Pmch (pro-melanin-concentrating hormone) - Rat Genome Database

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Gene: Pmch (pro-melanin-concentrating hormone) Rattus norvegicus
Analyze
Symbol: Pmch
Name: pro-melanin-concentrating hormone
RGD ID: 3358
Description: Enables type 1 melanin-concentrating hormone receptor binding activity. Involved in several processes, including lactation; modulation of chemical synaptic transmission; and positive regulation of circadian sleep/wake cycle, REM sleep. Located in extracellular space. Biomarker of obesity. Orthologous to several human genes including PMCH (pro-melanin concentrating hormone); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: pro-MCH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pmchm1Hubr  
Genetic Models: WI-Pmchm1Hubr
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8724,399,404 - 24,400,720 (+)NCBIGRCr8
mRatBN7.2722,511,934 - 22,513,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,511,934 - 22,513,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,506,585 - 24,507,901 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,669,288 - 26,670,604 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,446,310 - 26,447,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,655,206 - 28,656,522 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,654,733 - 28,657,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,764,993 - 28,766,309 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,778,133 - 24,779,449 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,798,403 - 24,799,720 (+)NCBI
Celera719,682,044 - 19,683,360 (+)NCBICelera
RH 3.4 Map7118.65RGD
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IDA)
nucleus  (IEA,ISO)
synapse  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The feeding response to melanin-concentrating hormone is attenuated by antagonism of the NPY Y(1)-receptor in the rat. Chaffer CL and Morris MJ, Endocrinology 2002 Jan;143(1):191-7.
2. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Chambers J, etal., Nature. 1999 Jul 15;400(6741):261-5.
3. Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats. Della-Zuana O, etal., Int J Obes Relat Metab Disord. 2002 Oct;26(10):1289-95.
4. The regulation of alcohol intake by melanin-concentrating hormone in rats. Duncan EA, etal., Pharmacol Biochem Behav. 2006 Dec;85(4):728-35. Epub 2006 Dec 22.
5. Increases in melanin-concentrating hormone and MCH receptor levels in the hypothalamus of dietary-obese rats. Elliott JC, etal., Brain Res Mol Brain Res. 2004 Sep 28;128(2):150-9.
6. Hypothalamic levels of NPY, MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat: role of prolactin. Garcia MC, etal., FASEB J 2003 Aug;17(11):1392-400.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone. Gomori A, etal., Am J Physiol Endocrinol Metab. 2003 Mar;284(3):E583-8. Epub 2002 Nov 26.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Lembo PM, etal., Nat Cell Biol. 1999 Sep;1(5):267-71.
12. Cardiovascular effects of melanin-concentrating hormone. Messina MM and Overton JM, Regul Pept. 2007 Mar 1;139(1-3):23-30. Epub 2006 Oct 11.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Pmch expression during early development is critical for normal energy homeostasis. Mul JD, etal., Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E477-88. doi: 10.1152/ajpendo.00154.2009. Epub 2009 Nov 24.
15. Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive. Mul JD, etal., PLoS One. 2013;8(3):e60214. doi: 10.1371/journal.pone.0060214. Epub 2013 Mar 26.
16. The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. Nahon JL, etal., Endocrinology 1989 Oct;125(4):2056-65.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Alterations of orexinergic and melanin-concentrating hormone neurons in experimental sleeping sickness. Palomba M, etal., Neuroscience. 2015 Apr 2;290:185-95. doi: 10.1016/j.neuroscience.2014.12.066. Epub 2015 Jan 13.
19. Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Pereira-da-Silva M, etal., Endocrinology. 2003 Nov;144(11):4831-40. Epub 2003 Jul 24.
20. Melanin-concentrating hormone induces insulin resistance through a mechanism independent of body weight gain. Pereira-da-Silva M, etal., J Endocrinol. 2005 Jul;186(1):193-201.
21. GOA pipeline RGD automated data pipeline
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Functional role of N-linked glycosylation on the rat melanin-concentrating hormone receptor 1. Saito Y, etal., FEBS Lett 2003 Jan 2;533(1-3):29-34.
24. Central and peripheral dysregulation of melanin-concentrating hormone in obese Zucker rats. Stricker-Krongrad A, etal., Brain Res Mol Brain Res. 2001 Aug 15;92(1-2):43-8.
25. Central and peripheral immunoreactivity of melanin-concentrating hormone in hypothalamic obese and lactating rats. Sun G, etal., J Neuroendocrinol. 2004 Jan;16(1):79-83.
26. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
27. Nucleotide sequence and tissue-specific expression of the rat melanin concentrating hormone gene. Thompson RC and Watson SJ, DNA Cell Biol 1990 Nov;9(9):637-45.
28. Melanin concentrating hormone increase hippocampal synaptic transmission in the rat. Varas M, etal., Peptides 2002 Jan;23(1):151-5.
29. A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. Verret L, etal., BMC Neurosci. 2003 Sep 9;4:19.
30. Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of dopamine in tuberoinfundibular neurons and serum prolactin levels: studies using estrogen, melanin concentrating hormone, and melanocortin. Yang SC and Shieh KR, Neuropharmacology. 2004 Dec;47(7):1070-80.
Additional References at PubMed
PMID:1327720   PMID:2759038   PMID:7617126   PMID:7647772   PMID:7783849   PMID:8593803   PMID:8724342   PMID:9700748   PMID:9809645   PMID:10037747   PMID:11867747   PMID:12706266  
PMID:12832098   PMID:15044362   PMID:15567347   PMID:17016031   PMID:17151950   PMID:17683785   PMID:17884195   PMID:17924541   PMID:17989139   PMID:19101033   PMID:19188611   PMID:21103352  
PMID:21530599   PMID:21925200   PMID:22209364   PMID:22967922   PMID:23123302   PMID:23531605   PMID:24676683   PMID:24780894   PMID:24893251   PMID:25084113   PMID:26456505   PMID:27845162  
PMID:28867197   PMID:31034718   PMID:31664021   PMID:31917877   PMID:36565982  


Genomics

Comparative Map Data
Pmch
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8724,399,404 - 24,400,720 (+)NCBIGRCr8
mRatBN7.2722,511,934 - 22,513,250 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl722,511,934 - 22,513,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx724,506,585 - 24,507,901 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0726,669,288 - 26,670,604 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0726,446,310 - 26,447,626 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0728,655,206 - 28,656,522 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl728,654,733 - 28,657,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0728,764,993 - 28,766,309 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4724,778,133 - 24,779,449 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1724,798,403 - 24,799,720 (+)NCBI
Celera719,682,044 - 19,683,360 (+)NCBICelera
RH 3.4 Map7118.65RGD
Cytogenetic Map7q13NCBI
PMCH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812102,196,459 - 102,197,833 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12102,196,459 - 102,197,833 (-)EnsemblGRCh38hg38GRCh38
GRCh3712102,590,237 - 102,591,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612101,114,367 - 101,115,744 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412101,092,705 - 101,094,069NCBI
Celera12102,254,196 - 102,255,573 (-)NCBICelera
Cytogenetic Map12q23.2NCBI
HuRef1299,649,705 - 99,651,082 (-)NCBIHuRef
CHM1_112102,556,902 - 102,558,279 (-)NCBICHM1_1
T2T-CHM13v2.012102,157,595 - 102,158,969 (-)NCBIT2T-CHM13v2.0
Pmch
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391087,926,934 - 87,928,236 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1087,926,934 - 87,928,237 (+)EnsemblGRCm39 Ensembl
GRCm381088,091,072 - 88,092,374 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1088,091,072 - 88,092,375 (+)EnsemblGRCm38mm10GRCm38
MGSCv371087,553,817 - 87,555,119 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361087,520,874 - 87,522,172 (+)NCBIMGSCv36mm8
Celera1090,075,720 - 90,077,022 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1043.7NCBI
Pmch
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540537,356,755 - 37,360,695 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540537,357,468 - 37,360,695 (-)NCBIChiLan1.0ChiLan1.0
PMCH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210110,269,790 - 110,271,177 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112110,266,188 - 110,267,581 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01299,783,925 - 99,785,292 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112103,181,777 - 103,183,197 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12103,181,497 - 103,182,616 (-)Ensemblpanpan1.1panPan2
PMCH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11541,036,428 - 41,037,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1541,036,428 - 41,037,553 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1541,404,422 - 41,405,547 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01541,690,821 - 41,691,974 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1541,690,821 - 41,691,946 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11540,958,046 - 40,959,171 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01541,054,180 - 41,055,305 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01541,328,497 - 41,329,622 (-)NCBIUU_Cfam_GSD_1.0
Pmch
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494518,937,096 - 18,938,482 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649211,947,489 - 11,948,896 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649211,947,489 - 11,948,896 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMCH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl582,018,915 - 82,020,266 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1582,018,915 - 82,020,267 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2585,944,967 - 85,946,320 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PMCH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11197,436,682 - 97,438,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037147,566,730 - 147,568,089 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmch
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247506,109,284 - 6,111,547 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247506,109,542 - 6,110,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pmch
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:110
Interacting mature miRNAs:115
Transcripts:ENSRNOT00000006174
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat

Markers in Region
RH94549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,513,064 - 22,513,234 (+)MAPPERmRatBN7.2
Rnor_6.0728,656,337 - 28,656,506NCBIRnor6.0
Rnor_5.0728,766,124 - 28,766,293UniSTSRnor5.0
RGSC_v3.4724,779,264 - 24,779,433UniSTSRGSC3.4
Celera719,683,175 - 19,683,344UniSTS
RH 3.4 Map7118.65UniSTS
Cytogenetic Map7q13UniSTS
RH137732  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2722,513,056 - 22,513,235 (+)MAPPERmRatBN7.2
Rnor_6.0728,656,329 - 28,656,507NCBIRnor6.0
Rnor_5.0728,766,116 - 28,766,294UniSTSRnor5.0
RGSC_v3.4724,779,256 - 24,779,434UniSTSRGSC3.4
Celera719,683,167 - 19,683,345UniSTS
RH 3.4 Map7120.2UniSTS
Cytogenetic Map7q13UniSTS


Genetic Models
This gene Pmch is modified in the following models/strains:
WI-Pmchm1Hubr    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system reproductive system respiratory system
High
Medium 2
Low 30
Below cutoff 1 8 2 8 2 23 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006174   ⟹   ENSRNOP00000006174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl728,654,733 - 28,657,522 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095213   ⟹   ENSRNOP00000091581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl722,511,934 - 22,513,250 (+)Ensembl
RefSeq Acc Id: NM_012625   ⟹   NP_036757
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8724,399,404 - 24,400,720 (+)NCBI
mRatBN7.2722,511,934 - 22,513,250 (+)NCBI
Rnor_6.0728,655,206 - 28,656,522 (+)NCBI
Rnor_5.0728,764,993 - 28,766,309 (+)NCBI
RGSC_v3.4724,778,133 - 24,779,449 (+)RGD
Celera719,682,044 - 19,683,360 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036757 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41580 (Get FASTA)   NCBI Sequence Viewer  
  AAA41581 (Get FASTA)   NCBI Sequence Viewer  
  EDM17019 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091581
  ENSRNOP00000091581.1
GenBank Protein P14200 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_036757   ⟸   NM_012625
- Peptide Label: precursor
- UniProtKB: P14200 (UniProtKB/Swiss-Prot),   A0A8I6ABX9 (UniProtKB/TrEMBL),   A6IFM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006174   ⟸   ENSRNOT00000006174
RefSeq Acc Id: ENSRNOP00000091581   ⟸   ENSRNOT00000095213

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14200-F1-model_v2 AlphaFold P14200 1-165 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3358 AgrOrtholog
BioCyc Gene G2FUF-34521 BioCyc
Ensembl Genes ENSRNOG00000004632 Ensembl
  ENSRNOG00000066777 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095213 ENTREZGENE
  ENSRNOT00000095213.1 UniProtKB/TrEMBL
InterPro Prepro-melanin_conc_hormone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24659 UniProtKB/Swiss-Prot
NCBI Gene 24659 ENTREZGENE
PANTHER PRO-MCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12091 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pro-MCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pmch PhenoGen
PRINTS PROMCHFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004632 RatGTEx
  ENSRNOG00000066777 RatGTEx
TIGR TC220489
UniProt A0A8I6ABX9 ENTREZGENE, UniProtKB/TrEMBL
  A6IFM9 ENTREZGENE, UniProtKB/TrEMBL
  MCH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pmch  Pro-melanin-concentrating hormone      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease disruption of the gene in mice results in a lean phenotype as a result of hypophagia and increased metabolic rate, whereas overexpression causes obesity and insulin-resistant 628540
gene_expression found in the brain lateral hypothalamic area 70437
gene_expression expressed in the lateral hypothalamus and zona incerta of the central nervous system 628540
gene_process regulates appetite 70437
gene_process activates Y1 receptor which in turn mediates Npy 70437
gene_process may play a role in retrograde facilitation on the inhibitory avoidance 729531
gene_process plays a role in regulation of feeding behavior 628540
gene_protein the mature product is a 19-amino acid cyclic peptide 628540