Mx1 (MX dynamin like GTPase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mx1 (MX dynamin like GTPase 1) Rattus norvegicus
Analyze
Symbol: Mx1
Name: MX dynamin like GTPase 1
RGD ID: 3127
Description: Predicted to enable GTPase activity; identical protein binding activity; and microtubule binding activity. Involved in response to virus. Located in nucleus. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IFI78; interferon-induced GTP-binding protein Mx1; myxoma resistance protein 1; myxovirus (influenza virus) resistance; myxovirus (influenza virus) resistance 1; Myxovirus (influenza) resistance homolog of murine Mx (also interferon-inducible protein IFI78); Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78); myxovirus resistance protein 1
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,269,056 - 50,294,699 (-)NCBIGRCr8
mRatBN7.21136,799,659 - 36,825,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1136,799,660 - 36,823,507 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,448,179 - 45,473,727 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,119,559 - 38,145,105 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,279,482 - 37,305,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,891,150 - 37,916,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,891,156 - 37,914,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,398,737 - 41,424,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,438,473 - 37,462,363 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,496,062 - 37,517,940 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mx1Ratalopecia areata onsetISOMX1 (Homo sapiens)126777672DNA:SNP:intron 6:g.9959C>T (human)RGD 
Mx1Ratavian influenza susceptibilityISOMX1 (Homo sapiens)126777675human gene in a mouse modelRGD 
Mx1RatChronic Hepatitis C treatmentISOMX1 (Homo sapiens)11067846DNA:SNPs:promoter:g.-123C>A and -88G>T(human)RGD 
Mx1RatChronic Hepatitis C treatmentIEP 40400915 RGD 
Mx1RatChronic Hepatitis C exacerbatesISOMX1 (Homo sapiens)126777679DNA:SNPs:promoter: (rs2071430 and rs17000900) (human)RGD 
Mx1RatEnterovirus Infections susceptibilityISOMX1 (Homo sapiens)126777678DNA:SNPs:promoter:g.-123C>A more ...RGD 
Mx1Ratinfluenza A amelioratesISOMx1 (Mus musculus)126777671fused with PTD 9-arginine sequenceRGD 
Mx1Ratinfluenza A amelioratesISOMX1 (Homo sapiens)126777673human gene in a mouse modelRGD 
Mx1Ratinfluenza A amelioratesISOMx1 (Mus musculus)126777676 RGD 
Mx1Ratinfluenza A amelioratesISOMX1 (Homo sapiens)126777680human gene in a mouse modelRGD 
Mx1Ratliver disease  ISOMX1 (Homo sapiens)126777674associated with human immunodeficiency virus infectious disease more ...RGD 
Mx1RatLung Injury  ISOMx1 (Mus musculus)9068941mRNA: increased expression: lung (mouse)RGDPMID:31921151 and REF_RGD_ID:126779575
Mx1Ratpapillomavirus infectious disease exacerbatesISOMX1 (Homo sapiens)126777683protein:increased expression:body wart (human)RGD 
Mx1Ratprostate cancer susceptibilityISOMX1 (Homo sapiens)126777681DNA:SNP:promoter:-g.88G>T (rs2071430) (human)RGD 
Mx1RatRespiratory Tract Infections  ISOMX1 (Homo sapiens)126777677protein:increased expression:blood (human)RGD 
Mx1RatStreptococcal Infections  ISOMX1 (Homo sapiens)126777682associated with pharyngitis and protein:increased expression:blood (human)RGD 
1 to 16 of 16 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mx1Ratautistic disorder  ISOMX1 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Mx1RatNeurodevelopmental Disorders  ISOMX1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mx1Ratacute myeloid leukemia  ISOMX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17330099
Mx1RatAnimal Disease Models  ISOMX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36071497
Mx1Ratavian influenza  ISOMX1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:178595
Mx1Ratcongestive heart failure  ISOMX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36071497
Mx1RatFanconi anemia  ISOMX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9389754
Mx1RatHuman Influenza  ISOMX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23326326
Mx1RatMyocardial Ischemia  ISOMX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
Mx1RatStomach Neoplasms  ISOMX1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16367923

1 to 20 of 210 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mx1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMX1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MX1 mRNACTDPMID:22079256
Mx1Rat(-)-epigallocatechin 3-gallate decreases expressionISOMX1 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of MX1 mRNACTDPMID:32512070
Mx1Rat(S)-nicotine multiple interactionsISOMX1 (Homo sapiens)6480464[nickel chloride co-treated with Nicotine] results in increased expression of MX1 mRNACTDPMID:37951547
Mx1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of MX1 mRNACTDPMID:15834898 and PMID:17351261
Mx1Rat17beta-estradiol multiple interactionsISOMX1 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of MX1 mRNACTDPMID:30165855
Mx1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of MX1 mRNACTDPMID:35192832
Mx1Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of MX1 mRNACTDPMID:32741896
Mx1Rat17beta-estradiol affects expressionISOMx1 (Mus musculus)6480464Estradiol affects the expression of MX1 mRNACTDPMID:15598610
Mx1Rat17beta-estradiol decreases expressionISOMX1 (Homo sapiens)6480464Estradiol results in decreased expression of MX1 mRNACTDPMID:23373633
Mx1Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of MX1 mRNACTDPMID:32741896
Mx1Rat2,2',4,4',5,5'-hexachlorobiphenyl increases expressionISOMX1 (Homo sapiens)64804642 more ...CTDPMID:23146750
Mx1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOMX1 (Homo sapiens)64804642 more ...CTDPMID:19095052 and PMID:23146750
Mx1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOMX1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Mx1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of MX1 mRNACTDPMID:15644576
Mx1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MX1 mRNACTDPMID:33387578
Mx1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of MX1 mRNACTDPMID:34747641
Mx1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMX1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of MX1 mRNACTDPMID:12377990
Mx1Rat2,3,7,8-Tetrachlorodibenzofuran increases expressionEXP 64804642 more ...CTDPMID:32109520
Mx1Rat2,6-dimethoxyphenol multiple interactionsISOMX1 (Homo sapiens)6480464[Furaldehyde co-treated with pyrogallol 1 more ...CTDPMID:38598786
Mx1Rat2-hydroxypropanoic acid increases expressionISOMX1 (Homo sapiens)6480464Lactic Acid results in increased expression of MX1 mRNACTDPMID:30851411

1 to 20 of 210 rows

Biological Process
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mx1Ratdefense response to virus involved_inIBAPANTHER:PTN002611415 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mx1Ratdefense response to virus involved_inIEAUniProtKB-KW:KW-00511600115GO_REF:0000043UniProtGO_REF:0000043
Mx1Ratimmune system process involved_inIEAUniProtKB-KW:KW-03911600115GO_REF:0000043UniProtGO_REF:0000043
Mx1Ratinnate immune response involved_inISSUniProtKB:P099221600115GO_REF:0000024UniProtGO_REF:0000024
Mx1Ratinnate immune response involved_inIEAUniProtKB-KW:KW-03991600115GO_REF:0000043UniProtGO_REF:0000043
Mx1Ratinterleukin-27-mediated signaling pathway involved_inISOMX1 (Homo sapiens)1624291 PMID:32270034RGDPMID:32270034
Mx1Ratnegative regulation of viral genome replication involved_inISOMX1 (Homo sapiens)1624291 PMID:14687945 more ...RGDPMID:14687945 more ...
Mx1Ratreceptor internalization involved_inIBAPANTHER:PTN008520579 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mx1Ratresponse to virus involved_inIEAARBA:ARBA000264921600115GO_REF:0000117UniProtGO_REF:0000117
Mx1Ratresponse to virus involved_inISOMX1 (Homo sapiens)1624291 PMID:15047845RGDPMID:15047845
Mx1Ratresponse to virus involved_inIDA 728936PMID:2173790UniProt 
Mx1Ratsynaptic vesicle budding from presynaptic endocytic zone membrane involved_inIBAFB:FBgn0003392 and PANTHER:PTN0009020931600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 12 of 12 rows

Cellular Component
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mx1Ratcytoplasm located_inISOMX1 (Homo sapiens)1624291 PMID:21859714RGDPMID:21859714
Mx1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Mx1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Mx1Ratcytoplasm is_active_inIBACGD:CAL0000188111 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mx1Ratcytosol located_inISOMX1 (Homo sapiens) and UniProtKB:P20591-11624291 RGDGO_REF:0000052
Mx1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Mx1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Mx1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Mx1Ratmicrotubule is_active_inIBAPANTHER:PTN000170013 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mx1Ratnuclear membrane located_inISOMX1 (Homo sapiens) and UniProtKB:P20591-11624291 RGDGO_REF:0000052
Mx1Ratnucleus is_active_inIBAPANTHER:PTN002611415 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mx1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Mx1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Mx1Ratnucleus located_inISOMx1 (Mus musculus)1624291 PMID:11716541RGDPMID:11716541
Mx1Ratnucleus located_inIDA 728936PMID:2173790UniProt 
Mx1Ratperinuclear region of cytoplasm located_inISOMX1 (Homo sapiens)1624291 PMID:15047845RGDPMID:15047845
Mx1Ratperinuclear region of cytoplasm located_inIEAUniProtKB-SubCell:SL-01981600115GO_REF:0000044UniProtGO_REF:0000044
Mx1Ratplasma membrane is_active_inIBAFB:FBgn0003392 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mx1Ratpresynapse located_inIEAGO:00161851600115GO_REF:0000108GOCGO_REF:0000108
Mx1Ratsynapse is_active_inIBAFB:FBgn0003392 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 20 of 20 rows

Molecular Function
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mx1RatGTP binding enablesIEAUniProtKB-KW:KW-03421600115GO_REF:0000043UniProtGO_REF:0000043
Mx1RatGTP binding enablesIEAInterPro:IPR001401 and InterPro:IPR0303811600115GO_REF:0000002InterProGO_REF:0000002
Mx1RatGTP binding enablesIEAInterPro:IPR001401 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mx1RatGTPase activity enablesIEAInterPro:IPR001401 and InterPro:IPR0031301600115GO_REF:0000002InterProGO_REF:0000002
Mx1RatGTPase activity enablesIBAMGI:107384 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mx1RatGTPase activity enablesIEAInterPro:IPR0014011600115GO_REF:0000002InterProGO_REF:0000002
Mx1Ratidentical protein binding enablesISOMX1 (Homo sapiens)1624291UniProtKB:P20591 more ...RGDPMID:20428112 more ...
Mx1Ratmicrotubule binding enablesIBAFB:FBgn0003392 and PANTHER:PTN0001700131600115GO_REF:0000033GO_CentralGO_REF:0000033
Mx1Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Mx1Ratprotein binding enablesISOMX1 (Homo sapiens)1624291UniProtKB:O00148 more ...RGDPMID:15047845 more ...
Mx1Ratprotein binding enablesISOMx1 (Mus musculus)1624291UniProtKB:O14747 more ...RGDPMID:11716541
1 to 11 of 11 rows


1 to 20 of 23 rows
#
Reference Title
Reference Citation
1. Human MxA is a potent interspecies barrier for the novel bat-derived influenza A-like virus H18N11. Ciminski K, etal., Emerg Microbes Infect. 2019;8(1):556-563. doi: 10.1080/22221751.2019.1599301.
2. In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein. Deeg CM, etal., J Exp Med. 2017 May 1;214(5):1239-1248. doi: 10.1084/jem.20161033. Epub 2017 Apr 10.
3. Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study. García-Álvarez M, etal., Sci Rep. 2017 Jan 31;7:41516. doi: 10.1038/srep41516.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The myxovirus resistance A (MxA) gene -88G>T single nucleotide polymorphism is associated with prostate cancer. Glymph S, etal., Infect Genet Evol. 2013 Jun;16:186-90. doi: 10.1016/j.meegid.2013.02.010. Epub 2013 Feb 22.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Aetiology of febrile pharyngitis in children: Potential of myxovirus resistance protein A (MxA) as a biomarker of viral infection. Ivaska L, etal., J Infect. 2017 Apr;74(4):385-392. doi: 10.1016/j.jinf.2017.01.002. Epub 2017 Jan 7.
8. Cell-Penetrating Mx1 Enhances Anti-Viral Resistance against Mucosal Influenza Viral Infection. Jung HE, etal., Viruses. 2019 Jan 28;11(2). pii: v11020109. doi: 10.3390/v11020109.
9. Resistance to influenza virus infection of Mx transgenic mice expressing Mx protein under the control of two constitutive promoters. Kolb E, etal., J Virol. 1992 Mar;66(3):1709-16. doi: 10.1128/JVI.66.3.1709-1716.1992.
10. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium. Lee S, etal., Sci Immunol. 2019 Oct 25;4(40). pii: 4/40/eaau4643. doi: 10.1126/sciimmunol.aau4643.
11. Activity of rat Mx proteins against a rhabdovirus. Meier E, etal., J Virol 1990 Dec;64(12):6263-9.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Hepatic IFNL4 expression is associated with non-response to interferon-based therapy through the regulation of basal interferon-stimulated gene expression in chronic hepatitis C patients. Murakawa M, etal., J Med Virol. 2017 Jul;89(7):1241-1247. doi: 10.1002/jmv.24763. Epub 2017 Feb 27.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Plasmacytoid dendritic cells and type I interferon in the immunological response against warts. Saadeh D, etal., Clin Exp Dermatol. 2017 Dec;42(8):857-862. doi: 10.1111/ced.13187. Epub 2017 Jul 24.
18. Gene polymorphisms of IL-10 and MxA in responders and non-responders to interferon therapy in HCV Egyptian patients genotype 4. Shaker OG, etal., Cell Biochem Biophys. 2015 Mar;71(2):617-25. doi: 10.1007/s12013-014-0241-9.
19. Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region. Tazi-Ahnini R, etal., Hum Genet. 2000 Jun;106(6):639-45. doi: 10.1007/s004390000318.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
1 to 20 of 23 rows
PMID:12477932   PMID:12892903   PMID:25930096   PMID:28064310   PMID:31904090  



Mx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,269,056 - 50,294,699 (-)NCBIGRCr8
mRatBN7.21136,799,659 - 36,825,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1136,799,660 - 36,823,507 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,448,179 - 45,473,727 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,119,559 - 38,145,105 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,279,482 - 37,305,028 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01137,891,150 - 37,916,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1137,891,156 - 37,914,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,398,737 - 41,424,277 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,438,473 - 37,462,363 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,496,062 - 37,517,940 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBICelera
Cytogenetic Map11q12NCBI
MX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382141,420,558 - 41,459,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2141,420,020 - 41,470,071 (+)EnsemblGRCh38hg38GRCh38
GRCh372142,792,485 - 42,831,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362141,720,024 - 41,753,008 (+)NCBINCBI36Build 36hg18NCBI36
Build 342141,720,023 - 41,753,008NCBI
Celera2127,990,716 - 28,029,320 (+)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2128,261,373 - 28,300,013 (+)NCBIHuRef
CHM1_12142,353,308 - 42,391,928 (+)NCBICHM1_1
T2T-CHM13v2.02139,807,998 - 39,847,898 (+)NCBIT2T-CHM13v2.0
Mx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,248,235 - 97,264,106 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1697,248,235 - 97,264,107 (-)EnsemblGRCm39 Ensembl
GRCm381697,447,035 - 97,462,906 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,447,035 - 97,462,907 (-)EnsemblGRCm38mm10GRCm38
MGSCv371697,668,642 - 97,684,513 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361697,551,947 - 97,567,815 (-)NCBIMGSCv36mm8
Celera1698,507,376 - 98,523,260 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.46NCBI

.

.
Variants in Mx1
286 total Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
11 37902953 37902954 A C snv SR/JrHsd (RGD), SHR/NHsd (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:393
Count of miRNA genes:189
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000039876
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 16 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat

1 to 10 of 16 rows
AA997168  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11261.71UniSTS
Cytogenetic Map11q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 113 91 90 59 25 59 6 216 95 93 45 60 31


1 to 22 of 22 rows
RefSeq Transcripts NM_001271058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC099784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 22 of 22 rows

Ensembl Acc Id: ENSRNOT00000002695   ⟹   ENSRNOP00000002695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1136,803,999 - 36,814,429 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000039876   ⟹   ENSRNOP00000043001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1136,799,660 - 36,823,507 (-)Ensembl
Rnor_6.0 Ensembl1137,891,156 - 37,914,983 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094076   ⟹   ENSRNOP00000086162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1136,799,660 - 36,823,507 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115496   ⟹   ENSRNOP00000091403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1136,799,660 - 36,814,429 (-)Ensembl
RefSeq Acc Id: NM_001271058   ⟹   NP_001257987
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,606 (-)NCBI
mRatBN7.21136,799,659 - 36,825,209 (-)NCBI
Rnor_6.01137,891,150 - 37,916,690 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271059   ⟹   NP_001257988
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,606 (-)NCBI
mRatBN7.21136,799,659 - 36,825,209 (-)NCBI
Rnor_6.01137,891,150 - 37,916,690 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,712,040 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271060   ⟹   NP_001257989
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,292,904 (-)NCBI
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271061   ⟹   NP_001257990
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,292,904 (-)NCBI
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271062   ⟹   NP_001257991
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,292,904 (-)NCBI
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: NM_173096   ⟹   NP_775119
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,292,904 (-)NCBI
mRatBN7.21136,799,659 - 36,823,507 (-)NCBI
Rnor_6.01137,891,150 - 37,914,983 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
RGSC_v3.41137,438,473 - 37,462,363 (-)RGD
Celera1136,686,487 - 36,710,338 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248146   ⟹   XP_006248208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,673 (-)NCBI
mRatBN7.21136,799,659 - 36,825,171 (-)NCBI
Rnor_6.01137,891,150 - 37,916,775 (-)NCBI
Rnor_5.01141,398,737 - 41,424,277 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597877   ⟹   XP_017453366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,699 (-)NCBI
mRatBN7.21136,799,659 - 36,825,170 (-)NCBI
Rnor_6.01137,891,150 - 37,916,775 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597878   ⟹   XP_017453367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,293,442 (-)NCBI
mRatBN7.21136,799,659 - 36,824,041 (-)NCBI
Rnor_6.01137,891,150 - 37,915,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087955   ⟹   XP_038943883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,293,455 (-)NCBI
mRatBN7.21136,799,659 - 36,824,040 (-)NCBI
RefSeq Acc Id: XM_039087956   ⟹   XP_038943884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,293,442 (-)NCBI
mRatBN7.21136,799,659 - 36,824,041 (-)NCBI
RefSeq Acc Id: XM_063270276   ⟹   XP_063126346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,269,056 - 50,294,646 (-)NCBI
1 to 5 of 16 rows
1 to 5 of 16 rows
RefSeq Acc Id: NP_775119   ⟸   NM_173096
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257988   ⟸   NM_001271059
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257987   ⟸   NM_001271058
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257990   ⟸   NM_001271061
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257989   ⟸   NM_001271060
- UniProtKB: P18588 (UniProtKB/Swiss-Prot),   Q499S4 (UniProtKB/TrEMBL),   F7EXA4 (UniProtKB/TrEMBL)
- Sequence:
Dynamin-type G   GED

Name Modeler Protein Id AA Range Protein Structure
AF-P18588-F1-model_v2 AlphaFold P18588 1-652 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698092
Promoter ID:EPDNEW_R8616
Type:single initiation site
Name:Mx1_1
Description:myxovirus resistance 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01137,914,983 - 37,915,043EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-21685 BioCyc
Ensembl Genes ENSRNOG00000001959 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000039876 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
  Dynamin, middle domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7933587 IMAGE-MGC_LOAD
InterPro Dynamin_central UniProtKB/Swiss-Prot
  Dynamin_GTPase UniProtKB/Swiss-Prot
  Dynamin_GTPase_CS UniProtKB/Swiss-Prot
  Dynamin_N UniProtKB/Swiss-Prot
  Dynamin_SF UniProtKB/Swiss-Prot
  G_DYNAMIN_dom UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
  GED_dom UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
MGC_CLONE MGC:124551 IMAGE-MGC_LOAD
NCBI Gene 24575 ENTREZGENE
PANTHER INTERFERON-INDUCED GTP-BINDING PROTEIN MX1 UniProtKB/Swiss-Prot
  PTHR11566 UniProtKB/Swiss-Prot
Pfam Dynamin_M UniProtKB/Swiss-Prot
  Dynamin_N UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
PhenoGen Mx1 PhenoGen
PRINTS DYNAMIN UniProtKB/Swiss-Prot
PROSITE G_DYNAMIN_1 UniProtKB/Swiss-Prot
  G_DYNAMIN_2 UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001959 RatGTEx
SMART DYNc UniProtKB/Swiss-Prot
  GED UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
TIGR TC216795
UniProt A0A8I6A1P4_RAT UniProtKB/TrEMBL
  A0A8I6AF56_RAT UniProtKB/TrEMBL
  F7EXA4 ENTREZGENE, UniProtKB/TrEMBL
  F7FNG9_RAT UniProtKB/TrEMBL
  MX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q499S4 ENTREZGENE, UniProtKB/TrEMBL
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-18 Mx1  MX dynamin like GTPase 1  Mx1  myxovirus (influenza virus) resistance 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Mx1  myxovirus (influenza virus) resistance 1    myxovirus (influenza virus) resistance  Name updated 1299863 APPROVED
2003-04-09 Mx1  myxovirus (influenza virus) resistance    Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78)  Name updated 629478 APPROVED
2002-06-10 Mx1  Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78)      Symbol and Name status set to approved 70586 APPROVED