Ppial4d (peptidylprolyl isomerase A (cyclophilin A)-like 4D) - Rat Genome Database

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Gene: Ppial4d (peptidylprolyl isomerase A (cyclophilin A)-like 4D) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ppial4d
Name: peptidylprolyl isomerase A (cyclophilin A)-like 4D
RGD ID: 2321083
Description: Predicted to enable heparan sulfate binding activity; integrin binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in several processes, including cell adhesion molecule production; regulation of intracellular signal transduction; and regulation of protein modification process. Predicted to be located in cytosol; extracellular region; and nucleus. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100360977; peptidyl-prolyl cis-trans isomerase A; TRIMCyp-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,361,379 - 21,362,147 (+)NCBIGRCr8
mRatBN7.21421,006,522 - 21,007,284 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,006,538 - 21,007,310 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01422,706,906 - 22,707,648 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1422,706,901 - 22,707,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01422,609,711 - 22,610,447 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41422,612,891 - 22,613,385 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic Map14p21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppial4dRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PPIAL4D mRNACTDPMID:32109520
Ppial4dRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Ppial4dRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of PPIAL4D mRNACTDPMID:36843608
Ppial4dRatparaquat increases expressionEXP 6480464Paraquat results in increased expression of PPIAL4D mRNACTDPMID:32680482


Biological Process
1 to 20 of 22 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppial4dRatactivation of protein kinase B activity involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatapoptotic process involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatcell adhesion molecule production involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatcellular response to oxidative stress involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatendothelial cell activation involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatleukocyte chemotaxis involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatnegative regulation of protein K48-linked ubiquitination involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatnegative regulation of protein kinase activity involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatnegative regulation of protein phosphorylation involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatnegative regulation of stress-activated MAPK cascade involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatneutrophil chemotaxis involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatplatelet activation involved_inISSUniProtKB:P177421600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatplatelet aggregation involved_inISSUniProtKB:P177421600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatpositive regulation of MAPK cascade involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatpositive regulation of NF-kappaB transcription factor activity involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatpositive regulation of protein phosphorylation involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatprotein folding involved_inIBAPANTHER:PTN008511653 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppial4dRatprotein peptidyl-prolyl isomerization involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatregulation of apoptotic signaling pathway involved_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
1 to 20 of 22 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppial4dRatcytoplasm located_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatcytoplasm is_active_inIBAFB:FBgn0002936 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppial4dRatcytosol located_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatextracellular region located_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatnucleus located_inISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppial4dRatcyclosporin A binding enablesIBAFB:FBgn0002936 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppial4dRatheparan sulfate binding enablesISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatintegrin binding enablesISSUniProtKB:P177421600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatpeptidyl-prolyl cis-trans isomerase activity enablesISSUniProtKB:P629371600115GO_REF:0000024UniProtGO_REF:0000024
Ppial4dRatpeptidyl-prolyl cis-trans isomerase activity enablesIBACGD:CAL0000183095 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppial4dRatRNA polymerase II CTD heptapeptide repeat P3 isomerase activity enablesIEAEC:5.2.1.81600115GO_REF:0000003UniProtGO_REF:0000003
Ppial4dRatRNA polymerase II CTD heptapeptide repeat P6 isomerase activity enablesIEAEC:5.2.1.81600115GO_REF:0000003UniProtGO_REF:0000003


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Ppial4d
20 total Variants

1 to 10 of 20 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat

1 to 10 of 20 rows
UniSTS:265677  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21421,006,765 - 21,007,058 (+)MAPPERmRatBN7.2
mRatBN7.2441,829,100 - 41,829,392 (+)MAPPERmRatBN7.2
Rnor_6.01422,707,130 - 22,707,422NCBIRnor6.0
Rnor_5.01422,609,939 - 22,610,231UniSTSRnor5.0
RGSC_v3.41422,613,076 - 22,613,368UniSTSRGSC3.4
Cytogenetic Map14q21UniSTS
Ppia  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21421,006,634 - 21,006,784 (+)MAPPERmRatBN7.2
Rnor_6.01422,706,999 - 22,707,148NCBIRnor6.0
Rnor_5.01422,609,808 - 22,609,957UniSTSRnor5.0
Cytogenetic Map14q21UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 12 62 68 60 36 12 36 12 116 48 38 20 38 24


RefSeq Transcripts XM_006250801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000088798   ⟹   ENSRNOP00000071404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1422,706,901 - 22,707,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106407   ⟹   ENSRNOP00000089529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1421,006,538 - 21,007,310 (+)Ensembl
RefSeq Acc Id: XM_006250801   ⟹   XP_006250863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,361,379 - 21,362,147 (+)NCBI
mRatBN7.21421,006,522 - 21,007,284 (+)NCBI
Rnor_6.01422,706,906 - 22,707,648 (+)NCBI
Rnor_5.01422,609,711 - 22,610,447 (+)NCBI
Sequence:
Protein RefSeqs XP_006250863 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000089529.1
RefSeq Acc Id: XP_006250863   ⟸   XM_006250801
- UniProtKB: P18303 (UniProtKB/Swiss-Prot),   Q5BK98 (UniProtKB/Swiss-Prot),   P10111 (UniProtKB/Swiss-Prot),   A6IKU0 (UniProtKB/TrEMBL),   A6IKT9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071404   ⟸   ENSRNOT00000088798
Ensembl Acc Id: ENSRNOP00000089529   ⟸   ENSRNOT00000106407
PPIase cyclophilin-type

Name Modeler Protein Id AA Range Protein Structure
AF-P10111-F1-model_v2 AlphaFold P10111 1-164 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699264
Promoter ID:EPDNEW_R9781
Type:single initiation site
Name:Ppial4d_1
Description:peptidylprolyl isomerase A -like 4D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01422,706,901 - 22,706,961EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-16096 BioCyc
Ensembl Genes ENSRNOG00000055068 Ensembl
  ENSRNOG00000068764 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000106407.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyclophilin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclophilin-type_PPIase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:100360977 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  rno:25518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 100360977 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pro_isomerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppial4d PhenoGen
PIRSF Peptidylpro_ismrse UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CSAPPISMRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CSA_PPIASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CSA_PPIASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055068 RatGTEx
  ENSRNOG00000068764 RatGTEx
Superfamily-SCOP Cyclophilin-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6IKT9 ENTREZGENE, UniProtKB/TrEMBL
  A6IKU0 ENTREZGENE, UniProtKB/TrEMBL
  P10111 ENTREZGENE
  P18303 ENTREZGENE
  PPIA_RAT UniProtKB/Swiss-Prot
  Q5BK98 ENTREZGENE
UniProt Secondary P18303 UniProtKB/Swiss-Prot
  Q5BK98 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Ppial4d  peptidylprolyl isomerase A (cyclophilin A)-like 4D  Ppial4d  peptidylprolyl isomerase A (cyclophilin A)-like 4D  Data merged from RGD:149736382 737654 PROVISIONAL
2021-08-09 Ppial4d  peptidylprolyl isomerase A (cyclophilin A)-like 4D      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-06-09 Ppial4d  peptidylprolyl isomerase A (cyclophilin A)-like 4D  LOC100360977  TRIMCyp-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100360977  TRIMCyp-like      Symbol and Name status set to provisional 70820 PROVISIONAL