Id1 (inhibitor of DNA binding 1) - Rat Genome Database

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Gene: Id1 (inhibitor of DNA binding 1) Rattus norvegicus
Analyze
Symbol: Id1
Name: inhibitor of DNA binding 1
RGD ID: 2858
Description: Enables identical protein binding activity and proteasome binding activity. Involved in several processes, including cell-abiotic substrate adhesion; negative regulation of cell differentiation; and regulation of gene expression. Located in centrosome. Used to study pulmonary hypertension. Biomarker of cholestasis. Orthologous to human ID1 (inhibitor of DNA binding 1); PARTICIPATES IN interleukin-3 signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA-binding protein inhibitor ID-1; ID125A; Idb1; inhibitor of differentiation 1; Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation); inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation); inhibitor of DNA binding 1, HLH protein; MGC156482
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,671,525 - 161,672,691 (+)NCBIGRCr8
mRatBN7.23141,210,666 - 141,212,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,211,267 - 141,212,419 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,116,210 - 145,117,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,700,048 - 153,701,175 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,439,728 - 151,440,855 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,214,623 - 148,216,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,215,540 - 148,216,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,619,728 - 154,621,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,086,162 - 143,087,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,991,791 - 142,992,906 (+)NCBI
Celera3139,960,608 - 139,961,735 (+)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Id1Ratcholestasis  IEP 9686088protein:increased expression:liver and nucleus (rat)RGD 
Id1Ratglaucoma  ISOID1 (Homo sapiens)155630605mRNA:increased expression:optic nerve head (human)RGD 
Id1Ratprimary pulmonary hypertension  ISOID1 (Homo sapiens)9686087protein:decreased expression:lung and wall of arteriole (human)RGD 
Id1Ratpulmonary hypertension  IDA 9686087 RGD 
Id1RatSpinal Cord Injuries  IEP 9686138mRNA:increased expression:spinal cord (rat)RGD 
Object Symbol
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Original Reference(s)
Id1Ratdisease of cellular proliferation  ISOID1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16966095
Id1RatExperimental Diabetes Mellitus  ISOID1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16123366
Id1RatExperimental Mammary Neoplasms  ISOID1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21283680
Id1RatMyocardial Ischemia  ISOID1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
Id1RatNeoplasm Metastasis  ISOID1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:24910342
Id1Rattype 2 diabetes mellitus  ISOID1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16123366

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Original Reference(s)
Id1Rat(1->4)-beta-D-glucan multiple interactionsISOId1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ID1 mRNACTDPMID:36331819
Id1Rat(R)-pantothenic acid increases expressionISOID1 (Homo sapiens)6480464Pantothenic Acid results in increased expression of ID1 mRNACTDPMID:19397697
Id1Rat(S)-nicotine decreases expressionISOId1 (Mus musculus)6480464Nicotine results in decreased expression of ID1 mRNACTDPMID:17997037
Id1Rat1,4-dioxane increases expressionISOId1 (Mus musculus)64804641 and 4-dioxane results in increased expression of ID1 mRNACTDPMID:33693819
Id1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of ID1 mRNACTDPMID:20551477
Id1Rat17alpha-ethynylestradiol affects expressionISOId1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of ID1 mRNACTDPMID:17555576
Id1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of ID1 mRNACTDPMID:12655037 more ...
Id1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ID1 mRNACTDPMID:16174780
Id1Rat17alpha-ethynylestradiol increases expressionISOId1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ID1 mRNACTDPMID:16174780 and PMID:17942748
Id1Rat17alpha-ethynylestradiol multiple interactionsISOId1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ID1 mRNACTDPMID:17942748
Id1Rat17beta-estradiol multiple interactionsISOID1 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ID1 mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of ID1 mRNACTDPMID:19619570 and PMID:30165855
Id1Rat17beta-estradiol decreases expressionISOId1 (Mus musculus)6480464Estradiol results in decreased expression of ID1 mRNACTDPMID:39298647
Id1Rat17beta-estradiol multiple interactionsISOId1 (Mus musculus)6480464fulvestrant inhibits the reaction [Estradiol results in increased expression of ID1 mRNA]CTDPMID:20031206
Id1Rat17beta-estradiol increases expressionISOId1 (Mus musculus)6480464Estradiol results in increased expression of ID1 mRNACTDPMID:20031206
Id1Rat17beta-estradiol decreases expressionISOID1 (Homo sapiens)6480464Estradiol results in decreased expression of ID1 mRNACTDPMID:23019147
Id1Rat17beta-estradiol multiple interactionsEXP 6480464[Estradiol co-treated with Testosterone] results in increased expression of ID1 mRNA and [Estradiol co-treated with Testosterone] results in increased expression of ID1 proteinCTDPMID:11375906
Id1Rat17beta-estradiol affects expressionISOId1 (Mus musculus)6480464Estradiol affects the expression of ID1 mRNACTDPMID:15598610
Id1Rat17beta-estradiol increases expressionISOID1 (Homo sapiens)6480464Estradiol results in increased expression of ID1 mRNACTDPMID:19619570
Id1Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOID1 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of ID1 mRNACTDPMID:16541417
Id1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOId1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ID1 mRNACTDPMID:21570461 more ...

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Biological Process
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Original Reference(s)
Id1Ratapoptotic process acts_upstream_ofIEAUniProtKB:P20067 and ensembl:ENSMUSP000000920191600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Ratapoptotic process acts_upstream_ofISOId1 (Mus musculus)1624291MGI:2679939 PMID:17717145RGDPMID:17717145
Id1RatBMP signaling pathway acts_upstream_of_or_withinISOId1 (Mus musculus)1624291 PMID:15820682RGDPMID:15820682
Id1RatBMP signaling pathway acts_upstream_of_or_withinIEAUniProtKB:P20067 and ensembl:ENSMUSP000000920191600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Ratcell differentiation involved_inIEAARBA:ARBA000274291600115GO_REF:0000117UniProtGO_REF:0000117
Id1Ratcell-abiotic substrate adhesion  IEP 9686083 RGD 
Id1Ratcellular response to dopamine  IEP 9686120 RGD 
Id1Ratcellular response to epidermal growth factor stimulus  IEP 9686118 RGD 
Id1Ratcellular response to nerve growth factor stimulus  IEP 9686118 RGD 
Id1Ratcellular response to peptide  IEP 9686121beta-endorphinRGD 
Id1Ratcellular response to transforming growth factor beta stimulus  IEP 9686088 RGD 
Id1Ratcircadian rhythm involved_inISOId1 (Mus musculus)1624291 PMID:19217292RGDPMID:19217292
Id1Ratcircadian rhythm involved_inIEAUniProtKB:P20067 and ensembl:ENSMUSP000000920191600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Ratcollagen metabolic process acts_upstream_of_or_withinIEAUniProtKB:P20067 and ensembl:ENSMUSP000000920191600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Ratcollagen metabolic process acts_upstream_of_or_withinISOId1 (Mus musculus)1624291MGI:2679939 PMID:17717145RGDPMID:17717145
Id1Ratendothelial cell apoptotic process acts_upstream_ofIEAUniProtKB:P20067 and ensembl:ENSMUSP000000920191600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Ratendothelial cell apoptotic process acts_upstream_ofISOId1 (Mus musculus)1624291MGI:2679939 PMID:17717145RGDPMID:17717145
Id1Ratendothelial cell morphogenesis acts_upstream_of_or_withinISOId1 (Mus musculus)1624291MGI:2679939 PMID:17717145RGDPMID:17717145
Id1Ratendothelial cell morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P20067 and ensembl:ENSMUSP000000920191600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Ratheart development acts_upstream_of_or_withinISOId1 (Mus musculus)1624291MGI:96397 more ...RGDPMID:15472070
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Cellular Component
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Original Reference(s)
Id1Ratcentrosome  IDA 2306262 RGD 
Id1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Id1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Id1Ratcytoplasm located_inIEAUniProtKB:P20067 and ensembl:ENSMUSP000000920191600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Ratcytoplasm located_inIEAInterPro:IPR0260521600115GO_REF:0000002InterProGO_REF:0000002
Id1Ratcytoplasm located_inISOId1 (Mus musculus)1624291 PMID:15322112 and PMID:9418957RGDPMID:15322112 and PMID:9418957
Id1Ratnucleoplasm located_inIEAUniProtKB:P41134 and ensembl:ENSP000003652801600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Ratnucleoplasm located_inISOID1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Id1Ratnucleus is_active_inIBAFB:FBgn0000575 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Id1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Id1Ratnucleus located_inISOId1 (Mus musculus)1624291 PMID:15322112 more ...RGDPMID:15322112 more ...
Id1Ratnucleus located_inIEAUniProtKB:P20067 and ensembl:ENSMUSP000000920191600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Id1Ratidentical protein binding  IPIId1 (Rattus norvegicus)729290homodimerizationRGD 
Id1Ratproteasome binding  IPIPsmd4 (Rattus norvegicus)9686139 RGD 
Id1Ratprotein binding  IDA 729290 RGD 
Id1Ratprotein binding enablesISOId1 (Mus musculus)1624291PR:P15806 more ...RGDPMID:11591653 more ...
Id1Ratprotein binding enablesISOID1 (Homo sapiens)1624291UniProtKB:A6NI15 more ...RGDPMID:15694377 more ...
Id1Ratprotein binding  IPICdc20 (Rattus norvegicus)2306262 RGD 
Id1Ratprotein binding  IPIPsmd4 (Mus musculus)9686139 RGD 
Id1Ratprotein dimerization activity enablesIEAInterPro:IPR011598 and InterPro:IPR0366381600115GO_REF:0000002InterProGO_REF:0000002
Id1Rattranscription corepressor activity enablesIBAFB:FBgn0000575 and PANTHER:PTN0009195481600115GO_REF:0000033GO_CentralGO_REF:0000033
Id1Rattranscription factor binding  IPIMyod1 (Mus musculus)729290 RGD 
Id1Rattranscription factor binding  IPITcf3 (Rattus norvegicus)9686118 RGD 
Id1Rattranscription regulator inhibitor activity enablesIEAUniProtKB:P41134 and ensembl:ENSP000003652801600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Rattranscription regulator inhibitor activity enablesIEAUniProtKB:P20067 and ensembl:ENSMUSP000000920191600115GO_REF:0000107EnsemblGO_REF:0000107
Id1Rattranscription regulator inhibitor activity enablesISOId1 (Mus musculus)1624291 PMID:17681138RGDPMID:17681138
Id1Rattranscription regulator inhibitor activity enablesISOID1 (Homo sapiens)1624291 PMID:7665172RGDPMID:7665172
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Imported Annotations - KEGG (archival)

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Original Reference(s)
Id1Rattransforming growth factor-beta superfamily mediated signaling pathway  IEA 6907045 KEGGrno:04350

Imported Annotations - PID (archival)

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Original Reference(s)
Id1Ratinterleukin-3 signaling pathway  ISOID1 (Homo sapiens)6484113 PIDPID:200145

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#
Reference Title
Reference Citation
1. Regeneration of three layers vascular wall by using BMP2-treated MSC involving HIF-1alpha and Id1 expressions through JAK/STAT pathways. Belmokhtar K, etal., Stem Cell Rev. 2011 Nov;7(4):847-59. doi: 10.1007/s12015-011-9254-6.
2. TGF-beta repression of Id2 induces apoptosis in gut epithelial cells. Cao Y, etal., Oncogene. 2009 Feb 26;28(8):1089-98. doi: 10.1038/onc.2008.456. Epub 2009 Jan 12.
3. Bone morphogenetic protein 4, inhibitor of differentiation 1, and epidermal growth factor receptor regulate the survival of cochlear sensory epithelial cells. Chen J, etal., J Neurosci Res. 2013 Apr;91(4):515-26. doi: 10.1002/jnr.23175. Epub 2013 Jan 18.
4. Regulation of Id1 and its association with basic helix-loop-helix proteins during nerve growth factor-induced differentiation of PC12 cells. Einarson MB and Chao MV, Mol Cell Biol. 1995 Aug;15(8):4175-83.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons. Kim AH, etal., Cell. 2009 Jan 23;136(2):322-36.
8. Id1, Id2 and Id3 are induced in rat melanotrophs of the pituitary gland by dopamine suppression under continuous stress. Konishi H, etal., Neuroscience. 2010 Sep 15;169(4):1527-34. doi: 10.1016/j.neuroscience.2010.06.030. Epub 2010 Jun 20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Activation of helix-loop-helix proteins Id1, Id2 and Id3 during neural differentiation. Nagata Y and Todokoro K, Biochem Biophys Res Commun 1994 Mar 30;199(3):1355-62.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning. Patil M, etal., Diabetes. 2017 Jun;66(6):1611-1625. doi: 10.2337/db16-1079. Epub 2017 Mar 7.
13. Requirement for Id1 in opioid-induced oligodendrogenesis in cultured adult rat hippocampal progenitors. Persson AI, etal., Eur J Neurosci. 2006 May;23(9):2277-88.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. The ubiquitin receptor S5a/Rpn10 links centrosomal proteasomes with dendrite development in the mammalian brain. Puram SV, etal., Cell Rep. 2013 Jul 11;4(1):19-30. doi: 10.1016/j.celrep.2013.06.006. Epub 2013 Jul 3.
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
19. FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. Spiekerkoetter E, etal., J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15.
20. Transcriptional regulation in cardiac muscle. Coordinate expression of Id with a neonatal phenotype during development and following a hypertrophic stimulus in adult rat ventricular myocytes in vitro. Springhorn JP, etal., J Biol Chem 1992 Jul 15;267(20):14360-5.
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PMID:1922066   PMID:7864897   PMID:8889548   PMID:9013644   PMID:9418957   PMID:12477932   PMID:12495223   PMID:12498716   PMID:15138269   PMID:15161906   PMID:15322112   PMID:15361847  
PMID:15472070   PMID:15564458   PMID:15647457   PMID:15809768   PMID:15820682   PMID:16304207   PMID:16638616   PMID:16728343   PMID:17149750   PMID:17681138   PMID:17717145   PMID:19217292  
PMID:19796622   PMID:20231428   PMID:22139302   PMID:25010525   PMID:25502463   PMID:27127787   PMID:29721855  



Id1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,671,525 - 161,672,691 (+)NCBIGRCr8
mRatBN7.23141,210,666 - 141,212,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,211,267 - 141,212,419 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,116,210 - 145,117,337 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,700,048 - 153,701,175 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,439,728 - 151,440,855 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,214,623 - 148,216,715 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,215,540 - 148,216,718 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,619,728 - 154,621,190 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,086,162 - 143,087,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13142,991,791 - 142,992,906 (+)NCBI
Celera3139,960,608 - 139,961,735 (+)NCBICelera
Cytogenetic Map3q41NCBI
ID1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,605,289 - 31,606,510 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,573,014 - 31,606,515 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,193,092 - 30,194,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,656,753 - 29,657,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 342029,656,752 - 29,657,974NCBI
Celera2026,949,273 - 26,950,494 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2026,981,781 - 26,983,013 (+)NCBIHuRef
CHM1_12030,096,962 - 30,098,194 (+)NCBICHM1_1
T2T-CHM13v2.02033,329,528 - 33,330,749 (+)NCBIT2T-CHM13v2.0
Id1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,578,171 - 152,579,330 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,578,171 - 152,579,330 (+)EnsemblGRCm39 Ensembl
GRCm382152,736,251 - 152,737,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,736,251 - 152,737,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,562,010 - 152,563,146 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,427,715 - 152,428,851 (+)NCBIMGSCv36mm8
Celera2158,552,315 - 158,553,451 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Id1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,337,757 - 29,339,178 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,337,969 - 29,339,178 (-)NCBIChiLan1.0ChiLan1.0
ID1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,296,445 - 37,299,392 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,290,399 - 37,292,483 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02027,895,177 - 27,896,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12028,535,470 - 28,536,726 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2028,535,582 - 28,536,311 (+)Ensemblpanpan1.1panPan2
ID1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,094,339 - 21,096,276 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,094,755 - 21,096,276 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,741,568 - 20,743,501 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,780,949 - 21,782,885 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,781,704 - 21,782,885 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,059,018 - 21,060,951 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,163,982 - 21,165,918 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,594,218 - 21,596,151 (+)NCBIUU_Cfam_GSD_1.0
Id1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,179,346 - 170,180,525 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648518,610,665 - 18,612,059 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648518,610,721 - 18,611,889 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ID1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,316,514 - 35,317,736 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,316,518 - 35,317,742 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,187,160 - 40,188,384 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247994
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,008,660 - 36,009,880 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,008,636 - 36,010,017 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,944,637 - 90,945,863 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Id1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741896,932 - 898,343 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741897,038 - 898,249 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Id1
8 total Variants

Predicted Target Of
Summary Value
Count of predictions:391
Count of miRNA genes:230
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000029660
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 32 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat

1 to 10 of 32 rows
PMC156147P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,531 - 141,211,611 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,827 - 148,215,906NCBIRnor6.0
Rnor_5.03154,620,302 - 154,620,381UniSTSRnor5.0
RGSC_v3.43143,086,401 - 143,086,480UniSTSRGSC3.4
Celera3139,960,847 - 139,960,926UniSTS
Cytogenetic Map3q41UniSTS
PMC305683P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,352 - 141,212,020 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,648 - 148,216,315NCBIRnor6.0
Rnor_5.03154,620,123 - 154,620,790UniSTSRnor5.0
RGSC_v3.43143,086,222 - 143,086,889UniSTSRGSC3.4
Celera3139,960,668 - 139,961,335UniSTS
Cytogenetic Map3q41UniSTS
PMC133998P5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,352 - 141,212,020 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,648 - 148,216,315NCBIRnor6.0
Rnor_5.03154,620,123 - 154,620,790UniSTSRnor5.0
RGSC_v3.43143,086,222 - 143,086,889UniSTSRGSC3.4
Celera3139,960,668 - 139,961,335UniSTS
Cytogenetic Map3q41UniSTS
PMC145454P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,592 - 141,211,668 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,888 - 148,215,963NCBIRnor6.0
Rnor_5.03154,620,363 - 154,620,438UniSTSRnor5.0
RGSC_v3.43143,086,462 - 143,086,537UniSTSRGSC3.4
Celera3139,960,908 - 139,960,983UniSTS
Cytogenetic Map3q41UniSTS
PMC33181P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23141,211,344 - 141,212,059 (+)MAPPERmRatBN7.2
Rnor_6.03148,215,640 - 148,216,354NCBIRnor6.0
Rnor_5.03154,620,115 - 154,620,829UniSTSRnor5.0
RGSC_v3.43143,086,214 - 143,086,928UniSTSRGSC3.4
Celera3139,960,660 - 139,961,374UniSTS
Cytogenetic Map3q41UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000029660   ⟹   ENSRNOP00000052261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3141,211,267 - 141,212,419 (+)Ensembl
Rnor_6.0 Ensembl3148,215,540 - 148,216,718 (+)Ensembl
RefSeq Acc Id: NM_012797   ⟹   NP_036929
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,671,564 - 161,672,691 (+)NCBI
mRatBN7.23141,211,293 - 141,212,420 (+)NCBI
Rnor_6.03148,215,588 - 148,216,715 (+)NCBI
Rnor_5.03154,619,728 - 154,621,190 (+)NCBI
RGSC_v3.43143,086,162 - 143,087,289 (+)RGD
Celera3139,960,608 - 139,961,735 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235267   ⟹   XP_006235329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,671,525 - 161,672,688 (+)NCBI
mRatBN7.23141,210,666 - 141,212,417 (+)NCBI
Rnor_6.03148,214,623 - 148,216,712 (+)NCBI
Rnor_5.03154,619,728 - 154,621,190 (+)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_036929 (Get FASTA)   NCBI Sequence Viewer  
  XP_006235329 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20403 (Get FASTA)   NCBI Sequence Viewer  
  AAA41090 (Get FASTA)   NCBI Sequence Viewer  
  AAI27449 (Get FASTA)   NCBI Sequence Viewer  
  BAA01633 (Get FASTA)   NCBI Sequence Viewer  
  EDL86049 (Get FASTA)   NCBI Sequence Viewer  
  EDL86050 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052261
GenBank Protein P41135 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_036929   ⟸   NM_012797
- UniProtKB: P41135 (UniProtKB/Swiss-Prot),   A0JPJ2 (UniProtKB/TrEMBL),   A6KHQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235329   ⟸   XM_006235267
- Peptide Label: isoform X1
- UniProtKB: P41135 (UniProtKB/Swiss-Prot),   A0A8L2QPI3 (UniProtKB/TrEMBL),   A6KHQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052261   ⟸   ENSRNOT00000029660
bHLH

Name Modeler Protein Id AA Range Protein Structure
AF-P41135-F1-model_v2 AlphaFold P41135 1-164 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692549
Promoter ID:EPDNEW_R3073
Type:single initiation site
Name:Id1_1
Description:inhibitor of DNA binding 1, HLH protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03148,215,562 - 148,215,622EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-47250 BioCyc
Ensembl Genes ENSRNOG00000021750 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000029660 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:8372348 IMAGE-MGC_LOAD
InterPro bHLH_dom UniProtKB/Swiss-Prot
  DNA-bd_prot-inh UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:25261 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156482 IMAGE-MGC_LOAD
NCBI Gene 25261 ENTREZGENE
PANTHER DNA-BINDING PROTEIN INHIBITOR ID-1 UniProtKB/Swiss-Prot
  PTHR11723 UniProtKB/Swiss-Prot
Pfam HLH UniProtKB/Swiss-Prot
PhenoGen Id1 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021750 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
TIGR TC204468
UniProt A0A8L2QPI3 ENTREZGENE, UniProtKB/TrEMBL
  A0JPJ2 ENTREZGENE, UniProtKB/TrEMBL
  A6KHQ6 ENTREZGENE, UniProtKB/TrEMBL
  ID1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-13 Id1  inhibitor of DNA binding 1  Id1  inhibitor of DNA binding 1, HLH protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-15 Id1  inhibitor of DNA binding 1, HLH protein  Id1  inhibitor of DNA binding 1, dominant negative helix-loop-helix protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Id1  inhibitor of DNA binding 1, dominant negative helix-loop-helix protein  Id1  inhibitor of DNA binding 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Id1  inhibitor of DNA binding 1    Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)  Name updated 1299863 APPROVED
2002-06-10 Id1  Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_process may be involved in control of cardiac muscle cell phenotype 727553
gene_process may be involved in the early stage of neural differentiation 729182