RGD Reference Report - Activity of rat Mx proteins against a rhabdovirus. - Rat Genome Database

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Activity of rat Mx proteins against a rhabdovirus.

Authors: Meier, E  Kunz, G  Haller, O  Arnheiter, H 
Citation: Meier E, etal., J Virol 1990 Dec;64(12):6263-9.
RGD ID: 728936
Pubmed: PMID:2173790   (View Abstract at PubMed)
PMCID: PMC248802   (View Article at PubMed Central)

Upon stimulation with alpha/beta interferon, rat cells synthesize three Mx proteins. Sequence analysis of corresponding cDNAs reveals that these three proteins are derived from three distinct genes. One of the rat cDNAs is termed Mx1 because it is most closely related to the mouse Mx1 cDNA and because it codes for a nuclear protein that, like the mouse Mx1 protein, inhibits influenza virus growth. However, this protein differs from mouse Mx1 protein, in that it also inhibits vesicular stomatitis virus (VSV), a rhabdovirus. A second rat cDNA is more closely related to the mouse Mx2 cDNA and directs the synthesis of a cytoplasmic protein that inhibits VSV but not influenza virus. The third rat cDNA codes for a cytoplasmic protein that differs from the second one in only eight positions and has no detectable activity against either virus. These results indicate that rat Mx proteins have antiviral specificities not anticipated from the analysis of the murine Mx1 protein.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Mx1Ratresponse to virus involved_inIDA PMID:2173790UniProt 
Mx2Ratresponse to virus involved_inIDA PMID:2173790UniProt 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Mx2Ratcytoplasm located_inIDA PMID:2173790UniProt 
Mx1Ratnucleus located_inIDA PMID:2173790UniProt 


Genes (Rattus norvegicus)
Mx1  (MX dynamin like GTPase 1) Mx2  (MX dynamin like GTPase 2)