Ube2i (ubiquitin-conjugating enzyme E2I) - Rat Genome Database

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Gene: Ube2i (ubiquitin-conjugating enzyme E2I) Rattus norvegicus
Analyze
Symbol: Ube2i
Name: ubiquitin-conjugating enzyme E2I
RGD ID: 3926
Description: Enables bHLH transcription factor binding activity; ionotropic glutamate receptor binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including positive regulation of DNA-binding transcription factor activity; protein sumoylation; and regulation of signal transduction. Located in dendrite and nucleus. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I); PARTICIPATES IN altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; sumoylation pathway; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC105476; RING-type E3 SUMO transferase UBC9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; Ubc9; UbcE2A; ubiquitin carrier protein 9; ubiquitin carrier protein I; Ubiquitin conjugating enzyme E2I; Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9); ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme UbcE2A; ubiquitin-protein ligase I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bmd4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,782,245 - 14,802,911 (-)NCBIGRCr8
mRatBN7.21014,277,749 - 14,294,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1069,701,618 - 69,702,443 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1014,277,749 - 14,295,136 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,019,943 - 19,034,557 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,508,805 - 18,523,419 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,008,012 - 14,022,626 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,618,615 - 14,639,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,620,531 - 14,630,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,436,200 - 14,456,889 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,509,948 - 14,524,551 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,509,950 - 14,524,551 (-)NCBI
Celera1013,951,568 - 13,966,171 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ube2iRatdilated cardiomyopathy  ISOUBE2I (Homo sapiens)13831294mRNA:increased expression:left ventricleRGD 
Ube2iRatExperimental Mammary Neoplasms  ISOUBE2I (Homo sapiens)2301345MCF-7 human breast cancer cell tumors grown in nude miceRGD 
Ube2iRatovarian cancer  ISOUBE2I (Homo sapiens)2301345mRNA:increased expression:tumor:relative to normal ovarian epithelium from the same patient (p<0.01) (human)RGD 
Ube2iRaturinary bladder cancer  ISOUBE2I (Homo sapiens)2301343radiation-induced dysplasia and carcinoma in situ and protein:increased expression:bladder urothelium:increased in Chernobyl victims vs controls from uncontaminated areas of the Ukraine (p<0.001) (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Ube2iRatepilepsy  ISOUBE2I (Homo sapiens)8554872ClinVar Annotator: match by term: EpilepsyClinVarPMID:28492532
Ube2iRatIdiopathic Generalized Epilepsy  ISOUBE2I (Homo sapiens)8554872ClinVar Annotator: match by term: Idiopathic generalized epilepsyClinVarPMID:28492532
Ube2iRatshort-rib thoracic dysplasia 9 with or without polydactyly  ISOUBE2I (Homo sapiens)8554872ClinVar Annotator: match by term: Saldino-Mainzer syndromeClinVarPMID:19370764 more ...
Ube2iRattuberous sclerosis 2  ISOUBE2I (Homo sapiens)8554872ClinVar Annotator: match by term: Tuberous sclerosis 2ClinVarPMID:16114042 more ...
Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Ube2iRatAnimal Mammary Neoplasms  ISOUBE2I (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942
Ube2iRatcarcinoma  ISOUBE2I (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942
Ube2iRatExperimental Mammary Neoplasms  ISOUBE2I (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942

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Object Symbol
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Qualifier
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Original Reference(s)
Ube2iRat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of UBE2I mRNACTDPMID:17971868
Ube2iRat(S)-nicotine decreases expressionISOUBE2I (Homo sapiens)6480464Nicotine results in decreased expression of UBE2I mRNACTDPMID:18247414
Ube2iRat1,2-dichloroethane increases expressionISOUbe2i (Mus musculus)6480464ethylene dichloride results in increased expression of UBE2I mRNACTDPMID:28960355
Ube2iRat1,2-dimethylhydrazine increases expressionISOUbe2i (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of UBE2I mRNACTDPMID:22206623
Ube2iRat1-chloro-2,4-dinitrobenzene affects bindingISOUBE2I (Homo sapiens)6480464Dinitrochlorobenzene binds to UBE2I proteinCTDPMID:32991956
Ube2iRat17beta-estradiol multiple interactionsISOUBE2I (Homo sapiens)6480464Estradiol promotes the reaction [UBE2I protein binds to ESR1 protein]CTDPMID:15666801
Ube2iRat17beta-estradiol increases expressionISOUbe2i (Mus musculus)6480464Estradiol results in increased expression of UBE2I mRNACTDPMID:39298647
Ube2iRat1H-pyrazole increases expressionISOUbe2i (Mus musculus)6480464pyrazole results in increased expression of UBE2I mRNACTDPMID:17945193
Ube2iRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOUbe2i (Mus musculus)6480464UBE2I promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]CTDPMID:23997114
Ube2iRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of UBE2I mRNACTDPMID:21346803
Ube2iRat2-naphthylamine increases expressionISOUBE2I (Homo sapiens)64804642-Naphthylamine results in increased expression of UBE2I mRNACTDPMID:18247414
Ube2iRat4,4'-sulfonyldiphenol increases expressionISOUbe2i (Mus musculus)6480464bisphenol S results in increased expression of UBE2I mRNACTDPMID:39298647
Ube2iRat4-hydroxynon-2-enal increases expressionISOUbe2i (Mus musculus)64804644-hydroxy-2-nonenal results in increased expression of UBE2I mRNACTDPMID:19191707
Ube2iRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of UBE2I mRNACTDPMID:30047161
Ube2iRatacrylamide decreases expressionISOUbe2i (Mus musculus)6480464Acrylamide results in decreased expression of UBE2I mRNACTDPMID:21319176
Ube2iRatactinomycin D multiple interactionsISOUBE2I (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of UBE2I proteinCTDPMID:38460933
Ube2iRataflatoxin B1 increases expressionISOUBE2I (Homo sapiens)6480464Aflatoxin B1 results in increased expression of UBE2I mRNACTDPMID:27153756
Ube2iRatall-trans-retinoic acid increases expressionISOUBE2I (Homo sapiens)6480464Tretinoin results in increased expression of UBE2I mRNACTDPMID:23724009
Ube2iRatamitrole increases expressionEXP 6480464Amitrole results in increased expression of UBE2I mRNACTDPMID:30047161
Ube2iRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of UBE2I mRNACTDPMID:16483693

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Biological Process
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Original Reference(s)
Ube2iRatcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Ube2iRatchromosome segregation involved_inIEAUniProtKB-KW:KW-01591600115GO_REF:0000043UniProtGO_REF:0000043
Ube2iRatmodulation of chemical synaptic transmission involved_inISOUbe2i (Mus musculus)1624291 PMID:25448527RGDPMID:25448527
Ube2iRatnegative regulation of DNA-templated transcription involved_inISOUBE2I (Homo sapiens)1624291 PMID:16631117RGDPMID:16631117
Ube2iRatnegative regulation of transcription by RNA polymerase II involved_inISOUBE2I (Homo sapiens)1624291 PMID:19955185RGDPMID:19955185
Ube2iRatnegative regulation of transcription by RNA polymerase II involved_inISOUbe2i (Mus musculus)1624291 PMID:16127449RGDPMID:16127449
Ube2iRatnuclear export involved_inISOUBE2I (Homo sapiens)1624291 PMID:27160050RGDPMID:27160050
Ube2iRatnuclear export involved_inISOUbe2i (Mus musculus)1624291 PMID:27160050RGDPMID:27160050
Ube2iRatpositive regulation of canonical NF-kappaB signal transduction acts_upstream_of_or_withinISOUbe2i (Mus musculus)1624291 PMID:9223278RGDPMID:9223278
Ube2iRatpositive regulation of cell migration involved_inISOUBE2I (Homo sapiens)1624291 PMID:20023705RGDPMID:20023705
Ube2iRatpositive regulation of DNA-binding transcription factor activity  IDA 2301354glucocorticoid receptor and independent of sumoylation activity or presence of a GMERGD 
Ube2iRatpositive regulation of intracellular steroid hormone receptor signaling pathway  IDA 2301354glucocorticoid receptor and independent of sumoylation activity or presence of a GMERGD 
Ube2iRatproteasome-mediated ubiquitin-dependent protein catabolic process  IMP 730030 RGD 
Ube2iRatprotein sumoylation  IDA 2301354 RGD 
Ube2iRatprotein sumoylation involved_inIBACGD:CAL0000200419 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ube2iRatprotein sumoylation involved_inISOUBE2I (Homo sapiens)1624291 PMID:15660128 more ...RGDPMID:15660128 more ...
Ube2iRatprotein sumoylation involved_inISOUbe2i (Mus musculus)1624291 PMID:9435231RGDPMID:9435231
Ube2iRatprotein sumoylation involved_inIEAUniPathway:UPA008861600115GO_REF:0000041UniProtGO_REF:0000041
Ube2iRatregulation of signaling receptor activity  IDA 2301354glucocorticoid receptor and independent of sumoylation activity or presence of a GMERGD 
Ube2iRatubiquitin-dependent protein catabolic process  TAS 730030 RGD 
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Cellular Component
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Original Reference(s)
Ube2iRatcytoplasm located_inISOUBE2I (Homo sapiens)1624291 PMID:9223278RGDPMID:9223278
Ube2iRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Ube2iRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Ube2iRatdendrite  IDA 1642482 RGD 
Ube2iRatfibrillar center  IDA 2301351 RGD 
Ube2iRatglutamatergic synapse is_active_inISOUbe2i (Mus musculus)1624291 PMID:31749687RGDPMID:31749687
Ube2iRatnuclear body located_inISOUbe2i (Mus musculus)1624291 PMID:18681895RGDPMID:18681895
Ube2iRatnuclear body  IDA 2301350 RGD 
Ube2iRatnuclear envelope  IDA 9835353 RGD 
Ube2iRatnucleoplasm is_active_inISOUbe2i (Mus musculus)1624291 PMID:18703419RGDPMID:18703419
Ube2iRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Ube2iRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Ube2iRatnucleus is_active_inIBAFB:FBgn0010602 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ube2iRatnucleus located_inISOUBE2I (Homo sapiens)1624291 PMID:14752048 more ...RGDPMID:14752048 more ...
Ube2iRatPML body located_inISOUBE2I (Homo sapiens)1624291 PMID:9885291RGDPMID:9885291
Ube2iRatpostsynaptic cytosol is_active_inISOUbe2i (Mus musculus)1624291 PMID:31749687RGDPMID:31749687
Ube2iRatpresynaptic cytosol is_active_inISOUbe2i (Mus musculus)1624291 PMID:31749687RGDPMID:31749687
Ube2iRatSchaffer collateral - CA1 synapse is_active_inISOUbe2i (Mus musculus)1624291 PMID:25448527RGDPMID:25448527
Ube2iRatSUMO ligase complex part_ofISOUBE2I (Homo sapiens)1624291 PMID:22194619RGDPMID:22194619
Ube2iRatSUMO ligase complex part_ofISOUbe2i (Mus musculus)1624291 PMID:22207709RGDPMID:22207709
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Molecular Function
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Original Reference(s)
Ube2iRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Ube2iRatATP binding enablesIEAUniRule:UR0001418271600115GO_REF:0000104UniProtGO_REF:0000104
Ube2iRatbHLH transcription factor binding  IPITCF3 (Homo sapiens)730030 RGD 
Ube2iRatenzyme binding enablesISOUBE2I (Homo sapiens)1624291UniProtKB:P35520 and PMID:17087506RGDPMID:17087506
Ube2iRatHLH domain binding enablesISOUbe2i (Mus musculus)1624291UniProtKB:P15923-1 more ...RGDPMID:9409784
Ube2iRationotropic glutamate receptor binding  IPIGrik2 (Rattus norvegicus)1642482protein C-terminus bindingRGD 
Ube2iRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Ube2iRatprotein binding  IPITollip (Rattus norvegicus)5508208 RGD 
Ube2iRatprotein binding  IPIGMEB1 (Homo sapiens)2301354 RGD 
Ube2iRatprotein binding enablesISOUbe2i (Mus musculus)1624291PR:O08900 more ...RGDPMID:11025202 more ...
Ube2iRatprotein binding enablesISOUBE2I (Sus scrofa)1624291UniProtKB:P21530-PRO_0000038063 and PMID:20800867RGDPMID:20800867
Ube2iRatprotein binding enablesIPIUniProtKB:P422601642482PMID:17486098IntAct 
Ube2iRatprotein binding enablesISOUBE2I (Homo sapiens)1624291UniProtKB:G2XKQ0 more ...RGDPMID:10871618 more ...
Ube2iRatprotein binding enablesIPIUniProtKB:P630338554673PMID:19498170UniProt 
Ube2iRatprotein binding  IPIRangap1 (Rattus norvegicus)9835353 RGD 
Ube2iRatprotein binding  IPIGMEB2 (Homo sapiens)2301354 RGD 
Ube2iRatRING-like zinc finger domain binding enablesISOUBE2I (Homo sapiens)1624291UniProtKB:Q969V5 and PMID:19407830RGDPMID:19407830
Ube2iRatsmall protein activating enzyme binding enablesISOUBE2I (Homo sapiens)1624291UniProtKB:Q9UBT2 and PMID:15660128RGDPMID:15660128
Ube2iRatSUMO conjugating enzyme activity enablesISOUbe2i (Mus musculus)1624291 PMID:9435231RGDPMID:9435231
Ube2iRatSUMO conjugating enzyme activity enablesIBAFB:FBgn0010602 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
Ube2iRatRNA transport pathway  IEA 6907045 KEGGrno:03013
Ube2iRatubiquitin/proteasome degradation pathway  IEA 6907045 KEGGrno:04120

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#
Reference Title
Reference Citation
1. TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy. Baumgarten A, etal., Int J Cardiol. 2013 Sep 30;168(2):1447-52. doi: 10.1016/j.ijcard.2012.12.094. Epub 2013 Jan 27.
2. The giant fibrillar center: a nucleolar structure enriched in upstream binding factor (UBF) that appears in transcriptionally more active sensory ganglia neurons. Casafont I, etal., J Struct Biol. 2007 Sep;159(3):451-61. Epub 2007 May 25.
3. Tollip is a mediator of protein sumoylation. Ciarrocchi A, etal., PLoS One. 2009;4(2):e4404. Epub 2009 Feb 9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors. Kaul S, etal., J Biol Chem. 2002 Apr 12;277(15):12541-9. Epub 2002 Jan 25.
6. Degradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2A. Kho CJ, etal., J Biol Chem 1997 Feb 7;272(6):3845-51.
7. Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue. Lee GW, etal., J Biol Chem. 1998 Mar 13;273(11):6503-7.
8. Defective ubiquitination of cerebral proteins in Alzheimer's disease. Lopez Salon M, etal., J Neurosci Res 2000 Oct 15;62(2):302-10.
9. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Martin S, etal., Nature. 2007 May 17;447(7142):321-5. Epub 2007 May 7.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. A role for Ubc9 in tumorigenesis. Mo YY, etal., Oncogene. 2005 Apr 14;24(16):2677-83.
12. Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells. Navascues J, etal., Chromosoma. 2007 Oct;116(5):441-51. Epub 2007 May 26.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans. Romanenko AM, etal., J Urol. 2006 Feb;175(2):739-43.
18. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Subramaniam S, etal., Science. 2009 Jun 5;324(5932):1327-30. doi: 10.1126/science.1172871.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
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PMID:9223278   PMID:9409784   PMID:9885291   PMID:10562557   PMID:10562558   PMID:12477932   PMID:14739995   PMID:14752048   PMID:15489334   PMID:15539428   PMID:15539951   PMID:15611122  
PMID:15660128   PMID:15802564   PMID:16127449   PMID:16631117   PMID:17087506   PMID:17911097   PMID:18555800   PMID:18681895   PMID:19039338   PMID:19407830   PMID:19744555   PMID:19955185  
PMID:20167237   PMID:20209145   PMID:21518833   PMID:21616059   PMID:21630459   PMID:21968017   PMID:22082260   PMID:22658674   PMID:26620705   PMID:30772377   PMID:38955308  



Ube2i
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,782,245 - 14,802,911 (-)NCBIGRCr8
mRatBN7.21014,277,749 - 14,294,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1069,701,618 - 69,702,443 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1014,277,749 - 14,295,136 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,019,943 - 19,034,557 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,508,805 - 18,523,419 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,008,012 - 14,022,626 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,618,615 - 14,639,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,620,531 - 14,630,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,436,200 - 14,456,889 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,509,948 - 14,524,551 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,509,950 - 14,524,551 (-)NCBI
Celera1013,951,568 - 13,966,171 (-)NCBICelera
Cytogenetic Map10q12NCBI
UBE2I
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,309,152 - 1,327,017 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,291,444 - 1,327,018 (+)EnsemblGRCh38hg38GRCh38
GRCh37161,359,153 - 1,377,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,299,181 - 1,315,391 (+)NCBINCBI36Build 36hg18NCBI36
Build 34161,299,180 - 1,315,391NCBI
Celera161,573,488 - 1,589,693 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,287,961 - 1,305,367 (+)NCBIHuRef
CHM1_1161,359,074 - 1,376,964 (+)NCBICHM1_1
T2T-CHM13v2.0161,325,332 - 1,343,194 (+)NCBIT2T-CHM13v2.0
Ube2i
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,479,484 - 25,494,965 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,479,482 - 25,493,856 (-)EnsemblGRCm39 Ensembl
GRCm381725,260,510 - 25,275,799 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,261,916 - 25,274,622 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,397,456 - 25,411,255 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,988,111 - 25,001,891 (-)NCBIMGSCv36mm8
Celera1725,787,805 - 25,801,616 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.53NCBI
Ube2i
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,901,980 - 15,913,037 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,902,026 - 15,913,033 (-)NCBIChiLan1.0ChiLan1.0
UBE2I
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,572,047 - 1,588,221 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,358,365 - 5,374,530 (+)NCBINHGRI_mPanPan1
PanPan1.1161,365,291 - 1,382,575 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,367,288 - 1,382,575 (+)Ensemblpanpan1.1panPan2
UBE2I
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,440,123 - 39,453,688 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,440,314 - 39,817,588 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,707,767 - 40,719,921 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,786,145 - 39,798,312 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1639,462,778 - 39,474,925 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,435,400 - 39,447,553 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,913,736 - 39,925,904 (-)NCBIUU_Cfam_GSD_1.0
Ube2i
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,133,975 - 104,147,758 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,561,681 - 2,576,647 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,561,701 - 2,571,284 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE2I
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1340,556,556 - 40,586,382 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,899,856 - 41,966,997 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2I
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,203,513 - 1,216,662 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,200,018 - 1,216,741 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,867,995 - 29,884,946 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ube2i
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249132,025,528 - 2,041,690 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249132,025,241 - 2,041,394 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Ube2i
63 total Variants

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir199a2rno-miR-199a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20965886

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:151
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000024406
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat

1 to 10 of 25 rows
RH127604  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21069,702,700 - 69,702,904 (+)MAPPERmRatBN7.2
mRatBN7.21014,279,208 - 14,279,412 (-)MAPPERmRatBN7.2
mRatBN7.21014,279,208 - 14,279,412 (+)MAPPERmRatBN7.2
mRatBN7.21069,702,700 - 69,702,904 (-)MAPPERmRatBN7.2
Rnor_6.01072,148,529 - 72,148,732NCBIRnor6.0
Rnor_6.01014,620,070 - 14,620,273NCBIRnor6.0
Rnor_5.01014,437,660 - 14,437,863UniSTSRnor5.0
Rnor_5.01072,055,388 - 72,055,591UniSTSRnor5.0
RGSC_v3.41014,510,002 - 14,510,205UniSTSRGSC3.4
RGSC_v3.41073,106,012 - 73,106,215UniSTSRGSC3.4
Celera1068,630,602 - 68,630,805UniSTS
Celera1013,951,622 - 13,951,825UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map10q12UniSTS
BE107288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,284,780 - 14,284,934 (+)MAPPERmRatBN7.2
Rnor_6.01014,625,642 - 14,625,795NCBIRnor6.0
Rnor_5.01014,443,232 - 14,443,385UniSTSRnor5.0
RGSC_v3.41014,515,574 - 14,515,727UniSTSRGSC3.4
Celera1013,957,194 - 13,957,347UniSTS
RH 3.4 Map10170.6UniSTS
Cytogenetic Map10q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 23 of 23 rows
RefSeq Transcripts NM_001428972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001428976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006245920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC094421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 23 of 23 rows

Ensembl Acc Id: ENSRNOT00000024406   ⟹   ENSRNOP00000024406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1069,701,618 - 69,702,443 (+)Ensembl
Rnor_6.0 Ensembl1014,620,531 - 14,630,151 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090085   ⟹   ENSRNOP00000075659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,279,155 - 14,295,136 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104064   ⟹   ENSRNOP00000085922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,277,749 - 14,293,782 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111980   ⟹   ENSRNOP00000091713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,277,749 - 14,294,101 (-)Ensembl
RefSeq Acc Id: NM_013050   ⟹   NP_037182
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,783,651 - 14,798,254 (-)NCBI
mRatBN7.21014,279,155 - 14,293,759 (-)NCBI
Rnor_6.01014,620,016 - 14,634,619 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
RGSC_v3.41014,509,948 - 14,524,551 (-)RGD
Celera1013,951,568 - 13,966,171 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245919   ⟹   XP_006245981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,797,531 (-)NCBI
mRatBN7.21014,277,749 - 14,293,627 (-)NCBI
Rnor_6.01014,618,615 - 14,634,501 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245920   ⟹   XP_006245982
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,799,168 (-)NCBI
mRatBN7.21014,277,749 - 14,294,681 (-)NCBI
Rnor_6.01014,618,615 - 14,635,541 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767549   ⟹   XP_008765771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,802,529 (-)NCBI
mRatBN7.21014,277,749 - 14,294,678 (-)NCBI
Rnor_6.01014,618,615 - 14,635,539 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597044   ⟹   XP_017452533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,798,993 (-)NCBI
mRatBN7.21014,277,749 - 14,294,214 (-)NCBI
Rnor_6.01014,618,615 - 14,635,243 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063268474   ⟹   XP_063124544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,802,831 (-)NCBI
RefSeq Acc Id: XM_063268476   ⟹   XP_063124546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,802,911 (-)NCBI
RefSeq Acc Id: XM_063268477   ⟹   XP_063124547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,782,245 - 14,798,318 (-)NCBI
1 to 5 of 12 rows
1 to 5 of 12 rows
RefSeq Acc Id: NP_037182   ⟸   NM_013050
- UniProtKB: P63281 (UniProtKB/Swiss-Prot),   A6HD16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245982   ⟸   XM_006245920
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006245981   ⟸   XM_006245919
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008765771   ⟸   XM_008767549
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KB55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452533   ⟸   XM_017597044
- Peptide Label: isoform X4
- Sequence:
UBC core

Name Modeler Protein Id AA Range Protein Structure
AF-P63281-F1-model_v2 AlphaFold P63281 1-158 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-25792 BioCyc
Ensembl Genes ENSRNOG00000017907 Ensembl
  ENSRNOG00000066579 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090085 ENTREZGENE
  ENSRNOT00000104064.1 UniProtKB/Swiss-Prot
  ENSRNOT00000154507 ENTREZGENE
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7305067 IMAGE-MGC_LOAD
  IMAGE:7310403 IMAGE-MGC_LOAD
InterPro Ub_conjugating_enzyme UniProtKB/Swiss-Prot
  UBQ-conjugat_E2 UniProtKB/Swiss-Prot
  UBQ-conjugating_AS UniProtKB/Swiss-Prot
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot
KEGG Report rno:25573 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105476 IMAGE-MGC_LOAD
  MGC:105477 IMAGE-MGC_LOAD
NCBI Gene 25573 ENTREZGENE
PANTHER UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/Swiss-Prot
Pfam UQ_con UniProtKB/Swiss-Prot
PhenoGen Ube2i PhenoGen
PROSITE UBIQUITIN_CONJUGAT_1 UniProtKB/Swiss-Prot
  UBIQUITIN_CONJUGAT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017907 RatGTEx
  ENSRNOG00000066579 RatGTEx
SMART UBCc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot
TIGR TC228339
UniProt A0A0G2KB55 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AG56_RAT UniProtKB/TrEMBL
  A0A8L2QCN1_RAT UniProtKB/TrEMBL
  A6HD16 ENTREZGENE, UniProtKB/TrEMBL
  P63281 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P50550 UniProtKB/Swiss-Prot
  Q15698 UniProtKB/Swiss-Prot
  Q86VB3 UniProtKB/Swiss-Prot
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Ube2i  ubiquitin-conjugating enzyme E2I  Ube2i  ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Ube2i  ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)  Ube2i  ubiquitin-conjugating enzyme E2I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ube2i  Ubiquitin conjugating enzyme E2I      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_physical_interaction protein binds helix-loop-helix protein E47 specificaly at a 54 aa region (477-530) 730030