RGD Reference Report - BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia. - Rat Genome Database

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BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia.

Authors: Tomozawa, H  Nishio, A  Okuhara, Y  Higuchi, K  Matsumoto, K  Mori, M 
Citation: Tomozawa H, etal., Exp Anim. 2010;59(4):469-78.
RGD ID: 5134976
Pubmed: PMID:20660993   (View Abstract at PubMed)

The Matsumoto Eosinophilia Shinshu (MES) rat strain develops hereditary blood eosinophilia and eosinophil-related inflammatory lesions in organs due to the mutant Cyba(mes) gene. We hypothesized that a new eosinophilia model with a different phenotype could be established by changing the genetic background of rats. We bred and characterized a congenic strain, in which the mutant Cyba(mes) gene was introduced into the background of a BN strain (BN.MES-Cyba(mes)). The congenic rats showed robust proliferation of eosinophils in the bone marrow. Nonetheless, blood eosinophil levels of the rats remained within the normal range. In addition, the rats manifested focal necrosis with eosinophilic infiltration in the liver, a phenotype rarely observed in the original MES rat strain. These results imply the presence of genetic polymorphisms between MES and BN strains which modulate the mobilization of eosinophils to the peripheral circulation and organs. The newly established BN.MES-Cyba(mes) congenic rat strain, together with the original MES strain, will provide useful models for elucidating the molecular genetic mechanisms involved in the development and trafficking of eosinophils.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MES/SlcRatEosinophilia  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BN.MES-Cyba/SnaRatdecreased eosinophil cell number  IAGP in blood and compared to MES/SLCRGD 
BN/SsNSlcRatdecreased eosinophil cell number  IAGP in bone marrow and compared to MES/SlcRGD 
BN.MES-Cyba/SnaRatfocal hepatic necrosis  IAGP  RGD 
BN.MES-Cyba/SnaRatincreased circulating alanine transaminase level  IAGP compared to BN/SsNSlcRGD 
BN.MES-Cyba/SnaRatincreased circulating aspartate transaminase level  IAGP compared to BN/SsNSlcRGD 
BN.MES-Cyba/SnaRatincreased eosinophil cell number  IAGP in bone marrow and compared to BN/SsNSlcRGD 
Objects Annotated

Strains
BN.MES-Cyba/Sna  (NA)
BN/SsNSlc  (NA)
MES/Slc  (Matsumoto Eosinophilia Shinshu)

Objects referenced in this article
Gene CYBA cytochrome b-245 alpha chain Homo sapiens
Gene Cyba cytochrome b-245, alpha polypeptide Mus musculus
Gene Cyba cytochrome b-245 alpha chain Rattus norvegicus
Gene Cybam1Sdi cytochrome b-245 alpha chain;mutant 1,Sdi Rattus norvegicus

Additional Information