyba Rat candesartan decreases expression ISO RGD:734174 6480464 candesartan results in decreased expression of CYBA protein CTD PMID:18551021 Cyba Rat candesartan decreases expression EXP 6480464 candesartan results in decreased expression of CYBA; candesartan results in decreased expression of CYBA mRNA CTD PMID:16685210|PMID:21107329 Cyba Rat candesartan multiple interactions EXP 6480464 Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA]; candesartan inhibits the reaction more ... CTD PMID:16139267|PMID:21107329 Cyba Rat canrenoic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid] results in increased expression of CYBA more ... CTD PMID:30298849 Cyba Rat carbamazepine multiple interactions EXP 6480464 [[Streptozocin co-treated with Carbamazepine] affects the susceptibility to Dietary Fats] which results in decreased expression more ... CTD PMID:35786680 Cyba Rat carbon nanotube affects expression ISO RGD:734175 6480464 Nanotubes, Carbon affects the expression of CYBA mRNA CTD PMID:23845593 Cyba Rat carbon nanotube increases expression ISO RGD:734175 6480464 Nanotubes, Carbon analog results in increased expression of CYBA mRNA; Nanotubes, Carbon results in increased more ... CTD PMID:25554681 Cyba Rat chloropicrin affects expression ISO RGD:734174 6480464 chloropicrin affects the expression of CYBA mRNA CTD PMID:26352163 Cyba Rat chloropicrin decreases expression ISO RGD:734174 6480464 chloropicrin results in decreased expression of CYBA mRNA CTD PMID:28476498 Cyba Rat choline multiple interactions ISO RGD:734175 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... CTD PMID:20938992 Cyba Rat chromium(6+) increases expression ISO RGD:734174 6480464 chromium hexavalent ion results in increased expression of CYBA protein CTD PMID:21742780 Cyba Rat cisplatin increases expression ISO RGD:734175 6480464 Cisplatin results in increased expression of CYBA mRNA CTD PMID:21151649 Cyba Rat cisplatin increases expression ISO RGD:734174 6480464 Cisplatin results in increased expression of CYBA mRNA CTD PMID:27594783 Cyba Rat cisplatin decreases expression ISO RGD:734175 6480464 Cisplatin results in decreased expression of CYBA mRNA CTD PMID:24865317 Cyba Rat cisplatin multiple interactions ISO RGD:734175 6480464 [Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA CTD PMID:24865317 Cyba Rat clofibrate multiple interactions EXP 6480464 Clofibrate inhibits the reaction [Niacinamide results in increased expression of CYBA mRNA] CTD PMID:23422569 Cyba Rat clothianidin decreases expression ISO RGD:734174 6480464 clothianidin results in decreased expression of CYBA mRNA CTD PMID:35690182 Cyba Rat cobalt dichloride increases expression ISO RGD:734175 6480464 cobaltous chloride results in increased expression of CYBA protein CTD PMID:16507596 Cyba Rat cocaine increases expression ISO RGD:734175 6480464 Cocaine results in increased expression of CYBA protein CTD PMID:18952886 Cyba Rat colistin multiple interactions EXP 6480464 [colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of CYBA more ... CTD PMID:33111558 Cyba Rat crocidolite asbestos multiple interactions ISO RGD:734175 6480464 CYBA protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein] CTD PMID:18403674 Cyba Rat Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of CYBA mRNA CTD PMID:27523638 Cyba Rat cyclosporin A increases expression ISO RGD:734174 6480464 Cyclosporine results in increased expression of CYBA mRNA CTD PMID:12352326 Cyba Rat cyclosporin A decreases expression ISO RGD:734174 6480464 Cyclosporine results in decreased expression of CYBA mRNA CTD PMID:25562108 Cyba Rat cyclosporin A multiple interactions ISO RGD:734174 6480464 Ramipril inhibits the reaction [Cyclosporine results in increased expression of CYBA mRNA] CTD PMID:12352326 Cyba Rat cytarabine decreases expression ISO RGD:734174 6480464 Cytarabine results in decreased expression of CYBA mRNA CTD PMID:21198554 Cyba Rat D-glucose increases expression EXP 6480464 Glucose results in increased expression of CYBA mRNA; Glucose results in increased expression of CYBA more ... CTD PMID:22245600|PMID:31838053 Cyba Rat D-glucose decreases expression ISO RGD:734174 6480464 Glucose results in decreased expression of CYBA mRNA CTD PMID:32942007 Cyba Rat D-glucose multiple interactions ISO RGD:734174 6480464 dorsomorphin inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA more ... CTD PMID:17916771|PMID:18088078 Cyba Rat D-glucose increases expression ISO RGD:734174 6480464 Glucose results in increased expression of CYBA protein CTD PMID:17916771|PMID:18088078 Cyba Rat D-glucose multiple interactions EXP 6480464 [[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression more ... CTD PMID:22245600|PMID:31838053 Cyba Rat daunorubicin multiple interactions EXP 6480464 telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein] CTD PMID:21054405 Cyba Rat daunorubicin increases expression EXP 6480464 Daunorubicin results in increased expression of CYBA protein CTD PMID:21054405 Cyba Rat DDE increases expression ISO RGD:734174 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of CYBA mRNA CTD PMID:25386960 Cyba Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of CYBA mRNA CTD PMID:23914054 Cyba Rat dehydroepiandrosterone increases expression EXP 6480464 Dehydroepiandrosterone results in increased expression of CYBA mRNA; Dehydroepiandrosterone results in increased expression of CYBA more ... CTD PMID:27634381 Cyba Rat dehydroepiandrosterone multiple interactions EXP 6480464 Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the more ... CTD PMID:27634381 Cyba Rat Deoxycorticosterone acetate multiple interactions ISO RGD:734175 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA; CXCR2 gene more ... CTD PMID:27678262 Cyba Rat dextran sulfate increases expression ISO RGD:734175 6480464 Dextran Sulfate results in increased expression of CYBA protein CTD PMID:20637373 Cyba Rat Di-n-octyl phthalate multiple interactions ISO RGD:734175 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated more ... CTD PMID:35739755 Cyba Rat diallyl trisulfide multiple interactions EXP 6480464 diallyl trisulfide inhibits the reaction [Doxorubicin results in increased expression of CYBA protein] CTD PMID:29087013 Cyba Rat diarsenic trioxide increases expression ISO RGD:734174 6480464 Arsenic Trioxide results in increased expression of CYBA mRNA CTD PMID:15070760|PMID:27750169 Cyba Rat diazinon increases methylation ISO RGD:734174 6480464 Diazinon results in increased methylation of CYBA gene CTD PMID:22964155 Cyba Rat dibenziodolium multiple interactions ISO RGD:734175 6480464 diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA mRNA]; diphenyleneiodonium inhibits the more ... CTD PMID:25726414 Cyba Rat dibutyl phthalate multiple interactions ISO RGD:734175 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated more ... CTD PMID:35739755 Cyba Rat diclofenac increases expression ISO RGD:734175 6480464 Diclofenac results in increased expression of CYBA mRNA CTD PMID:26934552 Cyba Rat diethyl phthalate multiple interactions ISO RGD:734175 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated more ... CTD PMID:35739755 Cyba Rat Diisodecyl phthalate multiple interactions ISO RGD:734175 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated more ... CTD PMID:35739755 Cyba Rat diisononyl phthalate multiple interactions ISO RGD:734175 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated more ... CTD PMID:35739755 Cyba Rat dioxygen multiple interactions ISO RGD:734175 6480464 MIR34C promotes the reaction [Oxygen results in increased expression of CYBA mRNA]; SRT1720 inhibits the more ... CTD PMID:35848756 Cyba Rat dioxygen increases expression ISO RGD:734175 6480464 Oxygen results in increased expression of CYBA mRNA; Oxygen results in increased expression of CYBA more ... CTD PMID:35848756 Cyba Rat diuron decreases expression ISO RGD:734174 6480464 Diuron results in decreased expression of CYBA mRNA CTD PMID:35967413 Cyba Rat dorsomorphin multiple interactions ISO RGD:734174 6480464 dorsomorphin inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA more ... CTD PMID:17916771 Cyba Rat doxorubicin multiple interactions EXP 6480464 diallyl trisulfide inhibits the reaction [Doxorubicin results in increased expression of CYBA protein] CTD PMID:29087013 Cyba Rat doxorubicin multiple interactions ISO RGD:734175 6480464 GSK2795039 inhibits the reaction [Doxorubicin results in increased expression of CYBA protein] CTD PMID:36764612 Cyba Rat doxorubicin increases expression ISO RGD:734175 6480464 Doxorubicin results in increased expression of CYBA protein CTD PMID:36764612 Cyba Rat doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of CYBA protein CTD PMID:29087013 Cyba Rat ellagic acid multiple interactions EXP 6480464 Ellagic Acid inhibits the reaction [AGT protein results in increased expression of CYBA mRNA] CTD PMID:38356441 Cyba Rat enalapril decreases expression ISO RGD:734175 6480464 Enalapril results in decreased expression of CYBA protein CTD PMID:20720404|PMID:25037058 Cyba Rat enalapril multiple interactions ISO RGD:734175 6480464 [paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein CTD PMID:20720404 Cyba Rat endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of CYBA mRNA CTD PMID:29391264 Cyba Rat eplerenone decreases expression EXP 6480464 eplerenone results in decreased expression of CYBA mRNA CTD PMID:17324946 Cyba Rat eplerenone multiple interactions EXP 6480464 [trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA CTD PMID:17324946 Cyba Rat ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of CYBA mRNA CTD PMID:17920746 Cyba Rat ethanol increases expression ISO RGD:734175 6480464 Ethanol results in increased expression of CYBA mRNA CTD PMID:20026259|PMID:23978445 Cyba Rat ethanol multiple interactions ISO RGD:734175 6480464 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Ethanol results in increased expression of CYBA mRNA]; SB 203580 inhibits more ... CTD PMID:23978445 Cyba Rat ethanol multiple interactions ISO RGD:734174 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ... CTD PMID:29432896 Cyba Rat farrerol multiple interactions EXP 6480464 farrerol inhibits the reaction [Glucose results in increased expression of CYBA mRNA]; farrerol inhibits the more ... CTD PMID:31838053 Cyba Rat fenamidone increases expression ISO RGD:734175 6480464 fenamidone results in increased expression of CYBA mRNA CTD PMID:27029645 Cyba Rat flavonoids multiple interactions ISO RGD:734174 6480464 Flavonoids inhibits the reaction [AGT protein results in increased expression of CYBA mRNA]; Flavonoids inhibits more ... CTD PMID:23994555 Cyba Rat folic acid multiple interactions ISO RGD:734175 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... CTD PMID:20938992 Cyba Rat folic acid decreases expression ISO RGD:734175 6480464 Folic Acid results in decreased expression of CYBA mRNA CTD PMID:25629700 Cyba Rat furan increases expression EXP 6480464 furan results in increased expression of CYBA mRNA CTD PMID:27387713 Cyba Rat furan decreases methylation EXP 6480464 furan results in decreased methylation of CYBA gene CTD PMID:27387713 Cyba Rat genistein decreases expression ISO RGD:734174 6480464 Genistein results in decreased expression of CYBA mRNA CTD PMID:16705744 Cyba Rat genistein decreases expression ISO RGD:734175 6480464 Genistein results in decreased expression of CYBA mRNA CTD PMID:24967385 Cyba Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of CYBA mRNA CTD PMID:22061828 Cyba Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of CYBA mRNA CTD PMID:22061828 Cyba Rat ginsenoside Re multiple interactions ISO RGD:734175 6480464 ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity more ... CTD PMID:29037473 Cyba Rat glucose increases expression EXP 6480464 Glucose results in increased expression of CYBA mRNA; Glucose results in increased expression of CYBA more ... CTD PMID:22245600|PMID:31838053 Cyba Rat glucose decreases expression ISO RGD:734174 6480464 Glucose results in decreased expression of CYBA mRNA CTD PMID:32942007 Cyba Rat glucose multiple interactions ISO RGD:734174 6480464 dorsomorphin inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in increased expression of CYBA more ... CTD PMID:17916771|PMID:18088078 Cyba Rat glucose increases expression ISO RGD:734174 6480464 Glucose results in increased expression of CYBA protein CTD PMID:17916771|PMID:18088078 Cyba Rat glucose multiple interactions EXP 6480464 [[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression more ... CTD PMID:22245600|PMID:31838053 Cyba Rat GW 6471 multiple interactions EXP 6480464 GW 6471 inhibits the reaction [resveratrol inhibits the reaction [Niacinamide results in increased expression of more ... CTD PMID:23422569 Cyba Rat hexadecanoic acid multiple interactions EXP 6480464 CYBA mutant form inhibits the reaction [Palmitic Acid results in increased expression of ALPL mRNA]; more ... CTD PMID:24080574 Cyba Rat hydrochlorothiazide multiple interactions EXP 6480464 Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA] CTD PMID:21107329 Cyba Rat hydrogen chloride increases expression ISO RGD:734175 6480464 Hydrochloric Acid results in increased expression of CYBA protein CTD PMID:31900028 Cyba Rat hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of CYBA mRNA; Hydrogen Peroxide results in increased expression more ... CTD PMID:23270704 Cyba Rat hydrogen peroxide multiple interactions ISO RGD:734174 6480464 anagliptin inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]; Ascorbic Acid more ... CTD PMID:25305479|PMID:31586451 Cyba Rat hydrogen peroxide increases expression ISO RGD:734174 6480464 Hydrogen Peroxide results in increased expression of CYBA mRNA; Hydrogen Peroxide results in increased expression more ... CTD PMID:25305479|PMID:31586451 Cyba Rat hydrogen peroxide multiple interactions EXP 6480464 4-chlorobenzyltetrahydroberberine inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]; 4-chlorobenzyltetrahydroberberine inhibits more ... CTD PMID:23270704 Cyba Rat iron dextran increases expression EXP 6480464 Iron-Dextran Complex results in increased expression of CYBA protein CTD PMID:15086920 Cyba Rat isobutanol multiple interactions ISO RGD:734174 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic more ... CTD PMID:29432896 Cyba Rat isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of CYBA mRNA CTD PMID:18594475 Cyba Rat isoprenaline multiple interactions EXP 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of CYBA mRNA]; pimagedine inhibits the more ... CTD PMID:18594475 Cyba Rat ketamine increases expression ISO RGD:734175 6480464 Ketamine results in increased expression of CYBA CTD PMID:18063801 Cyba Rat ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of CYBA mRNA CTD PMID:37077353 Cyba Rat L-ascorbic acid multiple interactions ISO RGD:734174 6480464 Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased expression of CYBA mRNA]; Ascorbic more ... CTD PMID:25305479 Cyba Rat L-methionine multiple interactions ISO RGD:734175 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ... CTD PMID:20938992 Cyba Rat Lasiocarpine decreases expression ISO RGD:734174 6480464 lasiocarpine results in decreased expression of CYBA mRNA CTD PMID:32234424|PMID:35690182 Cyba Rat lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results more ... CTD PMID:33111558 Cyba Rat lipoic acid multiple interactions ISO RGD:734175 6480464 Thioctic Acid inhibits the reaction [Bleomycin results in increased expression of CYBA mRNA] CTD PMID:35187969 Cyba Rat lipopolysaccharide increases expression ISO RGD:734175 6480464 Lipopolysaccharides results in increased expression of CYBA mRNA CTD PMID:27339419 Cyba Rat lipopolysaccharide increases expression ISO RGD:734174 6480464 Lipopolysaccharides results in increased expression of CYBA mRNA CTD PMID:31059760 Cyba Rat lipopolysaccharide multiple interactions ISO RGD:734174 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of CYBA mRNA; CYBA protein affects the more ... CTD PMID:18414230|PMID:31059760 Cyba Rat liraglutide multiple interactions ISO RGD:734174 6480464 Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBA mRNA] CTD PMID:35985417 Cyba Rat loganin affects expression ISO RGD:734175 6480464 loganin affects the expression of CYBA protein CTD PMID:21864639 Cyba Rat losartan multiple interactions EXP 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of CYBA mRNA] CTD PMID:38356441 Cyba Rat lutein multiple interactions ISO RGD:734175 6480464 [Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA CTD PMID:24865317 Cyba Rat lutein decreases expression ISO RGD:734175 6480464 Lutein results in decreased expression of CYBA mRNA CTD PMID:24865317 Cyba Rat manidipine multiple interactions ISO RGD:734174 6480464 [sodium arsenite co-treated with manidipine] results in decreased expression of CYBA mRNA; [sodium arsenite co-treated more ... CTD PMID:15085064 Cyba Rat manidipine decreases expression ISO RGD:734174 6480464 manidipine results in decreased expression of CYBA mRNA CTD PMID:15085064 Cyba Rat melatonin multiple interactions ISO RGD:734175 6480464 Melatonin inhibits the reaction [bisphenol A results in increased expression of CYBA mRNA] CTD PMID:36633214 Cyba Rat menadione increases expression ISO RGD:734175 6480464 Vitamin K 3 results in increased expression of CYBA protein CTD PMID:16507596 Cyba Rat mercury dichloride increases expression EXP 6480464 Mercuric Chloride results in increased expression of CYBA mRNA CTD PMID:28987480 Cyba Rat mercury dichloride multiple interactions EXP 6480464 Peptides inhibits the reaction [Mercuric Chloride results in increased expression of CYBA mRNA] CTD PMID:28987480 Cyba Rat metformin multiple interactions EXP 6480464 Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the more ... CTD PMID:27634381 Cyba Rat metformin decreases expression ISO RGD:734174 6480464 Metformin results in decreased expression of CYBA mRNA CTD PMID:15531508 Cyba Rat methanol multiple interactions ISO RGD:734175 6480464 diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA mRNA]; diphenyleneiodonium inhibits the more ... CTD PMID:25726414 Cyba Rat methanol increases expression ISO RGD:734175 6480464 Methanol results in increased expression of CYBA protein CTD PMID:25726414 Cyba Rat methyl methanesulfonate decreases expression ISO RGD:734174 6480464 Methyl Methanesulfonate results in decreased expression of CYBA mRNA CTD PMID:23649840 Cyba Rat methylglyoxal increases expression ISO RGD:734174 6480464 Pyruvaldehyde results in increased expression of CYBA mRNA CTD PMID:35985417 Cyba Rat methylglyoxal multiple interactions ISO RGD:734174 6480464 Liraglutide inhibits the reaction [Pyruvaldehyde results in increased expression of CYBA mRNA] CTD PMID:35985417 Cyba Rat methylmercury chloride increases expression ISO RGD:734174 6480464 methylmercuric chloride results in increased expression of CYBA mRNA CTD PMID:29581082 Cyba Rat Morroniside affects expression ISO RGD:734175 6480464 morroniside affects the expression of CYBA protein CTD PMID:21963495 Cyba Rat N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein] CTD PMID:21195169 Cyba Rat N-formyl-L-methionyl-L-leucyl-L-phenylalanine multiple interactions EXP 6480464 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein] promotes the more ... CTD PMID:19445920 Cyba Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Dietary Fats co-treated with Canrenoic Acid] results in increased expression of CYBA more ... CTD PMID:20360939|PMID:28943392|PMID:30298849 Cyba Rat N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of CYBA mRNA CTD PMID:20360939 Cyba Rat N-nitrosomorpholine increases expression EXP 6480464 N-nitrosomorpholine results in increased expression of CYBA mRNA CTD PMID:19716841 Cyba Rat N-Nitrosopyrrolidine decreases expression ISO RGD:734174 6480464 N-Nitrosopyrrolidine results in decreased expression of CYBA mRNA CTD PMID:32234424|PMID:35690182 Cyba Rat naringin multiple interactions ISO RGD:734174 6480464 naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits more ... CTD PMID:25391245 Cyba Rat nebivolol multiple interactions EXP 6480464 Nebivolol inhibits the reaction [AGT protein results in increased expression of CYBA mRNA] CTD PMID:16940222 Cyba Rat nickel atom increases expression ISO RGD:734174 6480464 Nickel results in increased expression of CYBA mRNA CTD PMID:25583101 Cyba Rat nickel sulfate increases expression ISO RGD:734174 6480464 nickel sulfate results in increased expression of CYBA mRNA CTD PMID:22714537 Cyba Rat nicotinamide multiple interactions EXP 6480464 Clofibrate inhibits the reaction [Niacinamide results in increased expression of CYBA mRNA]; GW 6471 inhibits more ... CTD PMID:23422569 Cyba Rat nicotinamide increases expression EXP 6480464 Niacinamide results in increased expression of CYBA mRNA CTD PMID:23422569 Cyba Rat nicotinic acid decreases expression EXP 6480464 Niacin results in decreased expression of CYBA protein CTD PMID:19420110 Cyba Rat nitrates multiple interactions ISO RGD:734175 6480464 [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of CYBA more ... CTD PMID:35964746 Cyba Rat O-methyleugenol decreases expression ISO RGD:734174 6480464 methyleugenol results in decreased expression of CYBA mRNA CTD PMID:32234424|PMID:35690182 Cyba Rat ochratoxin A increases expression ISO RGD:734174 6480464 ochratoxin A results in increased expression of CYBA mRNA CTD PMID:17316727|PMID:29098329 Cyba Rat ochratoxin A multiple interactions ISO RGD:734174 6480464 [ochratoxin A results in increased acetylation of CYBA promoter] which results in increased expression of more ... CTD PMID:29098329 Cyba Rat ochratoxin A increases acetylation ISO RGD:734174 6480464 ochratoxin A results in increased acetylation of CYBA promoter CTD PMID:29098329 Cyba Rat ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of CYBA mRNA CTD PMID:23358140 Cyba Rat okadaic acid decreases expression ISO RGD:734174 6480464 Okadaic Acid results in decreased expression of CYBA mRNA CTD PMID:38832940 Cyba Rat olmesartan decreases expression EXP 6480464 olmesartan results in decreased expression of CYBA protein CTD PMID:17170375 Cyba Rat oxalic acid increases expression ISO RGD:734174 6480464 Oxalic Acid results in increased expression of CYBA mRNA CTD PMID:24145091 Cyba Rat oxalic acid multiple interactions ISO RGD:734174 6480464 resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CYBA mRNA] CTD PMID:24145091 Cyba Rat oxycodone decreases expression EXP 6480464 Oxycodone results in decreased expression of CYBA mRNA CTD PMID:23439660 Cyba Rat paracetamol affects expression ISO RGD:734175 6480464 Acetaminophen affects the expression of CYBA mRNA CTD PMID:17562736 Cyba Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of CYBA mRNA CTD PMID:33387578 Cyba Rat paracetamol decreases expression ISO RGD:734174 6480464 Acetaminophen results in decreased expression of CYBA mRNA CTD PMID:29067470|PMID:31059760 Cyba Rat paracetamol multiple interactions ISO RGD:734174 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of CYBA mRNA CTD PMID:31059760 Cyba Rat paracetamol increases expression ISO RGD:734174 6480464 Acetaminophen results in increased expression of CYBA mRNA CTD PMID:25704631 Cyba Rat paraquat increases expression ISO RGD:734174 6480464 Paraquat results in increased expression of CYBA mRNA CTD PMID:34097952 Cyba Rat paricalcitol decreases expression ISO RGD:734175 6480464 paricalcitol results in decreased expression of CYBA protein CTD PMID:20720404 Cyba Rat paricalcitol multiple interactions ISO RGD:734175 6480464 [paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein CTD PMID:20720404 Cyba Rat perfluorohexanesulfonic acid increases expression ISO RGD:734175 6480464 perfluorohexanesulfonic acid results in increased expression of CYBA mRNA CTD PMID:37995155 Cyba Rat perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:734175 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of CYBA mRNA CTD PMID:36331819 Cyba Rat phencyclidine multiple interactions ISO RGD:734175 6480464 acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of more ... CTD PMID:29037473 Cyba Rat phencyclidine increases activity ISO RGD:734175 6480464 Phencyclidine results in increased activity of CYBA protein CTD PMID:29037473 Cyba Rat phenethyl caffeate multiple interactions EXP 6480464 caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of CYBA mRNA] CTD PMID:20360939 Cyba Rat phenol increases expression EXP 6480464 Phenol results in increased expression of CYBA mRNA CTD PMID:16785328 Cyba Rat phorbol 13-acetate 12-myristate multiple interactions ISO RGD:734174 6480464 Bezafibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA]; CYBA protein more ... CTD PMID:11172467|PMID:20523355|PMID:21705328 Cyba Rat phorbol 13-acetate 12-myristate increases expression ISO RGD:734174 6480464 Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA CTD PMID:11172467 Cyba Rat pioglitazone decreases expression ISO RGD:734174 6480464 pioglitazone results in decreased expression of CYBA mRNA CTD PMID:11172467 Cyba Rat pioglitazone affects activity ISO RGD:734175 6480464 pioglitazone affects the activity of CYBA protein CTD PMID:21962020 Cyba Rat pirinixic acid decreases expression ISO RGD:734175 6480464 pirinixic acid results in decreased expression of CYBA mRNA CTD PMID:11798191|PMID:17426115 Cyba Rat potassium chromate increases expression ISO RGD:734174 6480464 potassium chromate(VI) results in increased expression of CYBA mRNA CTD PMID:22714537 Cyba Rat pravastatin decreases expression EXP 6480464 Pravastatin results in decreased expression of CYBA protein CTD PMID:17170375 Cyba Rat probenecid multiple interactions ISO RGD:734174 6480464 Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of CYBA mRNA] CTD PMID:23325087 Cyba Rat progesterone increases expression ISO RGD:734175 6480464 Progesterone results in increased expression of CYBA mRNA CTD PMID:16195479 Cyba Rat quercetin multiple interactions EXP 6480464 Quercetin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Quercetin inhibits the more ... CTD PMID:27634381 Cyba Rat quercetin multiple interactions ISO RGD:734174 6480464 Quercetin inhibits the reaction [o,p'-DDT results in increased expression of CYBA mRNA] CTD PMID:35122929 Cyba Rat quercetin increases expression ISO RGD:734174 6480464 Quercetin results in increased expression of CYBA mRNA CTD PMID:21632981 Cyba Rat rac-lactic acid decreases expression ISO RGD:734174 6480464 Lactic Acid results in decreased expression of CYBA mRNA CTD PMID:30851411 Cyba Rat ramipril multiple interactions ISO RGD:734174 6480464 Ramipril inhibits the reaction [Cyclosporine results in increased expression of CYBA mRNA]; Ramipril inhibits the more ... CTD PMID:12352326 Cyba Rat ramipril decreases expression ISO RGD:734175 6480464 Ramipril results in decreased expression of CYBA mRNA CTD PMID:16891913 Cyba Rat reactive oxygen species multiple interactions EXP 6480464 [[[Glucose results in increased expression of CYBA protein] co-treated with [Glucose results in increased expression more ... CTD PMID:21562509|PMID:22245600 Cyba Rat resveratrol multiple interactions EXP 6480464 [resveratrol co-treated with Streptozocin] results in increased expression of CYBA mRNA; GW 6471 inhibits the more ... CTD PMID:22245600|PMID:23422569|PMID:25905778 Cyba Rat resveratrol multiple interactions ISO RGD:734174 6480464 resveratrol inhibits the reaction [Oxalic Acid results in increased expression of CYBA mRNA] CTD PMID:24145091 Cyba Rat resveratrol increases expression EXP 6480464 resveratrol results in increased expression of CYBA mRNA CTD PMID:25905778 Cyba Rat resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of CYBA mRNA CTD PMID:20081535 Cyba Rat resveratrol increases expression ISO RGD:734175 6480464 resveratrol results in increased expression of CYBA mRNA CTD PMID:22610192 Cyba Rat rosuvastatin calcium multiple interactions EXP 6480464 [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased more ... CTD PMID:21562509 Cyba Rat rosuvastatin calcium decreases expression EXP 6480464 Rosuvastatin Calcium results in decreased expression of CYBA CTD PMID:21562509 Cyba Rat rotenone affects expression ISO RGD:734175 6480464 Rotenone affects the expression of CYBA mRNA CTD PMID:23186747 Cyba Rat rotenone increases expression EXP 6480464 Rotenone results in increased expression of CYBA mRNA CTD PMID:28374803 Cyba Rat SB 203580 multiple interactions ISO RGD:734175 6480464 SB 203580 inhibits the reaction [Ethanol results in increased expression of CYBA mRNA] CTD PMID:23978445 Cyba Rat silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of CYBA mRNA CTD PMID:21602193 Cyba Rat simvastatin affects response to substance ISO RGD:734174 6480464 CYBA gene SNP affects the susceptibility to Simvastatin CTD PMID:15936011 Cyba Rat sirolimus multiple interactions EXP 6480464 Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein] CTD PMID:21195169 Cyba Rat sirtinol increases expression EXP 6480464 sirtinol results in increased expression of CYBA mRNA CTD PMID:23422569 Cyba Rat sodium arsenite multiple interactions ISO RGD:734174 6480464 [sodium arsenite co-treated with manidipine] results in decreased expression of CYBA mRNA; [sodium arsenite co-treated more ... CTD PMID:15085064 Cyba Rat sodium arsenite decreases expression ISO RGD:734175 6480464 sodium arsenite results in decreased expression of CYBA mRNA CTD PMID:37682722 Cyba Rat sodium arsenite decreases expression ISO RGD:734174 6480464 sodium arsenite results in decreased expression of CYBA mRNA CTD PMID:29301061 Cyba Rat sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of CYBA mRNA CTD PMID:25218292|PMID:26079204 Cyba Rat sodium arsenite multiple interactions EXP 6480464 Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of CYBA mRNA] CTD PMID:25218292 Cyba Rat sodium arsenite increases expression ISO RGD:734174 6480464 sodium arsenite results in increased expression of CYBA protein CTD PMID:19414066 Cyba Rat sodium chloride multiple interactions ISO RGD:734175 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of CYBA mRNA; CXCR2 gene more ... CTD PMID:27678262 Cyba Rat sodium chloride multiple interactions EXP 6480464 [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of CYBA protein CTD PMID:22431579 Cyba Rat sodium fluoride increases expression ISO RGD:734174 6480464 Sodium Fluoride results in increased expression of CYBA mRNA CTD PMID:27750169 Cyba Rat Soman increases expression EXP 6480464 Soman results in increased expression of CYBA mRNA CTD PMID:19281266 Cyba Rat streptozocin multiple interactions EXP 6480464 [[Streptozocin co-treated with Carbamazepine] affects the susceptibility to Dietary Fats] which results in decreased expression more ... CTD PMID:12967931|PMID:16139267|PMID:25905778|PMID:35786680 Cyba Rat streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of CYBA mRNA CTD PMID:12967931|PMID:16139267 Cyba Rat sunitinib decreases expression ISO RGD:734174 6480464 Sunitinib results in decreased expression of CYBA mRNA CTD PMID:31533062 Cyba Rat superoxide increases abundance ISO RGD:734174 6480464 CYBA protein results in increased abundance of Superoxides CTD PMID:20523355 Cyba Rat superoxide increases abundance EXP 6480464 CYBA protein results in increased abundance of Superoxides CTD PMID:14871555 Cyba Rat superoxide multiple interactions ISO RGD:734174 6480464 CYBA protein promotes the reaction [arsenite results in increased abundance of Superoxides] CTD PMID:10720412 Cyba Rat tacrolimus hydrate multiple interactions ISO RGD:734174 6480464 Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA] CTD PMID:12352326 Cyba Rat tacrolimus hydrate increases expression ISO RGD:734174 6480464 Tacrolimus results in increased expression of CYBA mRNA CTD PMID:12352326 Cyba Rat tamibarotene increases expression ISO RGD:734174 6480464 tamibarotene results in increased expression of CYBA mRNA CTD PMID:15498508 Cyba Rat tamoxifen affects expression ISO RGD:734175 6480464 Tamoxifen affects the expression of CYBA mRNA CTD PMID:17555576 Cyba Rat tebuconazole increases expression ISO RGD:734174 6480464 tebuconazole results in increased expression of CYBA mRNA CTD PMID:30458266 Cyba Rat telmisartan decreases expression ISO RGD:734175 6480464 telmisartan results in decreased expression of CYBA mRNA; telmisartan results in decreased expression of CYBA more ... CTD PMID:16141465 Cyba Rat telmisartan decreases expression EXP 6480464 telmisartan results in decreased expression of CYBA mRNA CTD PMID:19171132 Cyba Rat telmisartan multiple interactions EXP 6480464 telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein] CTD PMID:21054405 Cyba Rat testosterone multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CYBA mRNA CTD PMID:32741896 Cyba Rat testosterone decreases expression ISO RGD:734174 6480464 Testosterone results in decreased expression of CYBA mRNA CTD PMID:33359661 Cyba Rat testosterone enanthate affects expression ISO RGD:734174 6480464 testosterone enanthate affects the expression of CYBA mRNA CTD PMID:17440010 Cyba Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of CYBA mRNA CTD PMID:17854599 Cyba Rat tetrachloromethane increases expression ISO RGD:734175 6480464 Carbon Tetrachloride results in increased expression of CYBA mRNA CTD PMID:27339419|PMID:31919559 Cyba Rat thapsigargin decreases expression ISO RGD:734174 6480464 Thapsigargin results in decreased expression of CYBA mRNA CTD PMID:29453283 Cyba Rat thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of CYBA mRNA CTD PMID:28943392 Cyba Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of CYBA mRNA CTD PMID:34492290 Cyba Rat titanium dioxide increases expression ISO RGD:734175 6480464 titanium dioxide results in increased expression of CYBA mRNA CTD PMID:23557971 Cyba Rat titanium dioxide decreases methylation ISO RGD:734175 6480464 titanium dioxide results in decreased methylation of CYBA gene; titanium dioxide results in decreased methylation more ... CTD PMID:35295148 Cyba Rat trandolapril multiple interactions EXP 6480464 [trandolapril co-treated with eplerenone] results in decreased expression of CYBA mRNA CTD PMID:17324946 Cyba Rat trandolapril decreases expression EXP 6480464 trandolapril results in decreased expression of CYBA mRNA CTD PMID:17324946 Cyba Rat triphenyl phosphate decreases expression EXP 6480464 triphenyl phosphate results in decreased expression of CYBA mRNA CTD PMID:30589522 Cyba Rat triphenyl phosphate affects expression ISO RGD:734174 6480464 triphenyl phosphate affects the expression of CYBA mRNA CTD PMID:37042841 Cyba Rat triphenylstannane increases expression ISO RGD:734174 6480464 triphenyltin results in increased expression of CYBA protein CTD PMID:12788061 Cyba Rat troglitazone multiple interactions ISO RGD:734174 6480464 troglitazone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CYBA mRNA] CTD PMID:11172467 Cyba Rat troglitazone decreases expression ISO RGD:734174 6480464 troglitazone results in decreased expression of CYBA mRNA CTD PMID:11172467 Cyba Rat valproic acid increases methylation ISO RGD:734174 6480464 Valproic Acid results in increased methylation of CYBA gene CTD PMID:29154799 Cyba Rat valproic acid increases expression ISO RGD:734174 6480464 Valproic Acid results in increased expression of CYBA mRNA CTD PMID:23179753 Cyba Rat vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of CYBA mRNA CTD PMID:23034163 Cyba Rat vitamin E decreases expression ISO RGD:734174 6480464 Vitamin E results in decreased expression of CYBA mRNA CTD PMID:15571180
Molecular Function
Only show annotations with direct experimental evidence (0 objects hidden)
Cyba Rat electron transfer activity enables IEA UniProtKB:P13498|ensembl:ENSP00000261623 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cyba Rat electron transfer activity enables ISO RGD:734174 1624291 PMID:12042318 RGD PMID:12042318 Cyba Rat heme binding enables IEA InterPro:IPR007732 1600115 GO_REF:0000002 InterPro GO_REF:0000002 Cyba Rat metal ion binding enables IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Cyba Rat metal ion binding enables IEA UniRule:UR000168455 1600115 GO_REF:0000104 UniProt GO_REF:0000104 Cyba Rat oxidoreductase activity enables IEA UniProtKB-KW:KW-0560 1600115 GO_REF:0000043 UniProt GO_REF:0000043 Cyba Rat protein binding IPI RGD:620598 1580287 RGD Cyba Rat protein binding enables ISO RGD:734174 1624291 UniProtKB:P04839|UniProtKB:P05109|UniProtKB:P06702|UniProtKB:P14598|UniProtKB:P19878|UniProtKB:Q15080|UniProtKB:Q8NFA2|UniProtKB:Q8NFA2-3|UniProtKB:Q8VCM2|UniProtKB:Q9HBY0 PMID:11733522, PMID:15824103, PMID:16326715, PMID:16460309, PMID:17126813, PMID:17140397, PMID:17803994, PMID:22808130, PMID:23957209, PMID:3305576, PMID:35031518 RGD PMID:11733522|PMID:15824103|PMID:16326715|PMID:16460309|PMID:17126813|PMID:17140397|PMID:17803994|PMID:22808130|PMID:23957209|PMID:3305576|PMID:35031518 Cyba Rat protein binding enables ISO RGD:734175 1624291 UniProtKB:O89032|UniProtKB:Q61093|UniProtKB:Q91Z40 PMID:19755709, PMID:21551061, PMID:24739962 RGD PMID:19755709|PMID:21551061|PMID:24739962 Cyba Rat protein binding IPI RGD:1307022 11040550 RGD Cyba Rat protein heterodimerization activity enables ISO RGD:734174 1624291 UniProtKB:P04839 PMID:12042318 RGD PMID:12042318 Cyba Rat protein heterodimerization activity enables IEA UniProtKB:P13498|ensembl:ENSP00000261623 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cyba Rat SH3 domain binding enables ISO RGD:734174 1624291 UniProtKB:P14598 PMID:7938008 RGD PMID:7938008 Cyba Rat SH3 domain binding enables IEA UniProtKB:P13498|ensembl:ENSP00000261623 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cyba Rat superoxide-generating NAD(P)H oxidase activity contributes_to ISO RGD:734174 1624291 PMID:1763037 RGD PMID:1763037 Cyba Rat superoxide-generating NAD(P)H oxidase activity contributes_to IEA UniProtKB:P13498|ensembl:ENSP00000261623 1600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cyba Rat superoxide-generating NAD(P)H oxidase activity contributes_to IMP 2317869 PMID:8798532 BHF-UCL
Imported Annotations - SMPDB
Imported Annotations - KEGG (archival)
(1->4)-beta-D-glucan (ISO) (R)-lipoic acid (EXP,ISO) 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (EXP,ISO) 1,2-dimethylhydrazine (EXP,ISO) 1-naphthyl isothiocyanate (EXP) 11-deoxycorticosterone (EXP) 17alpha-ethynylestradiol (EXP,ISO) 17beta-estradiol (EXP,ISO) 17beta-estradiol 3-benzoate (EXP) 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2-amino-2-deoxy-D-galactopyranose (ISO) 2-amino-2-deoxy-D-glucopyranose (ISO) 2-aminobiphenyl (ISO) 2-hydroxypropanoic acid (ISO) 3-chloropropane-1,2-diol (EXP) 3H-1,2-dithiole-3-thione (EXP) 4,4'-diaminodiphenylmethane (EXP) 4,4'-sulfonyldiphenol (ISO) 4-hydroxy-TEMPO (EXP) 7,9-dihydro-1H-purine-2,6,8(3H)-trione (ISO) acetamide (EXP) aflatoxin B1 (ISO) AICA ribonucleotide (EXP) aldehydo-D-glucosamine (ISO) aldehydo-D-glucose (EXP,ISO) all-trans-retinoic acid (ISO) aminoguanidine (EXP) amlodipine (EXP) ammonium chloride (EXP) anagliptin (ISO) anthra[1,9-cd]pyrazol-6(2H)-one (EXP) antirheumatic drug (ISO) apocynin (EXP,ISO) aristolochic acid A (ISO) Aroclor 1254 (ISO) arsane (ISO) arsenic atom (ISO) arsenite(3-) (ISO) arsenous acid (ISO) atorvastatin calcium (EXP) benzo[a]pyrene (ISO) beta-D-glucosamine (ISO) bezafibrate (EXP,ISO) bis(2-ethylhexyl) phthalate (ISO) bisphenol A (EXP,ISO) bisphenol F (ISO) bleomycin A2 (ISO) bortezomib (ISO) butan-1-ol (ISO) Butylbenzyl phthalate (ISO) Butylparaben (ISO) C60 fullerene (EXP) cadmium dichloride (EXP,ISO) caffeine (ISO) calcitriol (EXP) candesartan (EXP,ISO) canrenoic acid (EXP) carbamazepine (EXP) carbon nanotube (ISO) chloropicrin (ISO) choline (ISO) chromium(6+) (ISO) cisplatin (ISO) clofibrate (EXP) clothianidin (ISO) cobalt dichloride (ISO) cocaine (ISO) colistin (EXP) crocidolite asbestos (ISO) Cuprizon (EXP) cyclosporin A (ISO) cytarabine (ISO) D-glucose (EXP,ISO) daunorubicin (EXP) DDE (ISO) decabromodiphenyl ether (EXP) dehydroepiandrosterone (EXP) Deoxycorticosterone acetate (ISO) dextran sulfate (ISO) Di-n-octyl phthalate (ISO) diallyl trisulfide (EXP) diarsenic trioxide (ISO) diazinon (ISO) dibenziodolium (ISO) dibutyl phthalate (ISO) diclofenac (ISO) diethyl phthalate (ISO) Diisodecyl phthalate (ISO) diisononyl phthalate (ISO) dioxygen (ISO) diuron (ISO) dorsomorphin (ISO) doxorubicin (EXP,ISO) ellagic acid (EXP) enalapril (ISO) endosulfan (EXP) eplerenone (EXP) ethanol (EXP,ISO) farrerol (EXP) fenamidone (ISO) flavonoids (ISO) folic acid (ISO) furan (EXP) genistein (ISO) gentamycin (EXP) ginsenoside Re (ISO) glucose (EXP,ISO) GW 6471 (EXP) hexadecanoic acid (EXP) hydrochlorothiazide (EXP) hydrogen chloride (ISO) hydrogen peroxide (EXP,ISO) iron dextran (EXP) isobutanol (ISO) isoprenaline (EXP) ketamine (ISO) ketoconazole (EXP) L-ascorbic acid (ISO) L-methionine (ISO) Lasiocarpine (ISO) lipoic acid (EXP,ISO) lipopolysaccharide (ISO) liraglutide (ISO) loganin (ISO) losartan (EXP) lutein (ISO) manidipine (ISO) melatonin (ISO) menadione (ISO) mercury dichloride (EXP) metformin (EXP,ISO) methanol (ISO) methyl methanesulfonate (ISO) methylglyoxal (ISO) methylmercury chloride (ISO) Morroniside (ISO) N-acetyl-L-cysteine (EXP) N-formyl-L-methionyl-L-leucyl-L-phenylalanine (EXP) N-nitrosodiethylamine (EXP) N-nitrosomorpholine (EXP) N-Nitrosopyrrolidine (ISO) naringin (ISO) nebivolol (EXP) nickel atom (ISO) nickel sulfate (ISO) nicotinamide (EXP) nicotinic acid (EXP) nitrates (ISO) O-methyleugenol (ISO) ochratoxin A (EXP,ISO) okadaic acid (ISO) olmesartan (EXP) oxalic acid (ISO) oxycodone (EXP) paracetamol (EXP,ISO) paraquat (ISO) paricalcitol (ISO) perfluorohexanesulfonic acid (ISO) perfluorooctane-1-sulfonic acid (ISO) phencyclidine (ISO) phenethyl caffeate (EXP) phenol (EXP) phorbol 13-acetate 12-myristate (ISO) pioglitazone (ISO) pirinixic acid (ISO) potassium chromate (ISO) pravastatin (EXP) probenecid (ISO) progesterone (ISO) quercetin (EXP,ISO) rac-lactic acid (ISO) ramipril (ISO) reactive oxygen species (EXP) resveratrol (EXP,ISO) rosuvastatin calcium (EXP) rotenone (EXP,ISO) SB 203580 (ISO) silicon dioxide (EXP) simvastatin (ISO) sirolimus (EXP) sirtinol (EXP) sodium arsenite (EXP,ISO) sodium chloride (EXP,ISO) sodium fluoride (ISO) Soman (EXP) streptozocin (EXP) sunitinib (ISO) superoxide (EXP,ISO) tacrolimus hydrate (ISO) tamibarotene (ISO) tamoxifen (ISO) tebuconazole (ISO) telmisartan (EXP,ISO) testosterone (EXP,ISO) testosterone enanthate (ISO) tetrachloromethane (EXP,ISO) thapsigargin (ISO) thioacetamide (EXP) titanium dioxide (ISO) trandolapril (EXP) triphenyl phosphate (EXP,ISO) triphenylstannane (ISO) troglitazone (ISO) valproic acid (ISO) vinclozolin (EXP) vitamin E (ISO)
Biological Process
cellular response to angiotensin (IEP) cellular response to gamma radiation (IEP) cellular response to glucose stimulus (IEP) cellular response to L-glutamine (IEP) cellular response to mechanical stimulus (IEP) cellular response to phorbol 13-acetate 12-myristate (IEP) cellular response to tumor necrosis factor (IEP) cytochrome complex assembly (IEA,ISO) establishment of localization in cell (IEA,ISO) hydrogen peroxide biosynthetic process (IMP) inflammatory response (IEA,ISO) innate immune response (IEA,ISO,ISS) mucus secretion (IEA,ISO) negative regulation of glomerular filtration by angiotensin (IMP) positive regulation of blood pressure (IMP) positive regulation of cell growth (IMP) positive regulation of defense response to bacterium (IEA,ISO) positive regulation of endothelial cell proliferation (IMP) positive regulation of interleukin-6 production (IEA,ISO) positive regulation of mucus secretion (IEA,ISO) positive regulation of NAD(P)H oxidase activity (IMP) positive regulation of oxygen metabolic process (ISO) positive regulation of phagocytosis (IEA,ISO) positive regulation of reactive oxygen species biosynthetic process (IEA,ISO) positive regulation of smooth muscle cell proliferation (IMP) positive regulation of superoxide anion generation (IMP) positive regulation of toll-like receptor 2 signaling pathway (IEA,ISO) positive regulation of tumor necrosis factor production (IEA,ISO) reactive oxygen species metabolic process (IEA,ISO) regulation of release of sequestered calcium ion into cytosol (IEA,ISO) respiratory burst (IEA,ISO) response to activity (IEP) response to aldosterone (IEP) response to hypoxia (IEP) response to interleukin-1 (IEP) response to nutrient levels (IEP) response to xenobiotic stimulus (IEP) smooth muscle hypertrophy (IMP) superoxide anion generation (IBA,IEA,IMP,ISO) superoxide metabolic process (IDA,IEA,IMP,ISO)
1.
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.
Ambasta RK, etal., J Biol Chem. 2004 Oct 29;279(44):45935-41. Epub 2004 Aug 18.
2.
Coronary microvascular endothelial cell growth regulates expression of the gene encoding p22-phox.
Bayraktutan U Free Radic Biol Med. 2005 Nov 15;39(10):1342-52. Epub 2005 Aug 29.
3.
Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth.
Bayraktutan U J Mol Cell Cardiol. 2004 Feb;36(2):277-86.
4.
Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells.
Bayraktutan U, etal., Arterioscler Thromb Vasc Biol 2000 Aug;20(8):1903-11.
5.
The genetic association database.
Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
6.
Expression of two temporally distinct microglia-related gene clusters after spinal cord injury.
Byrnes KR, etal., Glia. 2006 Mar;53(4):420-33.
7.
Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils.
Chang LC, etal., Eur J Pharmacol. 2009 Aug 1;615(1-3):207-17. Epub 2009 May 13.
8.
NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE.
Cho KH, etal., Am J Physiol Renal Physiol. 2009 May 6.
9.
NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells.
Collins-Underwood JR, etal., Free Radic Biol Med. 2008 Sep 15;45(6):929-38. Epub 2008 Jun 30.
10.
The role of NOX2 and "novel oxidases" in airway chemoreceptor O(2) sensing.
Cutz E, etal., Adv Exp Med Biol. 2009;648:427-38.
11.
Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox).
de Boer M, etal., Am J Hum Genet. 1992 Nov;51(5):1127-35.
12.
Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in vascular smooth muscle.
De Keulenaer GW, etal., Biochem J. 1998 Feb 1;329 ( Pt 3):653-7.
13.
Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat.
DeMarco VG, etal., Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2659-68. Epub 2008 Apr 18.
14.
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.
Dinauer MC, etal., J Clin Invest 1990 Nov;86(5):1729-37.
15.
Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction.
Fukui T, etal., Biochem Biophys Res Commun. 2001 Mar;281(5):1200-6.
16.
Cytochrome b-558 alpha-subunit cloning and expression in rat aortic smooth muscle cells.
Fukui T, etal., Biochim Biophys Acta 1995 Oct 10;1231(3):215-9.
17.
Role of kallistatin in prevention of cardiac remodeling after chronic myocardial infarction.
Gao L, etal., Lab Invest. 2008 Nov;88(11):1157-66. Epub 2008 Sep 1.
18.
The p22 phox A640G gene polymorphism but not the C242T gene variation is associated with coronary heart disease in younger individuals.
Gardemann A, etal., Atherosclerosis. 1999 Aug;145(2):315-23.
19.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20.
Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: relationship with tyrosine hydroxylase immunoreactive neurons.
Glass MJ, etal., Neuroscience. 2006 Dec 1;143(2):547-64. Epub 2006 Oct 4.
21.
Rat ISS GO annotations from GOA human gene data--August 2006
GOA data from the GO Consortium
22.
Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis.
Haruna Y, etal., Arthritis Rheum. 2007 Jun;56(6):1827-35.
23.
Acute effects of desmin mutations on cytoskeletal and cellular integrity in cardiac myocytes.
Haubold K, etal., Cell Motil Cytoskeleton. 2003 Feb;54(2):105-21.
24.
[Expression of WAVE1 and p22phox in children with acute lymphocytic leukemia and the relationship of WAVE1 with oxidative stress].
He YL, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2009 Feb;11(2):88-92.
25.
Synergistic effect of mechanical stretch and angiotensin II on superoxide production via NADPH oxidase in vascular smooth muscle cells.
Hitomi H, etal., J Hypertens. 2006 Jun;24(6):1089-95.
26.
Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone.
Huang BS, etal., Exp Physiol. 2011 Oct;96(10):1028-38. doi: 10.1113/expphysiol.2011.059840. Epub 2011 Aug 8.
27.
Haplotype analysis of the NADPH oxidase p22 phox gene in patients with bronchial asthma.
Izakovicova Holla L, etal., Int Arch Allergy Immunol. 2009;148(1):73-80. Epub 2008 Aug 21.
28.
p22phox-derived superoxide mediates enhanced proliferative capacity of diabetic vascular smooth muscle cells.
Jeong HY, etal., Diabetes Res Clin Pract. 2004 Apr;64(1):1-10.
29.
Increased superoxide anion production by interleukin-1beta impairs nitric oxide-mediated relaxation in resistance arteries.
Jimenez-Altayo F, etal., J Pharmacol Exp Ther. 2006 Jan;316(1):42-52. Epub 2005 Sep 23.
30.
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.
Kusaka I, etal., Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2442-51.
31.
Genetic polymorphisms and susceptibility to lung disease.
Lee PL, etal., J Negat Results Biomed. 2006 Apr 11;5:5.
32.
Relationship between reduced nicotinamide adenine dinucleotide phosphate oxidase subunit p22phox gene polymorphism and obstructive sleep apnea-hypopnea syndrome in the Chinese Han population.
Liu HG, etal., Chin Med J (Engl). 2009 Jun 20;122(12):1369-74.
33.
[Nicotinamide-adenine dinucleotide phosphate oxidase p22phox expression in induced sputum cells for patients with obstructive sleep apnea hypopnea syndrome.]
Liu HG, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2010 Feb;33(2):118-22.
34.
Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells.
Lyle AN, etal., Circ Res. 2009 Jul 31;105(3):249-59. doi: 10.1161/CIRCRESAHA.109.193722. Epub 2009 Jul 2.
35.
Relation between development of nephropathy and the p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patients.
Matsunaga-Irie S, etal., Diabetes Care. 2004 Feb;27(2):303-7.
36.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
37.
RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response.
Modlinger P, etal., Hypertension. 2006 Feb;47(2):238-44. Epub 2006 Jan 3.
38.
Preliminary characterisation of the promoter of the human p22(phox) gene: identification of a new polymorphism associated with hypertension.
Moreno MU, etal., FEBS Lett. 2003 May 8;542(1-3):27-31.
39.
Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba).
Mori M, etal., J Leukoc Biol. 2009 Sep;86(3):473-8. doi: 10.1189/jlb.1108715. Epub 2009 Apr 30.
40.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
41.
The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice.
Nisbet RE, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):601-9. Epub 2008 Oct 23.
42.
p22phox in the macula densa regulates single nephron GFR during angiotensin II infusion in rats.
Nouri P, etal., Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1685-9. Epub 2007 Jan 12.
43.
Apocynin restores endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions.
Olukman M, etal., J Diabetes Complications. 2010 Mar 10.
44.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
45.
Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome.
Picchi A, etal., Circ Res. 2006 Jul 7;99(1):69-77. Epub 2006 Jun 1.
46.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
47.
SMPDB Annotation Import Pipeline
Pipeline to import SMPDB annotations from SMPDB into RGD
48.
Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils.
Pithon-Curi TC, etal., Clin Sci (Lond). 2002 Oct;103(4):403-8.
49.
[Polymorphism -930A > G of the cytochrome b gene is a novel genetic marker of predisposition to bronchial asthma]
Polonikov AV, etal., Ter Arkh. 2009;81(3):31-5.
50.
GOA pipeline
RGD automated data pipeline
51.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
53.
Asymmetric dimethylarginine in angiotensin II-induced hypertension.
Sasser JM, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R740-6. Epub 2009 Dec 16.
54.
Possible role of exogenous cAMP to improve vascular endothelial dysfunction in hypertensive rats.
Shah DI and Singh M, Fundam Clin Pharmacol. 2006 Dec;20(6):595-604.
55.
Association of gene polymorphisms with coronary artery disease in individuals with or without nonfamilial hypercholesterolemia.
Shimokata K, etal., Atherosclerosis. 2004 Jan;172(1):167-73.
56.
Characterization of six novel mutations in CYBA: the gene causing autosomal recessive chronic granulomatous disease.
Teimourian S, etal., Br J Haematol. 2008 Jun;141(6):848-51. Epub 2008 Apr 18.
57.
BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia.
Tomozawa H, etal., Exp Anim. 2010;59(4):469-78.
58.
Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1.
Tomozawa H, etal., Exp Anim. 2011;60(2):151-60.
59.
p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells.
Ushio-Fukai M, etal., J Biol Chem. 1996 Sep 20;271(38):23317-21.
60.
CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD.
Vibhuti A, etal., Clin Chim Acta. 2010 Apr 2;411(7-8):474-80. Epub 2010 Jan 18.
61.
High glucose mediates pro-oxidant and antioxidant enzyme activities in coronary endothelial cells.
Weidig P, etal., Diabetes Obes Metab. 2004 Nov;6(6):432-41.
62.
Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells.
Whiteside C, etal., Exp Diabetes Res. 2009;2009:910783. Epub 2009 Jul 7.
63.
[Effect of danzhi jiangtang capsule combined exercise on the protein expression of NADPH oxidase p22phox in pancreatic tissues of diabetic rats].
Wu YJ, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 May;33(5):641-5.
64.
Genetic studies of three Japanese patients with p22-phox-deficient chronic granulomatous disease: detection of a possible common mutant CYBA allele in Japan and a genotype-phenotype correlation in these patients.
Yamada M, etal., Br J Haematol. 2000 Mar;108(3):511-7.
65.
Homocysteine enhances TIMP-1 expression and cell proliferation associated with NADH oxidase in rat mesangial cells.
Yang ZZ and Zou AP, Kidney Int. 2003 Mar;63(3):1012-20.
66.
Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy.
Yoshida Y, etal., Diabetes Metab Res Rev. 2009 Oct;25(7):678-86.
67.
High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex.
Zhang X, etal., Exp Neurol. 2005 Feb;191(2):318-25.
68.
Effects of various degrees of oxidative stress induced by intermittent hypoxia in rat myocardial tissues.
Zhou W, etal., Respirology. 2012 Jul;17(5):821-9. doi: 10.1111/j.1440-1843.2012.02157.x.
Cyba Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 19 67,396,143 - 67,404,214 (-) NCBI GRCr8 mRatBN7.2 19 50,487,598 - 50,495,669 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 19 50,487,597 - 50,495,721 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 19 57,282,778 - 57,290,847 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 19 57,962,531 - 57,970,602 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 19 60,181,396 - 60,189,465 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 19 55,249,634 - 55,257,824 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 19 55,249,616 - 55,257,876 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 19 65,959,818 - 65,967,224 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 19 52,713,150 - 52,721,609 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 19 52,718,030 - 52,726,490 (-) NCBI Celera 19 49,727,142 - 49,735,154 (-) NCBI Celera Cytogenetic Map 19 q12 NCBI
CYBA Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 16 88,643,289 - 88,651,053 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 16 88,643,275 - 88,651,083 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 16 88,709,697 - 88,717,461 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 16 87,237,198 - 87,244,958 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 16 87,237,198 - 87,244,950 NCBI Celera 16 73,779,369 - 73,787,129 (-) NCBI Celera Cytogenetic Map 16 q24.2 NCBI HuRef 16 74,403,728 - 74,411,523 (-) NCBI HuRef CHM1_1 16 90,120,999 - 90,128,842 (-) NCBI CHM1_1 T2T-CHM13v2.0 16 94,711,169 - 94,718,983 (-) NCBI T2T-CHM13v2.0
Cyba Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 8 123,151,510 - 123,159,679 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 8 123,151,515 - 123,159,669 (-) Ensembl GRCm39 Ensembl GRCm38 8 122,424,771 - 122,432,940 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 8 122,424,776 - 122,432,930 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 8 124,948,671 - 124,956,840 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 8 125,310,866 - 125,319,017 (-) NCBI MGSCv36 mm8 Celera 8 126,653,882 - 126,662,049 (-) NCBI Celera Cytogenetic Map 8 E1 NCBI cM Map 8 71.04 NCBI
LOC102004641 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955541 2,569,727 - 2,574,118 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955541 2,570,843 - 2,573,822 (-) NCBI ChiLan1.0 ChiLan1.0
LOC100986914 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 18 98,416,331 - 98,424,174 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 16 104,328,442 - 104,336,271 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 16 69,356,396 - 69,364,225 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 16 89,016,349 - 89,024,719 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 16 89,016,349 - 89,024,719 (-) Ensembl panpan1.1 panPan2
CYBA Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 5 64,692,865 - 64,701,056 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 5 64,692,123 - 64,704,893 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 5 64,703,545 - 64,711,735 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 5 64,912,202 - 64,920,393 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 5 64,911,577 - 64,920,464 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 5 64,938,335 - 64,946,503 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 5 64,770,091 - 64,778,279 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 5 65,176,122 - 65,184,313 (+) NCBI UU_Cfam_GSD_1.0
LOC101967032 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024409349 25,283,408 - 25,291,407 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936641 1,036,967 - 1,044,991 (+) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936641 1,036,967 - 1,044,954 (+) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
CYBA
CYBA Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 5 74,023,134 - 74,030,793 (-) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 5 74,023,082 - 74,030,750 (-) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666047 1,654,155 - 1,661,751 (+) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
LOC101717043
.
Predicted Target Of
Count of predictions: 123 Count of miRNA genes: 106 Interacting mature miRNAs: 118 Transcripts: ENSRNOT00000017564 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
2313395 Anxrr26 Anxiety related response QTL 26 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 19 49976481 53225766 Rat 1578764 Stresp19 Stress response QTL 19 3.6 0.001 blood renin amount (VT:0003349) plasma renin activity level (CMO:0000116) 19 15630201 57337602 Rat 61350 Bp32 Blood pressure QTL 32 0.012 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 19 20483575 57337602 Rat 5135224 Leukc1 Leukocyte quantity QTL 1 eosinophil quantity (VT:0002602) blood eosinophil count (CMO:0000033) 19 44340214 55283277 Rat 724546 Kidm3 Kidney mass QTL 3 3.1 kidney mass (VT:0002707) calculated kidney weight (CMO:0000160) 19 29322490 57337602 Rat 7411549 Bw130 Body weight QTL 130 5 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 19 15455860 57337602 Rat 1358200 Insglur2 Insulin/glucose ratio QTL 2 4.1 blood glucose amount (VT:0000188) serum glucose level (CMO:0000543) 19 33838214 55283146 Rat 724566 Uae12 Urinary albumin excretion QTL 12 5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 19 2187927 56457239 Rat 1331737 Uae29 Urinary albumin excretion QTL 29 5.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 19 4096155 55283277 Rat 2298478 Eau8 Experimental allergic uveoretinitis QTL 8 0.0163 uvea integrity trait (VT:0010551) experimental autoimmune uveitis score (CMO:0001504) 19 17154433 57337602 Rat
RH138637
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 19 50,487,946 - 50,488,149 (+) MAPPER mRatBN7.2 Rnor_6.0 19 55,249,983 - 55,250,185 NCBI Rnor6.0 Rnor_5.0 19 65,960,167 - 65,960,369 UniSTS Rnor5.0 RGSC_v3.4 19 52,713,499 - 52,713,701 UniSTS RGSC3.4 Celera 19 49,727,491 - 49,727,693 UniSTS RH 3.4 Map 19 696.9 UniSTS Cytogenetic Map 19 q12 UniSTS
RH131095
Rat Assembly Chr Position (strand) Source JBrowse Rnor_5.0 19 65,967,927 - 65,968,109 NCBI Rnor5.0 Rnor_5.0 1 149,620,644 - 149,620,826 NCBI Rnor5.0 RGSC_v3.4 19 52,722,313 - 52,722,494 UniSTS RGSC3.4 RGSC_v3.4 X 155,617,504 - 155,617,685 UniSTS RGSC3.4 Celera 19 49,735,858 - 49,736,039 UniSTS Celera 1 133,317,703 - 133,317,884 UniSTS Cytogenetic Map 19 q12 UniSTS Cytogenetic Map X q37 UniSTS
This gene Cyba is modified in the following models/strains:
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
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Ensembl Acc Id:
ENSRNOT00000017564 ⟹ ENSRNOP00000017564
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 19 50,487,597 - 50,495,721 (-) Ensembl Rnor_6.0 Ensembl 19 55,249,616 - 55,257,876 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000109691 ⟹ ENSRNOP00000083515
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 19 50,487,598 - 50,495,669 (-) Ensembl
RefSeq Acc Id:
NM_024160 ⟹ NP_077074
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 19 67,396,143 - 67,404,214 (-) NCBI mRatBN7.2 19 50,487,598 - 50,495,669 (-) NCBI Rnor_6.0 19 55,249,634 - 55,257,824 (-) NCBI Rnor_5.0 19 65,959,818 - 65,967,224 (-) NCBI RGSC_v3.4 19 52,713,150 - 52,721,609 (-) RGD Celera 19 49,727,142 - 49,735,154 (-) RGD
Sequence:
CCACGCGTCCGGGACCGAGCGGCTGCGTGTGCTGGGTCCTCACCATGGGGCAGATCGAGTGGGCCATGTGGGCCAACGAACAGGCGCTGGCATCTGGCCTGATCCTCATCACAGGGGGCATCGTGGCT
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RefSeq Acc Id:
NP_077074 ⟸ NM_024160
- UniProtKB:
Q9ER27 (UniProtKB/Swiss-Prot), Q62737 (UniProtKB/Swiss-Prot), A6IZR8 (UniProtKB/TrEMBL), A0A8L2Q8Y6 (UniProtKB/TrEMBL)
- Sequence:
MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVLICLLEYPRGKRKKGSTMERCGQKYLTAVVKLFGPLTRNYYVRAVLHLLLSVPAGFLLATILGTVCLAIASVIYLLAAIRG
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Ensembl Acc Id:
ENSRNOP00000017564 ⟸ ENSRNOT00000017564
Ensembl Acc Id:
ENSRNOP00000083515 ⟸ ENSRNOT00000109691
RGD ID: 13701205 Promoter ID: EPDNEW_R11728 Type: initiation region Name: Cyba_1 Description: cytochrome b-245 alpha chain SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 19 55,257,830 - 55,257,890 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2004-09-10
Cyba
cytochrome b-245, alpha polypeptide
cytochrome b558 alpha-subunit
Name updated
1299863 APPROVED
2002-08-07
Cyba
cytochrome b558 alpha-subunit
Symbol and Name status set to provisional
70820 PROVISIONAL
